| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Mo Kang, Jae-Chul Jung, Heejeong Kim, Heena Lim, Soyong Jang, Seikwan O. Neuroprotective effect of benzylideneacetophenone derivative on the MPTP model of neurodegeneration in mice. Archives of pharmacal research. vol 31. issue 9. 2008-10-28. PMID:18806951. |
immunohistochemistry and western blot were used to determine the expression levels of tyrosine hydroxylase (th), dopamine transporter (dat), ox-42 (a marker of microglial activation), and glial fibrillary acid protein (gfap, a marker of astrocyte activation) in the substantia nigra (sn) and striatum (st). |
2008-10-28 |
2023-08-12 |
mouse |
| Yajie Liang, Shurong Li, Qiang Zou, Bingyin S. Potential neuroprotective effect of low dose whole-body gamma-irradiation against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic toxicity in C57 mice. Neuroscience letters. vol 400. issue 3. 2006-08-18. PMID:16540245. |
one week after the last mptp treatment, hplc determination of striatal dopamine and immunostaining for tyrosine hydroxylase (th), cd11b and gfap to detect dopamine neurons and associated glial reaction in the substantia nigra pars compacta (snpc) were performed. |
2006-08-18 |
2023-08-12 |
mouse |
| Krishnan Sriram, Joanna M Matheson, Stanley A Benkovic, Diane B Miller, Michael I Luster, James P O'Callagha. Deficiency of TNF receptors suppresses microglial activation and alters the susceptibility of brain regions to MPTP-induced neurotoxicity: role of TNF-alpha. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 6. 2006-05-08. PMID:16581975. |
mptp-induced expression of microglia-derived factors, tnf-alpha, mcp-1, and il-1alpha, preceded the degeneration of striatal dopaminergic nerve terminals and astrogliosis, as assessed by loss of striatal dopamine and th, and an increase in striatal gfap. |
2006-05-08 |
2023-08-12 |
mouse |
| Vânia Gomide, Theo Bibancos, Gerson Chad. Dopamine cell morphology and glial cell hypertrophy and process branching in the nigrostriatal system after striatal 6-OHDA analyzed by specific sterological tools. The International journal of neuroscience. vol 115. issue 4. 2005-05-04. PMID:15804725. |
after behavioral analysis, fats were killed and their brains processed for the immunohistochemistry tyrosine hydroxylase (th), a marker for dopamine cells, as well as glial fibrillary acidic protein (gfap) and ox-42, markers for astrocyte and microglia, respectively. |
2005-05-04 |
2023-08-12 |
rat |
| V C Gomide, G A Silveira, G Chad. Transient and widespread astroglial activation in the brain after a striatal 6-OHDA-induced partial lesion of the nigrostriatal system. The International journal of neuroscience. vol 115. issue 1. 2005-05-02. PMID:15768855. |
immunohistochemistry was employed for visualization of the tyrosine hydroxylase (th), marker for dopamine cells, and glial fibrillary acidic protein (gfap), marker for astrocytes. |
2005-05-02 |
2023-08-12 |
rat |
| Jesus A Angulo, Nieves Angulo, Jing Y. Antagonists of the neurokinin-1 or dopamine D1 receptors confer protection from methamphetamine on dopamine terminals of the mouse striatum. Annals of the New York Academy of Sciences. vol 1025. 2005-02-18. PMID:15542715. |
exposure to meth induces long-term deficits in dopamine transporter (dat) and tyrosine hydroxylase (th) levels as well as induction of glial fibrillary acidic protein (gfap) in the caudate putamen (cpu) and the nucleus accumbens (nac). |
2005-02-18 |
2023-08-12 |
mouse |
| Rumiko Kurosaki, Yasuko Muramatsu, Hiroyuki Kato, Tsutomu Arak. Biochemical, behavioral and immunohistochemical alterations in MPTP-treated mouse model of Parkinson's disease. Pharmacology, biochemistry, and behavior. vol 78. issue 1. 2005-01-07. PMID:15159144. |
