| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rong Zhang, Tamar Kadar, Ernest Sirimanne, Alastair MacGibbon, Jian Gua. Age-related memory decline is associated with vascular and microglial degeneration in aged rats. Behavioural brain research. vol 235. issue 2. 2013-02-25. PMID:22889927. |
without seen neuronal degeneration, the aged rats with memory impairments have displayed dopamine depletion, profound vascular and microglial degeneration with reduced vascular endothelial growth factor and elevated gfap expression in the hippocampus. |
2013-02-25 |
2023-08-12 |
rat |
| D B Miller, J P O'Callaghan, E A Johnso. Prior exposure to a behaviorally sensitizing regimen of d-methamphetamine does not alter the striatal dopaminergic damage induced by a neurotoxic regimen. Addiction biology. vol 5. issue 3. 2012-10-02. PMID:20575853. |
this was evidenced by equivalent reductions in dopamine and elevations in gfap protein, a marker of astrocytic response to injury, gfap. |
2012-10-02 |
2023-08-12 |
mouse |
| S A Sands, B M Chronwal. GFAP expression induced by dopamine D(2) receptor agonists in the rat pituitary intermediate lobe. Endocrine. vol 4. issue 1. 2012-10-02. PMID:21153289. |
gfap expression induced by dopamine d(2) receptor agonists in the rat pituitary intermediate lobe. |
2012-10-02 |
2023-08-12 |
rat |
| S A Sands, B M Chronwal. GFAP expression induced by dopamine D(2) receptor agonists in the rat pituitary intermediate lobe. Endocrine. vol 4. issue 1. 2012-10-02. PMID:21153289. |
dopamine d(2) receptor mrna and protein were detected in melanotropes, but not in cells expressing gfap or vimentin. |
2012-10-02 |
2023-08-12 |
rat |
| Akiko Muroyama, Aya Fujita, Cheng Lv, Shota Kobayashi, Yoshiyasu Fukuyama, Yasuhide Mitsumot. Magnolol Protects against MPTP/MPP(+)-Induced Toxicity via Inhibition of Oxidative Stress in In Vivo and In Vitro Models of Parkinson's Disease. Parkinson's disease. vol 2012. 2012-08-23. PMID:22655218. |
western blot analysis revealed that mptp injections substantially decreased protein levels of dopamine transporter (dat) and tyrosine hydroxylase (th) and increased glial fibrillary acidic protein (gfap) levels in the striatum. |
2012-08-23 |
2023-08-12 |
mouse |
| D Domenger, D Dea, L Theroux, L Moquin, A Gratton, J Poirie. The MPTP neurotoxic lesion model of Parkinson's disease activates the apolipoprotein E cascade in the mouse brain. Experimental neurology. vol 233. issue 1. 2012-03-25. PMID:22155743. |
in the striatum, upregulations of gfap, apoe and lrp mrnas at 1 day post-treatment were associated with marked decreases in dopamine (da) levels, loss in tyrosine hydroxylase protein content, as well as to a compensatory increase in dopaminergic metabolism. |
2012-03-25 |
2023-08-12 |
mouse |
| Cynthia H Kern, Donald R Smit. Preweaning Mn exposure leads to prolonged astrocyte activation and lasting effects on the dopaminergic system in adult male rats. Synapse (New York, N.Y.). vol 65. issue 6. 2012-03-12. PMID:20963817. |
to determine if early mn exposure produces lasting neurobehavioral and neurochemical effects, we treated neonate rats with oral mn (0, 25, or 50 mg mn/kg/d over pnd 1-21) and evaluated (1) behavioral performance in the open arena in the absence (pnd 97) and presence (pnd 98) of a d-amphetamine challenge, (2) brain dopamine d1 and d2-like receptors and dopamine transporter densities in the prefrontal cortex, striatum, and nucleus accumbens (pnd 107), and (3) astrocyte marker glial fibrillary acidic protein (gfap) levels in these same brain regions (pnd 24 and 107). |
2012-03-12 |
2023-08-12 |
rat |
