| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hanna M Molla, Anabel M M Miguelez Fernández, Kuei Y Tsen. Late-adolescent onset of prefrontal endocannabinoid control of hippocampal and amygdalar inputs and its impact on trace-fear conditioning behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-03-12. PMID:38467844. |
prefrontal cortex (pfc) maturation during adolescence is characterized by structural and functional changes, which involve the remodeling of gaba and glutamatergic synapses, as well as changes in the endocannabinoid system. |
2024-03-12 |
2024-03-14 |
rat |
| Hanna M Molla, Anabel M M Miguelez Fernández, Kuei Y Tsen. Late-adolescent onset of prefrontal endocannabinoid control of hippocampal and amygdalar inputs and its impact on trace-fear conditioning behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-03-12. PMID:38467844. |
yet, the way pfc endocannabinoid signaling interacts with local gaba and glutamatergic function to impact its processing of afferent transmission during the adolescent transition to adulthood remains unknown. |
2024-03-12 |
2024-03-14 |
rat |
| George Ntoulas, Charalampos Brakatselos, Gerasimos Nakas, Michail-Zois Asprogerakas, Foteini Delis, Leonidas J Leontiadis, George Trompoukis, Costas Papatheodoropoulos, Dimitrios Gkikas, Dimitrios Valakos, Giannis Vatsellas, Panagiotis K Politis, Alexia Polissidis, Katerina Antonio. Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic function. Translational psychiatry. vol 14. issue 1. 2024-02-20. PMID:38378836. |
we found that these rats exhibit hyperactivity and cognitive deficits, along with characteristic bidirectional glutamatergic and gabaergic alterations in the prefrontal cortex and the hippocampus. |
2024-02-20 |
2024-02-23 |
mouse |
| Sebastian A Pace, Ema Lukinic, Tyler Wallace, Carlie McCartney, Brent Myer. Cortical-brainstem circuitry attenuates physiological stress reactivity. The Journal of physiology. 2024-02-14. PMID:38353989. |
key points: glutamatergic efferents from the ventromedial prefrontal cortex target catecholaminergic neurons throughout the ventrolateral medulla. |
2024-02-14 |
2024-02-16 |
rat |
| Yu-Jie Su, Pei-Lu Yi, Fang-Chia Chan. Transcranial Direct Current Stimulation (tDCS) Ameliorates Stress-Induced Sleep Disruption via Activating Infralimbic-Ventrolateral Preoptic Projections. Brain sciences. vol 14. issue 1. 2024-01-26. PMID:38275525. |
we hypothesized that anodal prefrontal cortex stimulation activates glutamatergic projections from the infralimbic cortex (il) to the ventrolateral preoptic area (vlpo) to promote sleep. |
2024-01-26 |
2024-01-28 |
mouse |
| Maya O Nesbit, Soyon Ahn, Haiyan Zou, Stan B Floresco, Anthony G Phillip. Potentiation of prefrontal cortex dopamine function by the novel cognitive enhancer d-govadine. Neuropharmacology. 2024-01-20. PMID:38244888. |
we hypothesize that d-gov acts in the mpfc to engage the mesocortical feedback loop through which prefrontal glutamatergic projections activate a population of vta da neurons that specifically project back to the pfc. |
2024-01-20 |
2024-01-23 |
rat |
| Mahum T Siddiqi, Dhruba Podder, Amanda R Pahng, Alexandria C Athanason, Tali Nadav, Chelsea Cates-Gatto, Max Kreifeldt, Candice Contet, Amanda J Roberts, Scott Edwards, Marisa Roberto, Florence P Varodaya. Prefrontal cortex glutamatergic adaptations in a mouse model of alcohol use disorder. Addiction neuroscience. vol 9. 2023-12-28. PMID:38152067. |
prefrontal cortex glutamatergic adaptations in a mouse model of alcohol use disorder. |
2023-12-28 |
2023-12-30 |
mouse |
| Eugenia Vivi, Lea R Seeholzer, Anastasiia Nagumanova, Barbara Di Benedett. Early Age- and Sex-Dependent Regulation of Astrocyte-Mediated Glutamatergic Synapse Elimination in the Rat Prefrontal Cortex: Establishing an Organotypic Brain Slice Culture Investigating Tool. Cells. vol 12. issue 23. 2023-12-09. PMID:38067189. |