the immunohistochemical study has shown that the acute treatment with mptp caused severe loss of tyrosine hydroxylase (th)- and dopamine transporter (dat)-immunoreactive dopaminergic neurons and marked increase in glial fibrillary acidic protein (gfap)-immunoreactive astrocytes in the striatum and the substantia nigra. |
2005-01-07 |
2023-08-12 |
mouse |
| R Kurosaki, Y Muramatsu, Y Imai, H Kato, T Arak. Neuroprotective effect of the angiotensin-converting enzyme inhibitor perindopril in MPTP-treated mice. Neurological research. vol 26. issue 6. 2005-01-07. PMID:15327754. |
in our immunohistochemical studies with antibodies against tyrosine hydroxylase (th), microtubule-associated protein 2a, b (map2), dopamine transporter (dat), parvalbumin (pv), glial fibrillary acidic protein (gfap) and cu/zn-superoxide dismutase (cu/zn-sod), the administration of perindopril significantly attenuated mptp-induced substantia nigra and striatal damage. |
2005-01-07 |
2023-08-12 |
mouse |
| Victoria Armstrong, Carmela M Reichel, Jonathan F Doti, Cynthia A Crawford, Sanders A McDougal. Repeated amphetamine treatment causes a persistent elevation of glial fibrillary acidic protein in the caudate-putamen. European journal of pharmacology. vol 488. issue 1-3. 2004-11-29. PMID:15044042. |
the ability of repeated d-amphetamine (2 mg/kg) treatment to induce behavioral sensitization in rats and alter glial fibrillary acidic protein (gfap), dopamine transporter (dat) and glutamate transporter-1 (glt-1) immunoreactivities was assessed after a 10-day drug abstinence period. |
2004-11-29 |
2023-08-12 |
rat |
| Hijiri Watanabe, Yasuko Muramatsu, Rumiko Kurosaki, Mari Michimata, Mitsunobu Matsubara, Yutaka Imai, Tsutomu Arak. Protective effects of neuronal nitric oxide synthase inhibitor in mouse brain against MPTP neurotoxicity: an immunohistological study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 14. issue 2. 2004-04-19. PMID:15013024. |
in the present study, we further examined whether 7-nitroindazole can also protect against the alterations of th-, microtubule-associated protein 2a,b (map2)-, glial fibrillary acidic protein (gfap)-, parvalbumin (pv)-, dopamine transporter (dat)-, nnos- or endothelial nos (enos)-positive cells, in comparison with pargyline as a relatively selective inhibitor of the monoamine oxidase-b (mao-b). |
2004-04-19 |
2023-08-12 |
mouse |
| R W P Rodrigues, V C Gomide, G Chad. Astroglial and microglial activation in the wistar rat ventral tegmental area after a single striatal injection of 6-hydroxydopamine. The International journal of neuroscience. vol 114. issue 2. 2004-03-15. PMID:14702208. |
the tyrosine hydroxylase (th) positive dopamine cells, the glial fibrillary acidic protein (gfap) immuno -labeled astrocytes, and the ox42 immunoreactive microglia were visualized by means of immunohistochemistry and quantified by stereologic methods employing the optical dissector and the point intercepts. |
2004-03-15 |
2023-08-12 |
rat |
| Y Muramatsu, R Kurosaki, H Watanabe, M Michimata, M Matsubara, Y Imai, T Arak. Cerebral alterations in a MPTP-mouse model of Parkinson's disease--an immunocytochemical study. Journal of neural transmission (Vienna, Austria : 1996). vol 110. issue 10. 2004-02-12. PMID:14523625. |
we investigated the immunohistochemical alterations of neuronal nitric oxide synthase (nnos), endothelial nos (enos), tyrosine hydroxylase (th), microtubule-associated protein 2a,b (map 2), glial fibrillary acidic protein (gfap), parvalbumin (pv), and dopamine transporter (dat) in the striatum and substantia nigra following the application of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) in mice. |
2004-02-12 |
2023-08-12 |
mouse |
| R Kurosaki, Y Muramatsu, H Watanabe, M Michimata, M Matsubara, Y Imai, T Arak. Role of dopamine transporter against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice. Metabolic brain disease. vol 18. issue 2. 2003-07-24. PMID:12822832. |
