| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joanne A Harrold, Joanne C Elliott, Peter J King, Peter S Widdowson, Gareth William. Down-regulation of cannabinoid-1 (CB-1) receptors in specific extrahypothalamic regions of rats with dietary obesity: a role for endogenous cannabinoids in driving appetite for palatable food? Brain research. vol 952. issue 2. 2003-01-07. PMID:12376184. |
to investigate whether endogenous cannabinoids might influence appetite for palatable food, we compared cb-1 receptor density in the forebrain and hypothalamus, between rats fed standard chow (n=8) and others given palatable food (n=8) for 10 weeks to induce dietary obesity. |
2003-01-07 |
2023-08-12 |
rat |
| Tim C Kirkham, Claire M Williams, Filomena Fezza, Vincenzo Di Marz. Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol. British journal of pharmacology. vol 136. issue 4. 2002-12-31. PMID:12055133. |
endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol. |
2002-12-31 |
2023-08-12 |
rat |
| Eva M Romero, Beatriz Fernández, Onintza Sagredo, Nuria Gomez, Leyre Urigüen, Carmen Guaza, Rosario De Miguel, Jose Antonio Ramos, M Paz Vivero. Antinociceptive, behavioural and neuroendocrine effects of CP 55,940 in young rats. Brain research. Developmental brain research. vol 136. issue 2. 2002-09-27. PMID:12101025. |
the cannabinoid agonist (0.6 mg/kg) induced a cb(1)-mediated increase in the serum corticosterone levels, but no effect on the dopaminergic systems of either the striatum or the limbic forebrain was found. |
2002-09-27 |
2023-08-12 |
rat |
| I Katona, E A Rancz, L Acsady, C Ledent, K Mackie, N Hajos, T F Freun. Distribution of CB1 cannabinoid receptors in the amygdala and their role in the control of GABAergic transmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 23. 2002-01-11. PMID:11717385. |
we propose that these anatomical and physiological features, characteristic of cb1 receptors in several forebrain regions, represent the neuronal substrate for endocannabinoids involved in retrograde synaptic signaling and may explain some of the emotionally relevant behavioral effects of cannabinoid exposure. |
2002-01-11 |
2023-08-12 |
mouse |
| V Di Marzo, F Berrendero, T Bisogno, S González, P Cavaliere, J Romero, M Cebeira, J A Ramos, J J Fernández-Rui. Enhancement of anandamide formation in the limbic forebrain and reduction of endocannabinoid contents in the striatum of delta9-tetrahydrocannabinol-tolerant rats. Journal of neurochemistry. vol 74. issue 4. 2000-04-11. PMID:10737621. |
enhancement of anandamide formation in the limbic forebrain and reduction of endocannabinoid contents in the striatum of delta9-tetrahydrocannabinol-tolerant rats. |
2000-04-11 |
2023-08-12 |
rat |
| V Di Marzo, F Berrendero, T Bisogno, S González, P Cavaliere, J Romero, M Cebeira, J A Ramos, J J Fernández-Rui. Enhancement of anandamide formation in the limbic forebrain and reduction of endocannabinoid contents in the striatum of delta9-tetrahydrocannabinol-tolerant rats. Journal of neurochemistry. vol 74. issue 4. 2000-04-11. PMID:10737621. |
in summary, the present results show that prolonged activation of cannabinoid receptors leads to decreased endocannabinoid contents and signaling in the striatum and to increased aea formation in the limbic forebrain. |
2000-04-11 |
2023-08-12 |
rat |
| G Marsicano, B Lut. Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain. The European journal of neuroscience. vol 11. issue 12. 2000-02-10. PMID:10594647. |
in trying to obtain further insights into the mechanisms underlying the modulatory effects of cannabinoids, cb1-positive neurons were determined in the murine forebrain at a single cell resolution. |
2000-02-10 |
2023-08-12 |
mouse |
| R A Ross, H C Brockie, S R Fernando, B Saha, R K Razdan, R G Pertwe. Comparison of cannabinoid binding sites in guinea-pig forebrain and small intestine. British journal of pharmacology. vol 125. issue 6. 1999-03-25. PMID:9863666. |
comparison of cannabinoid binding sites in guinea-pig forebrain and small intestine. |
1999-03-25 |
2023-08-12 |
Not clear |
| L Belayev, A Bar-Joseph, J Adamchik, A Biego. HU-211, a nonpsychotropic cannabinoid, improves neurological signs and reduces brain damage after severe forebrain ischemia in rats. Molecular and chemical neuropathology. vol 25. issue 1. 1995-10-24. PMID:7546016. |
hu-211, a nonpsychotropic cannabinoid, improves neurological signs and reduces brain damage after severe forebrain ischemia in rats. |
1995-10-24 |
2023-08-12 |
human |
| L Belayev, A Bar-Joseph, J Adamchik, A Biego. HU-211, a nonpsychotropic cannabinoid, improves neurological signs and reduces brain damage after severe forebrain ischemia in rats. Molecular and chemical neuropathology. vol 25. issue 1. 1995-10-24. PMID:7546016. |
the purpose of the present study was to examine the dose-response relationship and the therapeutic time window for the synthetic nonpsychotropic cannabinoid (hu-211) as a neuroprotective agent in transient, severe forebrain ischemia in the rat. |
1995-10-24 |
2023-08-12 |
human |
