| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria B Pazi, Daria V Belan, Elena Y Komarova, Irina V Ekimov. Intranasal Administration of GRP78 Protein (HSPA5) Confers Neuroprotection in a Lactacystin-Induced Rat Model of Parkinson's Disease. International journal of molecular sciences. vol 25. issue 7. 2024-04-13. PMID:38612761. |
grp78 overexpression can modulate the upr, block apoptosis, and promote the survival of nigral dopamine neurons in a rat model of α-synuclein pathology. |
2024-04-13 |
2024-04-15 |
rat |
| Xiaokang Jia, Qiliang Chen, Ciyu Yao, Tetsuya Asakawa, Yuanyuan Zhan. α-synuclein regulates Cyclin D1 to promote abnormal initiation of the cell cycle and induce apoptosis in dopamine neurons. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 173. 2024-03-19. PMID:38503238. |
α-synuclein regulates cyclin d1 to promote abnormal initiation of the cell cycle and induce apoptosis in dopamine neurons. |
2024-03-19 |
2024-03-23 |
mouse |
| Xiaokang Jia, Qiliang Chen, Ciyu Yao, Tetsuya Asakawa, Yuanyuan Zhan. α-synuclein regulates Cyclin D1 to promote abnormal initiation of the cell cycle and induce apoptosis in dopamine neurons. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 173. 2024-03-19. PMID:38503238. |
in a cell model induced by α-syn in dopamine neuron injury cells, knockdown of cyclin d1 led to similar results as those observed in animal experiments: knocking down cyclin d1 improved the abnormal initiation of the cell cycle caused by α-syn and regulated cellular autophagy, resulting in a reduction of apoptosis in dopamine neurons. |
2024-03-19 |
2024-03-23 |
mouse |
| Xiaokang Jia, Qiliang Chen, Ciyu Yao, Tetsuya Asakawa, Yuanyuan Zhan. α-synuclein regulates Cyclin D1 to promote abnormal initiation of the cell cycle and induce apoptosis in dopamine neurons. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 173. 2024-03-19. PMID:38503238. |
in summary, exogenous α-syn can lead to the accumulation of α-syn and phosphorylated α-syn in dopamine neurons, increase key factors of the g1/s phase cell cycle such as cyclin d1, and regulate downstream related indicators, causing the cell cycle to restart and leading to apoptosis of dopamine neurons. |
2024-03-19 |
2024-03-23 |
mouse |
| Min Huang, Yong Zhang, Xuehong Li. The mechanism of cuproptosis in Parkinson's disease. Ageing research reviews. vol 95. 2024-02-07. PMID:38311254. |
the pathogenesis pd has not been fully elucidated, and whatever mechanism is involved, it ultimately leads to dopamine (da) neuronal apoptosis. |
2024-02-07 |
2024-02-10 |
Not clear |
| Dongxue Zhu, Shenyang Zhang, Xiaoying Wang, Chenghua Xiao, Guiyun Cui, Xinxin Yan. Secretory Clusterin Inhibits Dopamine Neuron Apoptosis in MPTP Mice by Preserving Autophagy Activity. Neuroscience. 2024-01-19. PMID:38242280. |
secretory clusterin inhibits dopamine neuron apoptosis in mptp mice by preserving autophagy activity. |
2024-01-19 |
2024-01-22 |
mouse |
| Giuseppe Lisco, Anna De Tullio, Michele Iovino, Olga Disoteo, Edoardo Guastamacchia, Vito Angelo Giagulli, Vincenzo Triggian. Dopamine in the Regulation of Glucose Homeostasis, Pathogenesis of Type 2 Diabetes, and Chronic Conditions of Impaired Dopamine Activity/Metabolism: Implication for Pathophysiological and Therapeutic Purposes. Biomedicines. vol 11. issue 11. 2023-11-25. PMID:38001993. |
on the other hand, although specific trials are probably needed, certain medications approved for t2d (e.g., metformin, pioglitazone, incretin-based therapy, and gliflozins) may have a therapeutic role in such dopamine-related disorders due to anti-inflammatory and anti-oxidative effects, improvement in insulin signaling, neuroinflammation, mitochondrial dysfunction, autophagy, and apoptosis, restoration of striatal dopamine synthesis, and modulation of dopamine signaling associated with reward and hedonic eating. |
