| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| A P Patel, C Cerruti, R A Vaughan, M J Kuha. Developmentally regulated glycosylation of dopamine transporter. Brain research. Developmental brain research vol 83 issue 1 1995 7697870 |
the dopamine transporter (dat) in rat striatum was examined during postnatal development and aging after photolabeling with [125i]deep. |
1995-05-02 |
2023-01-24 |
rat |
| S C Wall, H Gu, G Rudnic. Biogenic amine flux mediated by cloned transporters stably expressed in cultured cell lines: amphetamine specificity for inhibition and efflux. Molecular pharmacology vol 47 issue 3 1995 7700252 |
llc-pk1 cells have been stably transfected with cdnas encoding the human norepinephrine transporter (net), rat dopamine transporter (dat), and rat serotonin transporter. |
1995-04-28 |
2023-01-24 |
rat |
| B J Ciliax, C Heilman, L L Demchyshyn, Z B Pristupa, E Ince, S M Hersch, H B Niznik, A I Leve. The dopamine transporter: immunochemical characterization and localization in brain. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 15 issue 3 Pt 1 1995 7534339 |
antibodies specific for the dopamine transporter (dat) was developed and characterized by immunoblot analysis, immunoprecipitation, and immunocytochemistry, and used for immunolocalization of transporter protein in rat brain at the light microscopic level. |
1995-04-20 |
2023-01-24 |
rat |
| B J Ciliax, C Heilman, L L Demchyshyn, Z B Pristupa, E Ince, S M Hersch, H B Niznik, A I Leve. The dopamine transporter: immunochemical characterization and localization in brain. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 15 issue 3 Pt 1 1995 7534339 |
however, certain mismatches between immunocytochemical distributions of dat and tyrosine hydroxylase were apparent, indicating that dopaminergic systems are heterogeneous and may use independent mechanisms for the regulation of dopamine levels in brain. |
1995-04-20 |
2023-01-24 |
rat |
| J Gelernter, H R Kranzler, S L Satel, P A Ra. Genetic association between dopamine transporter protein alleles and cocaine-induced paranoia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol 11 issue 3 1995 7865100 |
several lines of evidence suggest that this phenomenon may be related to function of the dopamine transporter protein (dat). |
1995-03-29 |
2023-01-24 |
Not clear |
| J Gelernter, H R Kranzler, S L Satel, P A Ra. Genetic association between dopamine transporter protein alleles and cocaine-induced paranoia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol 11 issue 3 1995 7865100 |
dat is the site of presynaptic reuptake of dopamine, an event that terminates its synaptic activity. |
1995-03-29 |
2023-01-24 |
Not clear |
| C Pifl, H Drobny, H Reither, O Hornykiewicz, E A Singe. Mechanism of the dopamine-releasing actions of amphetamine and cocaine: plasmalemmal dopamine transporter versus vesicular monoamine transporter. Molecular pharmacology vol 47 issue 2 1995 7870046 |
the effects of amphetamine and cocaine were studied in [3h]-dopamine-loaded and superfused cos-7 cells transfected with either the cdna of the plasmalemmal dopamine transporter ("dat cells") or the cdna of the vesicular amine transporter ("vat cells"), or with both transporters ("dat/vat cells"). |
1995-03-29 |
2023-01-24 |
Not clear |
| C Pifl, H Drobny, H Reither, O Hornykiewicz, E A Singe. Mechanism of the dopamine-releasing actions of amphetamine and cocaine: plasmalemmal dopamine transporter versus vesicular monoamine transporter. Molecular pharmacology vol 47 issue 2 1995 7870046 |
amphetamine (0.01-100 microm, added for 4 min of superfusion) led to a concentration-dependent increase in dopamine release in dat cells, as well as in dat/vat cells. |
1995-03-29 |
2023-01-24 |
Not clear |
| C Pifl, H Drobny, H Reither, O Hornykiewicz, E A Singe. Mechanism of the dopamine-releasing actions of amphetamine and cocaine: plasmalemmal dopamine transporter versus vesicular monoamine transporter. Molecular pharmacology vol 47 issue 2 1995 7870046 |
with longer exposure to amphetamine, dopamine efflux from dat cells reached a peak and quickly returned to baseline, in spite of the continued presence of the drug, whereas in dat/vat cells and in vat cells the effect was sustained. |
1995-03-29 |
2023-01-24 |
Not clear |
| C Pifl, H Drobny, H Reither, O Hornykiewicz, E A Singe. Mechanism of the dopamine-releasing actions of amphetamine and cocaine: plasmalemmal dopamine transporter versus vesicular monoamine transporter. Molecular pharmacology vol 47 issue 2 1995 7870046 |
cocaine (up to 100 microm) did not exert any effect of its own in dat cells or vat cells but inhibited the amphetamine-induced release of dopamine from dat cells in a competitive manner. |
1995-03-29 |
2023-01-24 |
Not clear |
