| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S A Lomenzo, S Izenwasser, J L Katz, P D Terry, N Zhu, C L Klein, M L Trudel. Synthesis, structure, dopamine transporter affinity, and dopamine uptake inhibition of 6-alkyl-3-benzyl-2-[(methoxycarbonyl)methyl]tropane derivatives. Journal of medicinal chemistry. vol 40. issue 26. 1998-02-13. PMID:9435910. |
a series of 6-alkyl-3 beta-benzyl-2-[(methoxycarbonyl)methyl]tropane analogues were synthesized and evaluated as cocaine binding site ligands at the dopamine transporter (dat). |
1998-02-13 |
2023-08-12 |
rat |
| S A Burchett, M J Banno. Serotonin, dopamine and norepinephrine transporter mRNAs: heterogeneity of distribution and response to 'binge' cocaine administration. Brain research. Molecular brain research. vol 49. issue 1-2. 1998-02-11. PMID:9387868. |
quantitative in situ hybridization was utilized to map the distribution and abundance of the serotonin, dopamine and norepinephrine transporter (sert, dat and net, respectively) mrnas. |
1998-02-11 |
2023-08-12 |
rat |
| W Lu, M E Wol. Expression of dopamine transporter and vesicular monoamine transporter 2 mRNAs in rat midbrain after repeated amphetamine administration. Brain research. Molecular brain research. vol 49. issue 1-2. 1998-02-11. PMID:9387873. |
the dopamine transporter (dat) in pre-synaptic membranes and the vesicular monoamine transporter 2 (vmat2) in membranes of synaptic vesicles are involved in mediating the acute effects of amphetamine on dopamine transmission. |
1998-02-11 |
2023-08-12 |
rat |
| W Lu, M E Wol. Expression of dopamine transporter and vesicular monoamine transporter 2 mRNAs in rat midbrain after repeated amphetamine administration. Brain research. Molecular brain research. vol 49. issue 1-2. 1998-02-11. PMID:9387873. |
thus, repeated amphetamine administration exerts modest and regionally selective effects on dat and vmat2 mrna expression in subpopulations of midbrain dopamine neurons. |
1998-02-11 |
2023-08-12 |
rat |
| J N Joyce, G Smutzer, C J Whitty, A Myers, M J Banno. Differential modification of dopamine transporter and tyrosine hydroxylase mRNAs in midbrain of subjects with Parkinson's, Alzheimer's with parkinsonism, and Alzheimer's disease. Movement disorders : official journal of the Movement Disorder Society. vol 12. issue 6. 1998-02-10. PMID:9399211. |
we examined the levels of tyrosine hydroxylase (th) protein, and the expression of th and dopamine transporter (dat) mrnas, in midbrain neurons of pd, ad, and ad/park cases. |
1998-02-10 |
2023-08-12 |
human |
| P W Leighton, D G Le Couteur, C C Pang, S J McCann, D Chan, L K Law, R Kay, S M Pond, J Wo. The dopamine transporter gene and Parkinson's disease in a Chinese population. Neurology. vol 49. issue 6. 1998-01-16. PMID:9409349. |
we studied a variable number tandem repeat polymorphism within the dopamine transporter gene (dat) for an association with parkinson's disease in a chinese population. |
1998-01-16 |
2023-08-12 |
human |
| V Villemagne, J Yuan, D F Wong, R F Dannals, G Hatzidimitriou, W B Mathews, H T Ravert, J Musachio, U D McCann, G A Ricaurt. Brain dopamine neurotoxicity in baboons treated with doses of methamphetamine comparable to those recreationally abused by humans: evidence from [11C]WIN-35,428 positron emission tomography studies and direct in vitro determinations. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 1. 1998-01-16. PMID:9412518. |
the present study sought to determine whether doses of methamphetamine in the range of those used recreationally by humans produce brain dopamine (da) neurotoxicity in baboons and to ascertain whether positron emission tomography (pet) imaging with the da transporter (dat) ligand [11c]win-35,428 ([11c]2beta-carbomethoxy-3beta-(4-fluorophenyl)-tropane) could be used to detect methamphetamine-induced dat loss in living primates. |
1998-01-16 |
2023-08-12 |
Not clear |
| J Logan, N D Volkow, J S Fowler, G J Wang, M W Fischman, R W Foltin, N N Abumrad, S Vitkun, S J Gatley, N Pappas, R Hitzemann, C E She. Concentration and occupancy of dopamine transporters in cocaine abusers with [11C]cocaine and PET. Synapse (New York, N.Y.). vol 27. issue 4. 1998-01-14. PMID:9372557. |
the concentration (bmax) of the dopamine transporter (dat) and the maximum and effective occupancies by cocaine doses of 0.1 mg/kg or 0.05 mg/kg were measured in the striatum of cocaine abusers (n = 12) by using [11c]cocaine as a radiotracer for the dat and positron emission tomography (pet). |
1998-01-14 |
2023-08-12 |
human |
| A P Kouzmenko, A M Pereira, B S Sing. Intronic sequences are involved in neural targeting of human dopamine transporter gene expression. Biochemical and biophysical research communications. vol 240. issue 3. 1998-01-13. PMID:9398650. |
dopamine transporter (dat) plays a key role in terminating synaptic dopaminergic transmission. |
1998-01-13 |
2023-08-12 |
human |