early age- and sex-dependent regulation of astrocyte-mediated glutamatergic synapse elimination in the rat prefrontal cortex: establishing an organotypic brain slice culture investigating tool. |
2023-12-09 |
2023-12-17 |
rat |
| Roxana E Mesías, Yosif Zaki, Christopher A Guevara, Lauren G Friedman, Ayan Hussein, Karen Therrien, Alexandra R Magee, Nikolaos Tzavaras, Pamela Del Valle, Mark G Baxter, George W Huntley, Deanna L Benso. Development and cadherin-mediated control of prefrontal corticostriatal projections in mice. iScience. vol 26. issue 10. 2023-10-20. PMID:37854688. |
mutant mice showed diminished pfc axon targeting and reduced spontaneous glutamatergic synaptic activity in the dorsal striatum. |
2023-10-20 |
2023-11-08 |
mouse |
| Aurore Thomazeau, Olivier Lassalle, Olivier J Manzon. Glutamatergic synaptic deficits in the prefrontal cortex of the Ts65Dn mouse model for Down syndrome. Frontiers in neuroscience. vol 17. 2023-10-16. PMID:37841687. |
glutamatergic synaptic deficits in the prefrontal cortex of the ts65dn mouse model for down syndrome. |
2023-10-16 |
2023-11-08 |
mouse |
| Seyedeh Leila Mousavi, Ameneh Rezayof, Sakineh Alijanpour, Ladan Delphi, Oveis Hosseinzadeh Sahaf. Activation of mediodorsal thalamic dopamine receptors inhibited nicotine-induced anxiety in rats: A possible role of corticolimbic NMDA neurotransmission and BDNF expression. Pharmacology, biochemistry, and behavior. 2023-10-01. PMID:37778541. |
the present study aimed to evaluate the functional interaction between the dopaminergic and glutamatergic systems of the mediodorsal thalamus (md), the ventral hippocampus (vh), and the prefrontal cortex (pfc) in nicotine-induced anxiogenic-like behaviors. |
2023-10-01 |
2023-10-07 |
rat |
| Seyedeh Leila Mousavi, Ameneh Rezayof, Sakineh Alijanpour, Ladan Delphi, Oveis Hosseinzadeh Sahaf. Activation of mediodorsal thalamic dopamine receptors inhibited nicotine-induced anxiety in rats: A possible role of corticolimbic NMDA neurotransmission and BDNF expression. Pharmacology, biochemistry, and behavior. 2023-10-01. PMID:37778541. |
these findings suggest that the functional interaction between the md dopaminergic d1/d2-like and the vh/pfc glutamatergic nmda receptors may be partially involved in the anxiogenic-like effects of nicotine, likely via the alteration of bdnf levels in the hippocampus and the pfc. |
2023-10-01 |
2023-10-07 |
rat |
| Kouji Fukuyama, Eishi Motomura, Motohiro Okad. A Novel Gliotransmitter, L-β-Aminoisobutyric Acid, Contributes to Pathophysiology of Clinical Efficacies and Adverse Reactions of Clozapine. Biomolecules. vol 13. issue 9. 2023-09-28. PMID:37759688. |
considering the expressions of gaba-b and iii-mglu receptors (localised in the presynaptic regions), the activation of gaba-b and iii-mglu receptors can explain the distinct therapeutic advantages of clozapine in schizophrenia or trs associated with n-methyl-d-aspartate (nmda) receptor disturbance compared with other atypical antipsychotics via the inhibition of the persistent tonic hyperactivation of thalamocortical glutamatergic transmission in the prefrontal cortex. |
2023-09-28 |
2023-10-07 |
Not clear |
| Zohreh Farsi, Ally Nicolella, Sean K Simmons, Sameer Aryal, Nate Shepard, Kira Brenner, Sherry Lin, Linnea Herzog, Sean P Moran, Katherine J Stalnaker, Wangyong Shin, Vahid Gazestani, Bryan J Song, Kevin Bonanno, Hasmik Keshishian, Steven A Carr, Jen Q Pan, Evan Z Macosko, Sandeep Robert Datta, Borislav Dejanovic, Eunjoon Kim, Joshua Z Levin, Morgan Shen. Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice. Neuron. 2023-09-01. PMID:37657442. |
by transcriptomic, proteomic, and behavioral analyses, we report that heterozygous grin2a mutant mice show (1) large-scale gene expression changes across multiple brain regions and in neuronal (excitatory and inhibitory) and non-neuronal cells (astrocytes and oligodendrocytes), (2) evidence of hypoactivity in the prefrontal cortex (pfc) and hyperactivity in the hippocampus and striatum, (3) an elevated dopamine signaling in the striatum and hypersensitivity to amphetamine-induced hyperlocomotion (aih), (4) altered cholesterol biosynthesis in astrocytes, (5) a reduction in glutamatergic receptor signaling proteins in the synapse, and (6) an aberrant locomotor pattern opposite of that induced by antipsychotic drugs. |
