| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L B Kuiper, J B Roberts, P M Estave, D Leo, R R Gainetdinov, S R Jone. Patterns of ethanol intake in male rats with partial dopamine transporter deficiency. Genes, brain, and behavior. 2023-07-18. PMID:37461188. |
these findings suggest that partial dat blockade and concomitant increase in brain dopamine levels has potential to reduce drinking and ameliorate alcohol use disorder (aud). |
2023-07-18 |
2023-08-14 |
human |
| Ganhua Luo, Xinchong Shi, LuLu Jiang, Lei Wu, Chang Yi, Wenbiao Xian, Yanmei Liu, Fuhua Wen, Hao Qian, Jie Chen, Xiaoli Fu, Jinlong Liu, Xiangsong Zhang, Ling Che. Effects of STN-DBS surgery on cerebral glucose metabolism and distribution of DAT in Parkinson's disease. Brain and behavior. 2023-07-17. PMID:37459244. |
subthalamic nucleus (stn) deep brain stimulation (dbs) has been shown to be an effective treatment for pd; however, the effects of this surgery on cerebral metabolism and presynaptic dopamine transporter (dat) distribution are still being studied. |
2023-07-17 |
2023-08-14 |
Not clear |
| Melinda Hersey, Mattingly K Bartole, Claire S Jones, Amy Hauck Newman, Gianluigi Tand. Are There Prevalent Sex Differences in Psychostimulant Use Disorder? A Focus on the Potential Therapeutic Efficacy of Atypical Dopamine Uptake Inhibitors. Molecules (Basel, Switzerland). vol 28. issue 13. 2023-07-14. PMID:37446929. |
preclinically, psychostimulants have been shown to increase synaptic dopamine (da) levels and may downregulate the dopamine transporter (dat). |
2023-07-14 |
2023-08-14 |
Not clear |
| Rachel A Davies, Vy T Nguyen, Jose M Eltit, Richard A Glenno. Structure-Activity Relationships for a Recently Controlled Synthetic Cathinone Dopamine Transporter Reuptake Inhibitor: α-Pyrrolidinohexiophenone (α-PHP). ACS chemical neuroscience. 2023-07-05. PMID:37406364. |
using a synaptosomal assay, we previously reported that α-php is at least as potent as α-pvp as a dopamine transporter (dat) reuptake inhibitor. |
2023-07-05 |
2023-08-14 |
Not clear |
| Carla Carratalá-Ros, Andrea Martínez-Verdú, Regulo Olivares-García, John D Salamone, Mercè Corre. Effects of the dopamine depleting agent tetrabenazine in tests evaluating different components of depressive-like behavior in mice: sex-dependent response to antidepressant drugs with SERT and DAT blocker profiles. Psychopharmacology. 2023-07-05. PMID:37407727. |
effects of the dopamine depleting agent tetrabenazine in tests evaluating different components of depressive-like behavior in mice: sex-dependent response to antidepressant drugs with sert and dat blocker profiles. |
2023-07-05 |
2023-08-14 |
mouse |
| Elena Missir, Patrick Begley, Maryam Jessop, Nitasha Singh, Mark Aplin, Helena McMeekin, Puja Parekh, Malgorzata Raczek, Sabina Dizdarevi. Quantitative [123]I-Ioflupane DaTSCAN single-photon computed tomography-computed tomography in Parkinsonism. Nuclear medicine communications. 2023-07-03. PMID:37395542. |
[123]i-ioflupane (datscan) binds to the presynaptic dopamine transporter (dat) and with a lower affinity to the serotonin transporter (sert). |
2023-07-03 |
2023-08-14 |
Not clear |
| Rita Caridade-Silva, Bruna Araújo, Joana Martins-Macedo, Fábio G Teixeir. N-Acetylcysteine Treatment May Compensate Motor Impairments through Dopaminergic Transmission Modulation in a Striatal 6-Hydroxydopamine Parkinson's Disease Rat Model. Antioxidants (Basel, Switzerland). vol 12. issue 6. 2023-06-28. PMID:37371987. |
the results revealed that nac enhanced dan viability, as we found that it could restore dopamine transporter (dat) levels compared to the untreated 6-ohda group. |
2023-06-28 |
