| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aruna Sharma, Lianyuan Feng, Dafin F Muresanu, Hongyun Huang, Preeti K Menon, Seaab Sahib, Z Ryan Tian, José Vicente Lafuente, Anca D Buzoianu, Rudy J Castellani, Ala Nozari, Lars Wiklund, Hari Shanker Sharm. Topical application of CNTF, GDNF and BDNF in combination attenuates blood-spinal cord barrier permeability, edema formation, hemeoxygenase-2 upregulation, and cord pathology. Progress in brain research. vol 266. 2021-11-24. PMID:34689864. |
topical application of cntf with bdnf and gdnf in combination (10ng each) after 90 and 120min over the injured spinal cord significantly attenuated the bscb breakdown, edema formation, cell injury and overexpression of ho-2. |
2021-11-24 |
2023-08-13 |
Not clear |
| Chang-Hong Liu, Bo-Lun Zhao, Wen-Tao Li, Xiao-Hua Zhou, Zhe Jin, Li-Bin A. Effects of body weight-supported treadmill training at different speeds on the motor function and depressive behaviors after spinal cord injury in rats. Neuroreport. vol 31. issue 18. 2021-11-15. PMID:33165200. |
based on our results, bwstt at 21 cm/s produced the best outcomes for motor function recovery and the spinal cord levels of brain-derived neurotrophic factor (bdnf) and tropomyosin receptor kinase b (trkb). |
2021-11-15 |
2023-08-13 |
rat |
| Jinghong Chen, Qingjie Li, Genevieve Saliuk, Sonia Bazhanov, John H Winsto. Estrogen and serotonin enhance stress-induced visceral hypersensitivity in female rats by up-regulating brain-derived neurotrophic factor in spinal cord. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 33. issue 10. 2021-11-09. PMID:33705592. |
we previously reported that female offspring of dams subjected to chronic prenatal stress (cps) develop enhanced visceral hypersensitivity (vhs) following exposure to chronic stress in adult life that is mediated by up-regulation of spinal cord bdnf. |
2021-11-09 |
2023-08-13 |
rat |
| Jinghong Chen, Qingjie Li, Genevieve Saliuk, Sonia Bazhanov, John H Winsto. Estrogen and serotonin enhance stress-induced visceral hypersensitivity in female rats by up-regulating brain-derived neurotrophic factor in spinal cord. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 33. issue 10. 2021-11-09. PMID:33705592. |
the aims of this study were to examine the roles of estrogen receptor alpha (erα) and an increase in spinal serotonin signaling in promoting this enhanced vhs in female rats and up-regulation of spinal cord bdnf transcription. |
2021-11-09 |
2023-08-13 |
rat |
| Francesco Ferrini, Chiara Salio, Elena M Boggio, Adalberto Merigh. Interplay of BDNF and GDNF in the Mature Spinal Somatosensory System and Its Potential Therapeutic Relevance. Current neuropharmacology. vol 19. issue 8. 2021-11-05. PMID:33200712. |
this review resumes the current literature on the interplay between bdnf and gdnf in the regulation of nociceptive neurotransmission in the superficial dorsal horn of the spinal cord. |
2021-11-05 |
2023-08-13 |
Not clear |
| Stefania Giotti Cioato, Liciane Fernandes Medeiros, Bettega Costa Lopes, Andressa de Souza, Helouise Richardt Medeiros, José Antônio Fagundes Assumpção, Wolnei Caumo, Rafael Roesler, Iraci L S Torre. Antinociceptive and neurochemical effects of a single dose of IB-MECA in chronic pain rat models. Purinergic signalling. vol 16. issue 4. 2021-10-26. PMID:33161497. |
interleukin 1β (il-1β), brain-derived neurotrophic factor (bdnf), and nerve growth factor (ngf) levels were measured in the brainstem and spinal cord using enzyme-linked immunosorbent assay (elisa). |
2021-10-26 |
2023-08-13 |
rat |
