| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A M Montgomery, I C Rose, L J Herber. 5-HT1A agonists and dopamine: the effects of 8-OH-DPAT and buspirone on brain-stimulation reward. Journal of neural transmission. General section. vol 83. issue 1-2. 1991-05-28. PMID:1826841. |
5-ht1a agonists and dopamine: the effects of 8-oh-dpat and buspirone on brain-stimulation reward. |
1991-05-28 |
2023-08-11 |
rat |
| P R Blowe. The role of specific 5-HT3 receptor antagonism in the control of cytostatic drug-induced emesis. European journal of cancer (Oxford, England : 1990). vol 26 Suppl 1. 1990-11-06. PMID:2169786. |
radioligand binding studies in rat brain revealed a high affinity (ki 0.26 nm) for 5-ht3 sites and much lower affinities (ki 1000 - greater than 10,000 nm) for 5-ht1, 5-ht2, 5-ht1a, 5-ht1b/c, 5-ht1c, alpha 1, alpha 2, dopamine d2, benzodiazepine, picrotoxin, beta, histamine h1 or opioid mu, kappa or delta binding sites. |
1990-11-06 |
2023-08-11 |
rat |
| S Ahlenius, V Hillegaart, A Wijkströ. Increased dopamine turnover in the ventral striatum by 8-OH-DPAT administration in the rat. The Journal of pharmacy and pharmacology. vol 42. issue 4. 1990-09-12. PMID:1974300. |
the administration of the 5-ht1a agonist 8-oh-dpat (0.8 mumols kg-1 s.c.-40 min) produced an increase in dopamine (da) turnover, estimated by the quotient (dopac + hva) da-1, in the ventral striatum of the rat. |
1990-09-12 |
2023-08-11 |
rat |
| P J Cowen, I M Anderson, D G Grahame-Smit. Neuroendocrine effects of azapirones. Journal of clinical psychopharmacology. vol 10. issue 3 Suppl. 1990-09-05. PMID:1973937. |
while animal studies implicate changes in dopamine function, current human investigations suggest that 5-ht1a receptors also may be involved in these endocrine responses. |
1990-09-05 |
2023-08-11 |
human |
| A E Dusser, S J Peroutk. Neurotransmitter receptors in adult tottering (tg/tg) mice. Epilepsia. vol 31. issue 4. 1990-08-21. PMID:2164468. |
the amount of radioligand binding to 5-hydroxytryptamine 1a (5-ht1a), non-5-ht1a, 5-ht2, dopamine d2, and benzodiazepine receptors was also identical in tottering and control mice. |
1990-08-21 |
2023-08-11 |
mouse |
| C P VanderMaelen, J P Braselto. Effects of a potential antipsychotic, BMY 14802, on firing of central serotonergic and noradrenergic neurons in rats. European journal of pharmacology. vol 179. issue 3. 1990-08-13. PMID:1973108. |
bmy 14802 (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1- piperazinebutanol hcl) is a novel potential antipsychotic drug which does not bind to dopamine receptors, does bind to 5-ht1a receptors, and also binds stereoselectively to sigma sites. |
1990-08-13 |
2023-08-11 |
rat |
| K A Cunningham, J M Lakosk. The interaction of cocaine with serotonin dorsal raphe neurons. Single-unit extracellular recording studies. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 3. issue 1. 1990-04-05. PMID:2137698. |
the putative 5-ht1a autoreceptor antagonist spiperone reversed the cocaine-induced depression of firing rate in 64% of 5-ht neurons tested whereas receptor antagonists for dopamine d2 (haloperidol), 5-ht2 (ketanserin), gamma-aminobutyric acid (picrotoxin) and 5-ht1/beta-adrenergic (propranolol) were ineffective. |
1990-04-05 |
2023-08-11 |
rat |
| J Svartengren, P Simonsso. Receptor binding properties of amperozide. Pharmacology & toxicology. vol 66 Suppl 1. 1990-03-29. PMID:2154737. |
