| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qurui Wang, Qinyuan Huang, Xiaowei Ying, Jinze Shen, Shiwei Dua. Unveiling the role of tRNA-derived small RNAs in MAPK signaling pathway: implications for cancer and beyond. Frontiers in genetics. vol 15. 2024-04-10. PMID:38596214. |
elevated tirna-gly-gcc-001, trf-gly-gcc-012, trf-gly-gcc-013, and trf-gly-gcc-016 target spinal cord injury (sci)-related brain-derived neurotrophic factor (bdnf), influencing mapk expression. |
2024-04-10 |
2024-04-12 |
Not clear |
| Serena-Kaye Sims, Madelynne Saddow, Lilly McGonegal, Catrina Sims-Robinso. Intranasal Administration of BDNF Improves Recovery and Promotes Neural Plasticity in a Neonatal Mouse Model of Hypoxic Ischemia. Experimental neurobiology. vol 33. issue 1. 2024-03-12. PMID:38471802. |
intranasal delivery is attractive in that it can promote widespread distribution of bdnf within both the brain and spinal cord. |
2024-03-12 |
2024-03-15 |
mouse |
| Nicholas J Collins, Taylor S Campbell, Aimee L Bozeman, Alleyna C Martes, Sydney E Ross, Tiffany S Doherty, Michele R Brumley, Tania L Rot. Epigenetic processes associated with neonatal spinal transection. Developmental psychobiology. vol 66. issue 2. 2024-02-22. PMID:38388192. |
in early development, the spinal cord in healthy or disease states displays remarkable activity-dependent changes in plasticity, which may be in part due to the increased activity of brain derived neurotrophic factor (bdnf). |
2024-02-22 |
2024-02-25 |
Not clear |
| Nicholas J Collins, Taylor S Campbell, Aimee L Bozeman, Alleyna C Martes, Sydney E Ross, Tiffany S Doherty, Michele R Brumley, Tania L Rot. Epigenetic processes associated with neonatal spinal transection. Developmental psychobiology. vol 66. issue 2. 2024-02-22. PMID:38388192. |
indeed, bdnf delivery has been efficacious in partially ameliorating many of the neurobiological and behavioral consequences of spinal cord injury (sci), making elucidating the role of bdnf in the normative developing and injured spinal cord a critical research focus. |
2024-02-22 |
2024-02-25 |
Not clear |
| Shuxia Zhang, Yeru Chen, Yongjie Wang, Hongwei Wang, Dandan Yao, Gang Che. Tau Accumulation in the Spinal Cord Contributes to Chronic Inflammatory Pain by Upregulation of IL-1β and BDNF. Neuroscience bulletin. 2023-12-26. PMID:38148427. |
tau accumulation in the spinal cord contributes to chronic inflammatory pain by upregulation of il-1β and bdnf. |
2023-12-26 |
2023-12-29 |
Not clear |
| Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Che. Intranasal oxytocin alleviates comorbid depressive symptoms in neuropathic pain via elevating hippocampal BDNF production in both female and male mice. Neuropharmacology. 2023-11-01. PMID:37913985. |
sni also decreased otr expression in the spinal cord and increased spinal glun2a and bdnf. |
2023-11-01 |
2023-11-08 |
mouse |
| Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Che. Intranasal oxytocin alleviates comorbid depressive symptoms in neuropathic pain via elevating hippocampal BDNF production in both female and male mice. Neuropharmacology. 2023-11-01. PMID:37913985. |
however, intranasal oxytocin treatment did not change the expression levels of otr, glun2a, or bdnf in the spinal cord of neuropathic mice. |
2023-11-01 |
2023-11-08 |
mouse |
| Si-Ying Qu, Han-Zhi Wang, Qun-Qi Hu, Yi-Qi Ma, Yu-Rong Kang, Li-Qian Ma, Xiang Li, Lu-Hang Chen, Bo-Yu Liu, Xiao-Mei Shao, Bo-Yi Liu, Jun-Ying Du, Yi Liang, Hong-Li Zhao, Yong-Liang Jiang, Jian-Qiao Fang, Xiao-Fen H. Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the microglia P2X4R and neuroinflammation. Purinergic signalling. 2023-10-23. PMID:37870716. |
