| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alejandro Pluma-Pluma, Guadalupe García, Janet Murbartiá. Chronic restraint stress and social transfer of stress produce tactile allodynia mediated by the HMGB1/TNF.Ñó./TNFR1 pathway in female and male rats. Physiology & behavior. 2023-12-02. PMID:38042454. |
rats under crs or sts enhanced hmgb1 and tnfr1 protein expression in drg and dorsal spinal cord. |
2023-12-02 |
2023-12-10 |
rat |
| Zhiwu Wu, Liping Liang, Qianliang Huan. Potential significance of high-mobility group protein box 1 in cerebrospinal fluid. Heliyon. vol 9. issue 11. 2023-12-01. PMID:38027583. |
csf hmgb1 is useful not only as a biomarker of cns diseases but may also be involved in interactions between different brain regions and the spinal cord. |
2023-12-01 |
2023-12-10 |
Not clear |
| Erick J Rodríguez-Palma, Isabel Velazquez-Lagunas, Ana Belen Salinas-Abarca, Guadalupe C Vidal-Cantú, María J Escoto-Rosales, Gabriela Castañeda-Corral, Alonso Fernández-Guasti, Vinicio Granados-Sot. Spinal alarmin HMGB1 and the activation of TLR4 lead to chronic stress-induced nociceptive hypersensitivity in rodents. European journal of pharmacology. 2023-05-27. PMID:37244377. |
moreover, chronic stress enhanced hmgb1 and tlr4 protein expression at the dorsal root ganglion, but not at the spinal cord. |
2023-05-27 |
2023-08-14 |
mouse |
| Fatemeh Abbaszadeh, Masoumeh Jorjani, Mohammad Taghi Joghataei, Samira Raminfard, Soraya Mehrab. Astaxanthin ameliorates spinal cord edema and astrocyte activation via suppression of HMGB1/TLR4/NF-κB signaling pathway in a rat model of spinal cord injury. Naunyn-Schmiedeberg's archives of pharmacology. 2023-05-05. PMID:37145127. |
the effects of ast were examined on the motor function, spinal cord edema, integrity of blood-spinal cord barrier (bscb), and expression of high mobility group box 1 (hmgb1), toll-like receptor 4 (tlr4), nuclear factor-kappa b (nf-κb), glial fibrillary acidic protein (gfap), and aquaporin-4 (aqp4), and matrix metallopeptidase- 9 (mmp-9) post-sci. |
2023-05-05 |
2023-08-14 |
rat |
| Fatemeh Abbaszadeh, Masoumeh Jorjani, Mohammad Taghi Joghataei, Samira Raminfard, Soraya Mehrab. Astaxanthin ameliorates spinal cord edema and astrocyte activation via suppression of HMGB1/TLR4/NF-κB signaling pathway in a rat model of spinal cord injury. Naunyn-Schmiedeberg's archives of pharmacology. 2023-05-05. PMID:37145127. |
we showed that ast potentially improved the recovery of motor function and inhibited the spinal cord edema via maintaining the integrity of bscb, reducing the expression of hmgb1, tlr4, and nf-κb, mmp-9 as well as downregulation of astrocyte activation (gfap) and aqp4 expression. |
2023-05-05 |
2023-08-14 |
rat |
| Tong-Tong Lin, Chun-Yi Jiang, Lei Sheng, Li Wan, Wen Fan, Jin-Can Li, Xiao-Di Sun, Chen-Jie Xu, Liang Hu, Xue-Feng Wu, Yuan Han, Wen-Tao Liu, Yin-Bing Pa. Suppressing high mobility group box-1 release alleviates morphine tolerance via the adenosine 5'-monophosphate-activated protein kinase/heme oxygenase-1 pathway. Neural regeneration research. vol 18. issue 9. 2023-03-17. PMID:36926733. |
we found that morphine induced rat spinal cord neurons to release a large amount of hmgb1. |
2023-03-17 |
2023-08-14 |
mouse |
| Man Li, Junqiao Lv, Zhiqiang Wang, Liping Wang, Zhixin Qin, Chen Deng, Jinming Liu, Lin Su. The inhibition of HMGB1 attenuates spinal cord edema by reducing the expression of Na+-K+-Cl- cotransporter-1 and Na+/H+ exchanger-1 in both astrocytes and endothelial cells after spinal cord injury in rats. Journal of neurotrauma. 2023-02-23. PMID:36815608. |
