| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Małgorzata Łupina, Maciej Tarnowski, Irena Baranowska-Bosiacka, Sylwia Talarek, Piotr Listos, Jolanta Kotlińska, Izabela Gutowska, Joanna Listo. SB-334867 (an Orexin-1 Receptor Antagonist) Effects on Morphine-Induced Sensitization in Mice-a View on Receptor Mechanisms. Molecular neurobiology. vol 55. issue 11. 2018-12-17. PMID:29557083. |
significant alterations were observed in mrna expression of orexin, dopamine, and adenosine receptors and in the expression of gfap and iba-1, showing a broad range of interactions in the mesolimbic system among orexin, dopamine, adenosine, and glial cells during behavioral sensitization. |
2018-12-17 |
2023-08-13 |
mouse |
| Mehmet Demır, Mustafa Cicek, Nadire Eser, Atila Yoldaş, Turgay Sısma. Effects of Acute Toluene Toxicity on Different Regions of Rabbit Brain. Analytical cellular pathology (Amsterdam). vol 2017. 2018-08-10. PMID:28458992. |
moreover, nerve growth factor (ngf), tumor necrosis factor-alpha (tnf-alpha), dopamine (da), and glial fibrillary acidic protein (gfap) tests were performed in order to designate the severity of the biochemical damage. |
2018-08-10 |
2023-08-13 |
rabbit |
| Mehmet Demır, Mustafa Cicek, Nadire Eser, Atila Yoldaş, Turgay Sısma. Effects of Acute Toluene Toxicity on Different Regions of Rabbit Brain. Analytical cellular pathology (Amsterdam). vol 2017. 2018-08-10. PMID:28458992. |
levels of dopamine, secreted from the substantia nigra, nerve growth factor (ngf) developed from the hippocampal neurons, and gfap, secreted from astrocyte cells, were detected to be significantly lower in the toluene-administration group than in the control group ( |
2018-08-10 |
2023-08-13 |
rabbit |
| C Requejo, J A Ruiz-Ortega, H Bengoetxea, A García-Blanco, E Herrán, A Aristieta, M Igartua, J L Pedraz, L Ugedo, R M Hernández, J V Lafuent. Morphological Changes in a Severe Model of Parkinson's Disease and Its Suitability to Test the Therapeutic Effects of Microencapsulated Neurotrophic Factors. Molecular neurobiology. vol 54. issue 10. 2018-07-02. PMID:27844282. |
administration of 6-ohda into mfb in addition to a remarkable depletion of dopamine in the nigrostriatal system induced an increase of glial fibrillary acidic protein (gfap)-positive cells in sn and an intense immunoreactivity for ox-42, vascular endothelial growth factor (vegf), and lycopersycum esculentum agglutinin (lea) in striatum and sn. |
2018-07-02 |
2023-08-13 |
rat |
| Jose V Lafuente, Catalina Requejo, Alejandro Carrasco, Harkaitz Bengoetxe. Nanoformulation: A Useful Therapeutic Strategy for Improving Neuroprotection and the Neurorestorative Potential in Experimental Models of Parkinson's Disease. International review of neurobiology. vol 137. 2018-06-25. PMID:29132545. |
in addition to a remarkable depletion of dopamine in the nigrostriatal system, the administration of 6-ohda into mfb induces some other neuropathological changes such as an increase of glial fibrillary acidic protein (gfap) positive cells in substantia nigra (sn) as well as in striatum. |
2018-06-25 |
2023-08-13 |
rat |
| Melanie Alpaugh, Danny Galleguillos, Juan Forero, Luis Carlos Morales, Sebastian W Lackey, Preeti Kar, Alba Di Pardo, Andrew Holt, Bradley J Kerr, Kathryn G Todd, Glen B Baker, Karim Fouad, Simonetta Sipion. Disease-modifying effects of ganglioside GM1 in Huntington's disease models. EMBO molecular medicine. vol 9. issue 11. 2018-06-12. PMID:28993428. |
gm1 administration results in decreased levels of mutant huntingtin, the protein that causes hd, and in a wide array of beneficial effects that include changes in levels of darpp32, ferritin, iba1 and gfap, modulation of dopamine and serotonin metabolism, and restoration of normal levels of glutamate, gaba, l-ser and d-ser. |
2018-06-12 |
2023-08-13 |
mouse |
| Nicholas B Miner, James P O'Callaghan, Tamara J Phillips, Aaron Janowsk. The combined effects of 3,4-methylenedioxymethamphetamine (MDMA) and selected substituted methcathinones on measures of neurotoxicity. Neurotoxicology and teratology. vol 61. 2018-03-21. PMID:28212938. |
