| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kavitha Ukkirapandian, Kayalvizhi Elumalai, Karthika Priyadharshini Udaykumar, Sundaravadivel Vp, Muthulakshmi Rangasm. Behavioral and Biochemical Assays for Autism Models of Wistar Rats. Cureus. vol 16. issue 1. 2024-02-13. PMID:38344592. |
the estimation of antioxidant profile (malondialdehyde {mda}, glutathione {gsh}, catalase (cat), and superoxide dismutase {sod}), proinflammatory markers (tumor necrosis factor {tnf} alpha, transforming growth factor {tgf} beta, interleukin {il} 6, and il-1 beta), neurotransmitters (gamma-aminobutyric acid {gaba} and serotonin), and brain-derived neurotrophic factor (bdnf) in the hippocampal region was done. |
2024-02-13 |
2024-02-15 |
rat |
| Kavitha Ukkirapandian, Kayalvizhi Elumalai, Karthika Priyadharshini Udaykumar, Sundaravadivel Vp, Muthulakshmi Rangasm. Behavioral and Biochemical Assays for Autism Models of Wistar Rats. Cureus. vol 16. issue 1. 2024-02-13. PMID:38344592. |
rats with autism had a significant decrease in gaba and bdnf levels. |
2024-02-13 |
2024-02-15 |
rat |
| Navneet Dhaliwal, Jatinder Dhaliwal, Kanwaljit Chopr. 7, 8-dihydroxyflavone Ameliorates Cholinergic Dysfunction, Inflammation, Oxidative Stress, and Apoptosis in a Rat Model of Vascular Dementia. Neurochemical research. 2024-02-01. PMID:38300457. |
p-akt, p-creb, bdnf, and neurotransmitter (nt) (glu, gaba, and ach) levels were also analyzed in the hippocampus of 2-vo rats. our results show that 7,8-dhf effectively improved memory performance and cholinergic dysfunction in 2-vo model rats. |
2024-02-01 |
2024-02-03 |
rat |
| Ahlam H Mahmoud, Doaa M Elhefnawei, Mohamed A El-Desouky, Mai O Kadr. Reciprocal crosslink among MeCP2/BDNF /CREB signaling pinpointed in autism spectrum disorder. Toxicology reports. vol 12. 2024-01-17. PMID:38229920. |
the neurotransmitters gamma amino-butyric acid (gaba), acetylcholine (ach), and acetylcholinesterase (ache) in addition to, the gene expressions of brain-derived neurotrophic factor (bdnf), camp response element-binding protein (creb), and methyl-cpg-binding protein 2 (mecp2) and the dna damage comet analysis at different time intervals of the study, were assessed. |
2024-01-17 |
2024-01-19 |
rat |
| Ahlam H Mahmoud, Doaa M Elhefnawei, Mohamed A El-Desouky, Mai O Kadr. Reciprocal crosslink among MeCP2/BDNF /CREB signaling pinpointed in autism spectrum disorder. Toxicology reports. vol 12. 2024-01-17. PMID:38229920. |
the results revealed that nq and lnq significantly down-regulated bdnf, gaba, and ache; on the other hand, they up-regulated mecp2, creb gene expressions, and ach action. |
2024-01-17 |
2024-01-19 |
rat |
| Ngoc Buu Tran, Sook-Jeong Le. Effects of Gryllus bimaculatus and Oxya chinensis sinuosa extracts on brain damage via blood-brain barrier control and apoptosis in mice with pentylenetetrazol-induced epilepsy. PloS one. vol 18. issue 9. 2023-09-11. PMID:37695764. |
in addition, gb and ocs extracts rescued ptz-induced hyperexcitable neurons to control mice level, as supported by the restored expression of gamma-aminobutyric acid (gaba) transporter 1, the metabotropic glutamate receptors-grm2/3, and bdnf. |
2023-09-11 |
2023-10-07 |
mouse |
| Huiwen Kang, Wei Zhang, Jiaru Jing, Danyang Huang, Lei Zhang, Jingyu Wang, Lin Han, Ziyan Liu, Ziyan Wang, Ai Ga. The gut-brain axis involved in polystyrene nanoplastics-induced neurotoxicity via reprogramming the circadian rhythm-related pathways. Journal of hazardous materials. vol 458. 2023-07-01. PMID:37392641. |
we found that 80 nm ps-nps could reach and cause neuronal damage in the hippocampus, and alter the expression of neuroplasticity-related molecules (5-ht, ache, gaba, bdnf and creb), and even affect the learning and memory ability of mice. |
2023-07-01 |
2023-08-14 |
mouse |
