| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eman Ali, Fakhar Latif, Yusra Mashkoor, Ayesha Sheikh, Amna Iqbal, Rabia Owais, Jawad Ahmed, Sadiq Naveed, Abdul Moeed, Irfan Ullah, Sanila Mugha. Role of adjunctive cariprazine for treatment-resistant depression in patients with major depressive disorder: A systematic review and meta-analysis of randomized controlled trials. Asian journal of psychiatry. vol 95. 2024-03-21. PMID:38513509. |
cariprazine is an orally active dopamine d3-preferring d3/d2 receptor and serotonin 5-ht1a receptor partial agonist, being considered as a treatment for refractory mdd. |
2024-03-21 |
2024-03-24 |
Not clear |
| Polona Rus Prelog, Anja Kokalj Palandaci. Hypersexuality during treatment with cariprazine in a patient with schizophrenia? A case report. BMC psychiatry. vol 23. issue 1. 2023-12-11. PMID:38082232. |
it functions as a partial agonist with high affinity for dopamine d2 and d3 and serotonin 5-ht1a receptors, an antagonist for 5-ht2a (moderate affinity) and 5-ht2b (high affinity) receptors. |
2023-12-11 |
2023-12-17 |
Not clear |
| Francesca Perini, Jadwiga Maria Nazimek, Shane Mckie, Liliana P Capitão, Jessica Scaife, Deepa Pal, Michael Browning, Gerard R Dawson, Hiroyuki Nishikawa, Una Campbell, Seth C Hopkins, Antony Loebel, Rebecca Elliott, Catherine J Harmer, Bill Deakin, Kenneth S Kobla. Effects of ulotaront on brain circuits of reward, working memory, and emotion processing in healthy volunteers with high or low schizotypy. Schizophrenia (Heidelberg, Germany). vol 9. issue 1. 2023-08-07. PMID:37550314. |
ulotaront, a trace amine-associated receptor 1 (taar1) and serotonin 5-ht1a receptor agonist without antagonist activity at dopamine d |
2023-08-07 |
2023-08-14 |
human |
| Savelii R Kuvarzin, Ilya Sukhanov, Kirill Onokhin, Konstantin Zakharov, Raul R Gainetdino. Unlocking the Therapeutic Potential of Ulotaront as a Trace Amine-Associated Receptor 1 Agonist for Neuropsychiatric Disorders. Biomedicines. vol 11. issue 7. 2023-07-29. PMID:37509616. |
ulotaront is an agonist of trace amine-associated receptor 1 and serotonin 5-ht1a receptors, but can modulate dopamine neurotransmission indirectly. |
2023-07-29 |
2023-08-14 |
Not clear |
| Tarun Gupta, Varinder Singh, Mohamed Hefnawy, Mohammed M Alanazi, Bader Alsuwayt, Atul Kabra, Amit Kumar, Chirag Pasricha, Ravinder Sing. Ameliorating the Role of Aripiprazole in Memory Deficits Induced by Intracerebroventricular Streptozotocin-Induced Dementia of Alzheimer's Type. ACS omega. vol 8. issue 28. 2023-07-24. PMID:37483219. |
dopamine d2 and 5-hydroxytryptamine receptor 1a (5-ht1a) receptors' activation has been reported to play a crucial role in managing neurological outcomes in the brain and other health disorders. |
2023-07-24 |
2023-08-14 |
mouse |
| Tarun Gupta, Varinder Singh, Mohamed Hefnawy, Mohammed M Alanazi, Bader Alsuwayt, Atul Kabra, Amit Kumar, Chirag Pasricha, Ravinder Sing. Ameliorating the Role of Aripiprazole in Memory Deficits Induced by Intracerebroventricular Streptozotocin-Induced Dementia of Alzheimer's Type. ACS omega. vol 8. issue 28. 2023-07-24. PMID:37483219. |
this study aimed to investigate the role of aripiprazole, a dopamine d2 and 5-ht1a selective receptors' activator, in the restoration of memory deficit induced by streptozotocin in mice. |
2023-07-24 |
2023-08-14 |
mouse |
