| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joseph S Lonstein, Taryn A Meinhardt, Pavlina Pavlidi, Nikos Kokras, Christina Dalla, Thierry D Charlier, Jodi L Pawlusk. Maternal probiotic Lactocaseibacillus rhamnosus HN001 treatment alters postpartum anxiety, cortical monoamines, and the gut microbiome. Psychoneuroendocrinology. vol 165. 2024-04-03. PMID:38569396. |
the results revealed that, even without pregnancy stress, hn001 reduced postpartum anxiety-related behavior, increased variability in behavioral fragmentation when dams interacted with pups, increased time away from pups, and decreased prefrontal cortex norepinephrine (ne), dopamine (da) and serotonin (5-ht). |
2024-04-03 |
2024-04-06 |
rat |
| Joseph S Lonstein, Taryn A Meinhardt, Pavlina Pavlidi, Nikos Kokras, Christina Dalla, Thierry D Charlier, Jodi L Pawlusk. Maternal probiotic Lactocaseibacillus rhamnosus HN001 treatment alters postpartum anxiety, cortical monoamines, and the gut microbiome. Psychoneuroendocrinology. vol 165. 2024-04-03. PMID:38569396. |
probiotic plus stress consistently reduced the latency to float in the forced swim test, increased da and 5-ht turnovers in the prefrontal cortex, increased hippocampal ne, and reduced hypothalamic da. |
2024-04-03 |
2024-04-06 |
rat |
| Roxana Patrícia Bezerra da Silva, Isabeli Lins Pinheiro, Regina Katiuska Bezerra da Silva, Eduarda Correia Moretti, Olavo Barbosa de Oliveira Neto, Kelli Ferraz-Pereira, Lígia Cristina Monteiro Galind. Social isolation and post-weaning environmental enrichment effects on rat emotional behavior and serotonergic system. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2024-03-25. PMID:38526313. |
on the other hand, environmental enrichment (ee) is associated with a reduction in anxiety-like and depression-like behavior, as well as an increase in serotonin (5-ht) levels in the prefrontal cortex and hippocampus in rodents. |
2024-03-25 |
2024-03-27 |
human |
| Roxana Patrícia Bezerra da Silva, Isabeli Lins Pinheiro, Regina Katiuska Bezerra da Silva, Eduarda Correia Moretti, Olavo Barbosa de Oliveira Neto, Kelli Ferraz-Pereira, Lígia Cristina Monteiro Galind. Social isolation and post-weaning environmental enrichment effects on rat emotional behavior and serotonergic system. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2024-03-25. PMID:38526313. |
furthermore, ee increased 5-ht levels in the hippocampus and prefrontal cortex of rodents. |
2024-03-25 |
2024-03-27 |
human |
| Karen K Y Lee, Bidisha Chattopadhyaya, Antônia Samia Fernandes do Nascimento, Luc Moquin, Pedro Rosa-Neto, Bénédicte Amilhon, Graziella Di Crist. Neonatal hypoxia impairs serotonin release and cognitive functions in adult mice. Neurobiology of disease. 2024-03-09. PMID:38460800. |
neurons that release serotonin (5-ht) project to the pfc, and compounds modulating 5-ht activity influence emotion and cognition. |
2024-03-09 |
2024-03-12 |
mouse |
| Karen K Y Lee, Bidisha Chattopadhyaya, Antônia Samia Fernandes do Nascimento, Luc Moquin, Pedro Rosa-Neto, Bénédicte Amilhon, Graziella Di Crist. Neonatal hypoxia impairs serotonin release and cognitive functions in adult mice. Neurobiology of disease. 2024-03-09. PMID:38460800. |
we found that 5-ht expression levels, quantified by immunohistochemistry, and 5-ht release, quantified by in vivo microdialysis in awake mice, are reduced in pfc of adult mpa mice. |
2024-03-09 |
2024-03-12 |
mouse |
| Roberto Ogelman, Luis E Gomez Wulschner, Victoria M Hoelscher, In-Wook Hwang, Victoria N Chang, Won Chan O. Serotonin modulates excitatory synapse maturation in the developing prefrontal cortex. Nature communications. vol 15. issue 1. 2024-02-16. PMID:38365905. |