| Junchao Tong, Yoshiaki Furukawa, Allan Sherwin, Oleh Hornykiewicz, Stephen J Kis. Heterogeneous intrastriatal pattern of proteins regulating axon growth in normal adult human brain. Neurobiology of disease. vol 41. issue 2. 2011-11-22. PMID:21029775. |
in contrast, distribution of glial markers including glial fibrillary acidic protein (gfap) and human leukocyte antigens (hla-drα and hla-dr/dq/dpβ), other bcl-2 family proteins, and control proteins neuron-specific enolase and α-tubulin in the striatum was either homogeneous or had a pattern unmatched to dopamine loss in pd. |
2011-11-22 |
2023-08-12 |
human |
| Anthony P Nichola. Dual immunofluorescence study of citrullinated proteins in Parkinson diseased substantia nigra. Neuroscience letters. vol 495. issue 1. 2011-09-13. PMID:21414385. |
in control sn sections, many tyrosine hydroxylase (th)-immunoreactive dopamine neurons were seen surrounded either by small fibers immunoreactive for deiminated proteins, or large reactive astrocytes, co-localized with glial fibrillary acidic protein (gfap). |
2011-09-13 |
2023-08-12 |
human |
| Noelia Granado, Sara Ares-Santos, Idaira Oliva, Esther O'Shea, Eduardo D Martin, M Isabel Colado, Rosario Moratall. Dopamine D2-receptor knockout mice are protected against dopaminergic neurotoxicity induced by methamphetamine or MDMA. Neurobiology of disease. vol 42. issue 3. 2011-08-23. PMID:21303698. |
in wild type animals, both drugs induced marked hyperthermia, decreased striatal dopamine content and th- and dat-immunoreactivity and increased striatal gfap and mac-1 expression as well as inos and interleukin 15 at 1 and 7days after drug exposure. |
2011-08-23 |
2023-08-12 |
mouse |
| Mohammed Emamussalehin Choudhury, Takashi Moritoyo, Madoka Kubo, Win Thiri Kyaw, Hayato Yabe, Noriko Nishikawa, Masahiro Nagai, Seiji Matsuda, Masahiro Nomot. Zonisamide-induced long-lasting recovery of dopaminergic neurons from MPTP-toxicity. Brain research. vol 1384. 2011-07-19. PMID:21320474. |
moreover, zonisamide increased the number of s100β-positive and glial fibrillary acidic protein (gfap)-positive astrocytes and dopamine turnover. |
2011-07-19 |
2023-08-12 |
mouse |
| Nian Xiong, Xuebing Cao, Zhentao Zhang, Jinsha Huang, Chunnuan Chen, Zhaowen Zhang, Min Jia, Jing Xiong, Zhihou Liang, Shenggang Sun, Zhicheng Lin, Tao Wan. Long-term efficacy and safety of human umbilical cord mesenchymal stromal cells in rotenone-induced hemiparkinsonian rats. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. vol 16. issue 11. 2011-03-04. PMID:20542126. |
by integrating with host cells and differentiating into nse, gfap, nestin, and tyrosine hydroxylase-positive cells, humscs prevented 48.4% dopamine neurons from degeneration and 56.9% dopamine terminals from loss, both correlating with improvement of apomorphine-induced rotations. |
2011-03-04 |
2023-08-12 |
human |
| Salma Bukhatwa, Bai-Yun Zeng, Sarah Rose, Peter Jenne. A comparison of changes in proteasomal subunit expression in the substantia nigra in Parkinson's disease, multiple system atrophy and progressive supranuclear palsy. Brain research. vol 1326. 2010-06-25. PMID:20176003. |
pa700-rpn10 subunit was not colocalized with th within dopamine cells but was co-expressed with glial fibrillary acid protein (gfap) positive astrocytes in the sn of all groups. |
2010-06-25 |
2023-08-12 |
Not clear |
| Kazuto Sakoori, Niall P Murph. Reduced degeneration of dopaminergic terminals and accentuated astrocyte activation by high dose methamphetamine administration in nociceptin receptor knock out mice. Neuroscience letters. vol 469. issue 3. 2010-04-12. PMID:20025929. |
