| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fumi Kaneko, Yukie Kawahara, Yuki Kishikawa, Yuuki Hanada, Makiko Yamada, Tatsuyuki Kakuma, Hiroshi Kawahara, Akinori Nish. Long-Term Citalopram Treatment Alters the Stress Responses of the Cortical Dopamine and Noradrenaline Systems: the Role of Cortical 5-HT1A Receptors. The international journal of neuropsychopharmacology. vol 19. issue 8. 2018-01-29. PMID:27029212. |
long-term citalopram treatment alters the stress responses of the cortical dopamine and noradrenaline systems: the role of cortical 5-ht1a receptors. |
2018-01-29 |
2023-08-13 |
Not clear |
| Christoph U Correll, Aleksandar Skuban, Mary Hobart, John Ouyang, Emmanuelle Weiller, Catherine Weiss, John M Kan. Efficacy of brexpiprazole in patients with acute schizophrenia: Review of three randomized, double-blind, placebo-controlled studies. Schizophrenia research. vol 174. issue 1-3. 2018-01-05. PMID:27157799. |
brexpiprazole, a serotonin-dopamine activity modulator, is a partial agonist at 5-ht1a and dopamine d2 receptors, and antagonist at 5-ht2a and noradrenaline α1b and α2c receptors, all at similar potency. |
2018-01-05 |
2023-08-13 |
Not clear |
| Yukio Ago, Shigeru Hasebe, Naoki Hiramatsu, Kazuya Mori, Yuji Watabe, Yusuke Onaka, Hitoshi Hashimoto, Kazuhiro Takuma, Toshio Matsud. Involvement of GABAA receptors in 5-HT1A and σ1 receptor synergism on prefrontal dopaminergic transmission under circulating neurosteroid deficiency. Psychopharmacology. vol 233. issue 17. 2017-12-12. PMID:27339616. |
we previously reported that the fluvoxamine-induced increase in prefrontal dopamine levels is enhanced by adrenalectomy/castration (which results in circulating neurosteroid deficiency), via combined activation of serotonin1a (5-ht1a) and σ1 receptors. |
2017-12-12 |
2023-08-13 |
Not clear |
| Domenico De Berardis, Laura Orsolini, Felice Iasevoli, Emiliano Prinzivalli, Andrea de Bartolomeis, Nicola Serroni, Monica Mazza, Alessandro Valchera, Michele Fornaro, Roberta Vecchiotti, Alessandro Carano, Gianna Sepede, Federica Vellante, Ilaria Matarazzo, Maurizio Pompili, Giampaolo Perna, Chiara Conti, Cristina Segura-García, Giovanni Martinotti, Massimo Di Giannantoni. The Novel Antipsychotic Cariprazine (RGH-188): State-of-the-Art in the Treatment of Psychiatric Disorders. Current pharmaceutical design. vol 22. issue 33. 2017-12-04. PMID:27396597. |
cariprazine (rgh-188) is a novel antipsychotic drug that exerts partial agonism of dopamine d2/d3 receptors with preferential binding to d3 receptor, antagonism of 5ht2b receptors and partial agonism of 5ht1a. |
2017-12-04 |
2023-08-13 |
Not clear |
| Mustafa Küçükköse, Bürge Kabukçu Başa. [Acute Dystonia due to Aripiprazole Use in Two Children with Autism Spectrum Disorder in the First Five Years of Life]. Turk psikiyatri dergisi = Turkish journal of psychiatry. vol 28. issue 1. 2017-08-28. PMID:28291301. |
aripiprazole is a partial agonist for the dopamine d2, serotonin 5-ht1a receptors, and an antagonist for 5ht2a receptors. |
2017-08-28 |
2023-08-13 |
Not clear |
| Feipu Yang, Xiangrui Jiang, Jianfeng Li, Yu Wang, Yongjian Liu, Minghao Bi, Chunhui Wu, Qingjie Zhao, Weiming Chen, Jingjing Yin, Jian Zhang, Yuanchao Xie, Tianwen Hu, Mingshuo Xu, Shuang Guo, Zhen Wang, Yang He, Jingshan She. Synthesis, structure-activity relationships, and biological evaluation of a series of benzamides as potential multireceptor antipsychotics. Bioorganic & medicinal chemistry letters. vol 26. issue 13. 2017-07-18. PMID:27173799. |
in the present study, a series of benzamides, endowed with potent dopamine d2, serotonin 5-ht1a and 5-ht2a receptors properties, was synthesized and evaluated as potential antipsychotics. |
