| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Begüm Harmancıoğlu, Seray Kabara. Maternal high fat diets: impacts on offspring obesity and epigenetic hypothalamic programming. Frontiers in genetics. vol 14. 2023-05-30. PMID:37252665. |
in addition, maternal hfd is associated with changes in the hypothalamic regulation of body weight and energy homeostasis by altering the expression of the leptin receptor, pomc, and neuropeptide y in the offspring, as well as altering methylation and gene expression of dopamine and opioid-related genes which cause changes in eating behavior. |
2023-05-30 |
2023-08-14 |
Not clear |
| Isabella Gaziano, Svenja Corneliussen, Nasim Biglari, René Neuhaus, Linyan Shen, Tamara Sotelo-Hitschfeld, Paul Klemm, Lukas Steuernagel, Alain J De Solis, Weiyi Chen, F Thomas Wunderlich, Peter Kloppenburg, Jens C Brünin. Dopamine-inhibited POMCDrd2+ neurons in the ARC acutely regulate feeding and body temperature. JCI insight. vol 7. issue 21. 2022-11-08. PMID:36345942. |
owing to the nature of these receptors, this translates into a predominant activation of agrp/npy neurons upon dopamine stimulation and a larger proportion of dopamine-inhibited pomc neurons. |
2022-11-08 |
2023-08-14 |
mouse |
| D Valent, L Arroyo, E Fàbrega, M Font-I-Furnols, M Rodríguez-Palmero, J A Moreno-Muñoz, J Tibau, A Bassol. Effects of a high-fat-diet supplemented with probiotics and ω3-fatty acids on appetite regulatory neuropeptides and neurotransmitters in a pig model. Beneficial microbes. vol 11. issue 4. 2021-04-13. PMID:32720835. |
the hypothalamus is the central part of the brain that regulates food intake by means of the production of food intake-regulatory hypothalamic neuropeptides, as neuropeptide y (npy), orexin a and pro-opiomelanocortin (pomc), and neurotransmitters, such as dopamine and serotonin. |
2021-04-13 |
2023-08-13 |
Not clear |
| L S Santos, R J B Matos, G S Cordeiro, G S Perez, D A E Santo, R T Silva, M S Gonçalves, G T Boaventura, T C B J Deiró, J M Barreto-Medeiro. Perinatal exposure to a high-fat diet alters proopiomelanocortin, neuropeptide Y and dopaminergic receptors gene expression and the food preference in offspring adult rats. Brazilian journal of biology = Revista brasleira de biologia. vol 82. 2021-03-19. PMID:33729380. |
the objective of this study was to investigate the effects of this diet on dopamine receptors (drd1 and drd2), proopiomelanocortin (pomc), neuropeptidey (npy) genes expression, and preference food in adult rats. |
2021-03-19 |
2023-08-13 |
rat |
| Alexandra G DiFeliceantonio, Paul J Kenn. Melanocortin 4 receptors switch reward to aversion. The Journal of clinical investigation. vol 128. issue 7. 2019-09-04. PMID:29911995. |
moreover, the authors provide evidence that avoidance behaviors are mediated by hypothalamic pomc neurons signaling to striatal dopamine d1 receptor-expressing medium spiny neurons. |
2019-09-04 |
2023-08-13 |
mouse |
| Mária Resc. [The addictive model of obesity: psychoneurobiological relationships]. Orvosi hetilap. vol 159. issue 27. 2018-08-21. PMID:29961372. |
another system participating in energy homeostasis besides the rewarding or dopamine controlling circles is the hypothalamic pro-opiomelanocortin (pomc) system. |
2018-08-21 |
2023-08-13 |
Not clear |
| Yu-Hui He, Ling Li, Xu-Fang Liang, Shan He, Luo Zhao, Yan-Peng Zhan. Inhibitory neurotransmitter serotonin and excitatory neurotransmitter dopamine both decrease food intake in Chinese perch (Siniperca chuatsi). Fish physiology and biochemistry. vol 44. issue 1. 2018-08-17. PMID:28929258. |
in the present study, the effects of serotonin (5-ht) and dopamine (da) on food intake were evaluated through intraventricular (icv) administration in chinese perch (siniperca chuatsi) and the mrna expression levels of neuropeptide y (npy), agouti gene-related protein (agrp), and pro-opiomelanocortin (pomc) were detected. |
2018-08-17 |