three days later, brains were immunohistochemically processed to visualize methamphetamine-induced loss of tyrosine hydroxylase (as a marker of damage to dopamine terminals), glial fibrillary acidic protein (gfap, as a marker of astrocytes), and ionized calcium-binding adapter molecule 1 (lba-1, as a marker of microglia) in the striatum. |
2010-04-12 |
2023-08-12 |
mouse |
| Ryohei Yano, Hironori Yokoyama, Hayato Kuroiwa, Hiroyuki Kato, Tsutomu Arak. A novel anti-Parkinsonian agent, zonisamide, attenuates MPTP-induced neurotoxicity in mice. Journal of molecular neuroscience : MN. vol 39. issue 1-2. 2010-02-12. PMID:19199078. |
we observed that zonisamide attenuated mptp-induced dopamine, 3,4-dihydroxyphenylacetic acid (dopac), and homovanillic acid (hva) depletion in the striatum and reduced the loss of tyrosine hidroxylase (th) positive neurons and the increase of glial fibrillary acidic protein (gfap) positive astrocytes in the striatum and substantia nigra after 5 days. |
2010-02-12 |
2023-08-12 |
mouse |
| Sanjay Kasture, Silvia Pontis, Annalisa Pinna, Nicoletta Schintu, Liliana Spina, Rosanna Longoni, Nicola Simola, Mauro Ballero, Micaela Morell. Assessment of symptomatic and neuroprotective efficacy of Mucuna pruriens seed extract in rodent model of Parkinson's disease. Neurotoxicity research. vol 15. issue 2. 2010-01-26. PMID:19384573. |
finally, in a subchronic mice model of 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine hydrochloride (mptp)-induced dopamine neuron degeneration, mp extract did not prove capable of preventing either tyrosine hydroxylase decrease induced by mptp or astroglial or microglial activation as assessed by means of gfap and cd11b immunohistochemistry, supporting the absence of neuroprotective effects by mp. |
2010-01-26 |
2023-08-12 |
mouse |
| Masanori Ookubo, Hironori Yokoyama, Hiroyuki Kato, Tsutomu Arak. Gender differences on MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in C57BL/6 mice. Molecular and cellular endocrinology. vol 311. issue 1-2. 2010-01-06. PMID:19631714. |
in the present study, we investigated the time-dependent alterations of dopamine and its metabolites, striatal tyrosine hydroxylase (th) protein, dopamine transporter (dat) protein, glial fibrillary acidic protein (gfap) protein and midbrain th protein and motor function in male and female mice 5h and 1, 3 and 7 days after four administrations of mptp (20mg/kg) at 2-h intervals. |
2010-01-06 |
2023-08-12 |
mouse |
| Gráinne C O'Keeffe, Pam Tyers, Dag Aarsland, Jeffrey W Dalley, Roger A Barker, Maeve A Caldwel. Dopamine-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 21. 2009-06-23. PMID:19433789. |
we also show that dopamine selectively expands the gfap(+) multipotent stem cell population in vitro by promoting their self-renewal. |
2009-06-23 |
2023-08-12 |
human |
| Enrico Marani, Tjitske Heida, Egbert A J F Lakke, Kamen G Usunof. The subthalamic nucleus. Part I: development, cytology, topography and connections. Advances in anatomy, embryology, and cell biology. vol 198. 2008-12-17. PMID:18727483. |
the cytochemistry encompasses enzymes, no, glial fibrillary acidic protein (gfap), calcium binding proteins, and receptors (dopamine, cannabinoid, opioid, glutamate, gamma-aminobutyric acid (gaba), serotonin, cholinergic, and calcium channels). |
2008-12-17 |
2023-08-12 |
human |
| Tjitske Heida, Enrico Marani, Kamen G Usunof. The subthalamic nucleus part II: modelling and simulation of activity. Advances in anatomy, embryology, and cell biology. vol 199. 2008-12-17. PMID:18727495. |
the cytochemistry encompasses enzymes, no, glial fibrillary acidic protein (gfap), calcium binding proteins, and receptors (dopamine, cannabinoid, opioid, glutamate, gamma-aminobutyric acid (gaba), serotonin, cholinergic, and calcium channels). |
2008-12-17 |
2023-08-12 |
human |