2017-07-18 |
2023-08-13 |
Not clear |
| Sylwia Łukasiewicz, Ewa Błasiak, Kinga Szafran-Pilch, Marta Dziedzicka-Wasylewsk. Dopamine D2 and serotonin 5-HT1A receptor interaction in the context of the effects of antipsychotics - in vitro studies. Journal of neurochemistry. vol 137. issue 4. 2017-06-05. PMID:26876117. |
dopamine d2 and serotonin 5-ht1a receptor interaction in the context of the effects of antipsychotics - in vitro studies. |
2017-06-05 |
2023-08-13 |
mouse |
| Sylwia Łukasiewicz, Ewa Błasiak, Kinga Szafran-Pilch, Marta Dziedzicka-Wasylewsk. Dopamine D2 and serotonin 5-HT1A receptor interaction in the context of the effects of antipsychotics - in vitro studies. Journal of neurochemistry. vol 137. issue 4. 2017-06-05. PMID:26876117. |
the serotonin 5-ht1a receptor (5-ht1 a r) and dopamine d2 receptor (d2 r) have been implicated as important sites of action in antipsychotics. |
2017-06-05 |
2023-08-13 |
mouse |
| Xiaxia Xu, Chenguang Zheng, Lei An, Rubin Wang, Tao Zhan. Effects of Dopamine and Serotonin Systems on Modulating Neural Oscillations in Hippocampus-Prefrontal Cortex Pathway in Rats. Brain topography. vol 29. issue 4. 2017-05-08. PMID:26969669. |
local field potentials (lfps) were recorded simultaneously at both vca1 and mpfc regions under anesthesia, before and after the injection of dopamine d1 receptor antagonist and 5-ht1a receptor agonist, respectively. |
2017-05-08 |
2023-08-13 |
rat |
| Dawn Bruijnzeel, Rajiv Tando. Spotlight on brexpiprazole and its potential in the treatment of schizophrenia and as adjunctive therapy for the treatment of major depression. Drug design, development and therapy. vol 10. 2017-05-08. PMID:27274197. |
brexpiprazole is a dopamine d-2 partial agonist with potent activity at the serotonin 5ht1a and 5ht2a and noradrenergic alpha-1b and alpha-2c receptors. |
2017-05-08 |
2023-08-13 |
Not clear |
| John L Beyer, Richard H Weisle. Adjunctive brexpiprazole for the treatment of major depressive disorder. Expert opinion on pharmacotherapy. vol 17. issue 17. 2017-02-27. PMID:27788337. |
it is thought to exert its antidepressant effect by a partial agonism of both the dopamine d2 and serotonin 5ht1a receptors. |
2017-02-27 |
2023-08-13 |
Not clear |
| Enza Lacivita, Sabina Podlewska, Luisa Speranza, Mauro Niso, Grzegorz Satała, Roberto Perrone, Carla Perrone-Capano, Andrzej J Bojarski, Marcello Leopold. Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study. European journal of medicinal chemistry. vol 120. 2017-02-13. PMID:27318552. |
the majority of the synthesized compounds maintained high affinity for 5-ht7 receptors and showed selectivity towards 5-ht6 and dopamine d2 receptors and different selectivity for 5-ht1a and α1 adrenergic receptors. |
2017-02-13 |
2023-08-13 |
mouse |
| Xiao-Wen Chen, Yuan-Yuan Sun, Lei Fu, Jian-Qi L. Synthesis and pharmacological characterization of novel N-(trans-4-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)cyclohexyl)amides as potential multireceptor atypical antipsychotics. European journal of medicinal chemistry. vol 123. 2017-02-13. PMID:27487565. |
a series of novel benzisothiazolylpiperazine derivatives combining potent dopamine d2 and d3, and serotonin 5-ht1a and 5-ht2a receptor properties were synthesized and evaluated for their potential antipsychotic properties. |
2017-02-13 |
2023-08-13 |
rat |
| Dane Aronsen, Natasha Bukholt, Susan Schen. Repeated administration of the 5-HT₁B/₁A agonist, RU 24969, facilitates the acquisition of MDMA self-administration: role of 5-HT₁A and 5-HT₁B receptor mechanisms. Psychopharmacology. vol 233. issue 8. 2016-12-13. PMID:26856853. |
