| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kevin Braunscheidel, Michael Okas, John J Woodwar. Toluene alters the intrinsic excitability and excitatory synaptic transmission of basolateral amygdala neurons. Frontiers in neuroscience. vol 18. 2024-04-10. PMID:38595974. |
however, studies from our lab and others have begun to reveal how inhalants such as the organic solvent toluene affect neurons in key addiction related areas of the brain including the ventral tegmental area, nucleus accumbens and medial prefrontal cortex. |
2024-04-10 |
2024-04-12 |
Not clear |
| Florian Schoukroun, Katia Befort, Romain Bourd. The rostromedial tegmental nucleus gates fat overconsumption through ventral tegmental area output in male rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-04-03. PMID:38570645. |
similar to addictive drugs, such foods activate the brain's reward circuit, involving mesolimbic dopaminergic projections from the ventral tegmental area (vta) to the nucleus accumbens (nac) and the prefrontal cortex. |
2024-04-03 |
2024-04-06 |
rat |
| Alaa Khayat, Rami Yak. Activation of nucleus accumbens projections to the ventral tegmental area alters molecular signaling and neurotransmission in the reward system. Frontiers in molecular neuroscience. vol 17. 2024-03-26. PMID:38528956. |
activation of nucleus accumbens projections to the ventral tegmental area alters molecular signaling and neurotransmission in the reward system. |
2024-03-26 |
2024-03-28 |
Not clear |
| Alaa Khayat, Rami Yak. Activation of nucleus accumbens projections to the ventral tegmental area alters molecular signaling and neurotransmission in the reward system. Frontiers in molecular neuroscience. vol 17. 2024-03-26. PMID:38528956. |
the nucleus accumbens (nac) and the ventral tegmental area (vta) are integral brain regions involved in reward processing and motivation, including responses to drugs of abuse. |
2024-03-26 |
2024-03-28 |
Not clear |
| Tsun Hay Jason Ng, Mohammed H Sarikahya, Roger Hudson, Hanna J Szkudlarek, Enzo Pérez-Valenzuela, Taygun C Uzuneser, Emma Proud, Dana Gummerson, Miray Youssef, Madeline Machado, Kuralay Zhaksylyk, Marieka V DeVuono, Chaochao Chen, Ken K-C Yeung, Walter J Rushlow, Steven R Laviolett. Adolescent nicotine exposure induces long-term, sex-specific disturbances in mood and anxiety-related behavioral, neuronal and molecular phenotypes in the mesocorticolimbic system. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-03-24. PMID:38521861. |
specifically, brain regions such as the medial prefrontal cortex (mpfc), the ventral tegmental area (vta), nucleus accumbens (nac) and hippocampus, are implicated in both nicotine dependence and pathological phenotypes linked to mood and anxiety disorders. |
2024-03-24 |
2024-03-26 |
rat |
| Alicia C Wells, Shahrdad Lotfipou. Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits. Advances in drug and alcohol research. vol 3. 2024-02-23. PMID:38389806. |
due to the large percentage of women utilizing nicotine products during pregnancy in the united states and globally, this review seeks to centralize pre-clinical and clinical studies focused on the neurobehavioral and neurodevelopmental complications associated with prenatal nicotine exposure (pne) such as alterations to the hypothalamic-pituitary-adrenal (hpa) axis and brain regions such as the prefrontal cortex (pfc), ventral tegmental area (vta), nucleus accumbens (na), hippocampus, and caudate as well as changes to nachr and cholinergic receptor signaling, long-term drug seeking behavior following pne, and other related developmental disorders. |
2024-02-23 |
2024-02-25 |
Not clear |
| Nan Song, Zhenhong Liu, Yan Gao, Shanshan Lu, Shenglian Yang, Chao Yua. NAc-DBS corrects depression-like behaviors in CUMS mouse model via disinhibition of DA neurons in the VTA. Molecular psychiatry. 2024-02-16. PMID:38361128. |
