| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ramanachary Namoju, Kavitha N Chilak. Protective effect of alpha‑lipoic acid against in utero cytarabine exposure-induced hepatotoxicity in rat female neonates. Naunyn-Schmiedeberg's archives of pharmacology. 2024-03-09. PMID:38459988. |
the pups exposed to cytarabine showed a significant and dose-dependent (a) decrease in body weight, liver weight, hepatosomatic index, catalase, superoxide dismutase, glutathione, glutathione peroxidase, serum albumin levels and (b) increase in malondialdehyde, alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase, ast/alt ratio, and histopathological anomalies. |
2024-03-09 |
2024-03-12 |
rat |
| Li Luo, Jiajie Ni, Jiahui Zhang, Jinxian Lin, Sixin Chen, Feihai Shen, Zhiying Huan. Toosendanin induces hepatotoxicity by restraining autophagy and lysosomal function through inhibiting STAT3/CTSC axis. Toxicology letters. 2024-03-09. PMID:38460807. |
tsn decreased cell viability, increased lactate dehydrogenase (ldh) production in vitro, and elevated serum aspartate transaminase (ast) and alanine aminotransferase (alt) levels as well as liver lesions in vivo, suggesting tsn had significant hepatotoxicity. |
2024-03-09 |
2024-03-12 |
mouse |
| Bardia Karim, Motahare Arabameri, Fatemeh Alimoradi, Razieh Mansoori, Ali A Moghadamnia, Sohrab Kazemi, Seyed M Hossein. Protective effect of thymoquinone nanoemulsion in reducing the cardiotoxic effect of 5-fluorouracil in rats. Drug development research. vol 85. issue 2. 2024-03-09. PMID:38459752. |
5-fu caused body weight loss, ecg changes (increased st segment, prolonged qrs, and qtc), increased cardiac enzymes (aspartate aminotransferase [ast], creatine kinase-myocardial band [ck-mb], and lactate dehydrogenase [ldh]), oxidative stress (increased malondialdehyde, myeloperoxidase, nitric acid; decreased glutathione peroxidase enzyme activity), and histological damage such as necrosis, hyperemia, and tissue hyalinization in rats. |
2024-03-09 |
2024-03-11 |
rat |
| Yuanyuan Tao, Wanqing Zhou, Cheng Chen, Qian Zhang, Zhuoyi Liu, Pingping Xia, Zhi Ye, Chunling L. O-sialoglycoprotein Endopeptidase (OSGEP) Suppresses Hepatic Ischemia-Reperfusion Injury-Induced Ferroptosis Through Modulating the MEK/ERK Signaling Pathway. Molecular biotechnology. 2024-03-08. PMID:38456959. |
at one day after hepatectomy, the negative association of osgep expression level with the elevated serum levels of aspartate aminotransferase (ast) and alanine aminotransferase (alt) was noted. |
2024-03-08 |
2024-03-10 |
mouse |
| Mohamad-Hasan Ghosian-Moghaddam, Parvaneh Mohseni-Moghaddam, Mehrdad Roghan. Therapeutic Potential of Diosgenin in Amelioration of Carbon Tetrachloride-Induced Murine Liver Injury. Drug research. 2024-03-08. PMID:38458224. |
finally, serum levels of aspartate aminotransferase (ast), alanine aminotransferase (alt), and also albumin were assessed. |
2024-03-08 |
2024-03-11 |
Not clear |
| Yaru Bi, Yang Yang, Xiaojie Yuan, Jiping Wang, Tuo Wang, Zhiyuan Liu, Suyan Tian, Chenglin Su. Association between liver enzymes and type 2 diabetes: a real-world study. Frontiers in endocrinology. vol 15. 2024-03-06. PMID:38444589. |
this study aimed to examine the association of liver enzymes, including alanine aminotransferase (alt), aspartate aminotransferase (ast), and gamma-glutamyl-transferase (ggt), with type 2 diabetes (t2d) risk, particularly their dose-response relationship. |
2024-03-06 |
2024-03-08 |
Not clear |
| Faouzia Derouiche, Randa Djemil, Fatima Zohra Sebihi, Lilia Douaouya, Hichem Maamar, Katia Benjeman. High methionine diet mediated oxidative stress and proteasome impairment causes toxicity in liver. Scientific reports. vol 14. issue 1. 2024-03-06. PMID:38448604. |
total homocysteine (thcy), total oxidant status (tos), total antioxidant status (tas), hepatic enzymes levels: aspartate aminotransferase (ast), alanine aminotransferase (alt), lactate dehydrogenase (ldh), alkaline phosphatase (alp), with total bilirubin (tbil), albumin (alb), and c-reactive protein (crp) were determined in plasma by biochemical assays. |
2024-03-06 |
2024-03-09 |
rat |
