| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yongchao Gao, Chao Sun, Ting Gao, Zhiyong Liu, Zhao Yang, Hui Deng, Peng Fan, Junhong Ga. Taurine ameliorates volatile organic compounds-induced cognitive impairment in young rats Frontiers in veterinary science. vol 9. 2022-10-03. PMID:36187803. |
moreover, taurine decreased malondialdehyde (mda), γ-aminobutyric acid (gaba), aspartate aminotransferase (ast), alanine aminotransferase (alt), urea, creatinine (crea) and injury biomarker level, enhanced superoxide dismutase (sod), reduced glutathione (gsh) and glutamic acid (glu) activities, up-regulated the protein expression of brain derived neurotrophic factor (bdnf) and n-methyl-d-aspartate receptor 1 (nmdar1) in model rats, and in most of cases 1% but not 0.5%, ameliorated the defects induced by vocs. |
2022-10-03 |
2023-08-14 |
rat |
| Nikita S Persaud, Hannah M Cate. The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review. eNeuro. 2022-08-23. PMID:35998298. |
in this review, we summarize and discuss a plethora of dna methylation, histone modification, and associated gene expression differences underscoring the anxiety phenotype.findings we outline include expression changes of various dmnts and changes in histone modifications that affect the hypothalamic pituitary adrenal axis and stress response as well as gaba, glutamate, and bdnf signaling in the pfc, amygdala, hypothalamus, and hippocampus. |
2022-08-23 |
2023-08-14 |
Not clear |
| Tessa J Helman, John P Headrick, Jason N Peart, Nicolas J C Stapelber. Central and cardiac stress resiliences consistently linked to integrated immuno-neuroendocrine responses across stress models in male mice. The European journal of neuroscience. 2022-06-28. PMID:35763309. |
highly integrated expression of hpa axis, neuro-inflammatory, bdnf, monoamine, gaba, cannabinoid and opioid signalling genes was confirmed across conditions, and consistent/potentially causal correlations identified for: i) locomotor activity (noradrenaline, ghrelin; fc crhr1, tnfrsf1b, il33, nfkb1, maoa, gabra1; hippocampal il33); ii) thigmotaxis (adrenaline, leptin); iii) anxiety-like behaviour (adrenaline, leptin; fc tnfrsf1a; hippocampal il33); iv) depressive-like behaviour (ghrelin; fc/hippocampal s100a8); and v) cardiac stress-resistance (noradrenaline, leptin; fc il33, tnfrsf1b, htr1a, gabra1, gabrg2; hippocampal il33, tnfrsf1a, maoa, drd2). |
2022-06-28 |
2023-08-14 |
mouse |
| Emilio Merlo Pich, Laura Cavalleri, Caterina Toma, Ginetta Coll. Involvement of DA D3 Receptors in Structural Neuroplasticity of Selected Limbic Brain Circuits: Possible Role in Treatment-Resistant Depression. Current topics in behavioral neurosciences. 2022-05-10. PMID:35538302. |
converging studies point to evidence of structural plasticity in circuits operated by glutamate, gaba, dopamine, and serotonin neurotransmitters, in concert with neurotrophic factors such as brain derived neurotrophic factor (bdnf) or insulin growth factor 1 (igf1) and a series of modulators that include circulating hormones. |
2022-05-10 |
2023-08-13 |
human |
| Maria Bove, Stefania Schiavone, Paolo Tucci, Vladyslav Sikora, Stefania Dimonte, Anna Laura Colia, Maria Grazia Morgese, Luigia Trabac. Ketamine administration in early postnatal life as a tool for mimicking Autism Spectrum Disorders core symptoms. Progress in neuro-psychopharmacology & biological psychiatry. 2022-04-23. PMID:35460811. |
in addition, we found decreased bdnf and enhanced gfap hippocampal expression levels, accompanied by elevations in glutamate amount, as well as reduction in gaba content in amygdala and hippocampus. |
2022-04-23 |
2023-08-13 |
mouse |
| Alex Brocchi, Eleni Rebelos, Angela Dardano, Michele Mantuano, Giuseppe Daniel. Effects of Intermittent Fasting on Brain Metabolism. Nutrients. vol 14. issue 6. 2022-03-26. PMID:35334932. |