2023-09-01 |
2023-09-07 |
mouse |
| Xinjuan Wang, Xueyu Hou, Yu Huo, Di Wang, Xiang Fan, Xiaorui Lin, Weidong Yu, Cailian Cui, Jingzhu Guo, Yijing L. Phosphorylated Ser187-SNAP25-modulated hyperfunction of glutamatergic system in the vmPFC mediates depressive-like behaviors in male mice. Neuropharmacology. 2023-08-25. PMID:37625690. |
here, we employed chronic unpredictable mild stress (cums) to induce depression-like behavior in male mice and to assess the alterations of glutamatergic system within the ventromedial prefrontal cortex (vmpfc). |
2023-08-25 |
2023-09-07 |
mouse |
| Jing Sun, Qijie Cong, Tingkai Sun, Siyu Xi, Yunxi Liu, Rongsen Zeng, Jia Wang, Weining Zhang, Jing Gao, Jinjun Qian, Shengying Qi. Prefrontal cortex-specific Dcc deletion induces schizophrenia-related behavioral phenotypes and fail to be rescued by olanzapine treatment. European journal of pharmacology. 2023-08-04. PMID:37541362. |
knockdown of dcc in prefrontal cortex results in glutamatergic dysfunction, including defects in glutamine synthetase and postsynaptic maturation. |
2023-08-04 |
2023-08-14 |
mouse |
| Yu-Ting Hu, Zhong-Lin Tan, Dusan Hirjak, Georg Northof. Brain-wide changes in excitation-inhibition balance of major depressive disorder: a systematic review of topographic patterns of GABA- and glutamatergic alterations. Molecular psychiatry. 2023-07-26. PMID:37495889. |
we found: i) brain-wide gaba- and glutamatergic alterations; ii) attenuated gabaergic with enhanced glutamatergic signaling in the cortical-subcortical limbic system; iii) that gabaergic signaling is decreased in regions comprising the default mode network (dmn) while it is increased in lateral prefrontal cortex (lpfc). |
2023-07-26 |
2023-08-14 |
human |
| Henk Karst, Marian Joël. Corticosterone rapidly reduces glutamatergic but not GABAergic transmission in the infralimbic prefrontal cortex of male mice. Steroids. 2023-07-24. PMID:37487816. |
corticosterone rapidly reduces glutamatergic but not gabaergic transmission in the infralimbic prefrontal cortex of male mice. |
2023-07-24 |
2023-08-14 |
mouse |
| Benedetta Demartini, Veronica Nisticò, Caroline Benayoun, Anna Chiara Cigognini, Roberta Ferrucci, Alessandra Vezzoli, Cinzia Dellanoce, Orsola Gambini, Alberto Priori, Simona Mrakic-Spost. Glutamatergic dysfunction, neuroplasticity, and redox status in the peripheral blood of patients with motor conversion disorders (functional movement disorders): a first step towards potential biomarkers discovery. Translational psychiatry. vol 13. issue 1. 2023-06-17. PMID:37330537. |
first evidence showed that, compared to healthy controls (ctr), fmd patients presented increased levels of glutamate+glutamine in the anterior cingulate cortex/medial prefrontal cortex, and decreased levels of glutamate in the cerebrospinal fluid, suggesting that a glutamatergic dysfunction might play a role in fmd pathophysiology. |
2023-06-17 |
2023-08-14 |
human |
| Lia Forti, Elona Ndoj, Jessica Mingardi, Emanuele Secchi, Tiziana Bonifacino, Emanuele Schiavon, Giulia Carini, Luca La Via, Isabella Russo, Marco Milanese, Massimo Gennarelli, Giambattista Bonanno, Maurizio Popoli, Alessandro Barbon, Laura Musazz. Dopamine-Dependent Ketamine Modulation of Glutamatergic Synaptic Plasticity in the Prelimbic Cortex of Adult Rats Exposed to Acute Stress. International journal of molecular sciences. vol 24. issue 10. 2023-05-27. PMID:37240064. |
here, we asked if acute fs may also induce any changes in glutamatergic synaptic plasticity in the pfc 24 h after stress exposure and whether ketamine administration 6 h after stress may have any effect. |
2023-05-27 |
2023-08-14 |
rat |