| Carles Espinós Ramírez, Anna Artigas Soler, Paula Gil Esteller, Noemí García Medina, Juan Tangarife Benjumea, María Martínez Garcí. Refractory hypotension secondary to chronic treatment with high doses of quetiapine. Revista espanola de anestesiologia y reanimacion. 2023-05-07. PMID:37150441. |
it acts on dopamine d1 and d2, histamine, and 5ht1a and 5ht2 receptors. |
2023-05-07 |
2023-08-14 |
Not clear |
| Akihiro Hasumi, Hideyuki Maed. Cannabidiol improves haloperidol-induced motor dysfunction in zebrafish: a comparative study with a dopamine activating drug. Journal of cannabis research. vol 5. issue 1. 2023-03-04. PMID:36871008. |
recent behavioral studies in rats have reported that cbd mediates serotonin (5-ht1a) receptor action to improve motor dysfunction induced by dopamine (d2) receptor blockade. |
2023-03-04 |
2023-08-14 |
rat |
| Ho-Geun Kang, Hee-Yun Kim, Hyunwoo Jee, Hwanseok Jun, Hosong Cho, Dongjun Park, Hyun-Jong Ahn, Hyung-Min Kim, Hyun-Ja Jeon. Compound of Cynanchum wilfordii and Humulus lupulus L. Ameliorates Menopausal Symptoms in Ovariectomized Mice. Reproductive sciences (Thousand Oaks, Calif.). 2022-11-05. PMID:36333646. |
values for hypothalamic serotonin (5-ht), dopamine, norepinephrine, estrogen receptor (er)-β, 5-ht1a, and 5-ht2a were significantly enhanced, while value for hypothalamic monoamine oxidase a was reduced in cwhl and caudatin groups compared with the ovx group. |
2022-11-05 |
2023-08-14 |
mouse |
| Noelia Cantero-García, Antonio Flores-Burgess, Juan Pedro Pineda-Gómez, Laura Orio, Antonia Serrano, Zaida Díaz-Cabiale, Carmelo Milló. Galanin N-terminal fragment (1-15) reduces alcohol seeking and alcohol relapse in rats: Involvement of mesocorticolimbic system. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-09-09. PMID:36076594. |
we have analysed the transcriptional changes of c-fos, dopamine receptors, gal receptors and 5ht1a receptors in the corticomesolimbic system. |
2022-09-09 |
2023-08-14 |
rat |
| Noelia Cantero-García, Antonio Flores-Burgess, Juan Pedro Pineda-Gómez, Laura Orio, Antonia Serrano, Zaida Díaz-Cabiale, Carmelo Milló. Galanin N-terminal fragment (1-15) reduces alcohol seeking and alcohol relapse in rats: Involvement of mesocorticolimbic system. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-09-09. PMID:36076594. |
notably, the mechanism of gal(1-15)-mediated actions involved changes in c-fos, dopamine receptors and 5ht1a expression in the ventral tegmental area, accumbens nucleus and prefrontal cortex. |
2022-09-09 |
2023-08-14 |
rat |
| Emanuela Dyrmishi, Marco De Pieri, Marco Ferrari, Rafael Traber, Matteo Preve, Luca De Peri, Emilio Boll. Case Report: Long-Acting Oral Cariprazine. Frontiers in psychiatry. vol 13. 2022-05-16. PMID:35573352. |
cariprazine is a partial agonist at dopamine receptors d2 and d3 and serotonin receptor 5ht1a and an antagonist at serotonin receptors 5ht2b and 5ht2a. |
2022-05-16 |
2023-08-13 |
Not clear |
| Yasuhiro Kyono, Lori Ellezian, YueYue Hu, Kanella Eliadis, Junlone Moy, Elizabeth B Hirsch, Michael J Federle, Stephanie A Flower. The Atypical Antipsychotic Quetiapine Promotes Multiple Antibiotic Resistance in Escherichia coli. Journal of bacteriology. 2022-04-13. PMID:35416690. |
while aaps primarily target dopamine (d2) and serotonin (5ht2a and 5ht1a) receptors, they also exhibit intrinsic antimicrobial activity as an off-target effect. |
2022-04-13 |
2023-08-13 |
Not clear |
