All Relations between spinal cord and microglial cell

Publication Sentence Publish Date Extraction Date Species
Chenxia Duan, Yi Zhu, Zhuoliang Zhang, Tiantian Wu, Mengwei Shen, Jinfu Xu, Wenxin Gao, Jianhua Pan, Lei Wei, Huibin Su, Chenghuan Sh. Esketamine inhibits the JNK-c-Jun pathway in the spinal dorsal horn to relieve bone cancer pain in rats. Molecular pain. 2024-02-28. PMID:38417838. immunofluorescence images showed activated microglia in the spinal cord on day 14 after tci and co-expression of cxcl12/cxcr4, p-mapks (p-jnk, p-erk, p-p38 mapk), and p-c-jun in microglia. 2024-02-28 2024-03-02 rat
Chenxia Duan, Yi Zhu, Zhuoliang Zhang, Tiantian Wu, Mengwei Shen, Jinfu Xu, Wenxin Gao, Jianhua Pan, Lei Wei, Huibin Su, Chenghuan Sh. Esketamine inhibits the JNK-c-Jun pathway in the spinal dorsal horn to relieve bone cancer pain in rats. Molecular pain. 2024-02-28. PMID:38417838. overall, our data suggest that the cxcl12/cxcr4-jnk-c-jun signaling pathway of microglia in the spinal cord mediates neuronal sensitization and pain hypersensitivity in cancer-induced bone pain and that esketamine exerts its analgesic effect by inhibiting the jnk-c-jun pathway. 2024-02-28 2024-03-02 rat
Hu Lv, Jiaojiao Huang, Xin Zhang, Zhiyong He, Jun Zhang, Wei Che. Xenon ameliorates chronic post-surgical pain by regulating mitophagy in microglia and rats mediated by PINK1/Parkin pathway. PeerJ. vol 12. 2024-02-23. PMID:38390390. chronic post-surgical pain (cpsp) is one of the important causes of poor postoperative outcomes, the activation of microglia in the spinal cord is closely related to the generation, transmission and maintenance of cpsp. 2024-02-23 2024-02-25 rat
Anup Bhusal, Jae-Hong Kim, Seung-Chan Kim, Eun Mi Hwang, Hoon Ryu, Md Sekendar Ali, Seung-Chun Park, Won-Ha Lee, Kyoungho Su. The microglial innate immune protein PGLYRP1 mediates neuroinflammation and consequent behavioral changes. Cell reports. vol 43. issue 3. 2024-02-23. PMID:38393947. we observed the upregulation of pglyrp1 in inflamed human and mouse spinal cord and brain, with microglia being the primary cellular source. 2024-02-23 2024-02-26 mouse
Jing Zhang, Xiaoyue Zhang, Qi Jiang, Di Qu, Yusheng Hu, Chao Qi, Haitao F. [Experimental study of M2 microglia transplantation promoting spinal cord injury repair in mice]. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery. vol 38. issue 2. 2024-02-22. PMID:38385233. [experimental study of m2 microglia transplantation promoting spinal cord injury repair in mice]. 2024-02-22 2024-02-24 mouse
Jing Zhang, Xiaoyue Zhang, Qi Jiang, Di Qu, Yusheng Hu, Chao Qi, Haitao F. [Experimental study of M2 microglia transplantation promoting spinal cord injury repair in mice]. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery. vol 38. issue 2. 2024-02-22. PMID:38385233. to investigate the effect of m2 microglia (m2-mg) transplantation on spinal cord injury (sci) repair in mice. 2024-02-22 2024-02-24 mouse
Jenna Ollodart, Laiton R Steele, E Alfonso Romero-Sandoval, Roy E Strowd, Yusuke Shiozaw. Contributions of neuroimmune interactions to chemotherapy-induced peripheral neuropathy development and its prevention/therapy. Biochemical pharmacology. 2024-02-22. PMID:38387528. interestingly, monocytes/macrophages in dorsal root ganglia; microglia and astrocytes in spinal cord; mast cells in skin; and schwann cell near peripheral nerves have been identified as inducers of cipn behaviors, whereas t cells have been found to contribute to cipn resolution. 2024-02-22 2024-02-25 Not clear
Hangyu Guo, Mingyu Du, Yang Yang, Xin Lin, Yufu Wang, Helin Li, Jiyu Ren, Wenbo Xu, Jinglong Yan, Nanxiang Wan. Sp1 regulates the M1 polarization of microglia through the HuR/NF-κB axis after spinal cord injury. Neuroscience. 2024-02-22. PMID:38387733. sp1 regulates the m1 polarization of microglia through the hur/nf-κb axis after spinal cord injury. 2024-02-22 2024-02-25 mouse
Hangyu Guo, Mingyu Du, Yang Yang, Xin Lin, Yufu Wang, Helin Li, Jiyu Ren, Wenbo Xu, Jinglong Yan, Nanxiang Wan. Sp1 regulates the M1 polarization of microglia through the HuR/NF-κB axis after spinal cord injury. Neuroscience. 2024-02-22. PMID:38387733. the m1 polarization of microglia, followed by the production of pro-inflammatory mediators, hinders functional recovery after spinal cord injury (sci). 2024-02-22 2024-02-25 mouse
Weixin Xie, Fan Li, Yi Han, Xiaoying Chi, Yi Qin, Fan Ye, Zhanchun Li, Jie Xia. Calcitonin gene-related peptide attenuated discogenic low back pain in rats possibly via inhibiting microglia activation. Heliyon. vol 10. issue 3. 2024-02-19. PMID:38371980. we observed obvious lumbar intervertebral disc degeneration and hyperalgesia at 12 weeks postoperation in dlbp group, with significantly activated microglia in the spinal cord. 2024-02-19 2024-02-21 rat
