| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sixiang Chen, Xingyu Huang, Xintong Zhang, Chan Li, Yuan-Wei Zhan. A Conserved Intramolecular Ion-Pair Plays a Critical but Divergent Role in Regulation of Dimerization and Transport Function among the Monoamine Transporters. International journal of molecular sciences. vol 25. issue 7. 2024-04-13. PMID:38612840. |
the monoamine transporters, including the serotonin transporter (sert), dopamine transporter (dat), and norepinephrine transporter (net), are the therapeutic targets for the treatment of many neuropsychiatric disorders. |
2024-04-13 |
2024-04-15 |
Not clear |
| Viktor Laskov, David Rothbauer, Hana Malikov. Robustness of radiomic features in 123I-ioflupane-dopamine transporter single-photon emission computer tomography scan. PloS one. vol 19. issue 4. 2024-04-11. PMID:38603674. |
thus, we are assessing the robustness of radiomic features in dopamine transporter imaging (dat). |
2024-04-11 |
2024-04-14 |
human |
| Zhiwei Huang, Junhao Wu, Yihui Guan, Yumei Wei, Fang Xie, Yifeng She. PET/CT study of dopamine transporter (DAT) binding with the triple reuptake inhibitor toludesvenlafaxine in rats and humans. European journal of nuclear medicine and molecular imaging. 2024-04-08. PMID:38587645. |
pet/ct study of dopamine transporter (dat) binding with the triple reuptake inhibitor toludesvenlafaxine in rats and humans. |
2024-04-08 |
2024-04-10 |
rat |
| Zhiwei Huang, Junhao Wu, Yihui Guan, Yumei Wei, Fang Xie, Yifeng She. PET/CT study of dopamine transporter (DAT) binding with the triple reuptake inhibitor toludesvenlafaxine in rats and humans. European journal of nuclear medicine and molecular imaging. 2024-04-08. PMID:38587645. |
despite the in vitro evidence that toludesvenlafaxine inhibits the reuptake of serotonin (5-ht), norepinephrine (ne) and dopamine (da), there is no in vivo evidence that toludesvenlafaxine binds to dat and increases da level, a mechanism thought to contribute to its favorable clinical performance. |
2024-04-08 |
2024-04-10 |
rat |
| Kuo Hao Lee, Sung Joon Won, Precious Oyinloye, Lei Sh. Unlocking the Potential of High-Quality Dopamine Transporter Pharmacological Data: Advancing Robust Machine Learning-Based QSAR Modeling. bioRxiv : the preprint server for biology. 2024-04-01. PMID:38558976. |
the dopamine transporter (dat) plays a critical role in the central nervous system and has been implicated in numerous psychiatric disorders. |
2024-04-01 |
2024-04-04 |
Not clear |
| Ping-Yue Pan, Jacqueline Saenz, Elnaz Khezerlou, Meha Aggarwal, Amina Shaikh, Naga Ganti, Freja Herbor. Parkinson's disease gene, Synaptojanin1, dysregulates the basal maintenance of the dopamine transporter. Research square. 2024-04-01. PMID:38559229. |
we now report fast depletion of evoked dopamine (da) and altered maintenance of the axonal dopamine transporter (dat) in the synj1+/- neurons. |
2024-04-01 |
2024-04-04 |
Not clear |
| Robert Goldsmith, Amal Aburahma, Jon E Spragu. Dopamine Concentration Changes Associated with the Retrodialysis of Methylone and 3,4-Methylenedioxypyrovalerone (MDPV) into the Caudate Putamen. Brain sciences. vol 14. issue 3. 2024-03-28. PMID:38539653. |
structural modifications to synthetic psychoactive cathinones (spcs), a class of drugs that contain a β-keto modification of the phenethylamine pharmacophore of amphetamine, induce differences in dopamine transporter (dat) activity. |
2024-03-28 |
2024-03-30 |
rat |
| Filip L H Fredensborg, Kasper Thilsing-Hansen, Jane A Simonsen, Peter Grupe, Ziba A Farahani, Christian W Andersen, Albert Gjedde, Svend Hvidste. Dynamic multi-pinhole collimated brain SPECT of Parkinson's disease by [ Scientific reports. vol 14. issue 1. 2024-03-20. PMID:38503852. |
dynamic multi-pinhole collimated brain spect of parkinson's disease by [ we investigated the feasibility of using a dopamine transporter (dat) tracer ligand ([ |
2024-03-20 |
2024-03-23 |
Not clear |
| Paige M Estave, Steven E Albertson, Anushree N Karkhanis, Sara R Jone. Co-targeting the kappa opioid receptor and dopamine transporter reduces motivation to self-administer cocaine and partially reverses dopamine system dysregulation. Scientific reports. vol 14. issue 1. 2024-03-19. PMID:38499566. |
single treatment therapies have not been successful for cocaine use disorder; therefore, this study focuses on a combination therapy targeting the dopamine transporter (dat) and kor. |
2024-03-19 |
2024-03-21 |
rat |
| Sherilyn Junelle Recinto, Shobina Premachandran, Sriparna Mukherjee, Alexis Allot, Adam MacDonald, Moein Yaqubi, Samantha Gruenheid, Louis-Eric Trudeau, Jo Anne Stratto. Characterizing enteric neurons in dopamine transporter (DAT)-Cre reporter mice reveals dopaminergic subtypes with dual-transmitter content. The European journal of neuroscience. 2024-03-15. PMID:38487941. |