| Che Aishah Nazariah Ismail, Rapeah Suppian, Che Badariah Ab Aziz, Idris Lon. Ifenprodil Reduced Expression of Activated Microglia, BDNF and DREAM Proteins in the Spinal Cord Following Formalin Injection During the Early Stage of Painful Diabetic Neuropathy in Rats. Journal of molecular neuroscience : MN. vol 71. issue 2. 2021-10-05. PMID:32671697. |
ifenprodil reduced expression of activated microglia, bdnf and dream proteins in the spinal cord following formalin injection during the early stage of painful diabetic neuropathy in rats. |
2021-10-05 |
2023-08-13 |
rat |
| Che Aishah Nazariah Ismail, Rapeah Suppian, Che Badariah Ab Aziz, Idris Lon. Ifenprodil Reduced Expression of Activated Microglia, BDNF and DREAM Proteins in the Spinal Cord Following Formalin Injection During the Early Stage of Painful Diabetic Neuropathy in Rats. Journal of molecular neuroscience : MN. vol 71. issue 2. 2021-10-05. PMID:32671697. |
this study aims to determine the effect of ifenprodil, a potent noncompetitive nmdar-2b antagonist, on activated microglia, brain-derived neurotrophic factors (bdnf) and downstream regulatory element antagonist modulator (dream) protein expression in the spinal cord of streptozotocin-induced painful diabetic neuropathy (pdn) rats following formalin injection. |
2021-10-05 |
2023-08-13 |
rat |
| Che Aishah Nazariah Ismail, Rapeah Suppian, Che Badariah Ab Aziz, Idris Lon. Ifenprodil Reduced Expression of Activated Microglia, BDNF and DREAM Proteins in the Spinal Cord Following Formalin Injection During the Early Stage of Painful Diabetic Neuropathy in Rats. Journal of molecular neuroscience : MN. vol 71. issue 2. 2021-10-05. PMID:32671697. |
as such, ifenprodil successfully demonstrated inhibition against microglia activation and suppressed the expression of bdnf and dream proteins in the spinal cord of pdn rats. |
2021-10-05 |
2023-08-13 |
rat |
| Morgana D da Silva, Giselle Guginski, Karina L Sato, Luciana Sayuri Sanada, Kathleen A Sluka, Adair R S Santo. Persistent pain induces mood problems and memory loss by the involvement of cytokines, growth factors, and supraspinal glial cells. Brain, behavior, & immunity - health. vol 7. 2021-10-01. PMID:34589875. |
in the spinal cord, there were increases in both pro and anti-inflammatory cytokines, as well as of bdnf and nerve growth factor (ngf). |
2021-10-01 |
2023-08-13 |
mouse |
| Jun-Jie Ma, Tie-Ming Ma, Lie Wang, Zhe H. [Effect of moxibustion on the expression of microglia and brain-derived neurotrophic factor protein in the spinal cord of rats with myofascial pain syndrome]. Zhen ci yan jiu = Acupuncture research. vol 46. issue 9. 2021-09-27. PMID:34558243. |
to observe the effect of moxibustion at myofascial trigger points on microglia activation and the expression of brain-derived neurotrophic factor (bdnf) in the spinal cord of rats with myofascial pain syndrome (mps), so as to explore the central mechanism of the analgesic effect of moxibustion. |
2021-09-27 |
2023-08-13 |
rat |
| Xiao-Yin Liu, Chong Chen, Hai-Huan Xu, Yu-Sheng Zhang, Lin Zhong, Nan Hu, Xiao-Li Jia, You-Wei Wang, Kun-Hong Zhong, Chang Liu, Xu Zhu, Dong Ming, Xiao-Hong L. Integrated printed BDNF/collagen/chitosan scaffolds with low temperature extrusion 3D printer accelerated neural regeneration after spinal cord injury. Regenerative biomaterials. vol 8. issue 6. 2021-09-14. PMID:34513004. |
in this study, we developed a collagen/chitosan scaffold integrated with brain-derived neurotrophic factor (3d-cc-bdnf) by low temperature extrusion 3d printing as a new type of artificial controlled release system, which could prolong the release of bdnf for the treatment of spinal cord injury (sci). |
2021-09-14 |
2023-08-13 |