intrathecal injection of a p2x4r antagonist or microglia inhibitor attenuated stz-induced nociceptive thermal hyperalgesia and reduced the overexpression of brain-derived neurotrophic factor (bdnf), interleukin-1β (il-1β) and tumor necrosis factor-α (tnf-α) in the spinal cord. |
2023-10-23 |
2023-11-08 |
rat |
| Si-Ying Qu, Han-Zhi Wang, Qun-Qi Hu, Yi-Qi Ma, Yu-Rong Kang, Li-Qian Ma, Xiang Li, Lu-Hang Chen, Bo-Yu Liu, Xiao-Mei Shao, Bo-Yi Liu, Jun-Ying Du, Yi Liang, Hong-Li Zhao, Yong-Liang Jiang, Jian-Qiao Fang, Xiao-Fen H. Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the microglia P2X4R and neuroinflammation. Purinergic signalling. 2023-10-23. PMID:37870716. |
in terms of mechanism, ea reduced the upregulation of p2x4r on activated microglia and decreased bdnf, il-1β and tnf-α in the spinal cord. |
2023-10-23 |
2023-11-08 |
rat |
| Bao-Lei Zhang, Xi-Liang Gu. Electroacupuncture promotes nerve regeneration and functional recovery in rats with spinal cord contusion through the coordinate interaction of CD4 and BDNF. Ibrain. vol 8. issue 3. 2023-10-03. PMID:37786738. |
electroacupuncture promotes nerve regeneration and functional recovery in rats with spinal cord contusion through the coordinate interaction of cd4 and bdnf. |
2023-10-03 |
2023-10-07 |
rat |
| Bao-Lei Zhang, Xi-Liang Gu. Electroacupuncture promotes nerve regeneration and functional recovery in rats with spinal cord contusion through the coordinate interaction of CD4 and BDNF. Ibrain. vol 8. issue 3. 2023-10-03. PMID:37786738. |
lastly, the expression of cd4 and brain-derived neurotrophic factor (bdnf) in spinal cord scar was verified by quantitative reverse-transcription polymerase chain reaction (qrt-pcr). |
2023-10-03 |
2023-10-07 |
rat |
| Chenxin Miao, Xiaoning Li, Yishu Zhan. Effect of acupuncture on BDNF signaling pathways in several nervous system diseases. Frontiers in neurology. vol 14. 2023-10-02. PMID:37780709. |
furthermore, this review discusses explicitly the regulation of bdnf by acupuncture in several nervous system diseases, including neuropathic pain, parkinson's disease, cerebral ischemia, depression, spinal cord injury, and other diseases. |
2023-10-02 |
2023-10-07 |
Not clear |
| Hong Su, Haiyan Chen, Xi Zhang, Shengyong Su, Jing Li, Yanjun Guo, Qiongxiao Wang, Caiyun Xie, Pu Yan. Electroacupuncture ameliorates pain in cervical spondylotic radiculopathy rat by inhibiting the CaMKII/CREB/BDNF signaling pathway and regulating spinal synaptic plasticity. Brain and behavior. 2023-08-07. PMID:37548586. |
recent studies have shown that the calmodulin-dependent protein kinase ii (camkii)/camp-response element binding protein (creb)/brain-derived neurotrophic factor (bdnf) signaling pathway mediates central sensitization through its involvement in spinal cord synaptic plasticity. |
2023-08-07 |
2023-08-14 |
rat |
| Mayra Zancanaro, Dirson J Stein, Bettega C Lopes, Andressa de Souza, Roberta Ströher Toledo, Alessandra H de Souza, Sara M Oliveira, Fernanda Visioli, Paulo R S Sanches, Felipe Fregni, Wolnei Caumo, Iraci L S Torre. Preemptive transcranial direct current stimulation induces analgesia, prevents chronic inflammation and fibrosis, and promotes tissue repair in a rat model of postoperative pain. Neuroscience letters. 2023-07-27. PMID:37499743. |
cytokines and bdnf levels were evaluated in the cerebral cortex, hippocampus, brainstem, and spinal cord. |
2023-07-27 |
2023-08-14 |
rat |
| Mayra Zancanaro, Dirson J Stein, Bettega C Lopes, Andressa de Souza, Roberta Ströher Toledo, Alessandra H de Souza, Sara M Oliveira, Fernanda Visioli, Paulo R S Sanches, Felipe Fregni, Wolnei Caumo, Iraci L S Torre. Preemptive transcranial direct current stimulation induces analgesia, prevents chronic inflammation and fibrosis, and promotes tissue repair in a rat model of postoperative pain. Neuroscience letters. 2023-07-27. PMID:37499743. |
