| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lindsey D McGill, Naze G Avci, Tina Kazemi, Yoshinori Sunaga, Yasemin M Akay, Metin Aka. Prenatal nicotine exposure alters gene expression profiles of neurons in the sub-regions of the VTA during early postnatal development. Scientific reports. vol 13. issue 1. 2023-03-25. PMID:36966190. |
real time pcr was used to find the relative expressions of gamma-aminobutyric acid (gaba), dopamine, and glutamate neuron markers within the three sub-regions of the vta including the parabrachial pigmented nucleus (pbp), parainterfascicular (pif), and paranigral nucleus (pn). |
2023-03-25 |
2023-08-14 |
human |
| Xia Liu, Yiqun Fang, Jiajun Xu, Tao Yang, Ji Xu, Jia He, Wenwu Liu, Xuhua Yu, Yukun Wen, Naixia Zhang, Ci L. Oxidative stress, dysfunctional energy metabolism, and destabilizing neurotransmitters altered the cerebral metabolic profile in a rat model of simulated heliox saturation diving to 4.0 MPa. PloS one. vol 18. issue 3. 2023-03-14. PMID:36917582. |
the significant metabolic abnormalities of amino acid neurotransmitters, such as gaba, glycine, and aspartate, decreased aromatic amino acids, including tyrosine and phenylalanine, both of which are involved in the metabolism of dopamine and noradrenaline, which are downregulated in the cortex. |
2023-03-14 |
2023-08-14 |
rat |
| Flavia Barreto Garcez, Júlio César Garcia de Alencar, Shirley Steffany Muñoz Fernandez, Vivian Iida Avelino-Silva, Ester Cerdeira Sabino, Roberta Cristina Ruedas Martins, Lucas Augusto Moysés Franco, Sandra Maria Lima Ribeiro, Heraldo Possolo de Souza, Thiago Junqueira Avelino-Silv. Association between gut microbiota and delirium in acutely ill older adults. The journals of gerontology. Series A, Biological sciences and medical sciences. 2023-03-04. PMID:36869725. |
bacterial taxa associated with pro-inflammatory pathways (enterobacteriaceae) and modulation of relevant neurotransmitters (serratia: dopamine; bacteroides, parabacteroides: gaba) were more common in participants with delirium. |
2023-03-04 |
2023-08-14 |
human |
| Nao Chuhma, Soo Jung Oh, Stephen Raypor. The dopamine neuron synaptic map in the striatum. Cell reports. vol 42. issue 3. 2023-03-03. PMID:36867530. |
dopamine neurons project to the striatum to control movement, cognition, and motivation via slower volume transmission as well as faster dopamine, glutamate, and gaba synaptic actions capable of conveying the temporal information in dopamine neuron firing. |
2023-03-03 |
2023-08-14 |
Not clear |
| Yajie Guo, Zhongxin Jiang, Tingting Jin, Jinfang Huang, Xiangrong Su. Activation of calcium-sensing receptors in the basolateral nucleus of the amygdala inhibits food intake and induces anxiety-depressive-like emotions via dopamine system. Behavioural brain research. 2023-02-22. PMID:36813182. |
our results showed that microinjection of r568 into the bla could inhibit both standard and palatable food intake in mice for 0-2h, induce anxiety-depression-like behaviours, increase glutamate levels in the bla, and activate dynorphin and gamma-aminobutyric acid neurons through the n-methyl-d-aspartate receptor and thus reduce the content of dopamine in the arcuate nucleus of the hypothalamus (arc) and ventral tegmental area (vta), respectively. |
2023-02-22 |
2023-08-14 |
mouse |
| Isaac Ostlund, Michael Von Gunten, Calvin Smith, Jeffrey G Edward. Chronic Δ9-tetrahydrocannabinol impact on plasticity, and differential activation requirement for CB1-dependent long-term depression in ventral tegmental area GABA neurons in adult versus young mice. Frontiers in neuroscience. vol 16. 2023-01-26. PMID:36699526. |
the ventral tegmental area (vta) mediates incentive salience and reward prediction error through dopamine (da) neurons that are regulated by local vta gaba neurons. |
2023-01-26 |
2023-08-14 |
mouse |
| Nittiya Nontunha, Ruchanok Tinikul, Supakant Chaichotranunt, Tanes Poomtong, Prasert Sobhon, Yotsawan Tiniku. The presence and distribution of gamma-aminobutyric acid and dopamine during the developmental stages of the sea cucumber, Holothuria scabra, with emphasis on settlement organs. Cell and tissue research. 2023-01-25. PMID:36697719. |
