| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Muralidhar Hegde, Velmarini Vasquez, Manohar Kodavati, Joy Mitra, Indira Vendula, Dale Hamilton, Ralph Garruto, K S Ra. Mitochondria-Targeted Oligomeric α-Synuclein Induces TOM40 Degradation and Mitochondrial Dysfunction in Parkinson's Disease and Parkinsonism-Dementia of Guam. Research square. 2024-03-11. PMID:38464024. |
parkinson's disease related etiological factors, such as 6-hydroxy dopamine or ros/metal ions stress, which promote α-syn oligomerization, exacerbate tom40 depletion in pd patient-derived cells with snca gene triplication. |
2024-03-11 |
2024-03-14 |
Not clear |
| Haneen Y Khidr, Noha F Hassan, S S Abdelrahman, Mona R El-Ansary, Mohammed F El-Yamany, Mostafa A Rabi. Formoterol attenuated mitochondrial dysfunction in rotenone-induced Parkinson's disease in a rat model: Role of PINK-1/PARKIN and PI3K/Akt/CREB/BDNF/TrKB axis. International immunopharmacology. vol 125. issue Pt B. 2023-11-13. PMID:37956489. |
β2-adrenoreceptors (β2ar have been identified recently as regulators of the α-synuclein gene (snca), one of the key milieus endorsed in injury of dopamine neurons in parkinson's disease (pd). |
2023-11-13 |
2023-11-20 |
rat |
| I O Ishola, I O Awogbindin, T G Olubodun-Obadun, A E Olajiga, O O Adeyem. Vinpocetine prevents rotenone-induced Parkinson disease motor and non-motor symptoms through attenuation of oxidative stress, neuroinflammation and α-synuclein expressions in rats. Neurotoxicology. 2023-03-25. PMID:36965781. |
immunostainings showed that rotenone-induced dopamine neuron loss, microglia reactivity, astrocytes activation, toll-like receptor 4 (tlr4) and α-synuclein (snca) expressions which were attenuated by vinpocetine administration. |
2023-03-25 |
2023-08-14 |
rat |
| Ji-Hye Oh, Sungyang Jo, Kye Won Park, Eun-Jae Lee, Seung Hyun Lee, Yun Su Hwang, Ha Ra Jeon, Yeonjin Ryu, Hee Jeong Yoon, Sung-Min Chun, Chong Jai Kim, Tae Won Kim, Chang Ohk Sung, Sehyun Chae, Sun Ju Chun. Whole-genome sequencing reveals an association between small genomic deletions and an increased risk of developing Parkinson's disease. Experimental & molecular medicine. 2023-03-03. PMID:36869069. |
gpr27 was found to be expressed specifically in brain tissue, and gpr27 copy number loss was associated with upregulated snca expression and downregulated dopamine neurotransmitter pathways. |
2023-03-03 |
2023-08-14 |
Not clear |
| Inka Brockhausen, John Schutzbach, Jiabei Wang, Beth Fishwick, Jennifer Brockhause. Glycoconjugate journal special issue on: the glycobiology of Parkinson's disease. Glycoconjugate journal. 2021-11-10. PMID:34757539. |
this review examines the role of membrane lipids, glycolipids, glycoproteins and dopamine in the aggregation of snca and development of pd. |
2021-11-10 |
2023-08-13 |
Not clear |
| Plamena R Angelova, Minee L Choi, Alexey V Berezhnov, Mathew H Horrocks, Craig D Hughes, Suman De, Margarida Rodrigues, Ratsuda Yapom, Daniel Little, Karamjit S Dolt, Tilo Kunath, Michael J Devine, Paul Gissen, Mikhail S Shchepinov, Sergiy Sylantyev, Evgeny V Pavlov, David Klenerman, Andrey Y Abramov, Sonia Gandh. Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation. Cell death and differentiation. vol 27. issue 10. 2021-11-08. PMID:32341450. |
in human ipsc-derived neurons with snca triplication, physiological concentrations of glutamate and dopamine induce abnormal calcium signaling owing to the incorporation of excess α-synuclein oligomers into membranes, leading to altered membrane conductance and abnormal calcium influx. |
2021-11-08 |
2023-08-13 |
human |
| Oh-Chan Kwon, Jae-Jin Song, Yunseon Yang, Seong-Hoon Kim, Ji Young Kim, Min-Jong Seok, Inhwa Hwang, Je-Wook Yu, Jenisha Karmacharya, Han-Joo Maeng, Jiyoung Kim, Eek-Hoon Jho, Seung Yeon Ko, Hyeon Son, Mi-Yoon Chang, Sang-Hun Le. SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models. EMBO molecular medicine. vol 13. issue 4. 2021-10-25. PMID:33646633. |