| J B Wang, A Moriwaki, G R Uh. Dopamine transporter cysteine mutants: second extracellular loop cysteines are required for transporter expression. Journal of neurochemistry vol 64 issue 3 1995 7861176 |
studies with thiol-modifying reagents have suggested that cysteines might play important roles in the function of the dopamine transporter (dat). |
1995-03-17 |
2023-01-24 |
Not clear |
| J B Wang, A Moriwaki, G R Uh. Dopamine transporter cysteine mutants: second extracellular loop cysteines are required for transporter expression. Journal of neurochemistry vol 64 issue 3 1995 7861176 |
to identify dat cysteines with important thiol groups, we have studied six mutant dopamine transporters in which cysteines were replaced by alanines. |
1995-03-17 |
2023-01-24 |
Not clear |
| M K Sanghera, K F Manaye, C L Liang, A M Lacopino, M J Bannon, D C Germa. Low dopamine transporter mRNA levels in midbrain regions containing calbindin. Neuroreport vol 5 issue 13 1995 7819538 |
the dopamine transporter (dat) is the site at which the neurotoxic metabolite of mptp gains access to midbrain dopaminergic (da) neurons. |
1995-02-10 |
2023-01-24 |
rat |
| M Fujita, S Shimada, K Fukuchi, M Tohyama, T Nishimur. Distribution of cocaine recognition sites in rat brain: in vitro and ex vivo autoradiography with [125I]RTI-55. Journal of chemical neuroanatomy vol 7 issue 1-2 1995 7802967 |
the distribution of binding sites of [125i]rti-55 (3 beta-(4-iodophenyl)tropan-2 beta-carboxylic acid methyl ester), a phenyl tropane analog of cocaine, and the selective labeling of the dopamine transporter (dat) were studied by in vitro and ex vivo autoradiography in the rat whole brain. |
1995-01-31 |
2023-01-24 |
rat |
| C A Leslie, M W Robertson, A B Jung, J Liebermann, J P Bennet. Effects of prenatal cocaine exposure upon postnatal development of neostriatal dopaminergic function. Synapse (New York, N.Y.) vol 17 issue 3 1994 7974205 |
brains from offspring were examined with quantitative receptor autoradiography [d1 receptor (d1r), d2 receptor (d2r) and dopamine transporter (dat)] and quantitative in situ hybridization [d1r mrna, d2r mrna, preproenkephalin (ppe) mrna] for markers of neostriatal dopaminergic function. |
1994-11-29 |
2023-01-24 |
rat |
| C Perrone-Capano, A Tino, U di Porzi. Target cells modulate dopamine transporter gene expression during brain development. Neuroreport vol 5 issue 9 1994 7521683 |
we have analysed the expression of the dopamine transporter (dat) gene and compared it with that of tyrosine hydroxylase, neuronal gaba transporter and synaptic vesicle monoamine transporter genes during pre- and post-natal development of rat mesencephalic dopaminergic (da) neurones. |
1994-10-11 |
2023-01-24 |
rat |
| D P Figlewicz, P Szot, M Chavez, S C Woods, R C Veit. Intraventricular insulin increases dopamine transporter mRNA in rat VTA/substantia nigra. Brain research vol 644 issue 2 1994 8050044 |
we determined the level of dopamine transporter (dat) mrna expression in the ventral tegmental area (vta)/substantia nigra compacta (snc) of rats which were chronically treated with vehicle or insulin via the third cerebral ventricle (i.c.v.). |
1994-09-08 |
2023-01-24 |
rat |
| D Lorang, S G Amara, R B Simerl. Cell-type-specific expression of catecholamine transporters in the rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 14 issue 8 1994 8046459 |
the dopamine transporter (dat) and norepinephrine transporter (net) terminate catecholaminergic neurotransmission at synapses by high-affinity sodium-dependent reuptake into presynaptic terminals, and are the initial sites of action for drugs of abuse and antidepressants. |
1994-08-30 |
2023-01-24 |
rat |
| V Blanchard, R Raisman-Vozari, S Vyas, P P Michel, F Javoy-Agid, G Uhl, Y Agi. Differential expression of tyrosine hydroxylase and membrane dopamine transporter genes in subpopulations of dopaminergic neurons of the rat mesencephalon. Brain research. Molecular brain research vol 22 issue 1-4 1994 7912404 |
in the present study, th protein, th mrna and dopamine membrane transporter (dat) mrna were quantified at cellular level in 4 arbitrary subregions of the rat ventral mesencephalon (lateral, middle, medial snc and vta), using in situ hybridization and immunoautoradiography. |
1994-07-25 |
2023-01-24 |
rat |
| V Blanchard, R Raisman-Vozari, S Vyas, P P Michel, F Javoy-Agid, G Uhl, Y Agi. Differential expression of tyrosine hydroxylase and membrane dopamine transporter genes in subpopulations of dopaminergic neurons of the rat mesencephalon. Brain research. Molecular brain research vol 22 issue 1-4 1994 7912404 |
the relative lower expression of the dat gene in vta neurons suggests a less efficient dopamine reuptake capacity, which may partly account for the relative sparing of the mesolimbic system reported in parkinson's disease and mptp-treated animals. |
1994-07-25 |
2023-01-24 |
rat |