the inhibition of hmgb1 attenuates spinal cord edema by reducing the expression of na+-k+-cl- cotransporter-1 and na+/h+ exchanger-1 in both astrocytes and endothelial cells after spinal cord injury in rats. |
2023-02-23 |
2023-08-14 |
rat |
| Man Li, Junqiao Lv, Zhiqiang Wang, Liping Wang, Zhixin Qin, Chen Deng, Jinming Liu, Lin Su. The inhibition of HMGB1 attenuates spinal cord edema by reducing the expression of Na+-K+-Cl- cotransporter-1 and Na+/H+ exchanger-1 in both astrocytes and endothelial cells after spinal cord injury in rats. Journal of neurotrauma. 2023-02-23. PMID:36815608. |
high-mobility group box-1 (hmgb1) promotes spinal cord edema after sci. |
2023-02-23 |
2023-08-14 |
rat |
| Man Li, Junqiao Lv, Zhiqiang Wang, Liping Wang, Zhixin Qin, Chen Deng, Jinming Liu, Lin Su. The inhibition of HMGB1 attenuates spinal cord edema by reducing the expression of Na+-K+-Cl- cotransporter-1 and Na+/H+ exchanger-1 in both astrocytes and endothelial cells after spinal cord injury in rats. Journal of neurotrauma. 2023-02-23. PMID:36815608. |
accordingly, we sought to identify both the role of hmgb1 and the mechanism of its effect on nkcc1 and nhe1 expression in astrocytes and endothelial cells as well as the role of the regulation of spinal cord edema after sci. |
2023-02-23 |
2023-08-14 |
rat |
| Man Li, Junqiao Lv, Zhiqiang Wang, Liping Wang, Zhixin Qin, Chen Deng, Jinming Liu, Lin Su. The inhibition of HMGB1 attenuates spinal cord edema by reducing the expression of Na+-K+-Cl- cotransporter-1 and Na+/H+ exchanger-1 in both astrocytes and endothelial cells after spinal cord injury in rats. Journal of neurotrauma. 2023-02-23. PMID:36815608. |
the inhibition of hmgb1 reduced nkcc1 and nhe1 expression in the spinal cord of sci rats, in cultured spinal cord astrocytes, and in cultured microvascular endothelial cells. |
2023-02-23 |
2023-08-14 |
rat |
| Man Li, Junqiao Lv, Zhiqiang Wang, Liping Wang, Zhixin Qin, Chen Deng, Jinming Liu, Lin Su. The inhibition of HMGB1 attenuates spinal cord edema by reducing the expression of Na+-K+-Cl- cotransporter-1 and Na+/H+ exchanger-1 in both astrocytes and endothelial cells after spinal cord injury in rats. Journal of neurotrauma. 2023-02-23. PMID:36815608. |
these results imply that hmgb1 inhibition results in a reduction in nkcc1 and nhe1 expression in both astrocytes and microvascular endothelial cells and thus decreases spinal cord edema after sci in rats and that these effects occur through the hmgb1-tlr4-trif-nf-κb signaling pathway. |
2023-02-23 |
2023-08-14 |
rat |
| Yizhang Mo, Kebing Che. Review: The role of HMGB1 in spinal cord injury. Frontiers in immunology. vol 13. 2023-01-30. PMID:36713448. |
review: the role of hmgb1 in spinal cord injury. |
2023-01-30 |
2023-08-14 |
Not clear |
| Yizhang Mo, Kebing Che. Review: The role of HMGB1 in spinal cord injury. Frontiers in immunology. vol 13. 2023-01-30. PMID:36713448. |
after spinal cord injury, hmgb1 is rapidly expressed by neurons, microglia and ependymal cells, and it is either actively or passively released into the extracellular matrix and blood circulation; furthermore, it also participates in the pathophysiological process of spinal cord injury. |
2023-01-30 |
2023-08-14 |
Not clear |