| J Romero, L García, J J Fernández-Ruiz, M Cebeira, J A Ramo. Changes in rat brain cannabinoid binding sites after acute or chronic exposure to their endogenous agonist, anandamide, or to delta 9-tetrahydrocannabinol. Pharmacology, biochemistry, and behavior. vol 51. issue 4. 1995-10-19. PMID:7675852. |
on the contrary, the [3h]cp-55,940 binding to cannabinoid receptors in the striatum, the limbic forebrain, the mesencephalon, and the medial basal hypothalamus was not altered after the acute exposure to anandamide or thc. |
1995-10-19 |
2023-08-12 |
rat |
| K L Morse, D J Fournier, X Li, J Grzybowska, A Makriyanni. A novel electrophilic high affinity irreversible probe for the cannabinoid receptor. Life sciences. vol 56. issue 23-24. 1995-07-11. PMID:7776819. |
this ligand, (-)-7'-isothiocyanato-1',1'-dimethylheptyl-delta 8-thc (7'-ncs-dmh-delta 8-thc), was evaluated for its affinity for cannabinoid binding sites using rat forebrain membrane preparations and found to have an apparent ic50 value of 660 pm. |
1995-07-11 |
2023-08-12 |
rat |
| V Nadler, R Mechoulam, M Sokolovsk. The non-psychotropic cannabinoid (+)-(3S,4S)-7-hydroxy-delta 6- tetrahydrocannabinol 1,1-dimethylheptyl (HU-211) attenuates N-methyl-D-aspartate receptor-mediated neurotoxicity in primary cultures of rat forebrain. Neuroscience letters. vol 162. issue 1-2. 1994-04-04. PMID:8121633. |
the non-psychotropic cannabinoid (+)-(3s,4s)-7-hydroxy-delta 6- tetrahydrocannabinol 1,1-dimethylheptyl (hu-211) attenuates n-methyl-d-aspartate receptor-mediated neurotoxicity in primary cultures of rat forebrain. |
1994-04-04 |
2023-08-12 |
rat |
| V Nadler, R Mechoulam, M Sokolovsk. The non-psychotropic cannabinoid (+)-(3S,4S)-7-hydroxy-delta 6- tetrahydrocannabinol 1,1-dimethylheptyl (HU-211) attenuates N-methyl-D-aspartate receptor-mediated neurotoxicity in primary cultures of rat forebrain. Neuroscience letters. vol 162. issue 1-2. 1994-04-04. PMID:8121633. |
the non-psychotropic cannabinoid (+)-(3s,4s)-7-hydroxy-delta 6- tetrahydrocannabinol 1,1-dimethylheptyl (hu-211), a stereoselective inhibitor of the n-methyl-d-aspartate (nmda) receptor, protects primary cultures of rat forebrain against nmda receptor-mediated neurotoxicity. |
1994-04-04 |
2023-08-12 |
rat |
| F Rodríguez de Fonseca, M A Gorriti, J J Fernández-Ruiz, T Palomo, J A Ramo. Downregulation of rat brain cannabinoid binding sites after chronic delta 9-tetrahydrocannabinol treatment. Pharmacology, biochemistry, and behavior. vol 47. issue 1. 1994-03-25. PMID:8115426. |
to this end, we first characterized the binding of cannabinoid receptors, by using [3h]cp-55,940 binding assays, in the striatum, limbic forebrain, and ventral mesencephalon of male rats, and, second, we measured the density and affinity of those receptors in these brain areas after 7 days of a daily treatment with thc. |
1994-03-25 |
2023-08-12 |
rat |
| F Rodríguez de Fonseca, M A Gorriti, J J Fernández-Ruiz, T Palomo, J A Ramo. Downregulation of rat brain cannabinoid binding sites after chronic delta 9-tetrahydrocannabinol treatment. Pharmacology, biochemistry, and behavior. vol 47. issue 1. 1994-03-25. PMID:8115426. |
this tolerance was accompanied by significant decreases in the density of cannabinoid receptors in the striatum and limbic forebrain, the areas where nerve terminals for nigrostriatal and mesolimbic dopaminergic systems, respectively, which play an important role in those processes, are located. |
1994-03-25 |
2023-08-12 |
rat |
| C J Hillard, J A Auchampac. In vitro activation of brain protein kinase C by the cannabinoids. Biochimica et biophysica acta. vol 1220. issue 2. 1994-03-21. PMID:8312360. |
the naturally occurring cannabinoid delta 9-tetrahydrocannabinol (delta 9-thc) increased the activity of protein kinase c isolated from rat forebrain at concentrations of 10 microm and above. |
1994-03-21 |
2023-08-12 |
rat |
| C R McLaughlin, M E Aboo. Developmental expression of cannabinoid receptor mRNA. Brain research. Developmental brain research. vol 76. issue 1. 1994-03-17. PMID:8306433. |
our results further indicate that cannabinoid mrna expression steadily increases in the cerebellum/brainstem until postnatal days 18-21, while expression in the forebrain does not change. |
1994-03-17 |
2023-08-12 |
rat |
| M Navarro, J J Fernández-Ruiz, R de Miguel, M L Hernández, M Cebeira, J A Ramo. An acute dose of delta 9-tetrahydrocannabinol affects behavioral and neurochemical indices of mesolimbic dopaminergic activity. Behavioural brain research. vol 57. issue 1. 1994-02-25. PMID:8292253. |
the present study has been designed to examine cannabinoid effects on certain behaviors, which have been currently located in the limbic forebrain, in parallel to their effects on mesolimbic dopaminergic neurons. |
1994-02-25 |
2023-08-12 |
rat |
| F Rodríguez de Fonseca, M Cebeira, J A Ramos, M Martín, J J Fernández-Rui. Cannabinoid receptors in rat brain areas: sexual differences, fluctuations during estrous cycle and changes after gonadectomy and sex steroid replacement. Life sciences. vol 54. issue 3. 1994-02-18. PMID:8289577. |
in the limbic forebrain, the affinity for the cannabinoid ligand was also higher in males than females with no changes in density. |
1994-02-18 |
2023-08-12 |
rat |