| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Tong, Genhong Yao, Yueqin Chen, Hairong Xie, Xinyu Zheng, Lingyun Sun, Zhenping Huang, Zhenggao Xi. Mesenchymal Stem Cells Regulate Microglial Polarization via Inhibition of the HMGB1/TLR4 Signaling Pathway in Diabetic Retinopathy. Inflammation. 2024-04-16. PMID:38625640. |
activated microglia express many pro-inflammatory cytokines that exacerbate retina inflammation and disruption. |
2024-04-16 |
2024-04-18 |
rat |
| Haoran Li, Biao Li, Yanlin Zhen. Role of microglia/macrophage polarisation in intraocular diseases (Review). International journal of molecular medicine. vol 53. issue 5. 2024-03-29. PMID:38551157. |
the neural retina is also populated by specialised resident macrophages called microglia. |
2024-03-29 |
2024-03-31 |
Not clear |
| Jiaxing Huang, Xiaotang Wang, Na Li, Wei Fan, Xingran Li, Qian Zhou, Jiangyi Liu, Wanqian Li, Zhi Zhang, Xiaoyan Liu, Shuhao Zeng, Hui Yang, Meng Tian, Peizeng Yang, Shengping Ho. YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-03-17. PMID:38493498. |
activated microglia in the retina are essential for the development of autoimmune uveitis. |
2024-03-17 |
2024-03-20 |
Not clear |
| Mandy Hector, Thomas Langmann, Anne Wol. Translocator protein (18 kDa) (Tspo) in the retina and implications for ocular diseases. Progress in retinal and eye research. 2024-03-02. PMID:38430990. |
this review summarizes state-of-the-art knowledge of tspo expression and its proposed functions in different cells of the retina including microglia, retinal pigment epithelium and müller cells. |
2024-03-02 |
2024-03-06 |
Not clear |
| Fazeleh Etebar, Damien G Harkin, Anthony R White, Samantha J Dand. Non-invasive Frontiers in cellular neuroscience. vol 18. 2024-02-13. PMID:38348116. |
microglia in the retina, as an extension of the cns, have also been shown to be affected in many neurological diseases. |
2024-02-13 |
2024-02-15 |
Not clear |
| Xingxing Wang, Changlin Xu, Cunxin Bian, Pengfei Ge, Jie Lei, Jingfan Wang, Tianhao Xiao, Yuanyuan Fan, Qinyuan Gu, Hong-Ying Li, Jingyi Xu, Zizhong Hu, Ping Xi. M2 microglia-derived exosomes promote vascular remodeling in diabetic retinopathy. Journal of nanobiotechnology. vol 22. issue 1. 2024-02-09. PMID:38336783. |
further in vivo and in vitro experiments showed that exosomes derived from m2 polarized microglia (m2-exo) could reduce pericyte apoptosis and promote endothelial cell proliferation, thereby promoting vascular remodeling and reducing vascular leakage from the diabetic retina. |
2024-02-09 |
2024-02-12 |
mouse |
| Derek Rodriguez, Kaira A Church, Alicia N Pietramale, Sandra M Cardona, Difernando Vanegas, Colin Rorex, Micah C Leary, Isabel A Muzzio, Kevin R Nash, Astrid E Cardon. Fractalkine isoforms differentially regulate microglia-mediated inflammation and enhance visual function in the diabetic retina. Journal of neuroinflammation. vol 21. issue 1. 2024-02-04. PMID:38311721. |
diabetic retinopathy (dr) affects about 200 million people worldwide, causing leakage of blood components into retinal tissues, leading to activation of microglia, the resident phagocytes of the retina, promoting neuronal and vascular damage. |
2024-02-04 |
2024-02-07 |
mouse |
| Nils Laudenberg, Urbanus Muthai Kinuthia, Thomas Langman. Microglia depletion/repopulation does not affect light-induced retinal degeneration in mice. Frontiers in immunology. vol 14. 2024-01-30. PMID:38288111. |
despite their role in driving detrimental inflammation, microglia also play supporting roles in the retina as they are a crucial cellular component of the regulatory innate immune system. |
2024-01-30 |
2024-02-01 |
mouse |
| Nils Laudenberg, Urbanus Muthai Kinuthia, Thomas Langman. Microglia depletion/repopulation does not affect light-induced retinal degeneration in mice. Frontiers in immunology. vol 14. 2024-01-30. PMID:38288111. |
interestingly, we found prominent cell debris accumulation in the outer retina under conditions of microglia depletion, presumably due to the lack of efficient phagocytosis that could not be compensated by the retinal pigment epithelium. |
2024-01-30 |
2024-02-01 |
mouse |
| Jia Xu, Si-Jian Yu, Shuning Sun, Yan-Ping Li, Xiao Zhang, Kangxin Jin, Zi-Bing Ji. Enhanced innate responses in microglia derived from retinoblastoma patient-specific iPSCs. Glia. 2024-01-23. PMID:38258347. |
in this study, microglia were successfully differentiated from rb patient- derived human induced pluripotent stem cells (hipscs) and human embryonic stem cells (hescs), and then we investigated the function of rb1 in microglia by live imaging phagocytosis assay, immunofluorescence, rna-seq, qrt-pcr, elisa and retina organoids/microglia co-culturing. |
2024-01-23 |
2024-01-25 |
human |
| Elena Beltramo, Aurora Mazzeo, Massimo Port. Release of Pro-Inflammatory/Angiogenic Factors by Retinal Microvascular Cells Is Mediated by Extracellular Vesicles Derived from M1-Activated Microglia. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203187. |