Jiarui Wei, Tao Li, Shengyuan Lin, Bin Zhang, Xing L. Dihydrotestosterone reduces neuroinflammation in spinal cord injury through NF-κB and MAPK pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 1. 2024-02-19. PMID:38372091. neuroinflammation induced by microglia following spinal cord injury (sci) leads to secondary neurologic injury. 2024-02-19 2024-02-21 mouse
Jing Zhang, Die Hu, Liping Li, Di Qu, Weipeng Shi, Lei Xie, Qi Jiang, Haifeng Li, Tengbo Yu, Chao Qi, Haitao F. M2 Microglia-derived Exosomes Promote Spinal Cord Injury Recovery in Mice by Alleviating A1 Astrocyte Activation. Molecular neurobiology. 2024-02-17. PMID:38367135. m2 microglia transplantation has previously demonstrated beneficial effects on spinal cord injury (sci) by regulating neuroinflammation and enhancing neuronal survival. 2024-02-17 2024-02-20 mouse
Xiaowen Liu, Huamei Cai, Liang Peng, Hongli Ma, Yun Yan, Weixia Li, Jing Zha. Microglial Nrf2/HO-1 signaling gates remifentanil-induced hyperalgesia via suppressing TRPV4-mediated M1 polarization. Free radical biology & medicine. 2024-02-13. PMID:38295888. this study aimed to unravel the role of spinal cord microglia, focusing on the nrf2/ho-1 signaling pathway and trpv4 channels in the development of rih. 2024-02-13 2024-02-15 Not clear
Xiaowen Liu, Huamei Cai, Liang Peng, Hongli Ma, Yun Yan, Weixia Li, Jing Zha. Microglial Nrf2/HO-1 signaling gates remifentanil-induced hyperalgesia via suppressing TRPV4-mediated M1 polarization. Free radical biology & medicine. 2024-02-13. PMID:38295888. we used both in vivo and in vitro models to investigate the activation state of spinal cord microglia, the expression of trpv4 channels, and the modulation of the nrf2/ho-1 pathway under remifentanil exposure. 2024-02-13 2024-02-15 Not clear
Xiaowen Liu, Huamei Cai, Liang Peng, Hongli Ma, Yun Yan, Weixia Li, Jing Zha. Microglial Nrf2/HO-1 signaling gates remifentanil-induced hyperalgesia via suppressing TRPV4-mediated M1 polarization. Free radical biology & medicine. 2024-02-13. PMID:38295888. our results revealed a prominent role of spinal cord microglia in rih, demonstrating an apparent microglial m1 polarization and increased trpv4 channel expression. 2024-02-13 2024-02-15 Not clear
Xiaowen Liu, Huamei Cai, Liang Peng, Hongli Ma, Yun Yan, Weixia Li, Jing Zha. Microglial Nrf2/HO-1 signaling gates remifentanil-induced hyperalgesia via suppressing TRPV4-mediated M1 polarization. Free radical biology & medicine. 2024-02-13. PMID:38295888. our research highlights the critical role of spinal cord microglia in rih mediated by the nrf2-trpv4 axis. 2024-02-13 2024-02-15 Not clear
Longyu Zhang, Jiao Xu, Shi Yin, Qiang Wang, Zhiwei Jia, Tianlin We. Albiflorin Attenuates Neuroinflammation and Improves Functional Recovery After Spinal Cord Injury Through Regulating LSD1-Mediated Microglial Activation and Ferroptosis. Inflammation. 2024-02-10. PMID:38340239. meanwhile, af attenuated neuron apoptosis and microglia activation, reduced the production of pro-inflammatory cytokines and iron accumulation, and inhibited spinal cord ferroptosis following sci in rats. 2024-02-10 2024-02-14 rat
Jie Ju, Zheng Li, Xiaoqian Jia, Xiaoling Peng, Jihong Wang, Feng Ga. Interleukin-18 in chronic pain: Focus on pathogenic mechanisms and potential therapeutic targets. Pharmacological research. vol 201. 2024-02-03. PMID:38295914. and il-18 is located in microglia, while il-18r is mostly located in astrocytes in the spinal cord. 2024-02-03 2024-02-06 Not clear
Yeqi Li, Cui Yin, Jinhong Jiang, Huan Yang, Feifei Zhang, Yanhong Xing, Wuyang Wang, Chen L. Tumor necrosis factor α-induced protein 8-like-2 controls microglia phenotype via metabolic reprogramming in BV2 microglial cells and responses to neuropathic pain. The international journal of biochemistry & cell biology. 2024-02-03. PMID:38309648. tnfaip8l2 suppresses inflammatory microglial activation and promotes restorative microglial activation in bv2 microglial cells and in spinal cord microglia after neuropathic pain. 2024-02-03 2024-02-06 Not clear
Alberto Granzotto, Amanda McQuade, Jean Paul Chadarevian, Hayk Davtyan, Stefano L Sensi, Ian Parker, Mathew Blurton-Jones, Ian Smit. ER and SOCE Ca bioRxiv : the preprint server for biology. 2024-01-31. PMID:38293075. er and soce ca the central nervous system (cns) is constantly surveilled by microglia, highly motile and dynamic cells deputed to act as the first line of immune defense in the brain and spinal cord. 2024-01-31 2024-02-02 Not clear