| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akihiro Hasumi, Hideyuki Maed. Cannabidiol improves haloperidol-induced motor dysfunction in zebrafish: a comparative study with a dopamine activating drug. Journal of cannabis research vol 5 issue 1 2023 36871008 |
recent behavioral studies in rats have reported that cbd mediates serotonin (5-ht1a) receptor action to improve motor dysfunction induced by dopamine (d2) receptor blockade. |
2023-03-04 |
2023-03-06 |
rat |
| Ho-Geun Kang, Hee-Yun Kim, Hyunwoo Jee, Hwanseok Jun, Hosong Cho, Dongjun Park, Hyun-Jong Ahn, Hyung-Min Kim, Hyun-Ja Jeon. Compound of Cynanchum wilfordii and Humulus lupulus L. Ameliorates Menopausal Symptoms in Ovariectomized Mice. Reproductive sciences (Thousand Oaks, Calif.) vol issue 2022 36333646 |
values for hypothalamic serotonin (5-ht), dopamine, norepinephrine, estrogen receptor (er)-\xce\xb2, 5-ht1a, and 5-ht2a were significantly enhanced, while value for hypothalamic monoamine oxidase a was reduced in cwhl and caudatin groups compared with the ovx group. |
2022-11-05 |
2023-01-30 |
mouse |
| Noelia Cantero-Garc\\xc3\\xada, Antonio Flores-Burgess, Juan Pedro Pineda-G\\xc3\\xb3mez, Laura Orio, Antonia Serrano, Zaida D\\xc3\\xadaz-Cabiale, Carmelo Mill\\xc3\\xb3. Galanin N-terminal fragment (1-15) reduces alcohol seeking and alcohol relapse in rats: Involvement of mesocorticolimbic system. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie vol 153 issue 2022 36076594 |
we have analysed the transcriptional changes of c-fos, dopamine receptors, gal receptors and 5ht1a receptors in the corticomesolimbic system. |
2022-09-09 |
2023-01-30 |
rat |
| Noelia Cantero-Garc\\xc3\\xada, Antonio Flores-Burgess, Juan Pedro Pineda-G\\xc3\\xb3mez, Laura Orio, Antonia Serrano, Zaida D\\xc3\\xadaz-Cabiale, Carmelo Mill\\xc3\\xb3. Galanin N-terminal fragment (1-15) reduces alcohol seeking and alcohol relapse in rats: Involvement of mesocorticolimbic system. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie vol 153 issue 2022 36076594 |
notably, the mechanism of gal(1-15)-mediated actions involved changes in c-fos, dopamine receptors and 5ht1a expression in the ventral tegmental area, accumbens nucleus and prefrontal cortex. |
2022-09-09 |
2023-01-30 |
rat |
| Emanuela Dyrmishi, Marco De Pieri, Marco Ferrari, Rafael Traber, Matteo Preve, Luca De Peri, Emilio Boll. Case Report: Long-Acting Oral Cariprazine. Frontiers in psychiatry vol 13 issue 2022 35573352 |
cariprazine is a partial agonist at dopamine receptors d2 and d3 and serotonin receptor 5ht1a and an antagonist at serotonin receptors 5ht2b and 5ht2a. |
2022-05-16 |
2023-01-27 |
Not clear |
| Yasuhiro Kyono, Lori Ellezian, YueYue Hu, Kanella Eliadis, Junlone Moy, Elizabeth B Hirsch, Michael J Federle, Stephanie A Flower. The Atypical Antipsychotic Quetiapine Promotes Multiple Antibiotic Resistance in Escherichia coli. Journal of bacteriology vol issue 2022 35416690 |
while aaps primarily target dopamine (d2) and serotonin (5ht2a and 5ht1a) receptors, they also exhibit intrinsic antimicrobial activity as an off-target effect. |
2022-04-13 |
2023-01-27 |
Not clear |
| Ashish Patel, Arya Patel, Darshini Patel, Krina Patel, Tushar Bambharoliy. Mini Review on Cariprazine: A Promising Antipsychotic Agent. CNS & neurological disorders drug targets vol issue 2022 35331126 |
however, due to the partial agonist action on dopamine d2, d3 receptors, and serotonin 5-ht1a receptors as well as antagonist effect on 5-ht2a, 5-ht2b, and h1 receptors, cariprazine differentiate pharmacologically from other apds, both typical and atypical. |