the 5-ht1a and 5-ht1b receptors are both well localized to regulate dopamine (da) release, and have been implicated in modulating the reinforcing effects of many drugs of abuse, but a role in acquisition of self-administration has not been determined. |
2016-12-13 |
2023-08-13 |
Not clear |
| Katarzyna Kucwaj-Brysz, Dawid Warszycki, Sabina Podlewska, Jagna Witek, Karolina Witek, Andrea González Izquierdo, Grzegorz Satała, María I Loza, Annamaria Lubelska, Gniewomir Latacz, Andrzej J Bojarski, Marián Castro, Katarzyna Kieć-Kononowicz, Jadwiga Handzli. Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation. European journal of medicinal chemistry. vol 112. 2016-11-07. PMID:26900658. |
a series of novel arylpiperazine 5-(4-fluorophenyl)-5-methylhydantoins with 2-hydroxypropyl linker (2-15) was synthesized and evaluated on their affinity towards serotonin 5-ht7 receptor (5-ht7r) in comparison to other closely related gpcrs: serotonin 5-ht1a, and dopamine d2 receptors. |
2016-11-07 |
2023-08-13 |
human |
| Yukihiro Ohno, Saki Shimizu, Kentaro Tokudome, Naofumi Kunisawa, Masashi Sas. New insight into the therapeutic role of the serotonergic system in Parkinson's disease. Progress in neurobiology. vol 134. 2016-08-25. PMID:26455457. |
specifically, stimulation of 5-ht1a receptors seems to be effective for multiple pd symptoms including parkinsonism, l-dopa-induced dyskinesia, cognitive impairment, mood disorders and neurodegeneration of dopamine neurons. |
2016-08-25 |
2023-08-13 |
Not clear |
| Serena Deiana, Akihito Watanabe, Yuki Yamasaki, Naoki Amada, Tetsuro Kikuchi, Colin Stott, Gernot Riede. MK-801-induced deficits in social recognition in rats: reversal by aripiprazole, but not olanzapine, risperidone, or cannabidiol. Behavioural pharmacology. vol 26. issue 8 Spec No. 2016-08-22. PMID:26287433. |
collectively, the combined activity of aripiprazole on dopamine d2 and serotonin 5ht1a receptors appears to provide a significant advantage over risperidone and olanzapine with respect to the rescue of cognitive deficits reminiscent of schizophrenia. |
2016-08-22 |
2023-08-13 |
human |
| Ana F Almeida-Santos, Renata C M Ferreira, Igor D Duarte, Daniele C Aguiar, Thiago R L Romero, Fabricio A Moreir. The antipsychotic aripiprazole induces antinociceptive effects: Possible role of peripheral dopamine D2 and serotonin 5-HT1A receptors. European journal of pharmacology. vol 765. 2016-08-12. PMID:26325094. |
the antipsychotic aripiprazole induces antinociceptive effects: possible role of peripheral dopamine d2 and serotonin 5-ht1a receptors. |
2016-08-12 |
2023-08-13 |
mouse |
| Ana F Almeida-Santos, Renata C M Ferreira, Igor D Duarte, Daniele C Aguiar, Thiago R L Romero, Fabricio A Moreir. The antipsychotic aripiprazole induces antinociceptive effects: Possible role of peripheral dopamine D2 and serotonin 5-HT1A receptors. European journal of pharmacology. vol 765. 2016-08-12. PMID:26325094. |
aripiprazole is an antipsychotic that acts by multiple mechanisms, including partial agonism at dopamine d2 and serotonin 5-ht1a receptors. |
2016-08-12 |
2023-08-13 |
mouse |
| Ana F Almeida-Santos, Renata C M Ferreira, Igor D Duarte, Daniele C Aguiar, Thiago R L Romero, Fabricio A Moreir. The antipsychotic aripiprazole induces antinociceptive effects: Possible role of peripheral dopamine D2 and serotonin 5-HT1A receptors. European journal of pharmacology. vol 765. 2016-08-12. PMID:26325094. |
similar to its antipsychotic activity, the possible peripheral mechanism involves dopamine d2 and serotoninergic 5-ht1a receptors. |
2016-08-12 |
2023-08-13 |
mouse |