along with those anti-inflammatory/neurotrophic functions, silencing and pharmacological inhibition of sgk1 protected midbrain dopamine neurons from degeneration and cured pathologic synuclein alpha (snca) aggregation and pd-associated behavioral deficits in multiple in vitro and in vivo pd models. |
2021-10-25 |
2023-08-13 |
Not clear |
| Kevin Burbidge, David J Rademacher, Jessica Mattick, Stephanie Zack, Andrea Grillini, Luc Bousset, Ochan Kwon, Konrad Kubicki, Alexander Simon, Ronald Melki, Edward M Campbel. LGALS3 (galectin 3) mediates an unconventional secretion of SNCA/α-synuclein in response to lysosomal membrane damage by the autophagic-lysosomal pathway in human midbrain dopamine neurons. Autophagy. 2021-10-06. PMID:34612142. |
here, we use a human midbrain dopamine (mda) neuronal culture model to provide evidence in support of a cellular mechanism that explains the cell-to-cell transfer of pathological forms of snca that are observed in pd. |
2021-10-06 |
2023-08-13 |
human |
| Kasthuri Bai Magalingam, Ammu Kutty Radhakrishnan, Sushela Devi Somanath, Shadab Md, Nagaraja Haleagrahar. Influence of serum concentration in retinoic acid and phorbol ester induced differentiation of SH-SY5Y human neuroblastoma cell line. Molecular biology reports. vol 47. issue 11. 2021-06-02. PMID:33098048. |
cells differentiated with ra/tpa or ra differentiated showed increased production of the α-synuclein (snca) neuroprotein and dopamine neurotransmitter compared to undifferentiated cells, regardless serum concentrations used. |
2021-06-02 |
2023-08-13 |
human |
| b' Irma J\\xc3\\xa4rvel\\xc3\\xa. Genomics studies on musical aptitude, music perception, and practice. Annals of the New York Academy of Sciences. 2019-11-20. PMID:29570792.' |
in addition to snca, several other genes were linked to dopamine metabolism. |
2019-11-20 |
2023-08-13 |
human |
| Sarah A McClymont, Paul W Hook, Alexandra I Soto, Xylena Reed, William D Law, Samuel J Kerans, Eric L Waite, Nicole J Briceno, Joey F Thole, Michael G Heckman, Nancy N Diehl, Zbigniew K Wszolek, Cedric D Moore, Heng Zhu, Jennifer A Akiyama, Diane E Dickel, Axel Visel, Len A Pennacchio, Owen A Ross, Michael A Beer, Andrew S McCallio. Parkinson-Associated SNCA Enhancer Variants Revealed by Open Chromatin in Mouse Dopamine Neurons. American journal of human genetics. vol 103. issue 6. 2019-05-14. PMID:30503521. |
parkinson-associated snca enhancer variants revealed by open chromatin in mouse dopamine neurons. |
2019-05-14 |
2023-08-13 |
mouse |
| Youngduk Seo, Kyoungjune Pak, Hyun Yeol Nam, Ju Won Seok, Myung Jun Lee, Eun Joo Kim, Jae Meen Lee, Seong Jang Kim, In Joo Ki. Effect of rs3910105 in the Synuclein Gene on Dopamine Transporter Availability in Healthy Subjects. Yonsei medical journal. vol 59. issue 6. 2018-07-31. PMID:29978616. |
the present study investigated associations between dopamine transporter (dat) availability and α-synuclein levels in cerebrospinal fluid, as well as synuclein gene (snca) transcripts, and the effect of single nucleotide polymorphism of snca on dat availability in healthy subjects. |
2018-07-31 |
2023-08-13 |
human |
| Xiaoxiao Hu, Xin Fu, A O Jiang, Xukui Yang, Xiaodong Fang, Guohua Gong, Chengxi We. Multiomic analysis of mice epilepsy models suggest that miR-21a expression modulates mRNA and protein levels related to seizure deterioration. Genetics research. vol 97. 2016-11-01. PMID:26689812. |
after isobaric tags for relative and absolute quantification (itraq) validation, only one gene, snca, remained, which was associated with apoptotic response of neuronal cells, and regulation of dopamine release and transport. |
2016-11-01 |
2023-08-13 |
mouse |