2023-08-13 |
Not clear |
| Ching-Han Yu, Yih-Shou Hsieh, Pei-Ni Chen, Jeng-Rung Chen, Dong-Yih Ku. Knockdown of the transcript of ERK in the brain modulates hypothalamic neuropeptide-mediated appetite control in amphetamine-treated rats. British journal of pharmacology. vol 175. issue 4. 2018-08-15. PMID:29215157. |
amphetamine is a releaser of dopamine stored in synaptic terminals, which can suppress appetite by changing the expression levels of neuropeptide y (npy) and proopiomelanocortin (pomc) in the hypothalamus. |
2018-08-15 |
2023-08-13 |
rat |
| L Recinella, S Leone, C Ferrante, A Chiavaroli, C Di Nisio, S Martinotti, M Vacca, L Brunetti, G Orland. Effects of central fibroblast growth factor 21 (FGF21) in energy balance. Journal of biological regulators and homeostatic agents. vol 31. issue 3. 2017-12-14. PMID:28889722. |
in addition, we evaluated the effects of fgf21 on orexigenic [agouti-related peptide (agrp) and neuropeptide y (npy)] and anorexigenic [cocaine and amphetamine-regulated transcript (cart) and proopiomelanocortin (pomc)] peptides, in the hypothalamus, and dopamine (da) and serotonin (5-hydroxytriptamine, 5-ht) levels in nucleus accumbens (nac). |
2017-12-14 |
2023-08-13 |
rat |
| Xiaobing Zhang, Anthony N van den Po. Hypothalamic arcuate nucleus tyrosine hydroxylase neurons play orexigenic role in energy homeostasis. Nature neuroscience. vol 19. issue 10. 2017-06-19. PMID:27548245. |
dopamine excited orexigenic neurons that synthesize agouti-related peptide and neuropeptide y but inhibited anorexigenic neurons that synthesize pomc, as determined by whole cell recording. |
2017-06-19 |
2023-08-13 |
mouse |
| Sarah J van Rijn, Marianne G Pouwer, Marianna A Tryfonidou, Guy C M Grinwis, Joanne E E van der Bend, Pauline E P F Beukers, Nadie Vastenhout, Jacques Drouin, Louis C Penning, Björn P Mei. Expression and clinical relevance of paired box protein 7 and sex determining region Y-box 2 in canine corticotroph pituitary adenomas. Veterinary journal (London, England : 1997). vol 204. issue 3. 2016-11-04. PMID:25956343. |
gene expression of pax7 target genes, such as proconvertase 2 (pc2), pro-opiomelanocortin (pomc), and dopamine d2 receptor (drd2), was significantly lower in the adenoma samples compared to normal tissue, indicating that pax7 signalling was not activated in adenomas. |
2016-11-04 |
2023-08-13 |
Not clear |
| Takayoshi Ubuka, You Lee Son, Kazuyoshi Tsutsu. Molecular, cellular, morphological, physiological and behavioral aspects of gonadotropin-inhibitory hormone. General and comparative endocrinology. vol 227. 2016-10-20. PMID:26409890. |
gnih neurons regulate not only gonadotropin synthesis and release in the pituitary, but also regulate various neurons in the brain, such as gnrh1, gnrh2, dopamine, pomc, npy, orexin, mch, crh, oxytocin, and kisspeptin neurons. |
2016-10-20 |
2023-08-13 |
Not clear |
| Yan Zhou, Francesco Leri, Erin Cummins, Mary Jeanne Kree. Individual differences in gene expression of vasopressin, D2 receptor, POMC and orexin: vulnerability to relapse to heroin-seeking in rats. Physiology & behavior. vol 139. 2015-08-19. PMID:25446223. |
in this study, we tested whether individual differences in the fs-induced heroin-seeking were associated with alterations of avp and v1b, as well as other stress responsive systems, including pro-opiomelanocortin (pomc), orexin, plasma acth and corticosterone, as well as dopamine d2 receptor (d2) and plasma prolactin. |
2015-08-19 |
2023-08-13 |
rat |
| Adimoolam Aruna, Ganesan Nagarajan, Ching-Fong Chan. The acute salinity changes activate the dual pathways of endocrine responses in the brain and pituitary of tilapia. General and comparative endocrinology. vol 211. 2015-05-21. PMID:25535862. |