2023-11-25 |
2023-11-28 |
Not clear |
| Yufeng Chen, Hao Lu, Yicheng Ding, Shulai Liu, Yuting Ding, Baiyi Lu, Jianbo Xiao, Xuxia Zho. Dietary Protective Potential of Fucoxanthin as an Active Food Component on Neurological Disorders. Journal of agricultural and food chemistry. 2023-02-21. PMID:36802555. |
the multiple targets include regulating apoptosis, reducing oxidative stress, activating the autophagy pathway, inhibiting aβ aggregation, improving dopamine secretion, reducing α-synuclein aggregation, attenuating neuroinflammation, modulating gut microbiota, and activating brain-derived neurotrophic factor, etc. |
2023-02-21 |
2023-08-14 |
Not clear |
| Aloke K Dutta, Christopher Armstrong, Dan Luo, Banibrata Das, Brian Spencer, Robert A Rissma. ACS chemical neuroscience. 2023-02-07. PMID:36749600. |
in the case of pd, it has been demonstrated that toxic aggregates of α-syn protein not only cause apoptosis of dopamine neurons but its accumulation in the neocortex and limbic area principally contributes to dementia. |
2023-02-07 |
2023-08-14 |
Not clear |
| Jimena Ferrari. Is prolactin receptor signaling a target in dopamine-resistant prolactinomas? Frontiers in endocrinology. vol 13. 2023-01-30. PMID:36714572. |
the hypothalamic neuroendocrine catecholamine dopamine regulates the lactotroph function, including prolactin (prl) secretion, proliferation, and apoptosis. |
2023-01-30 |
2023-08-14 |
Not clear |
| Chenglian Bai, Haojia Dong, Junyan Tao, Yuanhong Chen, Hui Xu, Jian Lin, Changjiang Huang, Qiaoxiang Don. Lifetime exposure to benzophenone-3 at an environmentally relevant concentration leads to female-biased social behavior and cognition deficits in zebrafish. The Science of the total environment. 2022-10-28. PMID:36306848. |
furthermore, these effects were accompanied by female-specific decreases in brain weight and brain dopamine concentration, female-biased decrease of neurogenesis in the telencephalon as well as female-specific increases in apoptotic cells and expression levels of genes and proteins related to the apoptosis pathway in the brain. |
2022-10-28 |
2023-08-14 |
human |
| Hai Duc Nguye. Resveratrol, Endocrine Disrupting Chemicals, Neurodegenerative Diseases and Depression: Genes, Transcription Factors, microRNAs, and Sponges Involved. Neurochemical research. 2022-10-16. PMID:36245065. |
detoxification was noted as the most important for als, dopamine metabolism for pd, apoptosis for ci, and the selenium micronutrient network for depression. |
2022-10-16 |
2023-08-14 |
Not clear |
| Zhi Jiang, Jie Wang, Gaohui Sun, Meijiang Fen. BDNF-modified human umbilical cord mesenchymal stem cells-derived dopaminergic-like neurons improve rotation behavior of Parkinson's disease rats through neuroprotection and anti-neuroinflammation. Molecular and cellular neurosciences. 2022-10-13. PMID:36228967. |
results showed that transplantation of bdnf-modified huc-mscs-derived daergic-like neurons improved the apomorphine induced rotation behavior of pd rats, increased the dopamine concentration and the expression of glial fibrillary acidic protein (gfap) and ionized calcium-binding adaptor molecule-1 (iba-1) in the striatum, promoted the expression of tyrosine hydroxylase (th), nuclear receptor-related factor 1 (nurr1), pituitary homeobox 3 (pitx3), bdnf, tyrosine kinase b (trkb), phosphatidylinositol-3-hydroxykinase (pi3k), phosphorylated protein kinase b (p-akt), heat shock protein 60 (hsp60), toll-like receptor 4 (tlr4) and myeloid differentiation factor 88 (myd88) and inhibited the neural apoptosis in the substantia nigra (sn) and striatum. |