in the sea cucumber, holothuria scabra, the competent larvae require main settlement organs (sos), including the ciliary bands (cibs), tentacles (ts), podia (pds), and cues from neurotransmitters, including gamma-aminobutyric acid (gaba) and dopamine (da), for successful settlement. |
2023-01-25 |
2023-08-14 |
Not clear |
| Jonaid Ahmad Malik, Zahid Yaseen, Lahari Thotapalli, Sakeel Ahmed, Mohd Farooq Shaikh, Sirajudheen Anwa. Understanding translational research in schizophrenia: A novel insight into animal models. Molecular biology reports. 2023-01-24. PMID:36692676. |
dopamine, glutamate, gaba, and serotonin are the neurotransmitters involved in the pathophysiology of schizophrenia. |
2023-01-24 |
2023-08-14 |
Not clear |
| Yifeng Shi, Mengqi Wang, Linglong Xiao, Luolan Gui, Wen Zheng, Lin Bai, Bo Su, Bin Li, Yangyang Xu, Wei Pan, Jie Zhang, Wei Wan. Potential therapeutic mechanism of deep brain stimulation of the nucleus accumbens in obsessive-compulsive disorder. Frontiers in cellular neuroscience. vol 16. 2023-01-23. PMID:36687525. |
furthermore, we found that the local levels of monoamines [dopamine (da) and serotonin (5-ht)] and amino acids [glutamate (glu) and gamma-aminobutyric acid (gaba)] in the nac were increased in ocd status, and that the expression of the two types of da receptors in the nac exhibited an opposite change. |
2023-01-23 |
2023-08-14 |
rat |
| Junhua Yang, Jianan Chen, Yongqing Liu, Kevin Hong Chen, Jay M Baraban, Zhaozhu Qi. Ventral tegmental area astrocytes modulate cocaine reward by tonically releasing GABA. Neuron. 2023-01-21. PMID:36681074. |
addictive drugs increase ventral tegmental area (vta) dopamine (da) neuron activity through distinct cellular mechanisms, one of which involves disinhibition of da neurons by inhibiting local gaba neurons. |
2023-01-21 |
2023-08-14 |
mouse |
| Claire Elena Manning, Michael Fritz, Julie Ann Kaue. Function of excitatory periaqueductal grey synapses in the ventral tegmental area following inflammatory injury. eNeuro. 2023-01-12. PMID:36635253. |
in this study, we used male and female mice in combination with identified dopamine and gaba neurons in the vta that receive excitatory inputs from the periaqueductal grey (pag), a nexus of ascending pain information. |
2023-01-12 |
2023-08-14 |
mouse |
| Yilu Sun, Jia Zhao, Jianhui Ron. Dissecting the molecular mechanisms underlying the antidepressant activities of herbal medicines through the comprehensive review of the recent literatures. Frontiers in psychiatry. vol 13. 2023-01-09. PMID:36620687. |
the pathophysiology of depression is tightly regulated by the biosynthesis, transport and signaling of neurotransmitters [e.g., serotonin, norepinephrine, dopamine, or γ-aminobutyric acid (gaba)] in the central nervous system. |
2023-01-09 |
2023-08-14 |
Not clear |
| Huan Sheng, Chao Lei, Yu Yuan, Yali Fu, Dongyang Cui, Li Yang, Da Shao, Zixuan Cao, Hao Yang, Xinli Guo, Chenshan Chu, Yaxian Wen, Zhangyin Cai, Ming Chen, Bin Lai, Ping Zhen. Nucleus accumbens circuit disinhibits lateral hypothalamus glutamatergic neurons contributing to morphine withdrawal memory in male mice. Nature communications. vol 14. issue 1. 2023-01-05. PMID:36604429. |
in the present study,our results showed that in male mice, during context-induced expression of morphine withdrawal memory, lh glutamatergic neurons played an important role; dopamine d1 receptor-expressing medium spiny neurons (d1-msns) projecting from the core of nucleus accumbens (nacc) to the lh were an important upstream circuit to activate lh glutamatergic neurons; d1-msns projecting from the nacc to the lh activated lh glutamatergic neurons through inhibiting lh local gamma-aminobutyric acid (gaba) neurons. |
2023-01-05 |
2023-08-14 |
mouse |
| Damian Dyńka, Katarzyna Kowalcze, Agnieszka Paziewsk. The Role of Ketogenic Diet in the Treatment of Neurological Diseases. Nutrients. vol 14. issue 23. 2022-12-11. PMID:36501033. |
