| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S D Dickinson, J Sabeti, G A Larson, K Giardina, M Rubinstein, M A Kelly, D K Grandy, M J Low, G A Gerhardt, N R Zahnise. Dopamine D2 receptor-deficient mice exhibit decreased dopamine transporter function but no changes in dopamine release in dorsal striatum. Journal of neurochemistry. vol 72. issue 1. 1999-01-21. PMID:9886065. |
presynaptic d2 dopamine (da) autoreceptors, which are well known to modulate da release, have recently been shown to regulate da transporter (dat) activity. |
1999-01-21 |
2023-08-12 |
mouse |
| C Mitsuhata, S Kitayama, K Morita, D Vandenbergh, G R Uhl, T Doh. Tyrosine-533 of rat dopamine transporter: involvement in interactions with 1-methyl-4-phenylpyridinium and cocaine. Brain research. Molecular brain research. vol 56. issue 1-2. 1999-01-14. PMID:9602072. |
to improve our understanding of structure-function relationships for neurotransmitter transporters, we performed site-directed mutagenesis of the rat dopamine transporter (dat) and assessed the functions of the mutants in transiently-expressing cos cells. |
1999-01-14 |
2023-08-12 |
human |
| M P Martres, B Demeneix, N Hanoun, M Hamon, B Giro. Up- and down-expression of the dopamine transporter by plasmid DNA transfer in the rat brain. The European journal of neuroscience. vol 10. issue 12. 1999-01-14. PMID:9875340. |
the functional role of the dopamine transporter (dat) in central dopaminergic neurotransmission was assessed further by investigating the consequences on dopamine (da) turn-over of up- and down-regulation of this protein induced by a non-viral gene transfer approach. |
1999-01-14 |
2023-08-12 |
rat |
| A P Kozikowski, G L Araldi, K R Prakash, M Zhang, K M Johnso. Synthesis and biological properties of new 2beta-alkyl- and 2beta-aryl-3-(substituted phenyl)tropane derivatives: stereochemical effect of C-3 on affinity and selectivity for neuronal dopamine and serotonin transporters. Journal of medicinal chemistry. vol 41. issue 25. 1999-01-07. PMID:9836615. |
in our efforts to identify molecules that might act as cocaine antagonists or cocaine partial agonists, we have been involved in efforts to further elucidate the nature of cocaine's binding to the dopamine transporter (dat) through strategic modifications of its structure. |
1999-01-07 |
2023-08-12 |
Not clear |
| L García-Gil, J A Ramos, T Rubino, D Parolaro, J J Fernández-Rui. Perinatal delta9-tetrahydrocannabinol exposure did not alter dopamine transporter and tyrosine hydroxylase mRNA levels in midbrain dopaminergic neurons of adult male and female rats. Neurotoxicology and teratology. vol 20. issue 5. 1998-12-17. PMID:9761594. |
in the present study, we have examined whether this loss in the responsiveness to amphetamine might be due to changes at the level of dopamine transporter (dat), the main molecular site for the action of amphetamine, following the perinatal exposure to delta9-thc. |
1998-12-17 |
2023-08-12 |
rat |
| A F Hoffman, C R Lupica, G A Gerhard. Dopamine transporter activity in the substantia nigra and striatum assessed by high-speed chronoamperometric recordings in brain slices. The Journal of pharmacology and experimental therapeutics. vol 287. issue 2. 1998-12-07. PMID:9808671. |
a comparison of da signals of similar amplitudes between brain regions revealed that da clearance was more rapid in the striatum than in the sn, consistent with the known greater distribution of the dopamine transporter (dat) in the striatum. |
1998-12-07 |
2023-08-12 |
rat |
| D J David, N R Zahniser, B J Hoffer, G A Gerhard. In vivo electrochemical studies of dopamine clearance in subregions of rat nucleus accumbens: differential properties of the core and shell. Experimental neurology. vol 153. issue 2. 1998-11-25. PMID:9784287. |
the dopamine (da) uptake/clearance properties of the da transporter (dat) in the core and shell of the nucleus accumbens were measured using in vivo electrochemical recordings. |
1998-11-25 |
2023-08-12 |
rat |
| E C Petrie, R C Veith, P Szo. Bupropion and desipramine increase dopamine transporter mRNA expression in the ventral tegmental area/substantia nigra of rat brain. Progress in neuro-psychopharmacology & biological psychiatry. vol 22. issue 5. 1998-11-18. PMID:9723124. |
regulation of dopamine transporter (dat) mrna was studied in rats treated with the dat blocker bupropion (bup; 15 or 30 mg/kg tid x 2d), the norepinephrine transporter blocker desipramine (dmi; 10 mg/kg/d x 2d), or saline. |
1998-11-18 |
2023-08-12 |
rat |
| S Kitayama, C Mitsuhata, S Davis, J B Wang, T Sato, K Morita, G R Uhl, T Doh. MPP+ toxicity and plasma membrane dopamine transporter: study using cell lines expressing the wild-type and mutant rat dopamine transporters. Biochimica et biophysica acta. vol 1404. issue 3. 1998-10-29. PMID:9739158. |
the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium (mpp+) causes specific cell death in dopaminergic neurons after accumulation by the dopamine transporter (dat). |
1998-10-29 |
2023-08-12 |
rat |
| U D McCann, D F Wong, F Yokoi, V Villemagne, R F Dannals, G A Ricaurt. Reduced striatal dopamine transporter density in abstinent methamphetamine and methcathinone users: evidence from positron emission tomography studies with [11C]WIN-35,428. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 20. 1998-10-23. PMID:9763484. |
