| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| James W Grau, Kelsey E Hudson, David T Johnston, Sienna R Partipil. Updating perspectives on spinal cord function: motor coordination, timing, relational processing, and memory below the brain. Frontiers in systems neuroscience. vol 18. 2024-03-06. PMID:38444825. |
new data show that spinal cord injury (sci) can enable plasticity within the spinal cord by reducing the inhibitory effect of gaba. |
2024-03-06 |
2024-03-08 |
Not clear |
| Armando Vega-López, Israel Lara-Vega, Genaro Atonal-Brioso, Minerva Nájera-Martíne. Neurotoxicant effects of bisphenol A, nonylphenol, and tert‑butyl phenol in the Nile tilapia (Oreochromis niloticus). Aquatic toxicology (Amsterdam, Netherlands). vol 268. 2024-02-22. PMID:38387248. |
in this study, the bisphenol a (bpa), 4-nonylphenol (np), and 3‑tert-butylphenol (tertbp) effects on brain and spinal cord of nile tilapia exposed to environmental concentrations were evaluated by assessing acetylcholinesterase (ache), butyrylcholinesterase (buche), and carboxylesterases (ces) activities, and γ-aminobutyric acid (gaba) levels and their effects were evaluated by molecular docking. |
2024-02-22 |
2024-02-25 |
Not clear |
| Amr A Mahrous, Lucy Liang, Josep-Maria Balaguer, Jonathan C Ho, Krishnapriya Hari, Erinn M Grigsby, Vahagn Karapetyan, Arianna Damiani, Daryl P Fields, Jorge A Gonzalez-Martinez, Peter C Gerszten, David J Bennett, C J Heckman, Elvira Pirondini, Marco Capogross. GABA Increases Sensory Transmission In Monkeys. bioRxiv : the preprint server for biology. 2024-01-18. PMID:38234767. |
for almost a century, gaba was believed to modulate this flow by inhibiting sensory axons in the spinal cord to sculpt neural inputs into skilled motor output. |
2024-01-18 |
2024-01-20 |
monkey |
| Samar Ahmed, Mahmoud Kharrat, Hesham Salah, Fouad Shearyia, Reem Alrimawi, Azizah Makhsoom, Sahal Al Sharif, Rozana Alyami, Faissal Shahee. Baclofen Toxicity in a Patient with End-stage Renal Disease on Maintenance Dialysis. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia. vol 34. issue 1. 2023-12-13. PMID:38092719. |
this centrally-acting gaba agonist is prescribed as therapy for spasticity in the spinal cord region. |
2023-12-13 |
2023-12-17 |
Not clear |
| Xunjia Qian, Xinyi Zhao, Lulu Yu, Yujian Yin, Xiao-Dan Zhang, Liyun Wang, Jun-Xu Li, Qing Zhu, Jia-Lie Lu. Current status of GABA receptor subtypes in analgesia. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 168. 2023-11-07. PMID:37935070. |
gamma-aminobutyric acid (gaba), a non-protein-producing amino acid synthesized from the excitatory amino acid glutamate via the enzyme glutamic acid decarboxylase, is extensively found in microorganisms, plants and vertebrates, and is abundantly expressed in the spinal cord and brain. |
2023-11-07 |
2023-11-20 |
Not clear |
| Xunjia Qian, Xinyi Zhao, Lulu Yu, Yujian Yin, Xiao-Dan Zhang, Liyun Wang, Jun-Xu Li, Qing Zhu, Jia-Lie Lu. Current status of GABA receptor subtypes in analgesia. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 168. 2023-11-07. PMID:37935070. |
as the major inhibitory neurotransmitter, gaba plays pivotal roles in the regulation of pain sensation, which is initiated by the activation of peripheral nociceptors and transmitted to the spinal cord and brain along nerves. |
2023-11-07 |
2023-11-20 |
Not clear |
| Tomonori Furukawa, Atsuo Fukud. Maternal taurine as a modulator of Cl Frontiers in cellular neuroscience. vol 17. 2023-08-21. PMID:37601283. |
