| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peiyao Mao, Yinchen Shen, Xiying Mao, Kun Liu, Jiawei Zhon. The single-cell landscape of alternative transcription start sites of diabetic retina. Experimental eye research. 2023-05-26. PMID:37236522. |
furthermore, by comparing tss expression between healthy and diabetic retina, we identified elevated apoptosis signal in müller glia and microglia, which can be served as a putative early sign of diabetic retinopathy. |
2023-05-26 |
2023-08-14 |
Not clear |
| Kevin Emmerich, David T White, Siva P Kambhampati, Grace L Casado, Tian-Ming Fu, Zeeshaan Chunawala, Arpan Sahoo, Saumya Nimmagadda, Nimisha Krishnan, Meera T Saxena, Steven L Walker, Eric Betzig, Rangaramanujam M Kannan, Jeff S Mum. Nanoparticle-based targeting of microglia improves the neural regeneration enhancing effects of immunosuppression in the zebrafish retina. Communications biology. vol 6. issue 1. 2023-05-18. PMID:37202450. |
nanoparticle-based targeting of microglia improves the neural regeneration enhancing effects of immunosuppression in the zebrafish retina. |
2023-05-18 |
2023-08-14 |
mouse |
| Kevin Emmerich, David T White, Siva P Kambhampati, Grace L Casado, Tian-Ming Fu, Zeeshaan Chunawala, Arpan Sahoo, Saumya Nimmagadda, Nimisha Krishnan, Meera T Saxena, Steven L Walker, Eric Betzig, Rangaramanujam M Kannan, Jeff S Mum. Nanoparticle-based targeting of microglia improves the neural regeneration enhancing effects of immunosuppression in the zebrafish retina. Communications biology. vol 6. issue 1. 2023-05-18. PMID:37202450. |
similarly, microglia ablation enhances regenerative outcomes in the mouse retina. |
2023-05-18 |
2023-08-14 |
mouse |
| Junjue Chen, Huimin Zhong, Huan Yu, Jun Sun, Bingqiao Shen, Xing Xu, Shouyue Huang, Ping Huang, Yisheng Zhon. Interleukin-17A modulates retinal inflammation by regulating microglial activation via the p38 MAPK pathway in experimental glaucoma neuropathy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 6. 2023-05-05. PMID:37144630. |
in the present study, we investigated the role of il-17a in the pathological process of glaucoma neuropathy as well as its relationship with the predominant immune inflammation mediator microglia in retina, trying to elucidate the underlying mechanisms from the view of inflammation modulation. |
2023-05-05 |
2023-08-14 |
mouse |
| Xi Chen, Xiao Wang, Zedu Cui, Qian Luo, Zihua Jiang, Yuke Huang, Jingyi Jiang, Jin Qiu, Yan Li, Keming Yu, Jing Zhuan. M1 Microglia-derived Exosomes Promote Activation of Resting Microglia and Amplifies Proangiogenic Effects through Irf1/miR-155-5p/Socs1 Axis in the Retina. International journal of biological sciences. vol 19. issue 6. 2023-04-17. PMID:37063422. |
m1 microglia-derived exosomes promote activation of resting microglia and amplifies proangiogenic effects through irf1/mir-155-5p/socs1 axis in the retina. |
2023-04-17 |
2023-08-14 |
Not clear |
| Annamaria Tisi, Giulia Carozza, Alessandro Leuti, Rita Maccarone, Mauro Maccarron. Dysregulation of Resolvin E1 Metabolism and Signaling in a Light-Damage Model of Age-Related Macular Degeneration. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047721. |
of note, amacrine cells highly expressed blt1, while chemr23 was highly expressed in the activated microglia of the outer retina. |
2023-04-13 |
2023-08-14 |
rat |
| Kaira A Church, Derek Rodriguez, Andrew S Mendiola, Difernando Vanegas, Irene L Gutierrez, Ian Tamayo, Abdul Amadu, Priscila Velazquez, Sandra M Cardona, Stefka Gyoneva, Anne C Cotleur, Richard M Ransohoff, Tejbeer Kaur, Astrid E Cardon. Pharmacological depletion of microglia alleviates neuronal and vascular damage in the diabetic CX3CR1-WT retina but not in CX3CR1-KO or hCX3CR1 Frontiers in immunology. vol 14. 2023-04-10. PMID:37033925. |
