| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David Gonzalez, Xiomara Cuenca, Miguel L Allend. Knockdown of Frontiers in cellular neuroscience. vol 18. 2024-04-22. PMID:38644973. |
knockdown of amyotrophic lateral sclerosis (als) corresponds to a neurodegenerative disorder marked by the progressive degeneration of both upper and lower motor neurons located in the brain, brainstem, and spinal cord. |
2024-04-22 |
2024-04-24 |
mouse |
| Gaurav Deepak Patel, Lichao Liu, Ailian Li, Yun-Hsuan Yang, Chia-Chi Shen, Beate Brand-Saberi, Xuesong Yan. Mesenchymal stem cell-based therapies for treating well-studied neurological disorders: a systematic review. Frontiers in medicine. vol 11. 2024-04-11. PMID:38601118. |
millions of people across the globe are affected by conditions like amyotrophic lateral sclerosis (als), parkinson's disease (pd), multiple sclerosis (ms), spinal cord injury (sci), and traumatic brain injury (tbi), although most occurrences are common in the elderly population. |
2024-04-11 |
2024-04-13 |
Not clear |
| Makoto Urushitani, Hitoshi Warita, Naoki Atsuta, Yuishin Izumi, Osamu Kano, Toshio Shimizu, Yuki Nakayama, Yugo Narita, Hiroyuki Nodera, Takuji Fujita, Koichi Mizoguchi, Mitsuya Morita, Masashi Aok. The clinical practice guideline for the management of amyotrophic lateral sclerosis in Japan-update 2023. Rinsho shinkeigaku = Clinical neurology. 2024-03-24. PMID:38522911. |
amyotrophic lateral sclerosis (als) is an adult-onset intractable motor neuron disease characterized by selective degeneration of cortical neurons in the frontotemporal lobe and motor neurons in the brainstem and spinal cord. |
2024-03-24 |
2024-03-27 |
Not clear |
| Jiaying Shi, Zhaokun Wang, Ming Yi, Shengyu Xie, Xinyue Zhang, Dachang Tao, Yunqiang Liu, Yuan Yan. Evidence based on Mendelian randomization and colocalization analysis strengthens causal relationships between structural changes in specific brain regions and risk of amyotrophic lateral sclerosis. Frontiers in neuroscience. vol 18. 2024-03-20. PMID:38505770. |
amyotrophic lateral sclerosis (als) is a neurodegenerative disease characterized by the degeneration of motor neurons in the brain and spinal cord with a poor prognosis. |
2024-03-20 |
2024-03-23 |
Not clear |
| LiJun Zhou, RenShi X. Invertebrate genetic models of amyotrophic lateral sclerosis. Frontiers in molecular neuroscience. vol 17. 2024-03-19. PMID:38500677. |
amyotrophic lateral sclerosis (als) is a common adult-onset neurodegenerative disease characterized by the progressive death of motor neurons in the cerebral cortex, brain stem, and spinal cord. |
2024-03-19 |
2024-03-21 |
human |
| Lynn George, BreAnna Cameron, Lauryn Torres-Hernandez, Virginia Montague, Karen Lewis, Heidi Smith, James Fox, Xueshui Guo, Robert G Kal. Titin is a nucleolar protein in neurons. Research square. 2024-03-18. PMID:38496572. |
additionally, we show that the levels of both titin mrna and protein are altered in the spinal cord of sod1g93a mice, a commonly used model of amyotrophic lateral sclerosis, indicating that titin mediated nucleolar events may in fact contribute to the pathobiology of disease. |
2024-03-18 |
2024-03-20 |
mouse |
| Jelena Scekic-Zahirovic, Cristina Benetton, Aurore Brunet, XiaoQian Ye, Evgeny Logunov, Vincent Douchamps, Salim Megat, Virginie Andry, Vanessa Wing Yin Kan, Geoffrey Stuart-Lopez, Johan Gilet, Simon J Guillot, Sylvie Dirrig-Grosch, Charlotte Gorin, Margaux Trombini, Stéphane Dieterle, Jérôme Sinniger, Mathieu Fischer, Frédérique René, Zeynep Gunes, Pascal Kessler, Luc Dupuis, Pierre-François Pradat, Yannick Goumon, Romain Goutagny, Véronique Marchand-Pauvert, Sabine Liebscher, Caroline Rouau. Cortical hyperexcitability in mouse models and patients with amyotrophic lateral sclerosis is linked to noradrenaline deficiency. Science translational medicine. vol 16. issue 738. 2024-03-13. PMID:38478631. |