in animals, methamphetamine and related drugs are known to damage brain dopamine (da) neurons, and this damage has recently been shown to be detectable in living nonhuman primates by means of positron emission tomography (pet) with [11c]win-35,428, a da transporter (dat) ligand. |
1998-10-23 |
2023-08-12 |
human |
| Z B Pristupa, F McConkey, F Liu, H Y Man, F J Lee, Y T Wang, H B Nizni. Protein kinase-mediated bidirectional trafficking and functional regulation of the human dopamine transporter. Synapse (New York, N.Y.). vol 30. issue 1. 1998-10-22. PMID:9704884. |
modification of the transport velocity of both the native neuronal and cloned presynaptic dopamine transporter (dat) has been reported following activation/inhibition of second messenger system pathways. |
1998-10-22 |
2023-08-12 |
human |
| Z B Pristupa, F McConkey, F Liu, H Y Man, F J Lee, Y T Wang, H B Nizni. Protein kinase-mediated bidirectional trafficking and functional regulation of the human dopamine transporter. Synapse (New York, N.Y.). vol 30. issue 1. 1998-10-22. PMID:9704884. |
in order to identify the mechanism by which the functional activity of human dat (hdat) is regulated, we assessed the [3h]dopamine uptake kinetics, [3h] cft binding characteristics, and, via immunofluorescent confocal microscopy, the cellular localization profiles of the hdat expressed in both sf9 and cos-7 cells following modulation of protein kinase c (pkc)- and protein kinase a (pka)-dependent pathways. |
1998-10-22 |
2023-08-12 |
human |
| B J Hoffman, S R Hansson, E Mezey, M Palkovit. Localization and dynamic regulation of biogenic amine transporters in the mammalian central nervous system. Frontiers in neuroendocrinology. vol 19. issue 3. 1998-10-08. PMID:9665836. |
subcellular localization of dat by electron microscopy suggests that these transporters are not at the synaptic density but are confined to perisynaptic areas, implying that dopamine diffuses away from the synapse and that contribution of diffusion to dopamine signalling may vary between brain regions. |
1998-10-08 |
2023-08-12 |
human |
| E G Jönsson, M M Nöthen, J P Gustavsson, H Neidt, R Bunzel, P Propping, G C Sedval. Polymorphisms in the dopamine, serotonin, and norepinephrine transporter genes and their relationships to monoamine metabolite concentrations in CSF of healthy volunteers. Psychiatry research. vol 79. issue 1. 1998-10-06. PMID:9676821. |
we investigated the possible relationships between dna polymorphisms in the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) genes and csf concentrations of homovanillic acid (hva), 5-hydroxyindoleacetic acid (5-hiaa), and 3-methoxy-4-hydroxyphenylglycol (mhpg) in healthy volunteers (n = 66). |
1998-10-06 |
2023-08-12 |
human |
| R T Malison, E McCance, L L Carpenter, R M Baldwin, J P Seibyl, L H Price, T R Kosten, R B Inni. [123I]beta-CIT SPECT imaging of dopamine transporter availability after mazindol administration in human cocaine addicts. Psychopharmacology. vol 137. issue 4. 1998-10-05. PMID:9676890. |
the in vivo potency of mazindol for binding to striatal dopamine transporters (dat) was assessed by [123i]beta-cit ([123i]2beta-carbomethoxy-3beta-(4-iodophenyl)tropane) single photon emission computed tomography (spect). |
1998-10-05 |
2023-08-12 |
human |
| L Zhang, L W Elmer, K Y Littl. Expression and regulation of the human dopamine transporter in a neuronal cell line. Brain research. Molecular brain research. vol 59. issue 1. 1998-09-23. PMID:9729282. |
human cocaine users exhibit increased striatal [3h]win35428 binding to the dopamine transporter (dat). |
1998-09-23 |
2023-08-12 |
human |
| L Zhang, L W Elmer, K Y Littl. Expression and regulation of the human dopamine transporter in a neuronal cell line. Brain research. Molecular brain research. vol 59. issue 1. 1998-09-23. PMID:9729282. |
to better understand the regulation of dat inhibitor binding sites and their relationship to the overall process of dopamine uptake, a neuronal model system expressing the human dat has been developed. |
1998-09-23 |
2023-08-12 |
human |
| L Zhang, L W Elmer, K Y Littl. Expression and regulation of the human dopamine transporter in a neuronal cell line. Brain research. Molecular brain research. vol 59. issue 1. 1998-09-23. PMID:9729282. |
after transfection with the human dat inserted in the pcdna vector, both dat binding and dopamine uptake were significantly and stably present. |
1998-09-23 |
2023-08-12 |
human |
| H H Sitte, S Huck, H Reither, S Boehm, E A Singer, C Pif. Carrier-mediated release, transport rates, and charge transfer induced by amphetamine, tyramine, and dopamine in mammalian cells transfected with the human dopamine transporter. Journal of neurochemistry. vol 71. issue 3. 1998-09-21. PMID:9721755. |
according to a traditional explanation, this dopamine release occurs in exchange for amphetamine by means of the dopamine transporter (dat). |
1998-09-21 |
2023-08-12 |
human |
| H H Sitte, S Huck, H Reither, S Boehm, E A Singer, C Pif. Carrier-mediated release, transport rates, and charge transfer induced by amphetamine, tyramine, and dopamine in mammalian cells transfected with the human dopamine transporter. Journal of neurochemistry. vol 71. issue 3. 1998-09-21. PMID:9721755. |
we tested this hypothesis in human embryonic kidney 293 cells stably transfected with the human dat by measuring the uptake of dopamine, tyramine, and d- and l-amphetamine as well as substrate-induced release of preloaded n-methyl-4-[3h]phenylpyridinium ([3h]mpp+). |
1998-09-21 |
2023-08-12 |
human |