| Jia He, Qing Ma, Zhongqiu Teng, Jingzhu Zhou, Na Zhao, Wenqin Liang, Miao Lu, Shijun Li, Tian Qi. Epidemiological and clinical characteristics of scrub typhus in Guizhou Province, China: An outbreak study of scrub typhus. PLoS neglected tropical diseases. vol 18. issue 3. 2024-03-05. PMID:38442086. |
the major clinical symptoms of these patients showed fever, chills, headache, eschar, fatigue and pneumonia, which were accompanied by a rise in c-reactive protein, neutrophils, alanine transaminase (alt) and aspartate aminotransferase (ast). |
2024-03-05 |
2024-03-08 |
mouse |
| Yu Sun, Qingfang Deng, Qiurong Zhang, Xin Zhou, Ruhai Chen, Siyu Li, Qing Wu, Huaguo Che. Hazards of microplastics exposure to liver function in fishes: A systematic review and meta-analysis. Marine environmental research. vol 196. 2024-03-05. PMID:38442589. |
the meta-analysis results indicate that compared to the control group, exposure to microplastics significantly affects fish liver indicators: aspartate aminotransferase (ast) (p < 0.001), alanine aminotransferase (alt) (p < 0.001), alkaline phosphatase (alp) (p < 0.001), total protein (tp) (p < 0.001), and lactate dehydrogenase (ldh) (p < 0.001), including oxidative stress indicators: superoxide dismutase (sod) (p < 0.001), glutathione s-transferase (gst) (p < 0.001), glutathione (gsh) (p < 0.001), and malondialdehyde (mda) (p < 0.001) in fish liver. |
2024-03-05 |
2024-03-08 |
Not clear |
| Mitsuyoshi Yamagata, Mutsumi Tsuchishima, Takashi Saito, Mikihiro Tsutsumi, Joseph Georg. Therapeutic implication of human placental extract to prevent liver cirrhosis in rats with metabolic dysfunction-associated steatohepatitis. Clinical science (London, England : 1979). vol 138. issue 5. 2024-03-05. PMID:38381799. |
serum aspartate aminotransferase (ast), alanine aminotransferase (alt), hepatic malondialdehyde (mda), and glutathione content were measured. |
2024-03-05 |
2024-03-07 |
human |
| Mansour Abbasi, Babak Choobi Anzali, Hamid Reza Mehrya. Liver enzymes as a predictor of mortality in patients with COVID-19? A cross-sectional study. Toxicology reports. vol 12. 2024-03-04. PMID:38433765. |
patient data were extracted from medical records and recorded in checklists, including demographic characteristics (age and gender), serum levels of alanine aminotransferase (alt) and aspartate aminotransferase (ast), and patient outcomes (recovery and mortality). |
2024-03-04 |
2024-03-06 |
Not clear |
| Mitchell R McGill, Steven C Curr. The Evolution of Circulating Biomarkers for Use in Acetaminophen/Paracetamol-Induced Liver Injury in Humans: A Scoping Review. Livers. vol 3. issue 4. 2024-03-04. PMID:38434489. |
the first reports of apap hepatotoxicity in humans were published in 1966, shortly after the development of alanine aminotransferase (alt) and aspartate aminotransferase (ast) as the first biomarkers of liver injury as opposed to liver function. |
2024-03-04 |
2024-03-06 |
Not clear |
| Belén Larrán, Marta López-Alonso, Marta Miranda, Almudena Graña, Lucas Rigueira, Inmaculada Orjale. Influence of haemolysis on blood biochemistry profiles in cattle. Research in veterinary science. vol 171. 2024-03-03. PMID:38432158. |
the effect of haemolysis and its clinical relevance were investigated in 70 samples in which haemolysis was artificially induced (by spiking with increasing amounts of haemolysate, yielding 0.0%, 0.2%, 0.5%, 1.0%, 2.5%, 5.0% and 10% haemolysis degree (hd)), focusing on key parameters for bovine metabolic health assessment, including albumin, alkaline phosphatase (alp), aspartate aminotransferase (ast), blood urea nitrogen (bun), calcium (ca), cholesterol, creatinine, creatine kinase (ck), gamma-glutamyl transferase (ggt), globulins, magnesium (mg), phosphorus (p), total bilirubin (tbil) and total proteins (tp). |
2024-03-03 |
2024-03-06 |
cattle |
| Marcela Machado, Luisa Nora, Tayse Burger Neto Zanin, Bianca F Bissacotti, Vera M Morsch, Marcelo Vedovatto, Giovana Pelisser, Ricardo E Mendes, Alessandro C Galvão, Caroline Sefrin Speroni, Eduardo M Gloria, Murilo F Rodrigues, Roger Wagner, Lenita M Stefani, Aleksandro S da Silv. Impacts of intake of trichothecenes (Fusarium sporotrichioides) for dairy calves: Effects on animal growth, oxidative and inflammatory response. Microbial pathogenesis. 2024-03-01. PMID:38428470. |