serotonin modulates excitatory synapse maturation in the developing prefrontal cortex. |
2024-02-16 |
2024-02-19 |
mouse |
| Roberto Ogelman, Luis E Gomez Wulschner, Victoria M Hoelscher, In-Wook Hwang, Victoria N Chang, Won Chan O. Serotonin modulates excitatory synapse maturation in the developing prefrontal cortex. Nature communications. vol 15. issue 1. 2024-02-16. PMID:38365905. |
serotonin (5-ht) imbalances in the developing prefrontal cortex (pfc) are linked to long-term behavioral deficits. |
2024-02-16 |
2024-02-19 |
mouse |
| Roberto Ogelman, Luis E Gomez Wulschner, Victoria M Hoelscher, In-Wook Hwang, Victoria N Chang, Won Chan O. Serotonin modulates excitatory synapse maturation in the developing prefrontal cortex. Nature communications. vol 15. issue 1. 2024-02-16. PMID:38365905. |
we found that chemogenetic suppression and enhancement of 5-ht release in the pfc during the first two postnatal weeks decreased and increased the density and strength of excitatory spine synapses, respectively, on prefrontal layer 2/3 pyramidal neurons in mice. |
2024-02-16 |
2024-02-19 |
mouse |
| Ryota Araki, Ayami Kita, Yukio Ago, Takeshi Yab. Chronic social defeat stress induces anxiety-like behaviors via downregulation of serotonin transporter in the prefrontal serotonergic system in mice. Neurochemistry international. 2024-02-01. PMID:38301899. |
monoamine content, serotonin (5-ht) release, 5-ht uptake, 5-ht transporter (sert) protein levels, and behaviors were investigated in mice subjected to chronic social defeat stress and in mice with knockdown of slc6a4, in 5-htergic neurons projecting to the prefrontal cortex (pfc). |
2024-02-01 |
2024-02-04 |
mouse |
| Ryota Araki, Ayami Kita, Yukio Ago, Takeshi Yab. Chronic social defeat stress induces anxiety-like behaviors via downregulation of serotonin transporter in the prefrontal serotonergic system in mice. Neurochemistry international. 2024-02-01. PMID:38301899. |
increased turnover, increased extracellular basal levels, decreased release and decreased uptake of 5-ht, and decreased sert protein levels were observed in the pfc of the stressed mice. |
2024-02-01 |
2024-02-04 |
mouse |
| Ryota Araki, Ayami Kita, Yukio Ago, Takeshi Yab. Chronic social defeat stress induces anxiety-like behaviors via downregulation of serotonin transporter in the prefrontal serotonergic system in mice. Neurochemistry international. 2024-02-01. PMID:38301899. |
similar to the stressed mice, mice with slc6a4 knockdown in 5-htergic neurons projecting to the pfc also showed decreased release and uptake of 5-ht in the pfc and increased anxiety-like behavior. |
2024-02-01 |
2024-02-04 |
mouse |
| Jennie Garcia-Olivares, Brittney Yegla, Frank P Bymaster, Jami Earnest, Jennifer Koch, Chungping Yu, Jonathan Rubi. Viloxazine Increases Extracellular Concentrations of Norepinephrine, Dopamine, and Serotonin in the Rat Prefrontal Cortex at Doses Relevant for the Treatment of Attention-Deficit/Hyperactivity Disorder. Journal of experimental pharmacology. vol 16. 2024-01-22. PMID:38249320. |
viloxazine increases extracellular concentrations of norepinephrine, dopamine, and serotonin in the rat prefrontal cortex at doses relevant for the treatment of attention-deficit/hyperactivity disorder. |
2024-01-22 |
2024-01-24 |
rat |
| Maria Bove, Maria Grazia Morgese, Stefania Dimonte, Vladyslav Sikora, Lisa Pia Agosti, Maria Adelaide Palmieri, Paolo Tucci, Stefania Schiavone, Luigia Trabac. Increased stress vulnerability in the offspring of socially isolated rats: Behavioural, neurochemical and redox dysfunctions. Progress in neuro-psychopharmacology & biological psychiatry. 2024-01-19. PMID:38242425. |