drug effects on thermoregulation were characterized and striatal tissue analyzed after 2 or 7days for dopamine (da) and tyrosine hydroxylase (th) levels, as well as glial fibrillary acidic protein (gfap) expression. |
2018-03-21 |
2023-08-13 |
mouse |
| Arnold Gutierrez, Sarah A Jablonski, Robyn M Amos-Kroohs, Anna C Barnes, Michael T Williams, Charles V Vorhee. Effects of Housing on Methamphetamine-Induced Neurotoxicity and Spatial Learning and Memory. ACS chemical neuroscience. vol 8. issue 7. 2018-01-30. PMID:28287691. |
ma reduced dopamine (da) and serotonin (5-ht) in the neostriatum and nucleus accumbens, 5-ht in the hippocampus, and increased gfap in neostriatum and nucleus accumbens compared with saline controls. |
2018-01-30 |
2023-08-13 |
rat |
| Neha Sharma, Bimla Nehr. Apocyanin, a Microglial NADPH Oxidase Inhibitor Prevents Dopaminergic Neuronal Degeneration in Lipopolysaccharide-Induced Parkinson's Disease Model. Molecular neurobiology. vol 53. issue 5. 2017-12-22. PMID:26081143. |
subsequently, this resulted in dopaminergic loss as depicted by decreased tyrosine hydroxylase (th) expression with substantial loss in neurotransmitter dopamine and its metabolites, whereas treatment with apocyanin significantly reduced the number of glial fibrillary acidic protein (gfap) and iba-1-positive cells in lps-treated animals. |
2017-12-22 |
2023-08-13 |
rat |
| Lei Xing, Maddie J Venables, Vance L Trudea. Role of aromatase and radial glial cells in neurotoxin-induced dopamine neuron degeneration and regeneration. General and comparative endocrinology. vol 241. 2017-09-07. PMID:26873632. |
the expression of genes in the telencephalon and hypothalamus related to rgc functions including gfap, gdnf and bdnf as well as genes related to mature dopamine neuron functions including th, slc6a3 and pitx3 are under modulation of estrogens. |
2017-09-07 |
2023-08-13 |
Not clear |
| Shreesh Ojha, Hayate Javed, Sheikh Azimullah, Salema B Abul Khair, M Emdadul Haqu. Glycyrrhizic acid Attenuates Neuroinflammation and Oxidative Stress in Rotenone Model of Parkinson's Disease. Neurotoxicity research. vol 29. issue 2. 2016-10-14. PMID:26607911. |
immunohistochemical analysis revealed significant increments in ionized calcium-binding adaptor molecule-1 (iba-1) levels, and in glial fibrillary acidic protein (gfap) levels, and loss of dopamine neurons in the substantia nigra pars compacta upon rotenone challenge. |
2016-10-14 |
2023-08-13 |
rat |
| Shreesh Ojha, Hayate Javed, Sheikh Azimullah, Salema B Abul Khair, M Emdadul Haqu. Glycyrrhizic acid Attenuates Neuroinflammation and Oxidative Stress in Rotenone Model of Parkinson's Disease. Neurotoxicity research. vol 29. issue 2. 2016-10-14. PMID:26607911. |
ga treatment significantly attenuated the dopamine neuron loss and decreased the iba-1 and gfap activation induced by the rotenone insult. |
2016-10-14 |
2023-08-13 |
rat |
| Subhashree Sridharan, Kumaravel Mohankumar, Syam Praveen Kumar Jeepipalli, Divya Sankaramourthy, Larance Ronsard, Kavimani Subramanian, Manivasagam Thamilarasan, Kumar Raja, Varshney Khub Chandra, Sudha Rani Sadra. Neuroprotective effect of Valeriana wallichii rhizome extract against the neurotoxin MPTP in C57BL/6 mice. Neurotoxicology. vol 51. 2016-10-12. PMID:26522450. |
vwe treatment significantly recuperated the altered behavioural test scores, striatal dopamine levels, mid brain th(+) cell count and th protein levels, increased gfap expression and the histopathological changes observed in pd mice. |
2016-10-12 |
2023-08-13 |
mouse |
| S Sarkar, B Gough, J Raymick, M A Beaudoin, S F Ali, A Virmani, Z K Biniend. Histopathological and electrophysiological indices of rotenone-evoked dopaminergic toxicity: Neuroprotective effects of acetyl-L-carnitine. Neuroscience letters. vol 606. 2016-03-01. PMID:26321151. |