maternal taurine as a modulator of cl during brain and spinal cord development, gaba and glycine, the inhibitory neurotransmitters, cause depolarization instead of hyperpolarization in adults. |
2023-08-21 |
2023-09-07 |
Not clear |
| Mariya A Prokhorenko, Jeremy T Smyt. Astrocyte store-operated calcium entry is required for centrally mediated neuropathic pain. bioRxiv : the preprint server for biology. 2023-06-19. PMID:37333230. |
central sensitization is defined by nociceptive and somatosensory circuitry changes in the spinal cord leading to dysfunction of antinociceptive gamma-aminobutyric acid (gaba)ergic cells (li et al., 2019), amplification of ascending nociceptive signals, and hypersensitivity (woolf, 2011). |
2023-06-19 |
2023-08-14 |
Not clear |
| Mehdi Zargani, Rodrigo Ramirez-Campillo, Ehsan Arabzade. Swimming and L-arginine loaded chitosan nanoparticles ameliorates aging-induced neuron atrophy, autophagy marker LC3, GABA and BDNF-TrkB pathway in the spinal cord of rats. Pflugers Archiv : European journal of physiology. 2023-03-04. PMID:36869900. |
swimming and l-arginine loaded chitosan nanoparticles ameliorates aging-induced neuron atrophy, autophagy marker lc3, gaba and bdnf-trkb pathway in the spinal cord of rats. |
2023-03-04 |
2023-08-14 |
rat |
| Mehdi Zargani, Rodrigo Ramirez-Campillo, Ehsan Arabzade. Swimming and L-arginine loaded chitosan nanoparticles ameliorates aging-induced neuron atrophy, autophagy marker LC3, GABA and BDNF-TrkB pathway in the spinal cord of rats. Pflugers Archiv : European journal of physiology. 2023-03-04. PMID:36869900. |
the study aim was to assess the effect of swimming training (sw) and l-arginine loaded chitosan nanoparticles (la-cnps) on the sensory and motor neuron population, autophagy marker lc3, total oxidant status/total antioxidant capacity, behavioural test, gaba and bdnf-trkb pathway in the spinal cord of aging rats. |
2023-03-04 |
2023-08-14 |
rat |
| Mehdi Zargani, Rodrigo Ramirez-Campillo, Ehsan Arabzade. Swimming and L-arginine loaded chitosan nanoparticles ameliorates aging-induced neuron atrophy, autophagy marker LC3, GABA and BDNF-TrkB pathway in the spinal cord of rats. Pflugers Archiv : European journal of physiology. 2023-03-04. PMID:36869900. |
the old sw + la-cnps group increased (improved) spinal cord gaba (p = 0.0187), bdnf (p = 0.0003), trkb (p < 0.0001) gene expression, decreased autophagy marker lc3 protein (p < 0.0001), nerve atrophy and jumping/licking latency (p < 0.0001), improved sciatic functional index score and total oxidant status/total antioxidant capacity compared to the old group (p < 0.0001). |
2023-03-04 |
2023-08-14 |
rat |
| Mehdi Zargani, Rodrigo Ramirez-Campillo, Ehsan Arabzade. Swimming and L-arginine loaded chitosan nanoparticles ameliorates aging-induced neuron atrophy, autophagy marker LC3, GABA and BDNF-TrkB pathway in the spinal cord of rats. Pflugers Archiv : European journal of physiology. 2023-03-04. PMID:36869900. |
in conclusion, swimming and la-cnps seems to ameliorate aging-induced neuron atrophy, autophagy marker lc3, oxidant-antioxidant status, functional restoration, gaba and bdnf-trkb pathway in the spinal cord of aging rats. |
2023-03-04 |
2023-08-14 |
rat |
| Kimberly Howard-Quijano, Yuki Kuwabara, Tomoki Yamaguchi, Kenny Roman, Siamak Salavatian, Bradley Taylor, Aman Mahaja. GABAergic Signaling During Spinal Cord Stimulation Reduces Cardiac Arrhythmias in a Porcine Model. Anesthesiology. 2023-02-01. PMID:36724342. |
