| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Y Little, D P McLaughlin, L Zhang, P R McFinton, G W Dalack, E H Cook, B J Cassin, S J Watso. Brain dopamine transporter messenger RNA and binding sites in cocaine users: a postmortem study. Archives of general psychiatry. vol 55. issue 9. 1998-09-16. PMID:9736005. |
results of recent radioligand binding experiments suggest that chronic cocaine exposure increases dopamine transporter (dat) synthesis throughout the striatum of humans. |
1998-09-16 |
2023-08-12 |
Not clear |
| J Drago, P Padungchaichot, D Accili, S Fuch. Dopamine receptors and dopamine transporter in brain function and addictive behaviors: insights from targeted mouse mutants. Developmental neuroscience. vol 20. issue 2-3. 1998-09-11. PMID:9691193. |
recent advances in molecular biology have resulted in a number of genetically manipulated mice with defined changes at dopamine receptor and the dopamine transporter (dat) loci. |
1998-09-11 |
2023-08-12 |
mouse |
| A K Dutta, C Xu, M E Reit. Tolerance in the replacement of the benzhydrylic O atom in 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives by an N atom: development of new-generation potent and selective N-analogue molecules for the dopamine transporter. Journal of medicinal chemistry. vol 41. issue 17. 1998-09-09. PMID:9703474. |
the replacement of the benzhydrylic oxygen atom of our previously developed dopamine transporter (dat)-specific ligands 4-[2-(diphenylmethoxy)ethyl]-1-[(4-fluorophenyl)methyl]piperidine, 1a, and 4-[2-(bis(4-fluorophenyl)methoxy)ethyl]-1-benzylpiperidine, 1b, by a nitrogen atom resulted in the development of the n-analogues 4-[2-((diphenylmethyl)amino)ethyl]-1-[(4-fluorophenyl)methyl]pi peridi ne, 4a, and 4-[2-((bis(4-fluorophenyl)methyl)amino)ethyl]-1-benzylpiperidine, 4b. |
1998-09-09 |
2023-08-12 |
human |
| A J Mandell, M J Owens, K A Selz, W N Morgan, M F Shlesinger, C B Nemerof. Mode matches in hydrophobic free energy eigenfunctions predict peptide-protein interactions. Biopolymers. vol 46. issue 2. 1998-08-31. PMID:9664843. |
the dominant statistical hydrophobic free energy inverse frequencies amino acid wavelengths as hydrophobic modes, of neurotensin (nt), cholescystokinin (cck), the human dopamine d2 receptor [(da)d2], and the human dopamine transporter (dat) were determined using orthogonal decomposition of the autocovariance matrices of their amino acid sequences as hydrophobic free energy equivalents in kcal/mol. |
1998-08-31 |
2023-08-12 |
human |
| R R Gainetdinov, S R Jones, F Fumagalli, R M Wightman, M G Caro. Re-evaluation of the role of the dopamine transporter in dopamine system homeostasis. Brain research. Brain research reviews. vol 26. issue 2-3. 1998-08-28. PMID:9651511. |
mice with a genetic deletion of the dopamine transporter (dat) were used to assess its role in the function of dopamine (da) neurons. |
1998-08-28 |
2023-08-12 |
mouse |
| T J Counihan, J B Penne. Regional dopamine transporter gene expression in the substantia nigra from control and Parkinson's disease brains. Journal of neurology, neurosurgery, and psychiatry. vol 65. issue 2. 1998-08-20. PMID:9703165. |
to test the hypothesis that differential regional dopamine transporter (dat) gene expression may underlie the selective vulnerability of certain nigral dopaminergic neurons in parkinson's disease, dat mrna expression was examined in neuronal subpopulations of human postmortem ventral mesencephalon from patients with parkinson's disease and controls. |
1998-08-20 |
2023-08-12 |
human |
| I Sora, C Wichems, N Takahashi, X F Li, Z Zeng, R Revay, K P Lesch, D L Murphy, G R Uh. Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 13. 1998-08-06. PMID:9636213. |
several lines of evidence have suggested that cocaine blockade of the dopamine transporter (dat), perhaps with additional contributions from serotonin transporter (5-htt) recognition, was key to its rewarding actions. |
1998-08-06 |
2023-08-12 |
mouse |
| A M Persico, M Catalan. Lack of association between dopamine transporter gene polymorphisms and delusional disorder. American journal of medical genetics. vol 81. issue 2. 1998-07-24. PMID:9613856. |
potential contributions of dopamine transporter (dat) gene variants to delusional disorder were investigated using association analysis. |
1998-07-24 |
2023-08-12 |
Not clear |
| B Jeon, J M Kim, J M Jeong, K M Kim, Y S Chang, D S Lee, M C Le. Dopamine transporter imaging with [123I]-beta-CIT demonstrates presynaptic nigrostriatal dopaminergic damage in Wilson's disease. Journal of neurology, neurosurgery, and psychiatry. vol 65. issue 1. 1998-07-23. PMID:9667562. |
(1r)-2beta-carbomethoxy-3beta-(4-iodophenyl)tropane (beta-cit) is a specific ligand that binds to the dopamine transporter (dat), and can examine the integrity of dopaminergic nerve terminals. |
1998-07-23 |
2023-08-12 |
Not clear |