2023-08-14 |
rat |
| Abubakar Atiq, Hyeon Jin Lee, Amjad Khan, Min Hwa Kang, Inayat Ur Rehman, Riaz Ahmad, Muhammad Tahir, Jawad Ali, Kyonghwan Choe, Jun Sung Park, Myeong Ok Ki. Vitamin E Analog Trolox Attenuates MPTP-Induced Parkinson's Disease in Mice, Mitigating Oxidative Stress, Neuroinflammation, and Motor Impairment. International journal of molecular sciences. vol 24. issue 12. 2023-06-28. PMID:37373089. |
our study showed that mptp increased the expression of α-synuclein, decreased tyrosine hydroxylase (th) and dopamine transporter (dat) levels in the striatum and substantia nigra pars compacta (snpc), and impaired motor function. |
2023-06-28 |
2023-08-14 |
mouse |
| Ross van de Wetering, Amy Ewald, Susan Welsh, Lindsay Kornberger, Samuel E Williamson, Bryan D McElroy, Eduardo R Butelman, Thomas E Prisinzano, Bronwyn M Kivel. The Kappa Opioid Receptor Agonist 16-Bromo Salvinorin A Has Anti-Cocaine Effects without Significant Effects on Locomotion, Food Reward, Learning and Memory, or Anxiety and Depressive-like Behaviors. Molecules (Basel, Switzerland). vol 28. issue 12. 2023-06-28. PMID:37375403. |
16-brsala increased dopamine transporter (dat) activity in hek-293 cells coexpressing dat and kor, as well as in rat nucleus accumbens and dorsal striatal tissue. |
2023-06-28 |
2023-08-14 |
mouse |
| Rene L Utianski, Nha Trang Thu Pham, Hugo Botha, Farwa Ali, Joseph R Duffy, Heather M Clark, Val J Lowe, Jennifer L Whitwell, Keith A Joseph. Longitudinal changes in dopamine transporter uptake scans in progressive apraxia of speech. Clinical parkinsonism & related disorders. vol 9. 2023-06-23. PMID:37351017. |
to describe qualitative and quantitative longitudinal changes in dopamine transporter uptake (dat) scan findings in progressive apraxia of speech (paos) patients. |
2023-06-23 |
2023-08-14 |
Not clear |
| Mia I Allen, Angela N Duke, Susan H Nader, Adrienne Adler-Neal, Kiran K Solingapuram Sai, Beth A Reboussin, H Donald Gage, Ronald J Voll, Akiva Mintz, Mark M Goodman, Michael A Nade. PET imaging of dopamine transporters and D2/D3 receptors in female monkeys: effects of chronic cocaine self-administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-06-22. PMID:37349473. |
brain imaging studies using positron emission tomography (pet) have shown that long-term cocaine use is associated with lower levels of dopamine (da) d2/d3 receptors (d2/d3r); less consistent are the effects on da transporter (dat) availability. |
2023-06-22 |
2023-08-14 |
human |
| Ilene Trinh, Angeni Muralidhar, Justin Yang, Nicolás Phielip. Quantified Striatal Dopaminergic Denervation as Predictor for Motor Outcomes in Parkinson's Disease. Movement disorders clinical practice. vol 10. issue 6. 2023-06-19. PMID:37332639. |
dopamine transporter single-photon emission computed tomography (dat-spect) can be used to assess dopaminergic denervation by detecting loss of striatal dopamine transporters (dat). |
2023-06-19 |
2023-08-14 |
Not clear |
| Kaoru Arai, Hitoshi Sakimoto, Yuka Urata, Mai Kariya, Takeshi Nakamura, Tatsuki Ikehata, Rion Shimojima, Naomi Furue, Takanori Ishizuka, Akira Sano, Masayuki Nakamur. Aging-Related Catatonia with Reversible Dopamine Transporter Dysfunction in Females with Depressive Symptoms: A Case Series. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 2023-06-16. PMID:37328402. |
the authors describe five depressive patients with initially decreased striatal accumulation of dopamine transporter (dat) single-photon emission computed tomography (spect), which improved in parallel with clinical symptoms. |
2023-06-16 |
2023-08-14 |
Not clear |