we investigated the alterations of dopamine transporter (dat)-immunopositive cells against mptp neurotoxicity, in comparison with tyrosine hydroxylase (th)-immunopositive neurons and glial fibrillary acidic protein (gfap)-immunopositive cells. |
2003-07-24 |
2023-08-12 |
mouse |
| Sau Cheung Tiu, David T Yew, Wood Yee Cha. Development of the human cerebral cortex: a histochemical study. Progress in histochemistry and cytochemistry. vol 38. issue 1. 2003-06-26. PMID:12599727. |
the temporal and spatial patterns of expression of the neuronal markers gamma-aminobutyric acid (gaba), choline acetyltransferase (chat), dopamine beta hydroxylase (dbh), dopamine receptor dr1 and synaptophysin, as well as the glial cell markers glial fibrillary acidic protein (gfap), s100b and excitatory amino acid transporter protein glt-1 are delineated in the fetal cortex using immunohistochemistry. |
2003-06-26 |
2023-08-12 |
human |
| Elizabeth Anne Johnson, Anna A Shvedova, Elena Kisin, James P O'Callaghan, Choudari Kommineni, Diane B Mille. d-MDMA during vitamin E deficiency: effects on dopaminergic neurotoxicity and hepatotoxicity. Brain research. vol 933. issue 2. 2002-07-12. PMID:11931860. |
the vitamin e-deficient group, treated with the low dose of d-mdma, exhibited neurotoxic responses, including reduced striatal dopamine (47%) and elevated gfap protein (3-fold): while the sufficient diet group was not altered. |
2002-07-12 |
2023-08-12 |
mouse |
| R W Rodrigues, V C Gomide, G Chad. Astroglial and microglial reaction after a partial nigrostriatal degeneration induced by the striatal injection of different doses of 6-hydroxydopamine. The International journal of neuroscience. vol 109. issue 1-2. 2002-02-21. PMID:11699344. |
following, animals were sacrificed and the tyrosine hydroxylase (th) positive dopamine cells, the glial fibrillary acidic protein (gfap) immunolabeled astrocytes and the ox42 immunoreactive microglia were visualized by mean of immunohistochemistry and quantified by stereologic method employing the optical disector and the point intercepts. |
2002-02-21 |
2023-08-12 |
rat |
| F Trejo, P Vergara, M Brenner, J Segovi. Gene therapy in a rodent model of Parkinson's disease using differentiated C6 cells expressing a GFAP-tyrosine hydroxylase transgene. Life sciences. vol 65. issue 5. 1999-09-08. PMID:10462075. |
these results indicate that the gfap promoter is sufficiently active to enable production of therapeutic levels of dopamine from a gfap-th transgene, and suggest the use of astrocytes for gene therapy for parkinson's disease. |
1999-09-08 |
2023-08-12 |
human |
| G M Pasinetti, M Hassler, D Stone, C E Finc. Glial gene expression during aging in rat striatum and in long-term responses to 6-OHDA lesions. Synapse (New York, N.Y.). vol 31. issue 4. 1999-05-07. PMID:10051108. |
young f344 rats were given 6-ohda lesions that cause striatal dopamine deficits and induce gfap. |
1999-05-07 |
2023-08-12 |
rat |
| F Fumagalli, R R Gainetdinov, K J Valenzano, M G Caro. Role of dopamine transporter in methamphetamine-induced neurotoxicity: evidence from mice lacking the transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 13. 1998-07-02. PMID:9634552. |
dopamine (da) and serotonin (5-ht) content, glial fibrillary acidic protein (gfap) expression, and free radical formation were assessed as markers of meth neurotoxicity in the striatum and/or hippocampus of wild-type, heterozygote, and homozygote (dat -/-) mice. |
1998-07-02 |
2023-08-12 |
mouse |
| R R Gainetdinov, F Fumagalli, Y M Wang, S R Jones, A I Levey, G W Miller, M G Caro. Increased MPTP neurotoxicity in vesicular monoamine transporter 2 heterozygote knockout mice. Journal of neurochemistry. vol 70. issue 5. 1998-05-18. PMID:9572281. |
striatal dopamine (da) content, the levels of da transporter (dat) protein, and the expression of glial fibrillary acidic protein (gfap) mrna, a marker of gliosis, were assessed as markers of mptp neurotoxicity. |
1998-05-18 |
2023-08-12 |
mouse |