| K S Avor, S Singh, T W Seale, B Pouw, G P Basmadjia. 2beta-Substituted analogues of 4'-iodococaine: synthesis and dopamine transporter binding potencies. Journal of medicinal chemistry. vol 41. issue 13. 1998-07-09. PMID:9632371. |
a series of 2beta-substituted analogues of 4'-iodococaine (3) was synthesized and evaluated in an in vitro dopamine transporter (dat) binding assay. |
1998-07-09 |
2023-08-12 |
mouse |
| F Fumagalli, R R Gainetdinov, K J Valenzano, M G Caro. Role of dopamine transporter in methamphetamine-induced neurotoxicity: evidence from mice lacking the transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 13. 1998-07-02. PMID:9634552. |
the role of the dopamine transporter (dat) in mediating the neurotoxic effects of methamphetamine (meth) was tested in mice lacking dat. |
1998-07-02 |
2023-08-12 |
mouse |
| F Fumagalli, R R Gainetdinov, K J Valenzano, M G Caro. Role of dopamine transporter in methamphetamine-induced neurotoxicity: evidence from mice lacking the transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 13. 1998-07-02. PMID:9634552. |
dopamine (da) and serotonin (5-ht) content, glial fibrillary acidic protein (gfap) expression, and free radical formation were assessed as markers of meth neurotoxicity in the striatum and/or hippocampus of wild-type, heterozygote, and homozygote (dat -/-) mice. |
1998-07-02 |
2023-08-12 |
mouse |
| A J Fischman, A A Bonab, J W Babich, E P Palmer, N M Alpert, D R Elmaleh, R J Callahan, S A Barrow, W Graham, P C Meltzer, R N Hanson, B K Madra. Rapid detection of Parkinson's disease by SPECT with altropane: a selective ligand for dopamine transporters. Synapse (New York, N.Y.). vol 29. issue 2. 1998-07-01. PMID:9593103. |
2beta-carbomethoxy-3beta-(4-fluorophenyl)-n-(1-iodoprop-1-en -3-yl) nortropane (iacft, altropane) is a cocaine analog with high affinity and selectivity for dopamine transporter (dat) sites in the striatum. |
1998-07-01 |
2023-08-12 |
human |
| B S Jeon, J M Jeong, S S Park, J M Kim, Y S Chang, H C Song, K M Kim, K Y Yoon, M C Lee, S B Le. Dopamine transporter density measured by [123I]beta-CIT single-photon emission computed tomography is normal in dopa-responsive dystonia. Annals of neurology. vol 43. issue 6. 1998-06-25. PMID:9629849. |
the dopamine transporter (dat) is a protein in the dopaminergic nerve terminals. |
1998-06-25 |
2023-08-12 |
human |
| S Higuchi, T Muramatsu, H Arai, M Hayashida, H Sasaki, J Q Trojanowsk. Polymorphisms of dopamine receptor and transporter genes and Parkinson's disease. Journal of neural transmission. Parkinson's disease and dementia section. vol 10. issue 2-3. 1998-06-17. PMID:9620058. |
we conducted a study to test the hypothesis that allelic variations of the dopamine receptors (d2, d3, d4) and the dopamine transporter (dat) contribute to the susceptibility to pd. |
1998-06-17 |
2023-08-12 |
Not clear |
| T Okada, S Shimada, K Sato, Y Kotake, H Kawai, S Ohta, M Tohyama, T Nishimur. Tetrahydropapaveroline and its derivatives inhibit dopamine uptake through dopamine transporter expressed in HEK293 cells. Neuroscience research. vol 30. issue 1. 1998-06-16. PMID:9572583. |
dopamine transporter (dat). |
1998-06-16 |
2023-08-12 |
rat |
| M G Murer, G Dziewczapolski, L B Menalled, M C García, Y Agid, O Gershanik, R Raisman-Vozar. Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions. Annals of neurology. vol 43. issue 5. 1998-05-21. PMID:9585350. |
in addition, for rats of the sham-lesioned and severely lesioned groups, immunoradiolabeling for th, the dopamine transporter (dat), and the vesicular monoamine transporter (vmat2) at the striatal level was not significantly different between rats treated with levodopa or vehicle. |
1998-05-21 |
2023-08-12 |
rat |
| R R Gainetdinov, F Fumagalli, Y M Wang, S R Jones, A I Levey, G W Miller, M G Caro. Increased MPTP neurotoxicity in vesicular monoamine transporter 2 heterozygote knockout mice. Journal of neurochemistry. vol 70. issue 5. 1998-05-18. PMID:9572281. |
striatal dopamine (da) content, the levels of da transporter (dat) protein, and the expression of glial fibrillary acidic protein (gfap) mrna, a marker of gliosis, were assessed as markers of mptp neurotoxicity. |
1998-05-18 |
2023-08-12 |
mouse |
| S R Jones, R R Gainetdinov, M Jaber, B Giros, R M Wightman, M G Caro. Profound neuronal plasticity in response to inactivation of the dopamine transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 7. 1998-05-01. PMID:9520487. |
the dopamine transporter (dat) plays an important role in calibrating the duration and intensity of dopamine neurotransmission in the central nervous system. |
1998-05-01 |
2023-08-12 |
mouse |
| S R Jones, R R Gainetdinov, M Jaber, B Giros, R M Wightman, M G Caro. Profound neuronal plasticity in response to inactivation of the dopamine transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 7. 1998-05-01. PMID:9520487. |
we find that removal of the dat dramatically prolongs the lifetime (300 times) of extracellular dopamine. |
1998-05-01 |
2023-08-12 |
mouse |