| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Genevra Hart, Thomas J Burton, Bernard W Ballein. What role does striatal dopamine play in goal-directed action? Neuroscience. 2024-03-23. PMID:38521480. |
plasticity in dorsomedial striatum, a central node in the network supporting goal-directed action, clearly requires dopamine release, the timing of which, relative to cortical and thalamic inputs, determines the degree and form of that plasticity. |
2024-03-23 |
2024-03-26 |
mouse |
| G Hart, T J Burton, C R Nolan, B W Ballein. Striatal dopamine release tracks the relationship between actions and their consequences. Cell reports. vol 43. issue 3. 2024-02-22. PMID:38386550. |
the acquisition and performance of goal-directed actions has long been argued to depend on the integration of glutamatergic inputs to the posterior dorsomedial striatum (pdms) under the modulatory influence of dopamine. |
2024-02-22 |
2024-02-25 |
rat |
| Robert M Sears, Erika C Andrade, Shanna B Samels, Lindsay C Laughlin, Danielle M Moloney, Donald A Wilson, Matthew R Alwood, Justin M Moscarello, Christopher K Cai. Devaluation of response-produced safety signals reveals circuits for goal-directed versus habitual avoidance in dorsal striatum. bioRxiv : the preprint server for biology. 2024-02-19. PMID:38370659. |
using chemogenetics and fb-devaluation, we also show that goal-directed vs. habitual ars depend on dorsomedial vs. dorsolateral striatum, suggesting a significant overlap between the mechanisms of avoidance and rewarded instrumental behavior. |
2024-02-19 |
2024-02-21 |
rat |
| BaDoi N Phan, Madelyn H Ray, Xiangning Xue, Chen Fu, Robert J Fenster, Stephen J Kohut, Jack Bergman, Suzanne N Haber, Kenneth M McCullough, Madeline K Fish, Jill R Glausier, Qiao Su, Allison E Tipton, David A Lewis, Zachary Freyberg, George C Tseng, Shelley J Russek, Yuriy Alekseyev, Kerry J Ressler, Marianne L Seney, Andreas R Pfenning, Ryan W Loga. Single nuclei transcriptomics in human and non-human primate striatum in opioid use disorder. Nature communications. vol 15. issue 1. 2024-01-31. PMID:38296993. |
in brain, the striatum is a heterogenous region involved in reward and goal-directed behaviors. |
2024-01-31 |
2024-02-03 |
human |
| Lior Tiroshi, Yara Atamna, Naomi Gilin, Noa Berkowitz, Joshua A Goldber. Striatal neurons are recruited dynamically into collective representations of self-initiated and learned actions in freely-moving mice. eNeuro. 2024-01-02. PMID:38164559. |
because the striatum is important for habitual behaviors and goal-directed learning, we conducted microendoscopic imaging in freely-moving mice that express a genetically-encoded ca |
2024-01-02 |
2024-01-05 |
mouse |
| Jacqueline R Giovanniello, Natalie Paredes, Anna Wiener, Kathia Ramírez-Armenta, Chukwuebuka Oragwam, Hanniel O Uwadia, Kayla Lim, Gift Nnamdi, Alicia Wang, Megha Sehgal, Fernando McV Reis, Ana C Sias, Alcino J Silva, Avishek Adhikari, Melissa Malvaez, Kate M Wassu. A dual-pathway architecture enables chronic stress to promote habit formation. bioRxiv : the preprint server for biology. 2023-10-24. PMID:37873076. |
chronic stress inhibits activity of basolateral amygdala projections to the dorsomedial striatum to impede the action-outcome learning that supports flexible, goal-directed decisions. |
2023-10-24 |
2023-11-08 |
mouse |
| Pol Bech, Sylvain Crochet, Robin Dard, Parviz Ghaderi, Yanqi Liu, Meriam Malekzadeh, Carl C H Petersen, Mauro Pulin, Anthony Renard, Christos Sourmpi. Striatal Dopamine Signals and Reward Learning. Function (Oxford, England). vol 4. issue 6. 2023-10-16. PMID:37841525. |
although many details of the hypothesis need further investigation, altogether, it seems likely that dopamine signals in the striatum might underlie important aspects of goal-directed reward-based learning. |
2023-10-16 |
2023-11-08 |
Not clear |
| Zachary W Hoisington, Alexandra Salvi, Sophie Laguesse, Yann Ehinger, Chhavi Shukla, Khanhky Phamluong, Dorit Ro. The small G-protein Rac1 in the dorsomedial striatum promotes alcohol-dependent structural plasticity and goal-directed learning in mice. bioRxiv : the preprint server for biology. 2023-09-11. PMID:37693512. |
the small g-protein rac1 in the dorsomedial striatum promotes alcohol-dependent structural plasticity and goal-directed learning in mice. |
2023-09-11 |
2023-10-07 |
mouse |
| Peter van Ruitenbeek, Luisa Franzen, Natasha Leigh Mason, Peter Stiers, Johannes G Ramaeker. Methylphenidate as a treatment option for substance use disorder: a transdiagnostic perspective. Frontiers in psychiatry. vol 14. 2023-08-21. PMID:37599874. |
both disorders are characterized by maladaptive goal-directed behavior, impaired cognitive control, hyperactive phasic dopaminergic neurotransmission in the striatum, prefrontal hypoactivation, and reduced frontal cortex gray matter volume/density. |
2023-08-21 |
2023-09-07 |
Not clear |
| Brooke N Bender, Sierra J Stringfield, Mary M Torregross. Changes in dorsomedial striatum activity mediate expression of goal-directed vs. habit-like cue-induced cocaine seeking. bioRxiv : the preprint server for biology. 2023-08-07. PMID:37546826. |