the affinity for several other rat brain receptors such as 5-ht1a, alpha 2-adrenergic, dopamine d1, muscarinic m1 and m2, opiate sigma and beta 2-adrenergic was low. |
1990-03-29 |
2023-08-11 |
human |
| T Matsuda, Y H Seong, H Aono, T Kanda, A Baba, K Saito, A Tobe, H Iwat. Agonist activity of a novel compound, 1-[3-(3,4-methylenedioxyphenoxy)propyl]-4-phenyl piperazine (BP-554), at central 5-HT1A receptors. European journal of pharmacology. vol 170. issue 1-2. 1990-03-06. PMID:2533078. |
we used an in vitro radioligand receptor binding assay with rat cerebral cortex, hippocampus and striatum membrane preparations to show that 1-[3-(3,4-methylenedioxyphenoxy)propyl]-4-phenyl piperazine (bp-554) had much higher affinity for 5-ht1a recognition sites than for 5-ht1-non-a, 5-ht2, benzodiazepine, dopamine d-2 and alpha 2-adrenergic recognition sites. |
1990-03-06 |
2023-08-11 |
mouse |
| P H Anderse. The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action. European journal of pharmacology. vol 166. issue 3. 1989-11-27. PMID:2530094. |
gbr 12909 was a potent and selective inhibitor of synaptosomal dopamine uptake (ki = 1 nm), with a 20-fold lower affinity for the histamine h1-receptor and a more than 100-fold affinity for the noradrenaline and 5-ht uptake carriers, the dopamine d-1, d-2, 5-ht2, 5-ht1a and alpha 1-receptors and voltage-dependent sodium channels. |
1989-11-27 |
2023-08-11 |
Not clear |
| S Ahlenius, V Hillegaart, A Wijkströ. Evidence for selective inhibition of limbic forebrain dopamine synthesis by 8-OH-DPAT in the rat. Naunyn-Schmiedeberg's archives of pharmacology. vol 339. issue 5. 1989-09-29. PMID:2570361. |
this increase in dopa accumulation was antagonized dose-dependently in the nucleus accumbens and ventro-medial neostriatum, but not in the other two regions, by treatment with the 5-ht1a receptor agonist 8-oh-dpat, 0.15-2.4 mumol kg-1, whereas the partial dopamine d2 receptor agonist (-)3-ppp, 2.5-10.0 mumol kg-1, or the full dopamine d2 receptor agonist quinpirole, 0.05-0.8 mumol kg-1, antagonized the reserpine-induced increase in dopa accumulation uniformly in all four regions of the striatum. |
1989-09-29 |
2023-08-11 |
rat |
| J M Liebman, S C Gerhardt, R Gerbe. Effects of 5-HT1A agonists and 5-HT2 antagonists on haloperidol-induced dyskinesias in squirrel monkeys: no evidence for reciprocal 5-HT-dopamine interaction. Psychopharmacology. vol 97. issue 4. 1989-06-27. PMID:2524857. |
in view of previous suggestions that brain serotonergic systems may tonically inhibit dopamine neurons, the effects of several new and selective 5-ht2 receptor antagonists and 5-ht1a receptor agonists were investigated in this model. |
1989-06-27 |
2023-08-11 |
monkey |
| J M Liebman, S C Gerhardt, R Gerbe. Effects of 5-HT1A agonists and 5-HT2 antagonists on haloperidol-induced dyskinesias in squirrel monkeys: no evidence for reciprocal 5-HT-dopamine interaction. Psychopharmacology. vol 97. issue 4. 1989-06-27. PMID:2524857. |
gepirone, a 5-ht1a agonist with less marked dopamine antagonist properties, induced dyskinesias in only one of six monkeys at 30 mg/kg and did not block haloperidol-induced dyskinesias. |
1989-06-27 |
2023-08-11 |
monkey |
| M Mynlieff, T V Dunwiddi. Noradrenergic depression of synaptic responses in hippocampus of rat: evidence for mediation by alpha 1-receptors. Neuropharmacology. vol 27. issue 4. 1988-10-27. PMID:2843779. |