pharmacological depletion of microglia alleviates neuronal and vascular damage in the diabetic cx3cr1-wt retina but not in cx3cr1-ko or hcx3cr1 diabetic retinopathy, a microvascular disease characterized by irreparable vascular damage, neurodegeneration and neuroinflammation, is a leading complication of diabetes mellitus. |
2023-04-10 |
2023-08-14 |
Not clear |
| Mishal Rao, Yu-Kai Huang, Chia-Chun Liu, Chandler Meadows, Hui-Chun Cheng, Mengli Zhou, Yu-Chih Chen, Xin Xia, Jeffrey L Goldberg, Andrew M Williams, Takaaki Kuwajima, Kun-Che Chan. Aldose reductase inhibition decelerates optic nerve degeneration by alleviating retinal microglia activation. Scientific reports. vol 13. issue 1. 2023-04-05. PMID:37019993. |
in vitro, we discovered that sorbinil, an ar inhibitor, attenuates bv2 microglia activation and migration in the lipopolysaccharide (lps) and monocyte chemoattractant protein-1 (mcp-1) treatments. in vivo, sorbinil suppressed onc-induced iba1 + microglia/macrophage infiltration in the retina and on and promoted rgc survival. |
2023-04-05 |
2023-08-14 |
Not clear |
| Anton Lennikov, Kin-Sang Ch. Editorial: Exploiting new methods to study microglia in healthy and diseased retina. Frontiers in immunology. vol 14. 2023-04-03. PMID:37006274. |
editorial: exploiting new methods to study microglia in healthy and diseased retina. |
2023-04-03 |
2023-08-14 |
Not clear |
| Zijing Huang, Jiajian Liang, Shaolang Chen, Tsz Kin Ng, Marten E Brelén, Qingping Liu, Rucui Yang, Biyao Xie, Shuping Ke, Weiqi Chen, Dingguo Huan. RIP3-mediated microglial necroptosis promotes neuroinflammation and neurodegeneration in the early stages of diabetic retinopathy. Cell death & disease. vol 14. issue 3. 2023-03-29. PMID:36991017. |
in the diabetic retina, key components of the necroptotic machinery, including rip1, rip3, and mlkl, were highly expressed and mainly localized in activated microglia. |
2023-03-29 |
2023-08-14 |
mouse |
| Wenchuan Zhou, Yutong Zhou, Jincan He, Yuqing Rao, Ping Fei, Jing L. TREM2 deficiency in microglia accelerates photoreceptor cell death and immune cell infiltration following retinal detachment. Cell death & disease. vol 14. issue 3. 2023-03-28. PMID:36977680. |
triggering receptor expressed on myeloid cells 2 (trem2) is an innate immune receptor exclusively expressed on microglial cells in the retina, and has been reported to affect microglial cell homeostasis, phagocytosis and inflammatory responses in the brain. |
2023-03-28 |
2023-08-14 |
Not clear |
| Xiang-Ling Yuan, Shao-Lang Chen, Yanxuan Xu, Yao Yao, Jia-Jian Liang, Xi Zhuang, Eric S Hald, Tsz Kin N. Green tea extract enhances retinal ganglion cell survival and axonal regeneration in rats with optic nerve injury. The Journal of nutritional biochemistry. 2023-03-25. PMID:36965783. |
rna sequencing analysis identified the downregulation of inflammation, apoptosis, and microglia activation genes in the retina of rats with pre- or post-treatment with 275 mg/kg gte as compared to the saline-treated rats. |
2023-03-25 |
2023-08-14 |
rat |
| María Vargas-Soria, Mónica García-Alloza, Miriam Corraliza-Góme. Effects of diabetes on microglial physiology: a systematic review of in vitro, preclinical and clinical studies. Journal of neuroinflammation. vol 20. issue 1. 2023-03-03. PMID:36869375. |
based on the title and abstracts, 830 papers were screened from which 250 primary research papers met the eligibility criteria (original research articles with patients or with a strict diabetes model without comorbidities, that included direct data about microglia in the brain or retina), and 17 additional research papers were included through forward and backward citations, resulting in a total of 267 primary research articles included in the scoping systematic review. |