mdd can be associated with abnormalities in the reward-system-dopaminergic mesolimbic pathway, in which the nucleus accumbens (nac) and ventral tegmental area (vta) play major roles. |
2024-02-16 |
2024-02-18 |
mouse |
| Julien Castel, Guangping Li, Oriane Onimus, Emma Leishman, Patrice D Cani, Heather Bradshaw, Ken Mackie, Amandine Everard, Serge Luquet, Giuseppe Gangaross. NAPE-PLD in the ventral tegmental area regulates reward events, feeding and energy homeostasis. Molecular psychiatry. 2024-02-16. PMID:38361126. |
reward-dependent behaviors depend on dopamine (da) transmission between the ventral tegmental area (vta) and the nucleus accumbens (nac), which conveys reward-values and scales reinforced behaviors. |
2024-02-16 |
2024-02-18 |
Not clear |
| R Heijkoop, J F Lalanza, M Solanas, A Álvarez-Monell, A Subias-Gusils, R M Escorihuela, E M S Snoere. Changes in reward-induced neural activity upon Cafeteria Diet consumption. Physiology & behavior. 2024-02-02. PMID:38307359. |
to this end, rats were exposed to a 6-week diet with either standard chow, or ad libitum daily access to caf diet, 30% restricted but daily access to caf diet, or one-day-a-week (intermittent) ad libitum access to caf diet, after which c-fos expression in the nucleus accumbens (nac), prefrontal cortex (pfc), and ventral tegmental area (vta) following consumption of a caf reward of choice was examined. |
2024-02-02 |
2024-02-05 |
rat |
| A Khayat, R Yak. Activation of RMTg projections to the VTA reverse cocaine-induced molecular adaptation in the reward system. Translational psychiatry. vol 14. issue 1. 2024-01-19. PMID:38242878. |
our study demonstrates that enhancing the gabaergic inputs from the rmtg to the vta can mitigate cocaine-induced molecular changes in key regions, namely the vta, nucleus accumbens (nac), and prefrontal cortex (pfc). |
2024-01-19 |
2024-01-22 |
Not clear |
| Cameron J Davidson, John H Hannigan, Shane A Perrine, Scott E Bowe. Abuse-like toluene exposure during early adolescence alters subsequent ethanol and cocaine behavioral effects and brain monoamines in male mice. Neurotoxicology and teratology. 2024-01-10. PMID:38199311. |
analysis of monoamines and their metabolites using high pressure liquid chromatography (hplc) within the medial prefrontal cortex (mpfc), nucleus accumbens (nac), dorsal striatum (dstr), and ventral tegmental area (vta) revealed subtle effects on monoamine or metabolite levels following cumulative dosing that varied by drug (cocaine and ethanol) and abstinence duration. |
2024-01-10 |
2024-01-13 |
mouse |
| Ki Bum Um, Soyoung Kwak, Sun-Ha Cheon, JuHyun Kim, Su-Kyeong Hwan. AST-001 Improves Social Deficits and Restores Dopamine Neuron Activity in a Mouse Model of Autism. Biomedicines. vol 11. issue 12. 2023-12-23. PMID:38137504. |
the core symptoms of asd are associated with deficits in mesocorticolimbic dopamine pathways that project from the ventral tegmental area (vta) to the nucleus accumbens (nac) and medial prefrontal cortex (mpfc). |
2023-12-23 |
2023-12-25 |
mouse |
| Julian Cheron, Leonardo Beccari, Perrine Hagué, Romain Icick, Chloé Despontin, Teresa Carusone, Matthieu Defrance, Sagar Bhogaraju, Elena Martin-Garcia, Roberto Capellan, Rafael Maldonado, Florence Vorspan, Jérôme Bonnefont, Alban de Kerchove d'Exaerd. USP7/Maged1-mediated H2A monoubiquitination in the paraventricular thalamus: an epigenetic mechanism involved in cocaine use disorder. Nature communications. vol 14. issue 1. 2023-12-20. PMID:38123574. |
while histone modifications such as methylation and acetylation have been studied in the ventral tegmental area and nucleus accumbens (nac), the role of h2a monoubiquitination remains unknown. |