rat |
| Sudhirkumar Yanpallewar, Gianluca Fulgenzi, Francesco Tomassoni-Ardori, Colleen Barrick, Lino Tessaroll. Delayed onset of inherited ALS by deletion of the BDNF receptor TrkB.T1 is non-cell autonomous. Experimental neurology. vol 337. 2021-09-13. PMID:33359475. |
in the inherited als g93a sod1 animal model, deletion of the bdnf receptor trkb.t1 delays spinal cord motoneuron cell death and muscle weakness through an unknown cellular mechanism. |
2021-09-13 |
2023-08-13 |
human |
| Gary C Sieck, Heather M Gransee, Wen-Zhi Zhan, Carlos B Mantill. Acute intrathecal BDNF enhances functional recovery after cervical spinal cord injury in rats. Journal of neurophysiology. vol 125. issue 6. 2021-08-17. PMID:33949892. |
acute intrathecal bdnf enhances functional recovery after cervical spinal cord injury in rats. |
2021-08-17 |
2023-08-13 |
rat |
| Roberta Ströher Toledo, Dirson João Stein, Paulo Roberto Stefani Sanches, Lisiane Santos da Silva, Helouise Richardt Medeiros, Felipe Fregni, Wolnei Caumo, Iraci L S Torre. rTMS induces analgesia and modulates neuroinflammation and neuroplasticity in neuropathic pain model rats. Brain research. vol 1762. 2021-08-11. PMID:33737061. |
biochemical assays to assess the levels of brain-derived neurotrophic factor (bdnf), tumor necrosis factor-alpha (tnf-α), and interleukin (il)-10, were performed in the prefrontal cortex (pfc) and spinal cord tissue homogenates. |
2021-08-11 |
2023-08-13 |
rat |
| Yuanyuan Huang, Dangwei Peng, Hao Geng, Yutian Dai, Hui Jiang, Xiansheng Zhan. Expression of brain-derived neurotrophic factor in rapid ejaculator rats: A further study. Andrologia. vol 53. issue 8. 2021-08-11. PMID:34101873. |
bdnf levels in specific brain regions, spinal cord and serum were determined by enzyme-linked immunosorbent assay (elisa). |
2021-08-11 |
2023-08-13 |
rat |
| Yuanyuan Huang, Dangwei Peng, Hao Geng, Yutian Dai, Hui Jiang, Xiansheng Zhan. Expression of brain-derived neurotrophic factor in rapid ejaculator rats: A further study. Andrologia. vol 53. issue 8. 2021-08-11. PMID:34101873. |
besides, in both brain regions and spinal cord, the sluggish group had the highest bdnf levels, while the rapid group had the lowest bdnf levels. |
2021-08-11 |
2023-08-13 |
rat |
| Yuanyuan Huang, Dangwei Peng, Hao Geng, Yutian Dai, Hui Jiang, Xiansheng Zhan. Expression of brain-derived neurotrophic factor in rapid ejaculator rats: A further study. Andrologia. vol 53. issue 8. 2021-08-11. PMID:34101873. |
regression analyses of the expression of bdnf presented positive correlations between serum and brain (r = 0.958, p < .001), and between serum and spinal cord (r = 0.967, p < .001) respectively. |
2021-08-11 |
2023-08-13 |
rat |
| Chihiro Tanji, Masayuki Hashimoto, Takeo Furuya, Junya Saito, Takuya Miyamoto, Masao Kod. Sigma 1 receptor agonist cutamesine promotes plasticity of serotonergic boutons in lumbar enlargement in spinal cord injured rats. Neuroscience letters. vol 759. 2021-08-06. PMID:34023415. |
first of all, in order to determine optimal cutamesine dose, cutamesine was administered to normal rats and bdnf protein levels in the lumbar spinal cord were assessed by western blot. |
2021-08-06 |
2023-08-13 |
rat |
| Chihiro Tanji, Masayuki Hashimoto, Takeo Furuya, Junya Saito, Takuya Miyamoto, Masao Kod. Sigma 1 receptor agonist cutamesine promotes plasticity of serotonergic boutons in lumbar enlargement in spinal cord injured rats. Neuroscience letters. vol 759. 2021-08-06. PMID:34023415. |
immunohistochemistry for bdnf and 5-ht was assessed at four and twelve weeks post-injury in the lumbar spinal cord. |
2021-08-06 |
2023-08-13 |
rat |