amyotrophic lateral sclerosis (als) is a devastating neurodegenerative disease, characterized by the death of upper (umn) and lower motor neurons (lmn) in the motor cortex, brainstem, and spinal cord. |
2024-03-13 |
2024-03-16 |
mouse |
| Maria Janina Wendebourg, Matthias Weigel, Claudia Weidensteiner, Laura Sander, Eva Kesenheimer, Nicole Naumann, Tanja Haas, Philipp Madoerin, Nathalie Braun, Christoph Neuwirth, Markus Weber, Kathleen Jahn, Ludwig Kappos, Cristina Granziera, Kathi Schweikert, Michael Sinnreich, Oliver Bieri, Regina Schlaege. Cervical and thoracic spinal cord gray matter atrophy is associated with disability in patients with amyotrophic lateral sclerosis. European journal of neurology. 2024-03-11. PMID:38465478. |
cervical and thoracic spinal cord gray matter atrophy is associated with disability in patients with amyotrophic lateral sclerosis. |
2024-03-11 |
2024-03-14 |
Not clear |
| Ingrid L Peterson, Austin D Thompson, Natalie E Scholpa, Tally Largent-Milnes, Rick G Schnellman. Isolation and monoculture of functional primary astrocytes from the adult mouse spinal cord. Frontiers in neuroscience. vol 18. 2024-03-04. PMID:38435055. |
astrocytes are a widely heterogenic cell population that play major roles in central nervous system (cns) homeostasis and neurotransmission, as well as in various neuropathologies, including spinal cord injury (sci), traumatic brain injury, and neurodegenerative diseases, such as amyotrophic lateral sclerosis. |
2024-03-04 |
2024-03-06 |
mouse |
| Cyril Jones Jagaraj, Sina Shadfar, Sara Assar Kashani, Sayanthooran Saravanabavan, Fabiha Farzana, Julie D Atki. Molecular hallmarks of ageing in amyotrophic lateral sclerosis. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-03-02. PMID:38430277. |
amyotrophic lateral sclerosis (als) is a fatal, severely debilitating and rapidly progressing disorder affecting motor neurons in the brain, brainstem, and spinal cord. |
2024-03-02 |
2024-03-04 |
Not clear |
| Andrée-Anne Berthiaume, Sherif M Reda, Kayla N Kleist, Sharay E Setti, Wei Wu, Jewel L Johnston, Robert W Taylor, Liana R Stein, Hans J Moebius, Kevin J Churc. ATH-1105, a small-molecule positive modulator of the neurotrophic HGF system, is neuroprotective, preserves neuromotor function, and extends survival in preclinical models of ALS. Frontiers in neuroscience. vol 18. 2024-02-23. PMID:38389786. |
amyotrophic lateral sclerosis (als), a progressive and fatal neurodegenerative disorder, primarily affects the motor neurons of the brain and spinal cord. |
2024-02-23 |
2024-02-25 |
Not clear |
| Mohammad Mohasin Miah, Maliha Afroj Zinnia, Nuzhat Tabassum, Abul Bashar Mir Md Khademul Isla. Association between DPP6 gene rs10260404 polymorphism and increased risk of sporadic amyotrophic lateral sclerosis (sALS): a meta-analysis. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2024-02-21. PMID:38381392. |
sporadic amyotrophic lateral sclerosis (sals) is a severe neurodegenerative disease characterized by continuous diminution of motor neurons in the brain and spinal cord. |
2024-02-21 |
2024-02-23 |
Not clear |
| Xin-Xin Wang, Wen-Zhi Chen, Cheng Li, Ren-Shi X. Current potential pathogenic mechanisms of copper-zinc superoxide dismutase 1 (SOD1) in amyotrophic lateral sclerosis. Reviews in the neurosciences. 2024-02-21. PMID:38381656. |
amyotrophic lateral sclerosis (als) is a rare neurodegenerative disease which damages upper and lower motor neurons (umn and lmn) innervating the muscles of the trunk, extremities, head, neck and face in cerebrum, brain stem and spinal cord, which results in the progressive weakness, atrophy and fasciculation of muscle innervated by the related umn and lmn, accompanying with the pathological signs leaded by the cortical spinal lateral tract lesion. |