| P D Shilling, J R Kelsoe, D S Sega. Dopamine transporter mRNA is up-regulated in the substantia nigra and the ventral tegmental area of amphetamine-sensitized rats. Neuroscience letters. vol 236. issue 3. 1998-01-12. PMID:9406754. |
converging evidence supports a significant role for dopamine (da) in the development of behavioral sensitization and it has been suggested that changes in either da transporter (dat) or d2 autoreceptors contribute to the effects of stimulant treatment. |
1998-01-12 |
2023-08-12 |
rat |
| S H Lee, H K Cho, H Son, Y S Le. Substrate transport and cocaine binding of human dopamine transporter is reduced by substitution of carboxyl tail with that of bovine dopamine transporter. Neuroreport. vol 8. issue 11. 1998-01-08. PMID:9261833. |
a chimeric dopamine transporter (dat) cdna encoding mutant human dat (hdat) protein in which the intracellular carboxyl-terminal tail is replaced by that of the bovine dopamine transporter (bdat) was constructed. |
1998-01-08 |
2023-08-12 |
human |
| H Mann, B Ladenheim, H Hirata, T H Moran, J L Cade. Differential toxic effects of methamphetamine (METH) and methylenedioxymethamphetamine (MDMA) in multidrug-resistant (mdr1a) knockout mice. Brain research. vol 769. issue 2. 1997-12-23. PMID:9374204. |
meth caused significant dose-dependent decreases of dopamine (da) and da transporters (dat) in the striatum and the nucleus accumbens (nac) of both wild-type and knockout mice. |
1997-12-23 |
2023-08-12 |
mouse |
| Y Itzhak, J L Martin, S F Ali, M D Norenber. Depletion of striatal dopamine transporter does not affect psychostimulant-induced locomotor activity. Neuroreport. vol 8. issue 15. 1997-12-22. PMID:9351651. |
the effect of neurotoxin-induced depletion of striatal dopamine transporter (dat) binding sites on animals' responses to psychostimulants was investigated. |
1997-12-22 |
2023-08-12 |
mouse |
| M K Sanghera, K Manaye, A McMahon, P K Sonsalla, D C Germa. Dopamine transporter mRNA levels are high in midbrain neurons vulnerable to MPTP. Neuroreport. vol 8. issue 15. 1997-12-22. PMID:9351666. |
the dopamine transporter (dat) is important to mptp toxicity because to be neurotoxic, an mptp metabolite must first gain access to the da neuron via the dat. |
1997-12-22 |
2023-08-12 |
mouse |
| S M Hersch, H Yi, C J Heilman, R H Edwards, A I Leve. Subcellular localization and molecular topology of the dopamine transporter in the striatum and substantia nigra. The Journal of comparative neurology. vol 388. issue 2. 1997-12-12. PMID:9368838. |
we have determined the subcellular location of the dopamine transporter (dat) by immunoperoxidase and immunogold electron microscopy, using monoclonal antibodies to both the n-terminus and the second extracellular loop. |
1997-12-12 |
2023-08-12 |
Not clear |
| S M Hersch, H Yi, C J Heilman, R H Edwards, A I Leve. Subcellular localization and molecular topology of the dopamine transporter in the striatum and substantia nigra. The Journal of comparative neurology. vol 388. issue 2. 1997-12-12. PMID:9368838. |
double immunocytochemistry demonstrated dat colocalization with two other markers of nigrostriatal terminals, tyrosine hydroxylase and d2 dopamine receptors. |
1997-12-12 |
2023-08-12 |
Not clear |
| S M Hersch, H Yi, C J Heilman, R H Edwards, A I Leve. Subcellular localization and molecular topology of the dopamine transporter in the striatum and substantia nigra. The Journal of comparative neurology. vol 388. issue 2. 1997-12-12. PMID:9368838. |
these localizations suggest that dat modulates the intracellular and extracellular dopamine levels of nigral dendrites. |
1997-12-12 |
2023-08-12 |
Not clear |
| B S Slusher, C W Tiffany, J L Olkowski, P F Jackso. Use of identical assay conditions for cocaine analog binding and dopamine uptake to identify potential cocaine antagonists. Drug and alcohol dependence. vol 48. issue 1. 1997-11-20. PMID:9330920. |
the addictive and euphorogenic properties of cocaine are thought to result from inhibition of the dopamine transporter (dat). |
1997-11-20 |
2023-08-12 |
human |
| B S Slusher, C W Tiffany, J L Olkowski, P F Jackso. Use of identical assay conditions for cocaine analog binding and dopamine uptake to identify potential cocaine antagonists. Drug and alcohol dependence. vol 48. issue 1. 1997-11-20. PMID:9330920. |
therefore it should be possible to design drugs which specifically inhibit cocaine recognition by the dat while permitting the transporter to maintain its function of accumulating dopamine. |
1997-11-20 |
2023-08-12 |
human |
| Y Fujiwara, K Yamaguchi, Y Tanaka, H Tomita, Y Shiro, K Kashihara, K Sato, S Kurod. Polymorphism of dopamine receptors and transporter genes in neuropsychiatric diseases. European neurology. vol 38 Suppl 1. 1997-10-16. PMID:9276194. |
the advances made in studies on the molecular biology of the dopamine transporter (dat) and receptors (d1, d2, d3, d4 and d5) are reviewed, and their pharmacological characteristics and the relationship between polymorphic variations of these human proteins and neuropsychiatric disorders are discussed. |
1997-10-16 |
2023-08-12 |
human |