2023-03-03 |
2023-08-14 |
Not clear |
| Nan Su, Uwe Hansen, Tanja Plagemann, Karin Gäher, M Dominik Leclaire, Jeannette König, Annika Höhn, Tilman Grune, Constantin E Uhlig, Nicole Eter, Peter Heiduschk. Sub-Retinal Injection of Human Lipofuscin in the Mouse - A Model of "Dry" Age-Related Macular Degeneration? Aging and disease. vol 14. issue 1. 2023-02-23. PMID:36818572. |
in an attemt to simulate aged retina and to study response of retinal microglia and rpe cells to lf, we injected a suspension of lf into the subretinal space of adult mice. |
2023-02-23 |
2023-08-14 |
mouse |
| Nan Su, Uwe Hansen, Tanja Plagemann, Karin Gäher, M Dominik Leclaire, Jeannette König, Annika Höhn, Tilman Grune, Constantin E Uhlig, Nicole Eter, Peter Heiduschk. Sub-Retinal Injection of Human Lipofuscin in the Mouse - A Model of "Dry" Age-Related Macular Degeneration? Aging and disease. vol 14. issue 1. 2023-02-23. PMID:36818570. |
in an attemt to simulate aged retina and to study response of retinal microglia and rpe cells to lf, we injected a suspension of lf into the subretinal space of adult mice. |
2023-02-23 |
2023-08-14 |
mouse |
| Ioanna Tsioti, Beatrice L Steiner, Pascal Escher, Martin S Zinkernagel, Peter M Benz, Despina Kokon. Endothelial Toll-like receptor 4 is required for microglia activation in the murine retina after systemic lipopolysaccharide exposure. Journal of neuroinflammation. vol 20. issue 1. 2023-02-04. PMID:36739425. |
endothelial toll-like receptor 4 is required for microglia activation in the murine retina after systemic lipopolysaccharide exposure. |
2023-02-04 |
2023-08-14 |
mouse |
| Ioanna Tsioti, Beatrice L Steiner, Pascal Escher, Martin S Zinkernagel, Peter M Benz, Despina Kokon. Endothelial Toll-like receptor 4 is required for microglia activation in the murine retina after systemic lipopolysaccharide exposure. Journal of neuroinflammation. vol 20. issue 1. 2023-02-04. PMID:36739425. |
clustering of microglia around the vasculature has been reported in the retina and the brain after systemic administration of lipopolysaccharides (lps) in mice. |
2023-02-04 |
2023-08-14 |
mouse |
| Ioanna Tsioti, Beatrice L Steiner, Pascal Escher, Martin S Zinkernagel, Peter M Benz, Despina Kokon. Endothelial Toll-like receptor 4 is required for microglia activation in the murine retina after systemic lipopolysaccharide exposure. Journal of neuroinflammation. vol 20. issue 1. 2023-02-04. PMID:36739425. |
the purpose of this study was to investigate the effect of systemic lps in the pigmented mouse retina and the involvement of endothelial tlr4 in lps-induced retinal microglia activation. |
2023-02-04 |
2023-08-14 |
mouse |
| Yanying Miao, Guo-Li Zhao, Shuo Cheng, Zhongfeng Wang, Xiong-Li Yan. Activation of retinal glial cells contributes to the degeneration of ganglion cells in experimental glaucoma. Progress in retinal and eye research. vol 93. 2023-02-03. PMID:36736070. |
elevated iop activates microglia, and following morphological and functional changes, these cells, as resident immune cells in the retina, show adaptive immune responses, including an enhanced release of pro-inflammatory factors (tumor neurosis factor-α, interleukins, etc.). |
2023-02-03 |
2023-08-14 |
Not clear |
| Valeria Chichagova, Maria Georgiou, Madeleine Carter, Birthe Dorgau, Gerrit Hilgen, Joseph Collin, Rachel Queen, Git Chung, Jila Ajeian, Marina Moya-Molina, Stefan Kustermann, Francois Pognan, Philip Hewitt, Michael Schmitt, Evelyne Sernagor, Lyle Armstrong, Majlinda Lak. Incorporating microglia-like cells in human induced pluripotent stem cell-derived retinal organoids. Journal of cellular and molecular medicine. 2023-01-16. PMID:36644817. |
microglia are the primary resident immune cells in the retina. |
2023-01-16 |
2023-08-14 |
human |