microglia is responsible for the immune response to inflammation inside the retina, which could be mediated by paracrine signals carried by extracellular vesicles (evs). |
2024-01-11 |
2024-01-13 |
human |
| Xingyu Zhu, Jiaxu Hong, Xujiao Zho. Biological Immune Mechanism of Retina. Frontiers in bioscience (Landmark edition). vol 28. issue 12. 2024-01-05. PMID:38179761. |
with the aim of better understanding the biology of immunological processes within the retina, this article reviews the brb and discusses the factors, systemic immune responses, microglia, rpe, and their associated enzymes that enable the brb. |
2024-01-05 |
2024-01-07 |
Not clear |
| Michael Morales, Anna P Findley, Diana M Mitchel. Intercellular contact and cargo transfer between Müller glia and to microglia precede apoptotic cell clearance in the developing retina. Development (Cambridge, England). vol 151. issue 1. 2024-01-04. PMID:38174987. |
intercellular contact and cargo transfer between müller glia and to microglia precede apoptotic cell clearance in the developing retina. |
2024-01-04 |
2024-01-06 |
zebrafish |
| Cristina Nuñez-Diaz, Emelie Andersson, Nina Schultz, Dovilė Pocevičiūtė, Oskar Hansson, K Peter R Nilsson, Malin Wennströ. The fluorescent ligand bTVBT2 reveals increased p-tau uptake by retinal microglia in Alzheimer's disease patients and App Alzheimer's research & therapy. vol 16. issue 1. 2024-01-03. PMID:38167557. |
the fluorescent ligand btvbt2 reveals increased p-tau uptake by retinal microglia in alzheimer's disease patients and app amyloid beta (aβ) deposits and hyperphosphorylated tau (p-tau) accumulation have been identified in the retina of alzheimer's disease (ad) patients and transgenic ad mice. |
2024-01-03 |
2024-01-06 |
mouse |
| Cristina Nuñez-Diaz, Emelie Andersson, Nina Schultz, Dovilė Pocevičiūtė, Oskar Hansson, K Peter R Nilsson, Malin Wennströ. The fluorescent ligand bTVBT2 reveals increased p-tau uptake by retinal microglia in Alzheimer's disease patients and App Alzheimer's research & therapy. vol 16. issue 1. 2024-01-03. PMID:38167557. |
in the current study, we use the p-tau-specific thiophene-based ligand btvbt2 to investigate the relationship between disease progression and p-tau uptake by microglia in the retina of ad patients and app |
2024-01-03 |
2024-01-06 |
mouse |
| Yan Chen, Sarah E Bounds, Xiang Ma, James Regun Karmoker, Yin Liu, Jian-Xing Ma, Jiyang Ca. Interleukin-17-mediated protective cytokine signaling against degeneration of the retinal pigment epithelium. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 51. 2023-12-12. PMID:38085785. |
injuries to the retinal pigment epithelium (rpe) and outer retina often result in the accumulation of retinal microglia within the subretinal space. |
2023-12-12 |
2023-12-17 |
mouse |
| Anitha Krishnan, Victor G Sendra, Diyan Patel, Amit Lad, Michelle K Greene, Peter Smyth, Samantha A Gallaher, Úna M Herron, Christopher J Scott, Mohamed Genead, Michael Tolentin. PolySialic acid-nanoparticles inhibit macrophage mediated inflammation through Siglec agonism: a potential treatment for age related macular degeneration. Frontiers in immunology. vol 14. 2023-12-04. PMID:38045700. |
age-related macular degeneration (amd) is a chronic, progressive retinal disease characterized by an inflammatory response mediated by activated macrophages and microglia infiltrating the inner layer of the retina. |
2023-12-04 |
2023-12-10 |
Not clear |
| Sofia Papadogkonaki, Dimitris Spyridakos, Emmanouela Lapokonstantaki, Nikos Chaniotakis, Alexandros Makriyannis, Michael S Malamas, Kyriaki Thermo. Investigating the Effects of Exogenous and Endogenous 2-Arachidonoylglycerol on Retinal CB1 Cannabinoid Receptors and Reactive Microglia in Naive and Diseased Retina. International journal of molecular sciences. vol 24. issue 21. 2023-11-14. PMID:37958673. |
investigating the effects of exogenous and endogenous 2-arachidonoylglycerol on retinal cb1 cannabinoid receptors and reactive microglia in naive and diseased retina. |
2023-11-14 |
2023-11-20 |
rat |
| Sofia Papadogkonaki, Dimitris Spyridakos, Emmanouela Lapokonstantaki, Nikos Chaniotakis, Alexandros Makriyannis, Michael S Malamas, Kyriaki Thermo. Investigating the Effects of Exogenous and Endogenous 2-Arachidonoylglycerol on Retinal CB1 Cannabinoid Receptors and Reactive Microglia in Naive and Diseased Retina. International journal of molecular sciences. vol 24. issue 21. 2023-11-14. PMID:37958673. |
all treatments, however, attenuated the activation of microglia via the cb2r activation, supporting the anti-inflammatory role of 2-ag in the retina. |
2023-11-14 |
2023-11-20 |
rat |
| Margarete M Karg, May Moorefield, Emma Hoffmann, Hannah Philipose, Drenushe Krasniqi, Cindy Hoppe, Daisy Y Shu, Shintaro Shirahama, Bruce R Ksander, Magali Saint-Genie. Correction: Microglia preserve visual function in the aging retina by supporting retinal pigment epithelial health. Immunity & ageing : I & A. vol 20. issue 1. 2023-11-11. PMID:37950253. |
correction: microglia preserve visual function in the aging retina by supporting retinal pigment epithelial health. |
2023-11-11 |
2023-11-20 |
Not clear |