2023-12-20 |
2023-12-23 |
Not clear |
| Emiko Senba, Katsuya Kam. Exercise therapy for chronic pain: How does exercise change the limbic brain function? Neurobiology of pain (Cambridge, Mass.). vol 14. 2023-12-15. PMID:38099274. |
the role of taking flexible and appropriate actions against threats is played by "the limbic system" and at the heart of it there is the ventral tegmental area and nucleus accumbens (brain reward system). |
2023-12-15 |
2023-12-17 |
Not clear |
| Oualid Abboussi, Zmarak Ahmad Khan, Hind Ibork, Simo S Zulu, William Daniels, Khalid Taghzouti, Tim G Hale. CB2 agonist mitigates cocaine-induced reinstatement of place preference and modulates the inflammatory response in mice. Behavioural pharmacology. 2023-12-12. PMID:38085651. |
specifically, jwh-133 administration was found to upregulate Δ-fosb expression in the nucleus accumbens (nac), elevate cx3cl1 levels in both the ventral tegmental area and prefrontal cortex (pfc), and concurrently reduce il-1β expression in the pfc and nac among cocaine-treated animals. |
2023-12-12 |
2023-12-17 |
mouse |
| Shelley M Warlow, Sarthak M Singhal, Nick G Hollon, Lauren Faget, Dina S Dowlat, Vivien Zell, Avery C Hunker, Larry S Zweifel, Thomas S Hnask. Mesoaccumbal glutamate neurons drive reward via glutamate release but aversion via dopamine co-release. Neuron. 2023-12-12. PMID:38086374. |
ventral tegmental area (vta) projections to the nucleus accumbens (nac) drive reward-related motivation. |
2023-12-12 |
2023-12-17 |
mouse |
| Jing Cai, Yanyan Jiang, Yuanzhong Xu, Zhiying Jiang, Claire Young, Hongli Li, Joshua Ortiz-Guzman, Yizhou Zhuo, Yulong Li, Yong Xu, Benjamin R Arenkiel, Qingchun Ton. An excitatory projection from the basal forebrain to the ventral tegmental area that underlies anorexia-like phenotypes. Neuron. 2023-12-06. PMID:38056455. |
importantly, activation of bf glutamatergic terminals in the vta reduced dopamine release in the nucleus accumbens. |
2023-12-06 |
2023-12-10 |
mouse |
| Bing Huang, Zifei Chen, Fang Huang, Fenfei Gao, Jieling Chen, Peipei Liu, Zhijie Lu, Weiyuan Chen, Jie W. Demyelination in the medial prefrontal cortex by withdrawal from chronic nicotine causes impaired cognitive memory. Progress in neuro-psychopharmacology & biological psychiatry. 2023-11-30. PMID:38036034. |
we found no effect of nicotine withdrawal on the myelination in both of the ventral tegmental area (vta) and nucleus accumbens (nac) regions, but unexpectedly, we observed a demyelination phenomenon in the medial prefrontal cortex (mpfc) after withdrawal from chronic nicotine. |
2023-11-30 |
2023-12-10 |
Not clear |
| Pratap S Markam, Clément Bourguignon, Lei Zhu, Martin Darvas, Paul V Sabatini, Maia V Kokoeva, Bruno Giros, Kai-Florian Storc. The neurons that drive infradian sleep-wake and mania-like behavioral rhythms. bioRxiv : the preprint server for biology. 2023-11-28. PMID:38014299. |
this cycling capacity is abrogated upon genetic disruption of da production in da neurons of the ventral tegmental area (vta) or ablation of nucleus accumbens (nac) projecting, dopamine (da) neurons. |
2023-11-28 |
2023-11-29 |
mouse |
| Austin Ganaway, Kousuke Tatsuta, Virgil Christian Garcia Castillo, Ryoma Okada, Yoshinori Sunaga, Yasumi Ohta, Jun Ohta, Masahiro Ohsawa, Metin Akay, Yasemin M Aka. Investigating the Influence of Morphine and Cocaine on the Mesolimbic Pathway Using a Novel Microimaging Platform. International journal of molecular sciences. vol 24. issue 22. 2023-11-25. PMID:38003493. |
specifically, the mesolimbic pathway connecting the ventral tegmental area (vta) and the nucleus accumbens (nac) is crucial in regulating memory, emotion, motivation, and behavior due to its responsibility to modulate dopamine. |
2023-11-25 |
2023-11-28 |
mouse |