key molecular players modified during if and involved in its beneficial central effects (ketone bodies, bdnf, gaba, gh/igf-1, fgf2, sirtuin-3, mtor, and gut microbiota) are identified and discussed. |
2022-03-26 |
2023-08-13 |
Not clear |
| Yosra A Hussien, Dina F Mansour, Somaia A Nada, Sahar S Abd El-Rahman, Rania M Abdelsalam, Amina S Attia, Dalia M El-Tanboul. Linagliptin attenuates thioacetamide-induced hepatic encephalopathy in rats: Modulation of C/EBP-β and CX3CL1/Fractalkine, neuro-inflammation, oxidative stress and behavioral defects. Life sciences. 2022-02-08. PMID:35134437. |
lng modulated taa-induced disturbances in hippocampal amino acids; glutamate, and gaba with a significant increase in hippocampal bdnf. |
2022-02-08 |
2023-08-13 |
rat |
| Andra Ionescu-Tucker, Christopher W Butler, Nicole C Berchtold, Dina P Matheos, Marcelo A Wood, Carl W Cotma. Exercise Reduces H3K9me3 and Regulates Brain Derived Neurotrophic Factor and GABRA2 in an Age Dependent Manner. Frontiers in aging neuroscience. vol 13. 2021-12-31. PMID:34970138. |
gaba receptor expression, which modulates bdnf secretion, is also modulated by exercise and h3k9me3. |
2021-12-31 |
2023-08-13 |
mouse |
| Andra Ionescu-Tucker, Christopher W Butler, Nicole C Berchtold, Dina P Matheos, Marcelo A Wood, Carl W Cotma. Exercise Reduces H3K9me3 and Regulates Brain Derived Neurotrophic Factor and GABRA2 in an Age Dependent Manner. Frontiers in aging neuroscience. vol 13. 2021-12-31. PMID:34970138. |
overall, h3k9me3 repression at bdnf and gaba receptor promoters decreased with age. |
2021-12-31 |
2023-08-13 |
mouse |
| Yanlan Chen, Nan Xiao, Yuxin Chen, Xinye Chen, Chunfei Zhong, Yuying Cheng, Bing Du, Pan L. Semen Sojae Praeparatum alters depression-like behaviors in chronic unpredictable mild stress rats via intestinal microbiota. Food research international (Ottawa, Ont.). vol 150. issue Pt B. 2021-12-05. PMID:34863499. |
in addition, semen sojae praeparatum significantly promoted the contents of norepinephrine (ne), 5-hydroxytryptamine (5-ht), brain-derived neurotrophic factor (bdnf), and gamma-aminobutyric acid (gaba) in the hippocampus and the content of bdnf in the serum (p < 0.05). |
2021-12-05 |
2023-08-13 |
rat |
| Yanlan Chen, Nan Xiao, Yuxin Chen, Xinye Chen, Chunfei Zhong, Yuying Cheng, Bing Du, Pan L. Semen Sojae Praeparatum alters depression-like behaviors in chronic unpredictable mild stress rats via intestinal microbiota. Food research international (Ottawa, Ont.). vol 150. issue Pt B. 2021-12-05. PMID:34863499. |
genus ruminococcaceae_ucg-008 was positively correlated with gaba and bdnf levels in the hippocampus; genus lactobacillus had a positive correlation with 5-ht; and genus bacteroides had negative correlations with 5-ht, bdnf, and ne. |
2021-12-05 |
2023-08-13 |
rat |
| Abdul Jalil Shah, Reyaz Hassan Mir, Roohi Mohi-Ud-Din, Faheem Hyder Pottoo, Mubashir Hussain Masoodi, Zulfiqar Ali Bha. Depression: An Insight into Heterocyclic and Cyclic Hydrocarbon Compounds Inspired from Natural Sources. Current neuropharmacology. vol 19. issue 11. 2021-11-25. PMID:33902421. |
the mechanisms include interplay with γ-aminobutyric acid (gaba) receptors, serotonergic, dopaminergic noradrenergic systems, and elevation of bdnf levels. |
2021-11-25 |
2023-08-13 |
Not clear |
| Brandon Kar Meng Choo, Mohd Farooq Shaik. Mechanism of Current neuropharmacology. vol 19. issue 9. 2021-11-25. PMID:33998991. |
this review also determined that the principal components possibly exert their anti-seizure effect via the reduction of corticosterone, modulation of neurotransmitters signalling, modulation of sodium ion channels, reduction of oxidative dna damage, reduction of lipid peroxidation, upgregulation of brain-derived neurotrophic factor (bdnf) and γ-aminobutyric acid (gaba) mediated inhibition. |
