| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B M Romero-Torres, Y A Alvarado-Ramírez, S R Duran-Alonzo, A E Ruiz-Contreras, A Herrera-Solis, O Amancio-Belmont, O E Prospéro-García, M Méndez-Día. A potential role of hippocampus on impulsivity and alcohol consumption though CB1R. Pharmacology, biochemistry, and behavior. 2023-04-23. PMID:37088449. |
our data further support the role of the hippocampus in impulsivity with the potential involvement of the endocannabinoid system, considering that cb1r in ca3 and dg is higher in adolescents, who display impulsivity and alcohol seeking and consumption. |
2023-04-23 |
2023-08-14 |
rat |
| Carlos A Lafourcade, Fraser T Sparks, Angelique Bordey, Ursula Wyneken, Michael H Mohammad. Cannabinoid regulation of neurons in the dentate gyrus during epileptogenesis. Role of CB1R-associated proteins and downstream pathways. Epilepsia. 2023-03-04. PMID:36869624. |
in this review, we summarize recent findings concerning the role of the dg in controlling hyperexcitability and propose how dg regulation by cannabinoids (cbs) could provide avenues for therapeutic interventions. |
2023-03-04 |
2023-08-14 |
Not clear |
| Carlos A Lafourcade, Fraser T Sparks, Angelique Bordey, Ursula Wyneken, Michael H Mohammad. Cannabinoid regulation of neurons in the dentate gyrus during epileptogenesis. Role of CB1R-associated proteins and downstream pathways. Epilepsia. 2023-03-04. PMID:36869624. |
importantly, lipid-derived endogenous cannabinoids (endocannabinoids, ecbs), which are produced-on-demand as retrograde messengers, are central regulators of neuronal activity in the dg circuit (sugaya et al., 2016). |
2023-03-04 |
2023-08-14 |
Not clear |
| Christine J Fontaine, Erin L Gräfe, Cristina Pinar, Itziar Bonilla-Del Río, Pedro Grandes, Brian R Christi. Endocannabinoid receptors contribute significantly to multiple forms of long-term depression in the rat dentate gyrus. Learning & memory (Cold Spring Harbor, N.Y.). vol 27. issue 9. 2021-09-02. PMID:32817304. |
we, and others, have shown in mice that cannabinoid type 1 receptors (cb1rs) are involved in a long-term depression (ltd) that can be induced by prolonged 10 hz stimulation of the medial perforant path (mpp)-granule cell synaptic input to the dg. |
2021-09-02 |
2023-08-13 |
mouse |
| Christine J Fontaine, Erin L Gräfe, Cristina Pinar, Itziar Bonilla-Del Río, Pedro Grandes, Brian R Christi. Endocannabinoid receptors contribute significantly to multiple forms of long-term depression in the rat dentate gyrus. Learning & memory (Cold Spring Harbor, N.Y.). vol 27. issue 9. 2021-09-02. PMID:32817304. |
cannabinoid receptors are widely expressed throughout the hippocampal formation, but are particularly dense in the dentate gyrus (dg) subregion. |
2021-09-02 |
2023-08-13 |
mouse |
| Yasukazu Hozumi, Hiroki Fujiwara, Kenya Kaneko, Satoshi Fujii, Matthew K Topham, Masahiko Watanabe, Kaoru Got. Diacylglycerol kinase ε localizes to subsurface cisterns of cerebellar Purkinje cells. Cell and tissue research. vol 368. issue 3. 2018-02-14. PMID:28191598. |
in dendrites of purkinje cells, dgkε was also distributed in close apposition to dg lipase-α, which catalyzes arachidonoyl-dg to produce 2-arachidonoyl glycerol, a major endocannabinoid in the brain. |
2018-02-14 |
2023-08-13 |
mouse |