| Kenta Deriha, Eri Hashimoto, Wataru Ukai, Francesca Marchisella, Emi Nishimura, Hanako Hashiguchi, Masaya Tayama, Takao Ishii, Marco A Riva, Chiaki Kawanish. Reduced sociability in a prenatal immune activation model: Modulation by a chronic blonanserin treatment through the amygdala-hippocampal axis. Journal of psychiatric research. vol 164. 2023-06-28. PMID:37379611. |
low dose of blonanserin and haloperidol altered gaba and glutamate-related mrna levels, the e/i ratio, and bdnf long 3'utr mrna levels in the ventral hippocampus and amygdala, but did not attenuate behavioral impairments. |
2023-06-28 |
2023-08-14 |
rat |
| Ka Wai Chan, Jennifer Hebert, Daniel Radford-Smith, Daniel C Anthony, Philip Wj Burne. Live or heat-killed probiotic administration reduces anxiety and central cytokine expression in BALB/c mice, but differentially alters brain neurotransmitter gene expression. Neuropharmacology. 2023-05-07. PMID:37150398. |
furthermore, probiotic administration elevated hippocampal bdnf and decreased gaba |
2023-05-07 |
2023-08-14 |
mouse |
| Ahd A Atta, Weam W Ibrahim, Ahmed F Mohamed, Noha F Abdelkade. Microglia polarization in nociplastic pain: mechanisms and perspectives. Inflammopharmacology. 2023-04-17. PMID:37069462. |
lps lipopolysaccharide, tnf-α tumor necrosis factor-α, inf-γ interferon gamma, atp adenosine triphosphate, 49 p2y12/13r purinergic p2y 12/13 receptor, p2x4/7r purinergic p2x 4/7 receptor, sp substance p, nk-1r neurokinin 1 receptor, ccl2 cc motif ligand 2, ccr2 cc motif ligand 2 receptor, csf-1 colony-stimulating factor 1, csf-1r colony-stimulating factor 1 receptor, cx3cl1 cx3c motif ligand 1, cx3xr1 cx3c motif ligand 1 receptor, tlr toll-like receptor, mapk mitogen-activated protein kinases, jnk jun n-terminal kinase, erk extracellular signal-regulated kinase, inos inducible nitric oxide synthase, il-1β interleukin-1β, il-6 interleukin-6, bdnf brain-derived neurotrophic factor, gaba γ-aminobutyric acid, gabar γ-aminobutyric acid receptor, nmdar n-methyl-d-aspartate receptor, ampar α-amino-3-hydroxy-5-methyl-4-isoxazolepropi-onic acid receptor, il-4 interleukin-4, il-13 interleukin-13, il-10 interleukin-10, arg-1 arginase 1, fgf fibroblast growth factor, gdnf glial cell-derived neurotrophic factor, igf-1 insulin-like growth factor-1, ngf nerve growth factor, cd cluster of differentiation. |
2023-04-17 |
2023-08-14 |
Not clear |
| Guanlan Liu, Israr Khan, Yuxi Li, Yun Yang, Xuerui Lu, Yafei Wang, Junxiang Li, Chunjiang Zhan. Overcoming Anxiety Disorder by Probiotic Foods (Basel, Switzerland). vol 11. issue 22. 2023-03-08. PMID:36429192. |
lzu-j-tsl6 was able to effectively increase the gaba content in the mice hippocampus (p < 0.0001) and restore some markers related to anxiety such as brain-derived neurotrophic factor (bdnf), glial fibrillary acidic protein (gfap), and 5-hydroxytryptamine (5-ht). |
2023-03-08 |
2023-08-16 |
mouse |
| Mehdi Zargani, Rodrigo Ramirez-Campillo, Ehsan Arabzade. Swimming and L-arginine loaded chitosan nanoparticles ameliorates aging-induced neuron atrophy, autophagy marker LC3, GABA and BDNF-TrkB pathway in the spinal cord of rats. Pflugers Archiv : European journal of physiology. 2023-03-04. PMID:36869900. |
the old sw + la-cnps group increased (improved) spinal cord gaba (p = 0.0187), bdnf (p = 0.0003), trkb (p < 0.0001) gene expression, decreased autophagy marker lc3 protein (p < 0.0001), nerve atrophy and jumping/licking latency (p < 0.0001), improved sciatic functional index score and total oxidant status/total antioxidant capacity compared to the old group (p < 0.0001). |
2023-03-04 |
2023-08-14 |
rat |
| Aya A Zayed, Mae M Seleem, Hebatallah A Darwish, Amira A Shahee. Role of long noncoding RNAs; BDNF-AS and 17A and their relation to GABAergic dysfunction in Egyptian epileptic patients. Metabolic brain disease. 2023-02-22. PMID:36807083. |