2021-11-25 |
2023-08-13 |
human |
| Yuan Zhou, Yujie Cheng, Yong Li, Jiyao Ma, Zhihan Wu, Yuenan Chen, Jinyu Mei, Ming Che. Soluble β-amyloid impaired the GABA inhibition by mediating KCC2 in early APP/PS1 mice. Bioscience trends. vol 15. issue 5. 2021-11-22. PMID:34526443. |
in addition, we found tnf-α and bdnf expression levels were increased, while kcc2 and gaba |
2021-11-22 |
2023-08-13 |
mouse |
| Bo-Wen Chen, Kai-Wen Zhang, Si-Jia Chen, Chun Yang, Peng-Gao L. Vitamin A Deficiency Exacerbates Gut Microbiota Dysbiosis and Cognitive Deficits in Amyloid Precursor Protein/Presenilin 1 Transgenic Mice. Frontiers in aging neuroscience. vol 13. 2021-11-19. PMID:34790112. |
our results show that vad aggravated the behavioral learning and memory deficits, reduced the retinol concentration in the liver and the serum, decreased the transcription of vitamin a (va)-related receptors and va-related enzymes in the cortex, increased amyloid-β peptides (aβ40 and aβ42) in the brain and gut, upregulate the translation of beta-site app-cleaving enzyme 1 (bace1) and phosphorylated tau in the cortex, and downregulate the expression of brain-derived neurotrophic factor (bdnf) and γ-aminobutyric acid (gaba) receptors in the cortex. |
2021-11-19 |
2023-08-13 |
mouse |
| Y Li, X Feng, H Ren, H Huang, Yu Wang, S Y. Low-Dose Ozone Therapy Improves Sleep Quality in Patients with Insomnia and Coronary Heart Disease by Elevating Serum BDNF and GABA. Bulletin of experimental biology and medicine. vol 170. issue 4. 2021-11-04. PMID:33713235. |
low-dose ozone therapy improves sleep quality in patients with insomnia and coronary heart disease by elevating serum bdnf and gaba. |
2021-11-04 |
2023-08-13 |
Not clear |
| Y Li, X Feng, H Ren, H Huang, Yu Wang, S Y. Low-Dose Ozone Therapy Improves Sleep Quality in Patients with Insomnia and Coronary Heart Disease by Elevating Serum BDNF and GABA. Bulletin of experimental biology and medicine. vol 170. issue 4. 2021-11-04. PMID:33713235. |
we studied the effects of low-dose ozone therapy on the sleep quality of patients with coronary heart disease (chd) and insomnia by measuring the levels of brain-derived neurotrophic factor (bdnf) and gaba in blood serum. |
2021-11-04 |
2023-08-13 |
Not clear |
| Y Li, X Feng, H Ren, H Huang, Yu Wang, S Y. Low-Dose Ozone Therapy Improves Sleep Quality in Patients with Insomnia and Coronary Heart Disease by Elevating Serum BDNF and GABA. Bulletin of experimental biology and medicine. vol 170. issue 4. 2021-11-04. PMID:33713235. |
the 3-month course of low-dose ozone therapy significantly elevated serum bdnf and gaba in chd patients with insomnia and improved parameters of anxiety, depression, and sleep quality according to hospital anxiety and depression scale (hads), pittsburgh sleep quality index (psqi), and self-rating scale of sleep (srss). |
2021-11-04 |
2023-08-13 |
Not clear |
| Y Li, X Feng, H Ren, H Huang, Yu Wang, S Y. Low-Dose Ozone Therapy Improves Sleep Quality in Patients with Insomnia and Coronary Heart Disease by Elevating Serum BDNF and GABA. Bulletin of experimental biology and medicine. vol 170. issue 4. 2021-11-04. PMID:33713235. |
the serum levels of bdnf and gaba negatively and closely correlated with psqi and hads scores. |
2021-11-04 |
2023-08-13 |
Not clear |
| Y Li, X Feng, H Ren, H Huang, Yu Wang, S Y. Low-Dose Ozone Therapy Improves Sleep Quality in Patients with Insomnia and Coronary Heart Disease by Elevating Serum BDNF and GABA. Bulletin of experimental biology and medicine. vol 170. issue 4. 2021-11-04. PMID:33713235. |
low-dose ozone therapy improved sleep quality and reduced psqi and hads scores due to up-regulation of bdnf and gaba. |
2021-11-04 |
2023-08-13 |
Not clear |