2022-03-25 |
2023-01-27 |
Not clear |
| Mauricio Tohe. Cariprazine as a Treatment Option for Depressive Episodes Associated with Bipolar 1 Disorder in Adults: An Evidence-Based Review of Recent Data. Drug design, development and therapy vol 15 issue 2021 34012253 |
cariprazine, a broad-spectrum dopamine antagonist/partial agonist with dopamine d3/d2 (preferring d3) and serotonin 5-ht1a receptor partial agonist properties, was recently approved. |
2021-11-23 |
2023-01-26 |
Not clear |
| Speranta Avram, Miruna Silvia Stan, Ana Maria Udrea, C\\xc4\\x83t\\xc4\\x83lin Buiu, Anca Andreea Boboc, Maria Merne. 3D-ALMOND-QSAR Models to Predict the Antidepressant Effect of Some Natural Compounds. Pharmaceutics vol 13 issue 9 2021 34575524 |
their antidepressant and neuroleptic activities were predicted by 3d-almond-qsar models built by considering three important targets, namely serotonin transporter (sert), 5-hydroxytryptamine receptor 1a (5-ht1a), and dopamine d2 receptor. |
2021-10-01 |
2023-01-26 |
Not clear |
| Francesca Calabrese, Frank I Tarazi, Giorgio Racagni, Marco A Riv. The role of dopamine D CNS spectrums vol 25 issue 3 2021 31010452 |
specifically, cariprazine acts as a partial agonist at the dopamine (da) d2 and d3 receptors and serotonin 5-ht1a receptors, and as an antagonist at the 5-ht2b receptors. |
2021-08-24 |
2023-01-26 |
Not clear |
| Nicholas Keks, Judith Hope, Darren Schwartz, Harold McLennan, David Copolov, Graham Meadow. Comparative Tolerability of Dopamine D2/3 Receptor Partial Agonists for Schizophrenia. CNS drugs vol 34 issue 5 2021 32246399 |
in contrast to aripiprazole, brexpiprazole has lower intrinsic dopamine d2 activity and higher affinity for the serotonin 5-ht1a and 5-ht2a receptors, while cariprazine has the highest affinity for the dopamine d3 receptor, and the longest half-life. |
2021-08-05 |
2023-01-26 |
Not clear |
| Roger S Mcintyre, Eduard Vieta, Willie Earley, Mehul Pate. Effects of\\xc2\\xa0Cariprazine\\xc2\\xa0on Cognition in Patients\\xc2\\xa0With\\xc2\\xa0Bipolar Mania or Mixed States: Post Hoc Analysis From 3 Randomized, Controlled Phase III Studies. CNS spectrums vol 26 issue 2 2021 34127095 |
cariprazine, a dopamine d3-preferring d3/d2 and serotonin 5-ht1a receptor partial agonist, is approved for the treatment of schizophrenia and for depressive, manic, or mixed episodes associated with bipolar i disorder. |
2021-07-23 |
2023-01-26 |
Not clear |
| Raheel Saeed, Khalid Mahmood, Sadia Basharat Ali, Darakhshan Jabeen Halee. Prevention of diet restriction induced hyperactivity but not body-weight reduction in rats co-treated with tryptophan: relationship with striatal serotonin and dopamine metabolism and serotonin-1A auto-receptor expression. Nutritional neuroscience vol issue 2021 33722185 |
the study suggests that the striatal metabolism of 5-ht and dopamine and mrna expression of 5-ht1a auto-receptor has an important role in the pathogenesis of an. |
2021-05-18 |
2023-01-26 |
rat |
| Rosaria Nardello, Fulvio Guccione, Claudia Gliubizzi, Antonio Marino, Mariarita Capizzi, Salvatore Mangan. Resolution of enuresis with aripiprazole in children with psychiatric disorders: two case reports. Journal of medical case reports vol 15 issue 1 2021 33883037 |
as partial agonist of the dopamine (d2) and serotonin (5-ht1a) receptors, it appears to be effective in reducing mania in patients with bipolar disorder, tics in tourette syndrome, aggression in schizophrenia and autism spectrum disorder. |