| Yizhang Mo, Kebing Che. Review: The role of HMGB1 in spinal cord injury. Frontiers in immunology. vol 13. 2023-01-30. PMID:36713448. |
this article reviews the specific timing of secretion and translocation, the release mechanism and the role of hmgb1 in spinal cord injury. |
2023-01-30 |
2023-08-14 |
Not clear |
| Yizhang Mo, Kebing Che. Review: The role of HMGB1 in spinal cord injury. Frontiers in immunology. vol 13. 2023-01-30. PMID:36713448. |
furthermore, the role and mechanism of hmgb1 in spinal cord injury and, the challenges that still need to be addressed are identified, and this work will provide a basis for future studies. |
2023-01-30 |
2023-08-14 |
Not clear |
| Chengwei Yang, Fang Kang, Xiang Huang, Wenjie Zhang, Sheng Wang, Mingming Han, Zhi Zhang, Juan L. Melatonin attenuates bone cancer pain via the SIRT1/HMGB1 pathway. Neuropharmacology. 2022-09-19. PMID:36122662. |
we found that the levels of sirtuin 1 (sirt1) and nucleus-high mobility group box-1 (hmgb1) were decreased, whilst the levels of hmgb1, cytoplasm-hmgb1 and inflammatory cytokines (tnf-α, il-6, il-1β) were increased in the spinal cord of bcp mice on days 7, 14 and 21 after implantation compared with the levels in sham mice. |
2022-09-19 |
2023-08-14 |
mouse |
| Zhiwu Wu, Meihua L. High-Mobility Group Box 1 in Spinal Cord Injury and Its Potential Role in Brain Functional Remodeling After Spinal Cord Injury. Cellular and molecular neurobiology. 2022-06-17. PMID:35715656. |
hmgb1 expression has been reported to be increased in the tissues of spinal cord injury (sci) patients and involved in the regulation of neuroinflammation, neuronal apoptosis, and ferroptosis. |
2022-06-17 |
2023-08-14 |
Not clear |
| Megan E Rouillard, Jingwen Hu, Pearl A Sutter, Hee Won Kim, Jeffrey K Huang, Stephen J Crocke. The Cellular Senescence Factor Extracellular HMGB1 Directly Inhibits Oligodendrocyte Progenitor Cell Differentiation and Impairs CNS Remyelination. Frontiers in cellular neuroscience. vol 16. 2022-05-16. PMID:35573828. |
herein, we report that administration of recombinant hmgb1 into the spinal cord at the time of lysolecithin administration resulted in arrest of opc differentiation |
2022-05-16 |
2023-08-13 |
Not clear |
| Yalan Sun, Dandan Jia, Meng Xue, Zhihua Huang, Cheng Huan. Trifluoro-icaritin alleviates chronic inflammatory pain through α7nAChR-mediated suppression of HMGB1/NF-κB signaling in the spinal cord of rats. Brain research bulletin. 2022-02-24. PMID:35202753. |
subsequently, we further observed that ictf (3.0mg/kg) dramatically decreased the mrna and protein levels of hmgb1, nf-κb p65, and il-1β but markedly enhanced α7nachr and il-10 expression in the spinal cord of cfa rats, and immunofluorescence staining also showed that ictf (3.0mg/kg) significantly increased the expression of α7nachr and reduced iba1 in the spinal cord of cfa rats, along with suppressing the alterations of gait parameters induced by cfa. |
2022-02-24 |
2023-08-13 |
rat |
| Zhiwu Wu, Zhihua Wang, Zhiping Xie, Huaxin Zhu, Chengcai Li, Shenke Xie, Wu Zhou, Zhixiong Zhang, Meihua L. Glycyrrhizic acid attenuates the inflammatory response after spinal cord injury by inhibiting HMGB1 through the p38/JNK signaling pathway. World neurosurgery. 2021-11-28. PMID:34838764. |
glycyrrhizic acid attenuates the inflammatory response after spinal cord injury by inhibiting hmgb1 through the p38/jnk signaling pathway. |
2021-11-28 |
2023-08-13 |
rat |