| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carlos A Lafourcade, Fraser T Sparks, Angelique Bordey, Ursula Wyneken, Michael H Mohammad. Cannabinoid regulation of neurons in the dentate gyrus during epileptogenesis. Role of CB1R-associated proteins and downstream pathways. Epilepsia vol issue 2023 36869624 |
in this review, we summarize recent findings concerning the role of the dg in controlling hyperexcitability and propose how dg regulation by cannabinoids (cbs) could provide avenues for therapeutic interventions. |
2023-03-04 |
2023-03-06 |
Not clear |
| Carlos A Lafourcade, Fraser T Sparks, Angelique Bordey, Ursula Wyneken, Michael H Mohammad. Cannabinoid regulation of neurons in the dentate gyrus during epileptogenesis. Role of CB1R-associated proteins and downstream pathways. Epilepsia vol issue 2023 36869624 |
importantly, lipid-derived endogenous cannabinoids (endocannabinoids, ecbs), which are produced-on-demand as retrograde messengers, are central regulators of neuronal activity in the dg circuit (sugaya et al., 2016). |
2023-03-04 |
2023-03-06 |
Not clear |
| Christine J Fontaine, Erin L Gr\\xc3\\xa4fe, Cristina Pinar, Itziar Bonilla-Del R\\xc3\\xado, Pedro Grandes, Brian R Christi. Endocannabinoid receptors contribute significantly to multiple forms of long-term depression in the rat dentate gyrus. Learning & memory (Cold Spring Harbor, N.Y.) vol 27 issue 9 2021 32817304 |
cannabinoid receptors are widely expressed throughout the hippocampal formation, but are particularly dense in the dentate gyrus (dg) subregion. |
2021-09-02 |
2023-01-26 |
rat |
| Christine J Fontaine, Erin L Gr\\xc3\\xa4fe, Cristina Pinar, Itziar Bonilla-Del R\\xc3\\xado, Pedro Grandes, Brian R Christi. Endocannabinoid receptors contribute significantly to multiple forms of long-term depression in the rat dentate gyrus. Learning & memory (Cold Spring Harbor, N.Y.) vol 27 issue 9 2021 32817304 |
we, and others, have shown in mice that cannabinoid type 1 receptors (cb1rs) are involved in a long-term depression (ltd) that can be induced by prolonged 10 hz stimulation of the medial perforant path (mpp)-granule cell synaptic input to the dg. |
2021-09-02 |
2023-01-26 |
rat |
| Yasukazu Hozumi, Hiroki Fujiwara, Kenya Kaneko, Satoshi Fujii, Matthew K Topham, Masahiko Watanabe, Kaoru Got. Diacylglycerol kinase \\xce\\xb5 localizes to subsurface cisterns of cerebellar Purkinje cells. Cell and tissue research vol 368 issue 3 2018 28191598 |
in dendrites of purkinje cells, dgk\xce\xb5 was also distributed in close apposition to dg lipase-\xce\xb1, which catalyzes arachidonoyl-dg to produce 2-arachidonoyl glycerol, a major endocannabinoid in the brain. |
2018-02-14 |
2023-01-26 |
mouse |
| B\\xc3\\xa1rbara S Pinheiro, Cristina Lemos, Fernanda Neutzling Kaufmann, Joana M Marques, Carla S da Silva-Santos, Eug\\xc3\\xa9nia Carvalho, Ken Mackie, Ricardo J Rodrigues, Rodrigo A Cunha, Attila K\\xc3\\xb6falv. Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin. Brain research bulletin vol 124 issue 2017 27208730 |
the synthetic cannabinoid agonist, win55212-2 (500nm) and the glucocorticoid dexamethasone (10\xce\xbcm), impaired insulin (300nm) action on [(3)h]dg uptake. |
2017-10-26 |
2023-01-25 |
Not clear |
| Chizu Aso, Mari Araki, Noriyasu Ohshima, Kazuaki Tatei, Tohko Hirano, Hideru Obinata, Mikiko Kishi, Koji Kishimoto, Akimitsu Konishi, Fumio Goto, Hiroyuki Sugimoto, Takashi Izum. Protein purification and cloning of diacylglycerol lipase from rat brain. Journal of biochemistry vol 159 issue 6 2017 26790472 |
diacylglycerol (dg) lipase, which hydrolyses 1-stearoyl-2-arachidonyl-sn-glycerol to produce an endocannabinoid, 2-arachidonoylglycerol, was purified from the soluble fraction of rat brain lysates. |
2017-01-30 |
2023-01-25 |
rat |
| M L\\xc3\\xb3pez-Gallardo, A B L\\xc3\\xb3pez-Rodr\\xc3\\xadguez, \\xc3\\x81 Llorente-Berzal, D Rotllant, K Mackie, A Armario, R Nadal, M-P Vivero. Maternal deprivation and adolescent cannabinoid exposure impact hippocampal astrocytes, CB1 receptors and brain-derived neurotrophic factor in a sexually dimorphic fashion. Neuroscience vol 204 issue 2012 22001306 |
adolescent cannabinoid exposure induced, in control non-deprived males, a significant increase in the number of gfap+ cells in the polymorphic layer of the dg. |
2012-07-23 |
2023-01-25 |
rat |
| Marco Koch, Susanne Kreutz, Charlotte B\\xc3\\xb6ttger, Urszula Grabiec, Chalid Ghadban, Horst-Werner Korf, Faramarz Dehghan. The cannabinoid WIN 55,212-2-mediated protection of dentate gyrus granule cells is driven by CB1 receptors and modulated by TRPA1 and Cav 2.2 channels. Hippocampus vol 21 issue 5 2012 20135626 |
in the present study we investigated the neuroprotective effects of the synthetic cannabinoid win 55,212-2 (win) on dentate gyrus (dg) granule cells and elucidated the involvement of trp and ca(v) 2.2 that are shown to participate in inflammatory processes. |
2012-03-26 |
2023-01-25 |
Not clear |
| Dilshani W N Dissanayake, Margarita Zachariou, Charles A Marsden, Robert Maso. Auditory gating in rat hippocampus and medial prefrontal cortex: effect of the cannabinoid agonist WIN55,212-2. Neuropharmacology vol 55 issue 8 2009 18809420 |
we studied auditory gating and the effects of the cannabinoid agonist win55,212-22 on gating in ca3 and dentate gyrus (dg) of the hippocampus and medial prefrontal cortex (mpfc) in male lister hooded rats using in vivo electrophysiology. |
2009-04-15 |
2023-01-25 |
rat |
| Sun Hee Kim, Seok Joon Won, Xiao Ou Mao, Catherine Ledent, Kunlin Jin, David A Greenber. Role for neuronal nitric-oxide synthase in cannabinoid-induced neurogenesis. The Journal of pharmacology and experimental therapeutics vol 319 issue 1 2006 16831955 |
accordingly, we measured neurogenesis in dentate gyrus (dg) and subventricular zone (svz) of cb1r-knockout (ko) and wild-type mice, some of whom were treated with the cannabinoid agonist r(+)-win 55212-2 [(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazin-yl]-(1-naphthalenyl)methanone] or the no synthase (nos) inhibitor 7-nitroindazole (7-ni). |
2006-11-02 |
2023-01-24 |
mouse |