| Bárbara S Pinheiro, Cristina Lemos, Fernanda Neutzling Kaufmann, Joana M Marques, Carla S da Silva-Santos, Eugénia Carvalho, Ken Mackie, Ricardo J Rodrigues, Rodrigo A Cunha, Attila Köfalv. Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin. Brain research bulletin. vol 124. 2017-10-26. PMID:27208730. |
the synthetic cannabinoid agonist, win55212-2 (500nm) and the glucocorticoid dexamethasone (10μm), impaired insulin (300nm) action on [(3)h]dg uptake. |
2017-10-26 |
2023-08-13 |
Not clear |
| Chizu Aso, Mari Araki, Noriyasu Ohshima, Kazuaki Tatei, Tohko Hirano, Hideru Obinata, Mikiko Kishi, Koji Kishimoto, Akimitsu Konishi, Fumio Goto, Hiroyuki Sugimoto, Takashi Izum. Protein purification and cloning of diacylglycerol lipase from rat brain. Journal of biochemistry. vol 159. issue 6. 2017-01-30. PMID:26790472. |
diacylglycerol (dg) lipase, which hydrolyses 1-stearoyl-2-arachidonyl-sn-glycerol to produce an endocannabinoid, 2-arachidonoylglycerol, was purified from the soluble fraction of rat brain lysates. |
2017-01-30 |
2023-08-13 |
rat |
| M López-Gallardo, A B López-Rodríguez, Á Llorente-Berzal, D Rotllant, K Mackie, A Armario, R Nadal, M-P Vivero. Maternal deprivation and adolescent cannabinoid exposure impact hippocampal astrocytes, CB1 receptors and brain-derived neurotrophic factor in a sexually dimorphic fashion. Neuroscience. vol 204. 2012-07-23. PMID:22001306. |
adolescent cannabinoid exposure induced, in control non-deprived males, a significant increase in the number of gfap+ cells in the polymorphic layer of the dg. |
2012-07-23 |
2023-08-12 |
rat |
| Marco Koch, Susanne Kreutz, Charlotte Böttger, Urszula Grabiec, Chalid Ghadban, Horst-Werner Korf, Faramarz Dehghan. The cannabinoid WIN 55,212-2-mediated protection of dentate gyrus granule cells is driven by CB1 receptors and modulated by TRPA1 and Cav 2.2 channels. Hippocampus. vol 21. issue 5. 2012-03-26. PMID:20135626. |
in the present study we investigated the neuroprotective effects of the synthetic cannabinoid win 55,212-2 (win) on dentate gyrus (dg) granule cells and elucidated the involvement of trp and ca(v) 2.2 that are shown to participate in inflammatory processes. |
2012-03-26 |
2023-08-12 |
Not clear |
| Dilshani W N Dissanayake, Margarita Zachariou, Charles A Marsden, Robert Maso. Auditory gating in rat hippocampus and medial prefrontal cortex: effect of the cannabinoid agonist WIN55,212-2. Neuropharmacology. vol 55. issue 8. 2009-04-15. PMID:18809420. |
we studied auditory gating and the effects of the cannabinoid agonist win55,212-22 on gating in ca3 and dentate gyrus (dg) of the hippocampus and medial prefrontal cortex (mpfc) in male lister hooded rats using in vivo electrophysiology. |
2009-04-15 |
2023-08-12 |
rat |
| Sun Hee Kim, Seok Joon Won, Xiao Ou Mao, Catherine Ledent, Kunlin Jin, David A Greenber. Role for neuronal nitric-oxide synthase in cannabinoid-induced neurogenesis. The Journal of pharmacology and experimental therapeutics. vol 319. issue 1. 2006-11-02. PMID:16831955. |
accordingly, we measured neurogenesis in dentate gyrus (dg) and subventricular zone (svz) of cb1r-knockout (ko) and wild-type mice, some of whom were treated with the cannabinoid agonist r(+)-win 55212-2 [(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazin-yl]-(1-naphthalenyl)methanone] or the no synthase (nos) inhibitor 7-nitroindazole (7-ni). |
2006-11-02 |
2023-08-12 |
mouse |