this study investigated the expression levels of lncrnas; bdnf-as and 17a in the sera of egyptian patients with idiopathic generalized and symptomatic focal epilepsy and correlated their levels with brain-derived neurotrophic factor (bdnf), phosphorylated camp reaction element -binding protein (p-creb), gamma- aminobutyric acid (gaba) and glutamate, to underline their related molecular mechanism. |
2023-02-22 |
2023-08-14 |
Not clear |
| Aya A Zayed, Mae M Seleem, Hebatallah A Darwish, Amira A Shahee. Role of long noncoding RNAs; BDNF-AS and 17A and their relation to GABAergic dysfunction in Egyptian epileptic patients. Metabolic brain disease. 2023-02-22. PMID:36807083. |
epileptic patients showed significantly lower levels of bdnf, p-creb, gaba along with significant increase of glutamate levels and glutamate/ gaba ratio, especially in symptomatic focal versus idiopathic generalized epileptic ones. |
2023-02-22 |
2023-08-14 |
Not clear |
| Heng-Chang Zhang, Yang Du, Lei Chen, Zeng-Qiang Yuan, Yong Chen. MicroRNA Schizophrenia: Etiology, Biomarkers and Therapeutic Targets. Neuroscience and biobehavioral reviews. 2023-01-27. PMID:36707012. |
it is now commonly believed that in addition to the traditional dopaminergic mesolimbic pathway, the etiology of schizophrenia also includes neuronal networks, such as glutamate, gaba, serotonin, bdnf, oxidative stress, inflammation and the immune system. |
2023-01-27 |
2023-08-14 |
human |
| Bich Phuong Bui, Phuong Linh Nguyen, Ha Thi Thu Do, Jungsook Ch. Corrigendum to' Anxiolytic effect of Korean Red Ginseng through upregulation of serotonin and GABA transmission and BDNF expression in immobilized mice' [Journal of Ginseng Research Volume 46, Issue 6, November 2022, Pages 819-829]. Journal of ginseng research. vol 47. issue 1. 2023-01-16. PMID:36644391. |
corrigendum to' anxiolytic effect of korean red ginseng through upregulation of serotonin and gaba transmission and bdnf expression in immobilized mice' [journal of ginseng research volume 46, issue 6, november 2022, pages 819-829]. |
2023-01-16 |
2023-08-14 |
mouse |
| Bich Phuong Bui, Phuong Linh Nguyen, Ha Thi Thu Do, Jungsook Ch. Anxiolytic effect of Korean Red Ginseng through upregulation of serotonin and GABA transmission and BDNF expression in immobilized mice. Journal of ginseng research. vol 46. issue 6. 2022-10-31. PMID:36312738. |
anxiolytic effect of korean red ginseng through upregulation of serotonin and gaba transmission and bdnf expression in immobilized mice. |
2022-10-31 |
2023-08-14 |
mouse |
| Bich Phuong Bui, Phuong Linh Nguyen, Ha Thi Thu Do, Jungsook Ch. Anxiolytic effect of Korean Red Ginseng through upregulation of serotonin and GABA transmission and BDNF expression in immobilized mice. Journal of ginseng research. vol 46. issue 6. 2022-10-31. PMID:36312738. |
the present study investigated the effect of krg on immobilization-induced anxiety-like behaviors in mice and explored the involvement of the serotonin and gaba systems and bdnf in the anxiolytic action. |
2022-10-31 |
2023-08-14 |
mouse |
| Yaiza M Arenas, Mar Martínez-García, Marta Llansola, Vicente Felip. Enhanced BDNF and TrkB Activation Enhance GABA Neurotransmission in Cerebellum in Hyperammonemia. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36233065. |
enhanced bdnf and trkb activation enhance gaba neurotransmission in cerebellum in hyperammonemia. |
2022-10-14 |
2023-08-14 |
rat |
| Yaiza M Arenas, Mar Martínez-García, Marta Llansola, Vicente Felip. Enhanced BDNF and TrkB Activation Enhance GABA Neurotransmission in Cerebellum in Hyperammonemia. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36233065. |
in the cerebellum of hyperammonemic rats, increased bdnf levels enhance trkb activation in purkinje neurons, leading to increased gad65, gad67 and gaba levels. |
2022-10-14 |
2023-08-14 |
rat |