| Tassilo Schiebler, Ivayla Apostolova, Franziska Lara Mathies, Catharina Lange, Susanne Klutmann, Ralph Bucher. No impact of attenuation and scatter correction on the interpretation of dopamine transporter SPECT in patients with clinically uncertain parkinsonian syndrome. European journal of nuclear medicine and molecular imaging. 2023-06-16. PMID:37328621. |
the benefit from attenuation and scatter correction (asc) of dopamine transporter (dat)-spect for the detection of nigrostriatal degeneration in clinical routine is still a matter of debate. |
2023-06-16 |
2023-08-14 |
Not clear |
| Jacqueline D Keighron, Jordi Bonaventura, Yang Li, Jae-Won Yang, Emily M DeMarco, Melinda Hersey, Jianjing Cao, Walter Sandtner, Michael Michaelides, Harald H Sitte, Amy Hauck Newman, Gianluigi Tand. Interactions of calmodulin kinase II with the dopamine transporter facilitate cocaine-induced enhancement of evoked dopamine release. Translational psychiatry. vol 13. issue 1. 2023-06-13. PMID:37311803. |
typical and atypical dopamine uptake inhibitors (duis) prefer distinct conformations of the dopamine transporter (dat) to form ligand-transporter complexes, resulting in markedly different effects on behavior, neurochemistry, and potential for addiction. |
2023-06-13 |
2023-08-14 |
Not clear |
| N J Clauss, F P Mayer, W A Owens, M Vitela, K M Clarke, M A Bowman, R E Horton, D Gründemann, D Schmid, M Holy, G G Gould, W Koek, H H Sitte, L C Daw. Ethanol inhibits dopamine uptake via organic cation transporter 3: Implications for ethanol and cocaine co-abuse. Molecular psychiatry. 2023-06-12. PMID:37308680. |
cocaine increases extracellular monoamines by blocking dopamine (da), norepinephrine (ne) and serotonin (5-ht) transporters (dat, net and sert, respectively). |
2023-06-12 |
2023-08-14 |
mouse |
| Young-Gun Lee, Seun Jeon, Kyoungwon Baik, Sung Woo Kang, Byoung Seok Y. Substantia nigral dopamine transporter uptake in dementia with Lewy bodies. NPJ Parkinson's disease. vol 9. issue 1. 2023-06-11. PMID:37296236. |
to identify the subregional dopamine transporter (dat) uptake patterns that improve the diagnostic accuracy of dlb, we analyzed n-(3-[ |
2023-06-11 |
2023-08-14 |
Not clear |
| Sevag Hamamah, Andras Hajnal, Mihai Covas. Reduced Striatal Dopamine Transporter Availability and Heightened Response to Natural and Pharmacological Stimulation in CCK-1R-Deficient Obese Rats. International journal of molecular sciences. vol 24. issue 11. 2023-06-11. PMID:37298724. |
in this study, we examined the relationship between oletf's hyperphagic behavior and striatal dopamine signaling by investigating basal and amphetamine stimulated motor activity in prediabetic oletf rats before and after access to sucrose solution (0.3 m) compared to non-mutant control leto rats, as well as availability of dopamine transporter (dat) using autoradiography. |
2023-06-11 |
2023-08-14 |
rat |
| Tarique Bagalkot, Alexander Sorki. Endocytic down-regulation of the striatal dopamine transporter by amphetamine in sensitized mice in sex-dependent manner. bioRxiv : the preprint server for biology. 2023-06-09. PMID:37293021. |
dopamine transporter (dat) controls dopamine signaling in the brain through the reuptake of synaptically released dopamine. |
2023-06-09 |
2023-08-14 |
mouse |
| Tarique Bagalkot, Alexander Sorki. Endocytic down-regulation of the striatal dopamine transporter by amphetamine in sensitized mice in sex-dependent manner. bioRxiv : the preprint server for biology. 2023-06-09. PMID:37293021. |
acute amph is proposed to cause transient dat endocytosis which among other amph effects on dopaminergic neurons elevates extracellular dopamine. |
2023-06-09 |
2023-08-14 |
mouse |