2022-10-13 |
2023-08-14 |
human |
| Yumin Wang, Shuang Wu, Qiang Li, Weihong Lang, Wenjing Li, Xiaodong Jiang, Zhirong Wan, Jichao Chen, Hongquan Wan. Epigallocatechin-3-gallate: A phytochemical as a promising drug candidate for the treatment of Parkinson's disease. Frontiers in pharmacology. vol 13. 2022-09-29. PMID:36172194. |
we focused on the effects of egcg on apoptosis, oxidative stress, inflammation, ferroptosis, modulation of dopamine production, and the aggregation of α-synuclein. |
2022-09-29 |
2023-08-14 |
Not clear |
| Yasemin Bicer, Hulya Elbe, Melike Karayakali, Gurkan Yigitturk, Umit Yilmaz, Osman Cengil, Mohammed Raed Abdullah Al Gburi, Eyup Altino. Neuroprotection by melatonin against acrylamide-induced brain damage in pinealectomized rats. Journal of chemical neuroanatomy. 2022-08-11. PMID:35952951. |
alterations of brain oxidant/antioxidant status, dopamine (da), brain-derived neurotropic factor (bdnf) inflammatory mediator and apoptosis during exposure to acr in pinealectomized rats were more than without pinealectomized rats. |
2022-08-11 |
2023-08-14 |
rat |
| Ying Jia, Yi-Fan He, Ye Tian, Yuan-Zhi Wang, Rui-Ting Zhao, Xiao-Chun Li, Jian Sun, Ying-Sheng Wei, Shuo An, Heng-Jie Yuan, Chun-Xiao Wan, Rong-Cai Jian. MicroRNA alteration in cerebrospinal fluid from comatose patients with traumatic brain injury after right median nerve stimulation. Experimental brain research. 2022-08-07. PMID:35933646. |
moreover, differentially expressed mirnas might reduce neuronal apoptosis and increase dopamine levels by regulating target gene expression, thus participating in the specific biological process after arousal therapy. |
2022-08-07 |
2023-08-14 |
Not clear |
| Zhili Kuang, Zheng Chen, Shaoqin Tu, Zhihui Mai, Lin Chen, Xiaoning Kang, Xiaochuan Chen, Jiaming Wei, Yuxuan Wang, Yun Peng, Hong A. Dopamine Suppresses Osteogenic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells via AKT/GSK-3 Stem cells international. vol 2022. 2022-07-11. PMID:35813889. |
in this study, we firstly investigated the effect of dopamine on the apoptosis, proliferation, and osteogenic differentiation of rbmscs. |
2022-07-11 |
2023-08-14 |
rat |
| Zhili Kuang, Zheng Chen, Shaoqin Tu, Zhihui Mai, Lin Chen, Xiaoning Kang, Xiaochuan Chen, Jiaming Wei, Yuxuan Wang, Yun Peng, Hong A. Dopamine Suppresses Osteogenic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells via AKT/GSK-3 Stem cells international. vol 2022. 2022-07-11. PMID:35813889. |
dopamine did not, however, interfere with the apoptosis and proliferation of rbmscs. |
2022-07-11 |
2023-08-14 |
rat |
| Yu Jin Jung, Hyunsu Choi, Eungseok O. Melatonin attenuates MPP Biochemical and biophysical research communications. vol 621. 2022-07-10. PMID:35810592. |
moreover, they protect dopamine neurons from oxidative stress, inflammation, and apoptosis, all well-known pathomechanisms of parkinson's disease (pd). |
2022-07-10 |
2023-08-14 |
Not clear |
| Lei Wang, Xinghong Wu, Ge Yang, Nan Hu, Zijian Zhao, Lei Zhao, Shengyu L. Cannabidiol alleviates the damage to dopaminergic neurons in MPTP-induced Parkinson's disease mice via regulating neuronal apoptosis and neuroinflammation. Neuroscience. 2022-07-06. PMID:35792194. |
this study aimed to investigate the protective effect of cannabidiol (cbd) on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced neuronal dopamine injury by inhibiting neuroinflammation, which was one of the factors that cause neuronal apoptosis. |
2022-07-06 |
2023-08-14 |
mouse |