| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jose Luis Labandeira-Garcia, Carmen M Labandeira, Maria J Guerra, Ana I Rodriguez-Pere. The role of the brain renin-angiotensin system in Parkinson´s disease. Translational neurodegeneration. vol 13. issue 1. 2024-04-15. PMID:38622720. |
a decrease in the dopaminergic function induces upregulation of the angiotensin type-1 (at1) receptor activity, leading to recovery of dopamine levels. |
2024-04-15 |
2024-04-18 |
Not clear |
| Kallirhoe Kalinderi, Vasileios Papaliagkas, Liana Fidan. GLP-1 Receptor Agonists: A New Treatment in Parkinson's Disease. International journal of molecular sciences. vol 25. issue 7. 2024-04-13. PMID:38612620. |
many data on animal models and preclinical studies show that glp1-r agonists can restore dopamine levels, inhibit dopaminergic loss, attenuate neuronal degeneration and alleviate motor and non-motor features of pd. |
2024-04-13 |
2024-04-15 |
Not clear |
| Virginie Rappeneau, Fernando Castillo-Día. Convergence of Oxytocin and Dopamine Signaling in Neuronal Circuits: Insights into the Neurobiology of Social Interactions Across Species. Neuroscience and biobehavioral reviews. 2024-04-12. PMID:38608828. |
dopamine (da), is released by ventral tegmental area (vta) dopaminergic neurons, regulating social cues in the mesolimbic system. |
2024-04-12 |
2024-04-15 |
human |
| Cui Liu, Wen-Hong Liu, Wu Yang, Lei Chen, Yan Xue, Xin-Yi Che. GLP-1 modulated the firing activity of nigral dopaminergic neurons in both normal and parkinsonian mice. Neuropharmacology. 2024-04-10. PMID:38599494. |
the spontaneous firing activity of nigral dopaminergic neurons is associated with some important roles including modulation of dopamine release, expression of tyrosine hydroxylase (th), as well as neuronal survival. |
2024-04-10 |
2024-04-13 |
mouse |
| Cesar C Ceballos, Lei Ma, Maozhen Qin, Haining Zhon. Prevalent co-release of glutamate and GABA throughout the mouse brain. bioRxiv : the preprint server for biology. 2024-04-08. PMID:38585864. |
although dopaminergic axons release both glutamate and gaba in the striatum, deletion of dopamine neurons did not eliminate biphasic minis, indicating that the co-release originates from another neuronal type. |
2024-04-08 |
2024-04-10 |
mouse |
| Riccardo Avvisati, Anna-Kristin Kaufmann, Callum J Young, Gabriella E Portlock, Sophie Cancemi, Rui Ponte Costa, Peter J Magill, Paul D Dodso. Distributional coding of associative learning in discrete populations of midbrain dopamine neurons. Cell reports. vol 43. issue 4. 2024-04-06. PMID:38581677. |
here, we investigated the organizational logic of dopaminergic signaling by recording and labeling individual midbrain dopamine neurons during associative behavior. |
2024-04-06 |
2024-04-10 |
Not clear |
| Masaya Harada, Laia Serratosa Capdevila, Maria Wilhelm, Denis Burdakov, Tommaso Patriarch. Stimulation of VTA dopamine inputs to LH upregulates orexin neuronal activity in a DRD2-dependent manner. eLife. vol 12. 2024-04-03. PMID:38567902. |
it is known that hypothalamic orexinergic neurons project to dopamine neurons in the ventral tegmental area (vta), where they can stimulate dopaminergic neuronal activity. |
2024-04-03 |
2024-04-05 |
mouse |
| Masaya Harada, Laia Serratosa Capdevila, Maria Wilhelm, Denis Burdakov, Tommaso Patriarch. Stimulation of VTA dopamine inputs to LH upregulates orexin neuronal activity in a DRD2-dependent manner. eLife. vol 12. 2024-04-03. PMID:38567902. |
although there are reciprocal connections between dopaminergic and orexinergic systems, whether and how dopamine regulates the activity of orexin neurons is currently not known. |
2024-04-03 |
2024-04-05 |
mouse |
| Masaya Harada, Laia Serratosa Capdevila, Maria Wilhelm, Denis Burdakov, Tommaso Patriarch. Stimulation of VTA dopamine inputs to LH upregulates orexin neuronal activity in a DRD2-dependent manner. eLife. vol 12. 2024-04-03. PMID:38567902. |
furthermore, orexin neuron activity could also be upregulated by local stimulation of dopaminergic terminals in the lh in a way that is partially dependent on dopamine d2 receptors (drd2). |
2024-04-03 |
2024-04-05 |
mouse |
| Seong-Jin Yu, Yun Wang, Hui Shen, Eun-Kyung Bae, Yazhou Li, Kumar Sambamurti, Michael A Tones, Margaret M Zaleska, Barry J Hoffer, Nigel H Grei. DPP-4 inhibitors sitagliptin and PF-00734,200 mitigate dopaminergic neurodegeneration, neuroinflammation and behavioral impairment in the rat 6-OHDA model of Parkinson's disease. GeroScience. 2024-04-02. PMID:38563864. |
measures of dopaminergic cell viability, dopamine content, neuroinflammation and neurogenesis were evaluated thereafter in ipsi- and contralateral brain. |
2024-04-02 |
2024-04-04 |
human |
| Maya Molinari, Ori J Lieberman, David Sulzer, Emanuela Santini, Anders Borgkvis. 5-HT1B receptors mediate dopaminergic inhibition of vesicular fusion and GABA release from striatonigral synapses. bioRxiv : the preprint server for biology. 2024-04-01. PMID:38559006. |