the results demonstrate that the surgery procedure increased bdnf and il-6 levels in the spinal cord levels in the hippocampus, and decreased il-1β and il-6 levels in the cerebral cortex, il-6 levels in the hippocampus, and il-10 levels in the brainstem and hippocampus. |
2023-07-27 |
2023-08-14 |
rat |
| Mayra Zancanaro, Dirson J Stein, Bettega C Lopes, Andressa de Souza, Roberta Ströher Toledo, Alessandra H de Souza, Sara M Oliveira, Fernanda Visioli, Paulo R S Sanches, Felipe Fregni, Wolnei Caumo, Iraci L S Torre. Preemptive transcranial direct current stimulation induces analgesia, prevents chronic inflammation and fibrosis, and promotes tissue repair in a rat model of postoperative pain. Neuroscience letters. 2023-07-27. PMID:37499743. |
in addition, preemptive tdcs was effective in controlling postoperative pain, increasing bdnf, il-6, and il-10 levels in the spinal cord and brainstem, increasing il-1β in the spinal cord, and decreasing il-6 levels in the cerebral cortex and hippocampus, il-1β and il-10 levels in the hippocampus. |
2023-07-27 |
2023-08-14 |
rat |
| Thomas Jacobus Geus, Glenn Franken, Bert Bert Jooste. Conventional, High Frequency and Differential Targeted Multiplexed Spinal Cord Stimulation in experimental Painful Diabetic Peripheral Neuropathy: pain behavior and role of the central inflammatory balance. Molecular pain. 2023-07-25. PMID:37488684. |
the inflammatory balance and glial response were analyzed in the dorsal spinal cord based on rna expression of pro- and anti-inflammatory cytokines (tnf-α, il-1ß, il-4, il-10), a microglia marker (itgam), an astrocyte marker (gfap), a t-cell marker (cd3d), microglia proliferation markers (irf8, adgre1) and p2x4, p13-mapk, bdnf signaling markers (p2x4, mapk14, bdnf). |
2023-07-25 |
2023-08-14 |
Not clear |
| Jie Zheng, Feng Yang, Pu-Wei Yuan, Jing-Jie Fan, Xiao-Hui Zheng, Rui Zhu, Yang-le L. [Effect of electroacupuncture on the expression of Iba-1 in spinal dorsal horn and hippocampus of chronic pain rats with knee osteoarthritis]. Zhen ci yan jiu = Acupuncture research. vol 48. issue 5. 2023-05-29. PMID:37247855. |
to observe the effect of electroacupuncture(ea) on pain-ralated behaviors, morphology of hippocampus, concentrations of inflammatory cytokines and expression of ionized calcium binding adapter molecule 1(iba-1) in dorsal horn of the spinal cord and the hippocampus, and brain-derived neurotrophic factor (bdnf) in hippocampus of rats with knee osteoarthritis (koa), so as to explore the mechanism of ea in improving chronic pain of koa. |
2023-05-29 |
2023-08-14 |
rat |
| Mehdi Zargani, Rodrigo Ramirez-Campillo, Ehsan Arabzade. Swimming and L-arginine loaded chitosan nanoparticles ameliorates aging-induced neuron atrophy, autophagy marker LC3, GABA and BDNF-TrkB pathway in the spinal cord of rats. Pflugers Archiv : European journal of physiology. 2023-03-04. PMID:36869900. |
the old sw + la-cnps group increased (improved) spinal cord gaba (p = 0.0187), bdnf (p = 0.0003), trkb (p < 0.0001) gene expression, decreased autophagy marker lc3 protein (p < 0.0001), nerve atrophy and jumping/licking latency (p < 0.0001), improved sciatic functional index score and total oxidant status/total antioxidant capacity compared to the old group (p < 0.0001). |
2023-03-04 |
2023-08-14 |
rat |
| Takahiro Shibata, Syoichi Tashiro, Shinsuke Shibata, Munehisa Shinozaki, Tomoko Shindo, Shogo Hashimoto, Momotaro Kawai, Takahiro Kitagawa, Kentaro Ago, Morio Matsumoto, Masaya Nakamura, Hideyuki Okano, Narihito Nagosh. Rehabilitative Training Enhances Therapeutic Effect of Human-iPSC-Derived Neural Stem/Progenitor Cells Transplantation in Chronic Spinal Cord Injury. Stem cells translational medicine. 2023-01-17. PMID:36647673. |
the combination therapy was able to enhance the expressions of the bdnf and nt-3 proteins in the spinal cord tissue. |
2023-01-17 |
2023-08-14 |
Not clear |