| Nadella Kumudini, Shaik Mohammad Naushad, Balraj Alex Stanley, Manoharan Niveditha, Gunasekaran Sharmila, Konda Kumaraswami, Rupam Borghain, Rukmini Mridula, Vijay Kumar Kutal. Comparative analysis of four disease prediction models of Parkinson's disease. Molecular and cellular biochemistry. vol 411. issue 1-2. 2016-10-28. PMID:26438087. |
to conclude, the ann model developed using snps in folate, xenobiotic, and dopamine pathways along with snca has higher clinical utility in predicting pd risk compared to other models. |
2016-10-28 |
2023-08-13 |
Not clear |
| Patricia Muñoz, Sergio Cardenas, Sandro Huenchuguala, Andrea Briceño, Eduardo Couve, Irmgard Paris, Juan Segura-Aguila. DT-Diaphorase Prevents Aminochrome-Induced Alpha-Synuclein Oligomer Formation and Neurotoxicity. Toxicological sciences : an official journal of the Society of Toxicology. vol 145. issue 1. 2016-05-16. PMID:25634539. |
it was reported that aminochrome induces the formation of alpha synuclein (snca) oligomers during dopamine oxidation. |
2016-05-16 |
2023-08-13 |
Not clear |
| Joseph J Locascio, Shirley Eberly, Zhixiang Liao, Ganqiang Liu, Ashley N Hoesing, Karen Duong, Ana Trisini-Lipsanopoulos, Kaltra Dhima, Albert Y Hung, Alice W Flaherty, Michael A Schwarzschild, Michael T Hayes, Anne-Marie Wills, U Shivraj Sohur, Nicte I Mejia, Dennis J Selkoe, David Oakes, Ira Shoulson, Xianjun Dong, Ken Marek, Bin Zheng, Adrian Ivinson, Bradley T Hyman, John H Growdon, Lewis R Sudarsky, Michael G Schlossmacher, Bernard Ravina, Clemens R Scherze. Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease. Brain : a journal of neurology. vol 138. issue Pt 9. 2015-11-16. PMID:26220939. |
here we show that snca transcripts in circulating blood cells are paradoxically reduced in early stage, untreated and dopamine transporter neuroimaging-supported parkinson's disease in three independent regional, national, and international populations representing 500 cases and 363 controls and on three analogue and digital platforms with p < 0.0001 in meta-analysis. |
2015-11-16 |
2023-08-13 |
human |
| Christina E Khodr, Amanda Becerra, Ye Han, Martha C Boh. Targeting alpha-synuclein with a microRNA-embedded silencing vector in the rat substantia nigra: positive and negative effects. Brain research. vol 1550. 2014-11-03. PMID:24463035. |
previously we showed that human (h)snca gene silencing using a short hairpin (sh)rna in rat substantia nigra (sn) protects against a hsnca-induced forelimb deficit, but not dopamine (da) neuron loss. |
2014-11-03 |
2023-08-12 |
human |
| Mickael Decressac, Anders Björklun. TFEB: Pathogenic role and therapeutic target in Parkinson disease. Autophagy. vol 9. issue 8. 2014-08-13. PMID:23715007. |
here we review our recent findings describing how snca impairs the function of the master regulator of the autophagy-lysosomal pathway (alp), the transcription factor eb (tfeb), and that genetic or pharmacological stimulation of its activity promotes protection of dopamine neurons. |
2014-08-13 |
2023-08-12 |
Not clear |
| Anna Oczkowska, Wojciech Kozubski, Jolanta Dorszewsk. [Alpha-synuclein in Parkinson's disease]. Przeglad lekarski. vol 71. issue 1. 2014-04-24. PMID:24712265. |
in pd aggregation of asn can be modulated by many factors like: oxidative stress, other neuronal proteins, parkin, catecholamines especially dopamine, and mutations of snca gene. |
2014-04-24 |
2023-08-13 |
Not clear |
| Anna Oczkowska, Wojciech Kozubski, Margarita Lianeri, Jolanta Dorszewsk. Mutations in PRKN and SNCA Genes Important for the Progress of Parkinson's Disease. Current genomics. vol 14. issue 8. 2014-02-17. PMID:24532983. |
despite numerous debates and controversies in the literature about the role of mutations in the snca and prkn genes in the pathogenesis of pd, it is evident that these genes play a key role in maintaining dopamine (da) neuronal homeostasis and that the dysfunction of this homeostasis is relevant to both familial (fpd) and sporadic (spd) pd with different onset. |
2014-02-17 |
2023-08-12 |
Not clear |