2024-02-21 |
2024-02-24 |
Not clear |
| Simran Soni, Mihir S Lukhey, Baban S Thawkar, Meena Chintamaneni, Ginpreet Kaur, Hemant Joshi, Seema Ramniwas, Hardeep Singh Tul. A current review on P2X7 receptor antagonist patents in the treatment of neuroinflammatory disorders: a patent review on antagonists. Naunyn-Schmiedeberg's archives of pharmacology. 2024-02-13. PMID:38349395. |
chronic inflammation is defined by an activated microglial state linked to all neurological disorders, including alzheimer's disease, parkinson's disease, and amyotrophic lateral sclerosis (a motor neuron disease that affects the brain and spinal cord). |
2024-02-13 |
2024-02-15 |
human |
| Patrizia Ratano, Germana Cocozza, Cecilia Pinchera, Ludovica Maria Busdraghi, Iva Cantando, Katiuscia Martinello, Mariarosaria Scioli, Maria Rosito, Paola Bezzi, Sergio Fucile, Heike Wulff, Cristina Limatola, Giuseppina D'Alessandr. Reduction of inflammation and mitochondrial degeneration in mutant SOD1 mice through inhibition of voltage-gated potassium channel Kv1.3. Frontiers in molecular neuroscience. vol 16. 2024-01-31. PMID:38292023. |
amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease with no effective therapy, causing progressive loss of motor neurons in the spinal cord, brainstem, and motor cortex. |
2024-01-31 |
2024-02-02 |
mouse |
| Jian Lu, An-Xu He, Zhuo-Ying Jin, Meng Zhang, Zhong-Xin Li, Fan Zhou, Lin Ma, Hong-Ming Jin, Jia-Ying Wang, Xu She. Desloratadine alleviates ALS-like pathology in hSOD1 Acta pharmacologica Sinica. 2024-01-29. PMID:38286832. |
desloratadine alleviates als-like pathology in hsod1 amyotrophic lateral sclerosis (als) is a fatal neurodegenerative disease with progressive loss of motor neurons in the spinal cord, cerebral cortex and brain stem. |
2024-01-29 |
2024-02-01 |
Not clear |
| Mario Díaz, Noemí Fabelo, M Virginia Martín, Guido Santos, Isidre Ferre. Evidence for alterations in lipid profiles and biophysical properties of lipid rafts from spinal cord in sporadic amyotrophic lateral sclerosis. Journal of molecular medicine (Berlin, Germany). 2024-01-29. PMID:38285093. |
evidence for alterations in lipid profiles and biophysical properties of lipid rafts from spinal cord in sporadic amyotrophic lateral sclerosis. |
2024-01-29 |
2024-01-31 |
human |
| Mario Díaz, Noemí Fabelo, M Virginia Martín, Guido Santos, Isidre Ferre. Evidence for alterations in lipid profiles and biophysical properties of lipid rafts from spinal cord in sporadic amyotrophic lateral sclerosis. Journal of molecular medicine (Berlin, Germany). 2024-01-29. PMID:38285093. |
amyotrophic lateral sclerosis (als) is an age-dependent neurodegenerative disease affecting motor neurons in the spinal cord and brainstem whose etiopathogenesis remains unclear. |
2024-01-29 |
2024-01-31 |
human |
| Mario Díaz, Noemí Fabelo, M Virginia Martín, Guido Santos, Isidre Ferre. Evidence for alterations in lipid profiles and biophysical properties of lipid rafts from spinal cord in sporadic amyotrophic lateral sclerosis. Journal of molecular medicine (Berlin, Germany). 2024-01-29. PMID:38285093. |
key messages: the lipid matrix of multimolecular membrane complexes named lipid rafts are altered in human spinal cord in sporadic amyotrophic lateral sclerosis (als). |
2024-01-29 |
2024-01-31 |
human |
| Younghwi Kwon, Minsung Kang, Yu-Mi Jeon, Shinrye Lee, Ho-Won Lee, Jin-Sung Park, Hyung-Jun Ki. Identification and characterization of novel ERBB4 variant associated with sporadic amyotrophic lateral sclerosis (ALS). Journal of the neurological sciences. 2024-01-26. PMID:38278691. |
amyotrophic lateral sclerosis (als) is the most common type of motor neuron disease characterized by progressive motor neuron degeneration in brain and spinal cord. |
2024-01-26 |
2024-01-29 |
Not clear |