a wide range of the mechanisms of action of the ketogenic diet has been demonstrated in neurological diseases, including, among other effects, its influence on the reduction in inflammatory conditions and the amount of reactive oxygen species (ros), the restoration of the myelin sheath of the neurons, the formation and regeneration of mitochondria, neuronal metabolism, the provision of an alternative source of energy for neurons (ketone bodies), the reduction in glucose and insulin concentrations, the reduction in amyloid plaques, the induction of autophagy, the alleviation of microglia activation, the reduction in excessive neuronal activation, the modulation of intestinal microbiota, the expression of genes, dopamine production and the increase in glutamine conversion into gaba. |
2022-12-11 |
2023-08-14 |
Not clear |
| Paul Pålsson, Jolanta Guldberg, Jenny M Gustafsson, Harald Aif. Coma, Severe Hypotension, and Pinpoint Pupils After Olanzapine Intoxication in the Intensive Care Unit with Symptom Reversal After Administration of Flumazenil. The American journal of case reports. vol 23. 2022-12-01. PMID:36451528. |
olanzapine mainly effects dopamine, serotonin, a1-adrenergic, histamine, and muscarinic receptors, but a low affinity to gaba and benzodiazepine sites can perhaps explain the observed effect. |
2022-12-01 |
2023-08-14 |
Not clear |
| Daniel C Lowes, Alexander Z Harri. Stressed and wired: The effects of stress on the VTA circuits underlying motivated behavior. Current opinion in endocrine and metabolic research. vol 26. 2022-11-21. PMID:36406203. |
stress has correspondingly diverse effects on vta neuron activity, tending to decrease lateral vta dopamine (da) neuron activity, while increasing medial vta da and gaba neuron activity. |
2022-11-21 |
2023-08-14 |
Not clear |
| Lihui Du, Liping Xiao, Chenglin Zou, Jinrong Huan. Vanillin attenuates the ethanol withdrawal syndrome and ethanol withdrawal induced anxiety by regulating the neurochemical balance. Folia neuropathologica. vol 60. issue 3. 2022-11-16. PMID:36382484. |
treatment with vanillin ameliorates the altered level of g-aminobutyric acid (gaba), dopamine and glutamate and level of corticosterone in ethanol withdrawal rats. |
2022-11-16 |
2023-08-14 |
rat |
| Wen-Liang Zhou, Kristen Kim, Farhan Ali, Steven T Pittenger, Cali A Calarco, Yann S Mineur, Charu Ramakrishnan, Karl Deisseroth, Alex C Kwan, Marina R Picciott. Activity of a direct VTA to ventral pallidum GABA pathway encodes unconditioned reward value and sustains motivation for reward. Science advances. vol 8. issue 42. 2022-10-19. PMID:36260661. |
this vta gaba projection provides information about reward value directly to the vp, likely distinct from the prediction error signal carried by vta dopamine neurons. |
2022-10-19 |
2023-08-14 |
mouse |
| Susen Becker, Anja Schulz, Sophia Kreyer, Jan Dreßler, Angelika Richter, Christin Helmschrod. Sensitive and simultaneous quantification of 16 neurotransmitters and metabolites in murine microdialysate by fast liquid chromatography-tandem mass spectrometry. Talanta. vol 253. 2022-10-08. PMID:36208557. |
the quantitative analysis of 16 neurotransmitters and metabolites, including serotonin (5-ht), 5-hydroxyindoleacetic acid (5-hiaa), melatonin (me), dopamine (da), levodopa (l-dopa), 3-methoxytyramine (3-mt), norepinephrine (ne), epinephrine (ep), homovanillinic acid (hva), acetylcholine (ach), deoxy carnitine (iso-ach), choline (ch), and ɣ-aminobutyric acid (gaba), adenosine (ade), glutamine (gln), and glutamic acid (glu) was achieved within a chromatographic separation time of 6.5 min by the application of a biphenyl column coupled to an api-qtrap 5500 (ab sciex) mass spectrometer. |
2022-10-08 |
2023-08-14 |
mouse |
| Soomin Jeong, Soogyeong Jang, Seong Soon Kim, Myung Ae Bae, Junnyung Shin, Ki-Baek Lee, Ki-Tae Ki. Size-dependent seizurogenic effect of polystyrene microplastics in zebrafish embryos. Journal of hazardous materials. vol 439. 2022-09-15. PMID:36104895. |
additionally, an increase in the levels of neurochemicals choline, betaine, dopamine, 3-methoxytyramine, and gamma-aminobutyric acid indicated that the observed hypoactivity and seizure-like behavior were associated with the dysregulation of the cholinergic, dopaminergic, and gabaergic systems. |
2022-09-15 |
2023-08-14 |
zebrafish |