the depressant effect of ne was not antagonized by the antagonist of serotonin and dopamine, spiperone (100 nm); conversely, the effect of 8-hydroxy-2-(di-n-propylamine) tetralin (50 microm), a 5-ht1a receptor-selective agonist, which also depresses the amplitude of the population spike, was not antagonized by phentolamine (5 microm). |
1988-10-27 |
2023-08-11 |
rat |
| J T Lum, M F Pierce. Electrophysiological evidence that spiperone is an antagonist of 5-HT1A receptors in the dorsal raphe nucleus. European journal of pharmacology. vol 149. issue 1-2. 1988-08-31. PMID:2969339. |
the neuroleptic spiperone, which binds to 5-ht1a, 5-ht2 and dopamine (da) receptors, was studied for its effects on serotonin (5-ht) and da neurons in dorsal raphe nucleus and substantia nigra pars compacta, respectively. |
1988-08-31 |
2023-08-11 |
Not clear |
| H Shimizu, N Karai, A Hirose, T Tatsuno, H Tanaka, Y Kumasaka, M Nakamur. Interaction of SM-3997 with serotonin receptors in rat brain. Japanese journal of pharmacology. vol 46. issue 3. 1988-07-25. PMID:2898033. |
sm-3997 possessed a high affinity towards 5-ht1a receptors, low affinity towards dopamine (d2) and 5-ht2 receptors, and no affinity towards benzodiazepine (bz), gaba, 5-ht1b and adrenergic receptors. |
1988-07-25 |
2023-08-11 |
rat |
| J G Cannon, P Mohan, J Bojarski, J P Long, R K Bhatnagar, P A Leonard, J R Flynn, T K Chatterje. (R)-(-)-10-methyl-11-hydroxyaporphine: a highly selective serotonergic agonist. Journal of medicinal chemistry. vol 31. issue 2. 1988-03-16. PMID:3339604. |
surprisingly, the target compound elicited no responses in any assays for effects at dopamine receptors, but rather it displayed pharmacological properties consistent with its being a serotonergic agonist with a high degree of selectivity for 5-ht1a receptors similar to the serotonergic agonist 8-hydroxy-2-(di-n-propylamino)tetralin. |
1988-03-16 |
2023-08-11 |
Not clear |
| R W Foote, H H Büscher, D Römer, R Maurer, A Enz, B H Gähwiler, G T Shearman, M P Seiler, H Wüthric. CY 208-243: a unique combination of atypical opioid antinociception and D1 dopaminomimetic properties. Life sciences. vol 42. issue 2. 1988-02-17. PMID:2826954. |
here we describe the potent antinociceptive action of the indolophenanthridine, cy 208-243, which has high affinities to the dopamine d1 binding and the opioid sites as well as to the 5-ht1a site. |
1988-02-17 |
2023-08-11 |
rat |
| T P Donohoe, P H Hutson, G Curzo. Blockade of dopamine receptors explains the lack of 5-HT stereotypy on treatment with the putative 5-HT1A agonist LY165163. Psychopharmacology. vol 93. issue 1. 1987-10-21. PMID:2957721. |
blockade of dopamine receptors explains the lack of 5-ht stereotypy on treatment with the putative 5-ht1a agonist ly165163. |
1987-10-21 |
2023-08-11 |
rat |
| J R Fozard, A K Mir, D N Middlemis. Cardiovascular response to 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) in the rat: site of action and pharmacological analysis. Journal of cardiovascular pharmacology. vol 9. issue 3. 1987-05-27. PMID:2437400. |
the response to 8-oh-dpat was blocked selectively by intracisternal injection of 8-methoxy-2-(n-2-chloroethyl-n-n propyl) amino tetralin (8-meo-ciepat), a putative irreversible 5-ht1a receptor antagonist, and was abolished in animals whose central monoamine transmitter stores were depleted selectively by combined treatment with dl-alpha-monofluoromethyl-dopa and dopamine. |
1987-05-27 |
2023-08-11 |
rat |