we hypothesize that spinal cord stimulation reduces myocardial ischemia/reperfusion induced sympathetic excitation and ventricular arrhythmias through γ-aminobutyric acid (gaba) mediated pathways in the thoracic spinal cord. |
2023-02-01 |
2023-08-14 |
Not clear |
| Xiaolong Zheng, Bo Zhu, Jiang Xu, Dong Liu, Yan Huang, Daiqi Chen, Zhixian Liu, Fangliang Guo, Yuanji Dong, Wenzhen Zhu, Dengji Pan, Su-Chun Zhang, Hong Chen, Wei Wan. Human spinal GABA neurons survive and mature in the injured nonhuman primate spinal cord. Stem cell reports. 2023-01-20. PMID:36669493. |
human spinal gaba neurons survive and mature in the injured nonhuman primate spinal cord. |
2023-01-20 |
2023-08-14 |
human |
| Xiaolong Zheng, Bo Zhu, Jiang Xu, Dong Liu, Yan Huang, Daiqi Chen, Zhixian Liu, Fangliang Guo, Yuanji Dong, Wenzhen Zhu, Dengji Pan, Su-Chun Zhang, Hong Chen, Wei Wan. Human spinal GABA neurons survive and mature in the injured nonhuman primate spinal cord. Stem cell reports. 2023-01-20. PMID:36669493. |
grafted human spinal gaba neurons survived for up to 7.5 months in the injured monkey spinal cord and retained their intrinsic properties, becoming mature and growing axons and forming synapses. |
2023-01-20 |
2023-08-14 |
human |
| Lauryn E New, Yuchio Yanagawa, Glenn A McConkey, Jim Deuchars, Susan A Deuchar. GABAergic regulation of cell proliferation within the adult mouse spinal cord. Neuropharmacology. 2022-11-06. PMID:36336067. |
thus, intrinsic spinal cord gaba levels are correlated with the extent of cell proliferation, providing important evidence for manipulating these levels. |
2022-11-06 |
2023-08-14 |
mouse |
| Lauryn E New, Yuchio Yanagawa, Glenn A McConkey, Jim Deuchars, Susan A Deuchar. GABAergic regulation of cell proliferation within the adult mouse spinal cord. Neuropharmacology. 2022-11-06. PMID:36336067. |
diazepam binding inhibitor, an endogenous protein that interacts with gaba receptors and its breakdown product, octadecaneuropeptide, which preferentially activates central benzodiazepine (cbr) sites, were highly expressed in spinal cord, especially in ependymal cells surrounding the central canal. |
2022-11-06 |
2023-08-14 |
mouse |
| Lauryn E New, Yuchio Yanagawa, Glenn A McConkey, Jim Deuchars, Susan A Deuchar. GABAergic regulation of cell proliferation within the adult mouse spinal cord. Neuropharmacology. 2022-11-06. PMID:36336067. |
altering endogenous gaba levels or modulating gabaergic signaling through specific sites on gaba receptors therefore influences nsc proliferation in the adult spinal cord. |
2022-11-06 |
2023-08-14 |
mouse |
| Xue Ya. The Role of GABA in Spinal Cord Injury. Neurospine. vol 19. issue 3. 2022-10-07. PMID:36203292. |
the role of gaba in spinal cord injury. |
2022-10-07 |
2023-08-14 |
Not clear |
| Krishnapriya Hari, Ana M Lucas-Osma, Krista Metz, Shihao Lin, Noah Pardell, David A Roszko, Sophie Black, Anna Minarik, Rahul Singla, Marilee J Stephens, Robert A Pearce, Karim Fouad, Kelvin E Jones, Monica A Gorassini, Keith K Fenrich, Yaqing Li, David J Bennet. GABA facilitates spike propagation through branch points of sensory axons in the spinal cord. Nature neuroscience. 2022-09-26. PMID:36163283. |
gaba facilitates spike propagation through branch points of sensory axons in the spinal cord. |
2022-09-26 |
2023-08-14 |
Not clear |