to analyze and compare the stress and osmoregulatory hormones and receptors in pituitary during acute salinity changes, the expression patterns of corticotropin releasing hormone (crh) in hypothalamus, prolactin (prl) releasing peptide (prrp) in telencephalon and diencephalon, glucocorticoid receptors 2 (gr2), and mineralocorticoid receptor (mr), crh-r, pro-opiomelanocorticotropin (pomc), prrp, prl, dopamine 2 receptor (d2-r), growth hormone (gh), gh-receptor (gh-r) and insulin-like growth hormone (igf-1) transcripts in pituitary were characterized in euryhaline tilapia. |
2015-05-21 |
2023-08-13 |
Not clear |
| Liheng Wang, Kana Meece, Damian J Williams, Kinyui Alice Lo, Matthew Zimmer, Garrett Heinrich, Jayne Martin Carli, Charles A Leduc, Lei Sun, Lori M Zeltser, Matthew Freeby, Robin Goland, Stephen H Tsang, Sharon L Wardlaw, Dieter Egli, Rudolph L Leibe. Differentiation of hypothalamic-like neurons from human pluripotent stem cells. The Journal of clinical investigation. vol 125. issue 2. 2015-04-10. PMID:25555215. |
application of a notch inhibitor and brain-derived neurotrophic factor (bdnf) further directed the cells into arcuate nucleus hypothalamic-like neurons that express hypothalamic neuron markers proopiomelanocortin (pomc), neuropeptide y (npy), agouti-related peptide (agrp), somatostatin, and dopamine. |
2015-04-10 |
2023-08-13 |
human |
| Kenkichi Takase, Satoko Oda, Masaru Kuroda, Hiromasa Funat. Monoaminergic and neuropeptidergic neurons have distinct expression profiles of histone deacetylases. PloS one. vol 8. issue 3. 2013-08-27. PMID:23469282. |
here, we examined the expression profile of the hdac protein family from hdac1 to hdac11 in corticotropin-releasing hormone, oxytocin, vasopressin, agouti-related peptide (agrp), pro-opiomelanocortin (pomc), orexin, histamine, dopamine, serotonin, and noradrenaline neurons. |
2013-08-27 |
2023-08-12 |
Not clear |
| Kenkichi Takase, Satoko Oda, Masaru Kuroda, Hiromasa Funat. Monoaminergic and neuropeptidergic neurons have distinct expression profiles of histone deacetylases. PloS one. vol 8. issue 3. 2013-08-27. PMID:23469282. |
hdac10 expression was found in agrp neurons, pomc neurons, dopamine neurons and noradrenaline neurons but not in other neuronal groups. |
2013-08-27 |
2023-08-12 |
Not clear |
| L Paternain, M A Batlle, A L De la Garza, F I Milagro, J A Martínez, J Campió. Transcriptomic and epigenetic changes in the hypothalamus are involved in an increased susceptibility to a high-fat-sucrose diet in prenatally stressed female rats. Neuroendocrinology. vol 96. issue 3. 2013-05-09. PMID:22986707. |
hypothalamic gene expression analysis revealed that the hfs diet decreased slc6a3 (dopamine active transporter), npy (neuropeptide y) and ir (insulin receptor) and increased pomc (pro-opiomelanocortin). |
2013-05-09 |
2023-08-12 |
rat |
| Cornelia Schöne, Denis Burdako. Glutamate and GABA as rapid effectors of hypothalamic "peptidergic" neurons. Frontiers in behavioral neuroscience. vol 6. 2012-11-29. PMID:23189047. |
we then discuss latest optogenetic studies of endogenous transmitter release from defined sets of axons in situ, which suggest that recently characterized vital peptidergic neurons [e.g., hcrt/orx, proopiomelanocortin (pomc), and agouti-related peptide (agrp) cells], as well as classical modulatory neurons (e.g., dopamine and acetylcholine cells), all use fast transmitters to control their postsynaptic targets. |
2012-11-29 |
2023-08-12 |
Not clear |
| Kae Itoh, Youhei Washio, Yuichiro Fujinami, Daisuke Shimizu, Susumu Uji, Hayato Yokoi, Tohru Suzuk. Continuous illumination through larval development suppresses dopamine synthesis in the suprachiasmatic nucleus, causing activation of α-MSH synthesis in the pituitary and abnormal metamorphic skin pigmentation in flounder. General and comparative endocrinology. vol 176. issue 2. 2012-08-15. PMID:22326352. |
we therefore hypothesize that continuous ll inhibited dopamine synthesis in the scn, which resulted in up-regulation of pomc mrna expression in the melanotrophs. |
2012-08-15 |
2023-08-12 |
Not clear |