characterizing enteric neurons in dopamine transporter (dat)-cre reporter mice reveals dopaminergic subtypes with dual-transmitter content. |
2024-03-15 |
2024-03-17 |
mouse |
| Avelina Petri, Abigail Sullivan, Kristen Allen, Benjamin D Sach. Genetic loss of the dopamine transporter significantly impacts behavioral and molecular responses to sub-chronic stress in mice. Frontiers in molecular neuroscience. vol 17. 2024-03-15. PMID:38486964. |
although the dopamine transporter (dat) is known to play a key role in maintaining dopamine (da) homeostasis, its importance for the regulation of stress susceptibility remains largely unknown. |
2024-03-15 |
2024-03-17 |
mouse |
| Emily J Miller, Habibeh Khoshboue. Immunity on ice: The impact of methamphetamine on peripheral immunity. Advances in pharmacology (San Diego, Calif.). vol 99. 2024-03-11. PMID:38467482. |
methamphetamine (meth) regulation of the dopamine transporter (dat) and central nervous system (cns) dopamine transmission have been extensively studied. |
2024-03-11 |
2024-03-14 |
Not clear |
| Emily J Miller, Habibeh Khoshboue. Immunity on ice: The impact of methamphetamine on peripheral immunity. Advances in pharmacology (San Diego, Calif.). vol 99. 2024-03-11. PMID:38467482. |
akin to dopamine neurons in the cns, a majority of peripheral immune cells also express dat, implying that in addition to their effect in the cns, dat ligands such as methamphetamine may have a role in modulating peripheral immunity. |
2024-03-11 |
2024-03-14 |
Not clear |
| Rong Che. Cholesterol modulation of interactions between psychostimulants and dopamine transporters. Advances in pharmacology (San Diego, Calif.). vol 99. 2024-03-11. PMID:38467486. |
the dopamine transporter (dat) is a key site of action for cocaine and amphetamines. |
2024-03-11 |
2024-03-14 |
Not clear |
| Rong Che. Cholesterol modulation of interactions between psychostimulants and dopamine transporters. Advances in pharmacology (San Diego, Calif.). vol 99. 2024-03-11. PMID:38467486. |
dysfunctional dat is associated with aberrant synaptic dopamine transmission and enhanced drug-seeking and taking behavior. |
2024-03-11 |
2024-03-14 |
Not clear |
| Rong Che. Cholesterol modulation of interactions between psychostimulants and dopamine transporters. Advances in pharmacology (San Diego, Calif.). vol 99. 2024-03-11. PMID:38467486. |
lastly, we discuss the therapeutic potential of cholesterol-modifying drugs as a new avenue to normalize dat function and dopamine transmission in patients with psychostimulant use disorder. |
2024-03-11 |
2024-03-14 |
Not clear |
| Melinda Hersey, Maddalena Mereu, Claire S Jones, Mattingly K Bartole, Andy Y Chen, Jianjing Cao, Takato Hiranita, Lauren E Chun, Jessica P Lopez, Jonathan L Katz, Amy Hauck Newman, Gianluigi Tand. Dual DAT and sigma receptor inhibitors attenuate cocaine effects on nucleus accumbens dopamine dynamics in rats. The European journal of neuroscience. 2024-03-06. PMID:38444104. |
dual dat and sigma receptor inhibitors attenuate cocaine effects on nucleus accumbens dopamine dynamics in rats. |
2024-03-06 |
2024-03-08 |
rat |
| Melinda Hersey, Maddalena Mereu, Claire S Jones, Mattingly K Bartole, Andy Y Chen, Jianjing Cao, Takato Hiranita, Lauren E Chun, Jessica P Lopez, Jonathan L Katz, Amy Hauck Newman, Gianluigi Tand. Dual DAT and sigma receptor inhibitors attenuate cocaine effects on nucleus accumbens dopamine dynamics in rats. The European journal of neuroscience. 2024-03-06. PMID:38444104. |
previous studies have shown that dual inhibitors of the dopamine transporter (dat) and sigma receptors significantly reduce the behavioral/reinforcing effects of cocaine, which have been associated with stimulation of extracellular dopamine (da) levels resulting from dat inhibition. |
2024-03-06 |
2024-03-08 |
rat |
| Gisela Andrea Camacho-Hernandez, Adithya Gopinath, Amarachi V Okorom, Habibeh Khoshbouei, Amy Hauck Newma. Development of a Fluorescently Labeled Ligand for Rapid Detection of DAT in Human and Mouse Peripheral Blood Monocytes. JACS Au. vol 4. issue 2. 2024-03-01. PMID:38425927. |
the dopamine transporter (dat) is one of the key regulators of dopamine (da) signaling in the central nervous system (cns) and in the periphery. |
2024-03-01 |
2024-03-03 |
mouse |
| Gisela Andrea Camacho-Hernandez, Adithya Gopinath, Amarachi V Okorom, Habibeh Khoshbouei, Amy Hauck Newma. Development of a Fluorescently Labeled Ligand for Rapid Detection of DAT in Human and Mouse Peripheral Blood Monocytes. JACS Au. vol 4. issue 2. 2024-03-01. PMID:38425927. |
recent reports in a model of parkinson's disease (pd) have shown that dopamine neuronal loss in the cns impacts the expression of dat in peripheral immune cells. |
2024-03-01 |
2024-03-03 |
mouse |