the substantia nigra pars reticulata (snr), a crucial basal ganglia output nucleus, contains a dense expression of dopamine d1 receptors (d1rs), along with dendrites belonging to dopaminergic neurons of substantia nigra pars compacta. |
2024-04-01 |
2024-04-04 |
Not clear |
| Meghan L Bucher, Amy R Dunn, Joshua M Bradner, Kristen Stout Egerton, James P Burkett, Michelle A Johnson, Gary W Mille. Synaptic vesicle glycoprotein 2C enhances vesicular storage of dopamine and counters dopaminergic toxicity. The European journal of neuroscience. 2024-03-27. PMID:38532289. |
synaptic vesicle glycoprotein 2c enhances vesicular storage of dopamine and counters dopaminergic toxicity. |
2024-03-27 |
2024-03-29 |
mouse |
| Natchadaporn Sorraksa, Palakorn Kaokaen, Phongsakorn Kunhorm, Nudjanad Heebkaew, Wilasinee Promjantuek, Parinya Nois. Rapid induction of dopaminergic neuron-like cells from human fibroblasts by autophagy activation with only 2-small molecules. 3 Biotech. vol 14. issue 4. 2024-03-25. PMID:38524239. |
the dopaminergic neurons are responsible for the release of dopamine. |
2024-03-25 |
2024-03-27 |
human |
| Natchadaporn Sorraksa, Palakorn Kaokaen, Phongsakorn Kunhorm, Nudjanad Heebkaew, Wilasinee Promjantuek, Parinya Nois. Rapid induction of dopaminergic neuron-like cells from human fibroblasts by autophagy activation with only 2-small molecules. 3 Biotech. vol 14. issue 4. 2024-03-25. PMID:38524239. |
different proteins and factors related to dopaminergic neurons (th, tuj1, and dopamine) were significantly increased in cells that behave like dopaminergic neurons after treatment. |
2024-03-25 |
2024-03-27 |
human |
| Aineng Peng, Jianbo Chai, Haiyuan Wu, Bing Bai, Huihui Yang, Weizhi He, Yonghou Zha. New Therapeutic Targets and Drugs for Schizophrenia Beyond Dopamine D2 Receptor Antagonists. Neuropsychiatric disease and treatment. vol 20. 2024-03-25. PMID:38525480. |
the first generation of antipsychotics was developed based on dopaminergic receptor antagonism, which blocks dopamine d2 receptors in the brain to exert antipsychotic effects. |
2024-03-25 |
2024-03-27 |
Not clear |
| Sheena K Au-Yeung, Don Chamith Halahakoon, Alexander Kaltenboeck, Philip Cowen, Michael Browning, Sanjay G Manoha. The effects of pramipexole on motivational vigour during a saccade task: a placebo-controlled study in healthy adults. Psychopharmacology. 2024-03-18. PMID:38494550. |
this effect, termed motivational vigour, has been proposed to rely on central dopamine, with dopaminergic agents showing promise in the treatment of depression. |
2024-03-18 |
2024-03-20 |
human |
| Dianmei Yu, Haiyan Wang, Yiwen Zhai, Zhixiang Lei, Minglu Sun, Si Chen, Panfeng Yin, Xianchun Wan. Effects of latroeggtoxin-VI on dopamine and α-synuclein in PC12 cells and the implications for Parkinson's disease. Biological research. vol 57. issue 1. 2024-03-16. PMID:38491377. |
parkinson's disease (pd) is characterized by death of dopaminergic neurons leading to dopamine deficiency, excessive α-synuclein facilitating lewy body formation, etc. |
2024-03-16 |
2024-03-19 |
spider |
| Xiaojuan Lu, Yixing Song, Jiaqi Wang, Yunyun Cai, Siwan Peng, Jiaqi Lin, Biqin Lai, Junjie Sun, Tianqing Liu, Gang Chen, Lingyan Xin. Developmental dopaminergic signaling modulates neural circuit formation and contributes to autism spectrum disorder (ASD)-related phenotypes. The American journal of pathology. 2024-03-16. PMID:38492733. |
these findings shed light on the mechanisms underlying the link between disrupted developmental dopamine signaling and asd, and they point to the possibility of targeting dopaminergic signaling in early development for asd treatment. |
2024-03-16 |
2024-03-19 |
human |
| Sherilyn Junelle Recinto, Shobina Premachandran, Sriparna Mukherjee, Alexis Allot, Adam MacDonald, Moein Yaqubi, Samantha Gruenheid, Louis-Eric Trudeau, Jo Anne Stratto. Characterizing enteric neurons in dopamine transporter (DAT)-Cre reporter mice reveals dopaminergic subtypes with dual-transmitter content. The European journal of neuroscience. 2024-03-15. PMID:38487941. |
characterizing enteric neurons in dopamine transporter (dat)-cre reporter mice reveals dopaminergic subtypes with dual-transmitter content. |
2024-03-15 |
2024-03-17 |
mouse |
| Wan-Hsuan Chang, Hung-Te Hsu, Chih-Cheng Lin, Li-Mei An, Chien-Hsing Lee, Horng-Huey Ko, Chih-Lung Lin, Yi-Ching L. Linalool, a Fragrance Compound in Plants, Protects Dopaminergic Neurons and Improves Motor Function and Skeletal Muscle Strength in Experimental Models of Parkinson's Disease. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38473763. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by the gradual loss of dopaminergic neurons in the substantia nigra pars compacta (snpc), resulting in reduced dopamine levels in the striatum and eventual onset of motor symptoms. |
2024-03-13 |
2024-03-15 |
Not clear |