levels of noradrenaline (na), serotonin (5-ht), 5-hydroxyindoleacetic acid (5-hiaa), glutamate (glu) and gaba were assessed in the prefrontal cortex (pfc). |
2024-01-19 |
2024-01-22 |
rat |
| Alberto Fernández-Teruel, Toni Cañete, Daniel Sampedro-Viana, Ignasi Oliveras, Rafael Torrubia, Adolf Tobeñ. Contribution of the Roman rat lines/strains to personality neuroscience: neurobehavioral modeling of internalizing/externalizing psychopathologies. Personality neuroscience. vol 6. 2023-12-19. PMID:38107777. |
for example, relative to rla rats, rhas exhibit decreased function of the prefrontal cortex (pfc), hippocampus and amygdala, increased functional tone of the mesolimbic dopamine system, a deficit of central metabotropic glutamate-2 (mglu2) receptors, increased density of serotonin 5-ht2a receptors in the pfc, impairment of gabaergic transmission in the pfc, alterations of several synaptic markers and increased density of pyramidal immature dendrític spines in the pfc. |
2023-12-19 |
2023-12-21 |
rat |
| Daniël J van Rensburg, Zander Lindeque, Brian H Harvey, Stephan F Stey. Ndufs4 KO mice: A model to study comorbid mood disorders associated with mitochondrial dysfunction. Pharmacology, biochemistry, and behavior. vol 234. 2023-12-13. PMID:38070656. |
serotonin, kynurenine, and redox status in brain areas relevant to psychiatric pathologies (i.e., prefrontal cortex, hippocampus, and striatum). |
2023-12-13 |
2023-12-17 |
mouse |
| Soraia Silva, Carla Fonseca, Joana Bicker, Amílcar Falcão, Ana Fortun. Intranasal administration of sertraline ensures sustained brain delivery and antidepressant effect in a mouse model of depression. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2023-12-13. PMID:38092320. |
noteworthy neurotransmitter alterations were observed, with in sertraline markedly reducing adrenaline in the prefrontal cortex, while serotonin and melatonin increased following both administration routes. |
2023-12-13 |
2023-12-17 |
mouse |
| Handan Deng, Yongjun Yu, Qi Sha, Weiyi Sun, Lundan Liang, Feier Ren, Hua Ji, Xiangdi Shen, Xingli Fa. Construction of antibiotic-induced depression mice model and the function of intestinal microbiota. Frontiers in microbiology. vol 14. 2023-12-13. PMID:38088959. |
by using these antibiotics, the concentrations of norepinephrine (ne), 5-hydroxytryptamine (5-ht), and brain-derived neurotrophic factor (bdnf) in mice hippocampus and prefrontal cortex tissues were significantly decreased. |
2023-12-13 |
2023-12-17 |
mouse |
| Pooja Gusain, Makiko Taketoshi, Yoko Tominaga, Takashi Tominag. Functional dissection of ipsilateral and contralateral neural activity propagation using voltage-sensitive dye imaging in mouse prefrontal cortex. eNeuro. 2023-11-17. PMID:37977827. |
these findings highlight the importance of understanding the pfc functional anatomy in evaluating neuromodulators like serotonin and dopamine, as well as other factors related to neuropsychiatric diseases. |
2023-11-17 |
2023-11-20 |
mouse |
| Tyler G Ekins, Isla Brooks, Sameer Kailasa, Chloe Rybicki-Kler, Izabela Jedrasiak-Cape, Ethan Donoho, George A Mashour, Jason Rech, Omar J Ahme. Cellular rules underlying psychedelic control of prefrontal pyramidal neurons. bioRxiv : the preprint server for biology. 2023-11-14. PMID:37961554. |
classical psychedelic drugs are thought to increase excitability of pyramidal cells in prefrontal cortex via activation of serotonin 2 |
2023-11-14 |
2023-11-20 |
Not clear |