changes in dorsomedial striatum activity mediate expression of goal-directed vs. habit-like cue-induced cocaine seeking. |
2023-08-07 |
2023-08-14 |
rat |
| Brooke N Bender, Sierra J Stringfield, Mary M Torregross. Changes in dorsomedial striatum activity mediate expression of goal-directed vs. habit-like cue-induced cocaine seeking. bioRxiv : the preprint server for biology. 2023-08-07. PMID:37546826. |
goal-directed and habitual behaviors differentially rely on the dorsomedial striatum (dms) and dorsolateral striatum (dls), but the effects of cue extinction on dorsal striatal responses to cue-induced drug seeking are unknown. |
2023-08-07 |
2023-08-14 |
rat |
| V J Lewitus, K T Blackwel. Estradiol receptors inhibit long-term potentiation in the dorsomedial striatum. eNeuro. 2023-07-24. PMID:37487741. |
estradiol modulates several types of learning that depend on the dorsomedial striatum (dms), a subregion of the basal ganglia involved in goal-directed learning, cued action-selection, and motor skills. |
2023-07-24 |
2023-08-14 |
Not clear |
| Danielle M Giangrasso, Kaliana M Veros, Maureen M Timm, Peter J West, Karen S Wilcox, Kristen A Keef. Glutamate dynamics in the dorsolateral striatum of rats with goal-directed and habitual cocaine-seeking behavior. Frontiers in molecular neuroscience. vol 16. 2023-05-30. PMID:37251646. |
glutamate dynamics in the dorsolateral striatum of rats with goal-directed and habitual cocaine-seeking behavior. |
2023-05-30 |
2023-08-14 |
rat |
| Danielle M Giangrasso, Kaliana M Veros, Maureen M Timm, Peter J West, Karen S Wilcox, Kristen A Keef. Glutamate dynamics in the dorsolateral striatum of rats with goal-directed and habitual cocaine-seeking behavior. Frontiers in molecular neuroscience. vol 16. 2023-05-30. PMID:37251646. |
preliminary evidence from the dorsal striatum of cocaine-experienced rats suggests that this region exhibits similar alterations to glutamate clearance and release, but it is not known whether these glutamate dynamics are associated with goal-directed or habitual control over cocaine-seeking behavior. |
2023-05-30 |
2023-08-14 |
rat |
| Kyna-Anne Conn, Simin Zou, Joyosmita Das, Suzy Alexander, Thomas Hj Burne, James P Kesb. Activating the dorsomedial and ventral midbrain projections to the striatum differentially impairs goal-directed action in male mice. Neuropharmacology. 2023-04-21. PMID:37085011. |
activating the dorsomedial and ventral midbrain projections to the striatum differentially impairs goal-directed action in male mice. |
2023-04-21 |
2023-08-14 |
mouse |
| Kyna-Anne Conn, Simin Zou, Joyosmita Das, Suzy Alexander, Thomas Hj Burne, James P Kesb. Activating the dorsomedial and ventral midbrain projections to the striatum differentially impairs goal-directed action in male mice. Neuropharmacology. 2023-04-21. PMID:37085011. |
these findings highlight the differential roles of the dorsomedial and ventral inputs into the striatum in goal-directed action and provides insight into how striatal dopamine signaling may contribute to the cognitive problems in those with schizophrenia. |
2023-04-21 |
2023-08-14 |
mouse |
| Patrick A LaChance, Jeffrey S Taub. A model for transforming egocentric views into goal-directed behavior. Hippocampus. 2023-02-13. PMID:36780179. |
we propose a model for how this signal may support goal-directed navigation via projections to the dorsomedial striatum. |
2023-02-13 |
2023-08-14 |
rat |
| Bradley O Jones, Adelis M Cruz, Tabitha H Kim, Haley F Spencer, Rachel J Smit. Discriminating goal-directed and habitual cocaine seeking in rats using a novel outcome devaluation procedure. Learning & memory (Cold Spring Harbor, N.Y.). vol 29. issue 12. 2023-01-09. PMID:36621907. |
importantly, reinforcement schedules and neural manipulations that produce goal-directed responding (i.e., ratio schedules or dorsolateral striatum lesions) caused sensitivity to outcome devaluation, whereas reinforcement schedules and neural manipulations that produce habitual responding (i.e., interval schedules or dorsomedial striatum lesions) caused insensitivity. |
2023-01-09 |
2023-08-14 |
rat |
| R K van der Merwe, J A Nadel, D Copes-Finke, S Pawelko, J S Scott, M Ghanem, M Fox, C Morehouse, R McLaughlin, C Maddox, R Albert-Lyons, G Malaki, V Groce, A Turocy, N Aggadi, X Jin, C D Howar. Characterization of striatal dopamine projections across striatal subregions in reversal learning. The European journal of neuroscience. 2023-01-08. PMID:36617434. |
while flexible, goal-directed behaviors are initially dependent on dorsomedial striatum, they become dependent on lateral striatum as behaviors become inflexible. |
2023-01-08 |
2023-08-14 |
mouse |
| Stefano Cataldi, Clay Lacefield, Shashaank N, Gautam Kumar, Siham Boumhaouad, David Sulze. Decreased dorsomedial striatum direct pathway neuronal activity is required for learned motor coordination. eNeuro. 2022-09-28. PMID:36171055. |
it has been suggested that the dorsomedial striatum (dms) is engaged in the early stages of motor learning for goal-directed actions, whereas at later stages, control is transferred to the dorsolateral striatum (dls), a process that enables learned motor actions to become a skill or habit. |
2022-09-28 |
2023-08-14 |
mouse |