rats were perfused immediately after testing with 4% paraformaldehyde and immunohistochemical analysis of dopamine transporter (dat), tyrosine hydroxylase (th), glial fibrillary acidic protein (gfap), and microglial cd11b marker was performed in the caudate-putamen (cpu) and the substantia nigra pars compacta (snc) in order to estimate dopaminergic neuronal and transporter damage. |
2016-03-01 |
2023-08-13 |
rat |
| Mariana Raineri, Betina González, Celeste Rivero-Echeto, Javier A Muñiz, María Laura Gutiérrez, Carolina I Ghanem, Jean Lud Cadet, Edgar García-Rill, Francisco J Urbano, Veronica Bisagn. Differential effects of environment-induced changes in body temperature on modafinil's actions against methamphetamine-induced striatal toxicity in mice. Neurotoxicity research. vol 27. issue 1. 2015-07-27. PMID:25261212. |
brains were dissected out 6 days after treatments and processed for tyrosine hydroxylase (th), dopamine transporter (dat), gfap and c-fos immunohistochemistry. |
2015-07-27 |
2023-08-13 |
mouse |
| Mingxin Zhu, Kai Shu, Heping Wang, Xiaopeng Li, Qungen Xiao, Waipan Chan, Bosomah Emmanuel, Wei Jiang, Ting Le. Microtransplantation of whole ganglionic eminence cells ameliorates motor deficit, enlarges the volume of grafts, and prolongs survival in a rat model of Huntington's disease. Journal of neuroscience research. vol 91. issue 12. 2014-06-17. PMID:24105649. |
the expression of neuronal nuclei (neun), dopamine, camp-regulated phosphoprotein of molecular weight 32 kda (darpp-32), and glial fibrillary acidic protein (gfap) was analyzed at 12 weeks after transplantation. |
2014-06-17 |
2023-08-12 |
rat |
| Maria Galuppo, Renato Iori, Gina Rosalinda De Nicola, Placido Bramanti, Emanuela Mazzo. Anti-inflammatory and anti-apoptotic effects of (RS)-glucoraphanin bioactivated with myrosinase in murine sub-acute and acute MPTP-induced Parkinson's disease. Bioorganic & medicinal chemistry. vol 21. issue 17. 2014-03-18. PMID:23810671. |
behavioural test, body weight changes measures and immunohistochemical localization of the main pd markers were performed and post-hoc analysis has shown as bioactive rs-gra is able to reduce dopamine transporter degradation, tyrosine hydroxylase expression, il-1β release, as well as the triggering of neuronal apoptotic death pathway (data about bax/bcl-2 balance and dendrite spines loss) and the generation of radicalic species by oxidative stress (results focused on nitrotyrosine, nrf2 and gfap immunolocalization). |
2014-03-18 |
2023-08-12 |
mouse |
| Kazue Kikuchi-Utsumi, Mami Ishizaka, Nobuko Matsumura, Masahiko Watabe, Koji Aoyama, Nobuyuki Sasakawa, Toshio Nakak. Involvement of the α(1D)-adrenergic receptor in methamphetamine-induced hyperthermia and neurotoxicity in rats. Neurotoxicity research. vol 24. issue 2. 2014-03-03. PMID:23283760. |
meth neurotoxicity was evaluated by (1) measuring body temperature; (2) determining tyrosine hydroxylase (th) immunoreactivity levels; (3) examining levels of dopamine and its metabolites; and (4) assessing glial fibrillary acidic protein (gfap) and microglial immunoreactivity in the striatum. |
2014-03-03 |
2023-08-12 |
rat |
| Byron C Jones, Diane B Miller, James P O'Callaghan, Lu Lu, Erica L Unger, Gelareh Alam, Robert W William. Systems analysis of genetic variation in MPTP neurotoxicity in mice. Neurotoxicology. vol 37. 2014-02-05. PMID:23558233. |
all dopamine measures, as well as th and gfap, demonstrated wide, genotype-dependent differences in response to mptp. |
2014-02-05 |
2023-08-12 |
mouse |
| Mei Yu, Haiyun Suo, Ming Liu, Lei Cai, Jie Liu, Yufang Huang, Jing Xu, Yancong Wang, Cuiqing Zhu, Jian Fei, Fang Huan. NRSF/REST neuronal deficient mice are more vulnerable to the neurotoxin MPTP. Neurobiology of aging. vol 34. issue 3. 2013-05-24. PMID:22766071. |
meanwhile, the cko mice exhibited a more dramatic depletion of striatal dopamine, accompanied by an increase in glial fibrillary acidic protein (gfap) expression and sustained interleukin-1β transcription. |
2013-05-24 |
2023-08-12 |
mouse |