the enzymes alanine transferase (alt), aspartate transferase (ast) and gamma glutamyl-transferase (ggt) showed higher serum activity in the t-c group (days 20 and 40). |
2024-03-01 |
2024-03-04 |
Not clear |
| Asal Neshatbini Tehrani, Behzad Hatami, Bizhan Helli, Zahra Yari, Ghazal Daftari, Amin Salehpour, Mehdi Hedayati, Elmira Khalili, Seyed Ahmad Hosseini, Azita Hekmatdoos. The effect of soy isoflavones on non-alcoholic fatty liver disease and the level of fibroblast growth factor-21 and fetuin A. Scientific reports. vol 14. issue 1. 2024-03-01. PMID:38429385. |
at week 12, the serum levels of alanine amino transferase (alt), aspartate amino transferase (ast) and controlled attenuation parameter (cap) score were significantly decreased only in the soy isoflavone group (p < 0.05). |
2024-03-01 |
2024-03-04 |
human |
| Weiwen Lai, Shipeng Zhou, Yan Bai, Qishi Che, Hua Cao, Jiao Guo, Zhengquan S. Glucosamine attenuates alcohol-induced acute liver injury via inhibiting oxidative stress and inflammation. Current research in food science. vol 8. 2024-02-29. PMID:38420347. |
the results showed that glc can significantly inhibit the abnormal increase of aspartate aminotransferase (ast), alanine aminotransferase (alt), alkaline phosphatase (alp), lactate dehydrogenase (ldh), triglycerides (tg), total cholesterol (tc), very low density lipoprotein (vldl), low-density lipoprotein cholesterol (ldl-c), and can significantly improve the level of high-density lipoprotein cholesterol (hdl-c). |
2024-02-29 |
2024-03-02 |
mouse |
| Ahmed Raza, Muhammad Ijaz, Khalid Mehmood, Arslan Ahmed, Muhammad Umar Javed, Farwa Anwaar, Hamza Rasheed, Nauman Zaheer Ghumma. THEILERIA EQUI INFECTION IN WORKING HORSES OF PAKISTAN: EPIDEMIOLOGY, MOLECULAR CHARACTERIZATION, AND HEMATOBIOCHEMICAL ANALYSIS. The Journal of parasitology. vol 110. issue 1. 2024-02-29. PMID:38421025. |
the hematobiochemical profile revealed a significant (p < 0.05) decrease in red blood cells (rbcs), hemoglobin (hb), packed cell volume (pcv), white blood cells (wbcs), platelet (plt), phosphorus, and an increase in lymphocytes, granulocytes, aspartate aminotransferase (ast), glucose, bilirubin, blood urea nitrogen (bun), and creatinine in t. equi-infected horses. |
2024-02-29 |
2024-03-02 |
Not clear |
| H Marahrens, K von Dörnberg, V Molnár, K M Gregor, E Leitzen, A von Altrock, A Polifka, M Ganter, M G Wagene. Copper Intoxication in South American Camelids-Review of the Literature and First Report of a Case in a Vicuña (Vicugna vicugna). Biological trace element research. 2024-02-29. PMID:38421580. |
laboratory findings from edta and serum samples revealed neutrophilia with a left shift, hypoproteinaemia, lymphopaenia, azotaemia, elevated levels of creatine kinase (ck), aspartate aminotransferase (ast) and glutamate dehydrogenase (gldh) in the serum. |
2024-02-29 |
2024-03-02 |
Not clear |
| Meng-Meng Lin, Ying-Ying Li, Bo Cao, Jing Xu, Xiao-He Xiao, Guo-Hui Li, Chun-Yu L. [Pseudo-targeted metabolomics study of immune stress-mediated idiosyncratic liver injury induced by synergistic effects of bavachin and epimedin B]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 2. 2024-02-25. PMID:38403320. |
lactate dehydrogenase(ldh) release in the cell culture supernatant, as well as the levels of alanine aminotransferase(alt) and aspartate transaminase(ast) in mouse plasma were measured. |
2024-02-25 |
2024-02-28 |
mouse |
| Yujuan Yu, Fumao Zeng, Peiheng Han, Li Zhang, Ling Yang, Feng Zhou, Qing Liu, Zheng Rua. Dietary chlorogenic acid alleviates high-fat diet-induced steatotic liver disease by regulating metabolites and gut microbiota. International journal of food sciences and nutrition. 2024-02-23. PMID:38389248. |
in comparison to the hf group, the tc (total cholesterol), tg (total triglycerides), ldl-c (low-density lipoprotein cholesterol), ast (aspartate aminotransferase) and alt (alanine transaminase) levels were reduced after cga supplement. |
2024-02-23 |
2024-02-25 |
mouse |