2021-05-14 |
2023-01-26 |
Not clear |
| Matheus Libarino-Santos, Ana Catherine Gomes de Santana Santos, Elisangela G Cata-Preta, Tha\\xc3\\xadsa Barros-Santos, Nina Rosa Nunes Brand\\xc3\\xa3o, Aurea Lorena Nunes Borges, Renan Santos-Baldaia, Andr\\xc3\\xa9 W Hollais, Marilia A Baldaia, La\\xc3\\xads F Berro, Eduardo A V Marinho, Roberto Frussa-Filho, Alexandre J Oliveira-Lim. Role of the treatment environment in the effects of aripiprazole on ethanol-induced behavioral sensitization and conditioned place preference in female mice. Drug and alcohol dependence vol 208 issue 2021 31954952 |
evidence suggests that aripiprazole, a partial dopamine d2 and serotonin 5-ht1a receptor agonist and 5-ht2a receptor antagonist, show significant efficacy in reducing alcohol use. |
2021-01-18 |
2023-01-26 |
mouse |
| Nami Isooka, Ikuko Miyazaki, Ryo Kikuoka, Kouichi Wada, Erika Nakayama, Kotaro Shin, Daichi Yamamoto, Yoshihisa Kitamura, Masato Asanum. Dopaminergic neuroprotective effects of rotigotine via 5-HT1A receptors: Possibly involvement of metallothionein expression in astrocytes. Neurochemistry international vol 132 issue 2021 31765686 |
rotigotine, an anti-parkinsonian drug, can bind to dopamine and 5-ht1a receptors. |
2021-01-07 |
2023-01-26 |
Not clear |
| Chara A Zika, Ioannis Nicolaou, Antonis Gavalas, George V Rekatas, Ekaterini Tani, Vassilis J Demopoulo. Behavioral and antioxidant activity of a tosylbenz[g]indolamine derivative. A proposed better profile for a potential antipsychotic agent. Annals of general hospital psychiatry vol 3 issue 1 2020 14711381 |
in a previous study we have shown that an indolamine molecule expresses a moderate binding affinity at the dopamine d2 and serotonin 5-ht1a receptors in in vitro competition binding assays. |
2020-09-30 |
2023-01-24 |
rat |
| Lakshmi N Yatham, Eduard Vieta, Roger S McIntyre, Rakesh Jain, Mehul Patel, Willie Earle. Broad Efficacy of Cariprazine on Depressive Symptoms in Bipolar Disorder and the Clinical Implications. The primary care companion for CNS disorders vol 22 issue 5 2020 32942346 |
cariprazine, a dopamine d\xe2\x82\x83-preferring d\xe2\x82\x83/d\xe2\x82\x82 receptor partial agonist with serotonin 5-ht1a receptor partial agonist and serotonin 5-ht2a antagonist properties, is approved to treat manic and depressive episodes of bipolar disorder. |
2020-09-29 |
2023-01-26 |
Not clear |
| Shrikant S Kolan, Tommy Lidstr\\xc3\\xb6m, Tom\\xc3\\xa1s Mediavilla, Andy Dernstedt, Sofie Degerman, Magnus Hultdin, Karl Bj\\xc3\\xb6rk, Daniel Marcellino, Mattias N E Forsel. Growth-inhibition of cell lines derived from B cell lymphomas through antagonism of serotonin receptor signaling. Scientific reports vol 9 issue 1 2020 30862884 |
neurotransmitters such as serotonin and dopamine influence activation of b cells and the effects of a selective serotonin 1a receptor (5ht1a) antagonist on growth of a number of b cell-derived lymphoma cell lines were investigated. |
2020-09-28 |
2023-01-26 |
human |
| L\\xc3\\xadgia Castanheira, Elsa Fernandes, Pedro Levy, Ricardo Coentr. Aripiprazole-induced Hepatitis: A Case Report. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology vol 17 issue 4 2020 31671495 |
aripiprazole is an atypical antipsychotic that acts as a partial agonist of dopamine type 2 receptors as well as 5-ht1a receptors. |
2020-09-28 |
2023-01-26 |
Not clear |