| Ashish Patel, Arya Patel, Darshini Patel, Krina Patel, Tushar Bambharoliy. Mini Review on Cariprazine: A Promising Antipsychotic Agent. CNS & neurological disorders drug targets. 2022-03-25. PMID:35331126. |
however, due to the partial agonist action on dopamine d2, d3 receptors, and serotonin 5-ht1a receptors as well as antagonist effect on 5-ht2a, 5-ht2b, and h1 receptors, cariprazine differentiate pharmacologically from other apds, both typical and atypical. |
2022-03-25 |
2023-08-13 |
Not clear |
| Mauricio Tohe. Cariprazine as a Treatment Option for Depressive Episodes Associated with Bipolar 1 Disorder in Adults: An Evidence-Based Review of Recent Data. Drug design, development and therapy. vol 15. 2021-11-23. PMID:34012253. |
cariprazine, a broad-spectrum dopamine antagonist/partial agonist with dopamine d3/d2 (preferring d3) and serotonin 5-ht1a receptor partial agonist properties, was recently approved. |
2021-11-23 |
2023-08-13 |
Not clear |
| Speranta Avram, Miruna Silvia Stan, Ana Maria Udrea, Cătălin Buiu, Anca Andreea Boboc, Maria Merne. 3D-ALMOND-QSAR Models to Predict the Antidepressant Effect of Some Natural Compounds. Pharmaceutics. vol 13. issue 9. 2021-10-01. PMID:34575524. |
their antidepressant and neuroleptic activities were predicted by 3d-almond-qsar models built by considering three important targets, namely serotonin transporter (sert), 5-hydroxytryptamine receptor 1a (5-ht1a), and dopamine d2 receptor. |
2021-10-01 |
2023-08-13 |
Not clear |
| Francesca Calabrese, Frank I Tarazi, Giorgio Racagni, Marco A Riv. The role of dopamine D CNS spectrums. vol 25. issue 3. 2021-08-24. PMID:31010452. |
specifically, cariprazine acts as a partial agonist at the dopamine (da) d2 and d3 receptors and serotonin 5-ht1a receptors, and as an antagonist at the 5-ht2b receptors. |
2021-08-24 |
2023-08-13 |
Not clear |
| Nicholas Keks, Judith Hope, Darren Schwartz, Harold McLennan, David Copolov, Graham Meadow. Comparative Tolerability of Dopamine D2/3 Receptor Partial Agonists for Schizophrenia. CNS drugs. vol 34. issue 5. 2021-08-05. PMID:32246399. |
in contrast to aripiprazole, brexpiprazole has lower intrinsic dopamine d2 activity and higher affinity for the serotonin 5-ht1a and 5-ht2a receptors, while cariprazine has the highest affinity for the dopamine d3 receptor, and the longest half-life. |
2021-08-05 |
2023-08-13 |
Not clear |
| Roger S Mcintyre, Eduard Vieta, Willie Earley, Mehul Pate. Effects of Cariprazine on Cognition in Patients With Bipolar Mania or Mixed States: Post Hoc Analysis From 3 Randomized, Controlled Phase III Studies. CNS spectrums. vol 26. issue 2. 2021-07-23. PMID:34127095. |
cariprazine, a dopamine d3-preferring d3/d2 and serotonin 5-ht1a receptor partial agonist, is approved for the treatment of schizophrenia and for depressive, manic, or mixed episodes associated with bipolar i disorder. |
2021-07-23 |
2023-08-13 |
Not clear |
| Raheel Saeed, Khalid Mahmood, Sadia Basharat Ali, Darakhshan Jabeen Halee. Prevention of diet restriction induced hyperactivity but not body-weight reduction in rats co-treated with tryptophan: relationship with striatal serotonin and dopamine metabolism and serotonin-1A auto-receptor expression. Nutritional neuroscience. 2021-05-18. PMID:33722185. |
the study suggests that the striatal metabolism of 5-ht and dopamine and mrna expression of 5-ht1a auto-receptor has an important role in the pathogenesis of an. |
2021-05-18 |
2023-08-13 |
rat |