| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kelsey E Hudson, James W Gra. Ionic Plasticity: Common Mechanistic Underpinnings of Pathology in Spinal Cord Injury and the Brain. Cells. vol 11. issue 18. 2022-09-23. PMID:36139484. |
spinal cord injury (sci) can bring about a modification that weakens the inhibitory effect of gaba in the central gray caudal to injury. |
2022-09-23 |
2023-08-14 |
Not clear |
| Stanislava Jergova, Melissa Hernandez, Jacqueline Sage. Analgesic effect of recombinant GABAergic precursors releasing MVIIA in a model of peripheral nerve injury in rats. Molecular pain. 2022-09-16. PMID:36113096. |
development of chronic pain has been attributed to dysfunctional gaba signaling in the spinal cord. |
2022-09-16 |
2023-08-14 |
rat |
| Thuỳ Linh Phạm, Chan Noh, Chiranjivi Neupane, Ramesh Sharma, Hyun Jin Shin, Ki Duk Park, C Justin Lee, Hyun-Woo Kim, So Yeong Lee, Jin Bong Par. MAO-B inhibitor, KDS2010, alleviates spinal nerve ligation-induced neuropathic pain in rats through competitively blocking the BDNF/TrkB/NR2B signaling. The journal of pain. 2022-08-08. PMID:35940543. |
our previous study has demonstrated that kds2010 (kds), a newly developed reversible mao-b inhibitor, could attenuate paclitaxel (ptx)-induced tactile hypersensitivity in mice through suppressing reactive oxidant species (ros)-decreased inhibitory gaba synaptic transmission in the spinal cord. |
2022-08-08 |
2023-08-14 |
mouse |
| Suyong Kim, Juan Gang, Ji-Hwan Lee, Hyejin Yang, Chunhoo Cheon, Seong-Gyu Ko, Hyunsu Bae, Woojin Ki. [6]-Shogaol Attenuates Oxaliplatin-Induced Allodynia through Serotonergic Receptors and GABA in the Spinal Cord in Mice. Pharmaceuticals (Basel, Switzerland). vol 15. issue 6. 2022-06-24. PMID:35745645. |
[6]-shogaol attenuates oxaliplatin-induced allodynia through serotonergic receptors and gaba in the spinal cord in mice. |
2022-06-24 |
2023-08-14 |
mouse |
| Tingting Cao, Huan Chen, Weiping Huang, Sisi Xu, Peilin Liu, Weiwei Zou, Mao Pang, Ying Xu, Xiaochun Bai, Bin Liu, Limin Rong, Zhong-Kai Cui, Mangmang L. hUC-MSC-mediated recovery of subacute spinal cord injury through enhancing the pivotal subunits β3 and γ2 of the GABA Theranostics. vol 12. issue 7. 2022-05-13. PMID:35547766. |
huc-msc-mediated recovery of subacute spinal cord injury through enhancing the pivotal subunits β3 and γ2 of the gaba |
2022-05-13 |
2023-08-13 |
Not clear |
| Diveyaa Sivakumar, Rosmaliza Raml. GABAergic signalling in modulation of dental pain. European journal of pharmacology. 2022-04-16. PMID:35429491. |
gaba and its receptors have been found in parts of the spinal cord and brain that are related to pain perception, thus providing compelling evidence of its role in mediating pain signalling. |
2022-04-16 |
2023-08-13 |
Not clear |
| Mingwei Zhao, Caifeng Shao, Jiaxue Dong, Qian Chen, Rui Ma, Ping Jiang, Wei-Ning Zhang, Kun Yan. GABA Brain structure & function. 2022-03-23. PMID:35318502. |
gaba the substantia gelatinosa (sg, lamina ii of spinal cord gray matter) is pivotal for modulating nociceptive information from the peripheral to the central nervous system. |
2022-03-23 |
2023-08-13 |
Not clear |
| Xiangzhe Li, Xinjian Song, Lu Fang, Jie Ding, Longju Qi, Qinghua Wang, Chuanming Dong, Sheng Wang, Jiahuan Wu, Tong Wang, Qinfeng W. Body Weight-Supported Treadmill Training Ameliorates Motoneuronal Hyperexcitability by Increasing GAD-65/67 and KCC2 Expression via TrkB Signaling in Rats with Incomplete Spinal Cord Injury. Neurochemical research. 2022-03-23. PMID:35320460. |
the critical reasons are reducing the synthesis of gamma-aminobutyric acid (gaba), glycine and potassium chloride co-transporter 2 (kcc2) inside the distal spinal cord. |
2022-03-23 |
2023-08-13 |
rat |
| Xiangzhe Li, Xinjian Song, Lu Fang, Jie Ding, Longju Qi, Qinghua Wang, Chuanming Dong, Sheng Wang, Jiahuan Wu, Tong Wang, Qinfeng W. Body Weight-Supported Treadmill Training Ameliorates Motoneuronal Hyperexcitability by Increasing GAD-65/67 and KCC2 Expression via TrkB Signaling in Rats with Incomplete Spinal Cord Injury. Neurochemical research. 2022-03-23. PMID:35320460. |
the current work aimed to test whether exercise training could increase the expression of glutamic acid decarboxylase 65/67 (gad-65/67, the key enzymes in gaba synthesis) and kcc2 in the distal spinal cord via tropomyosin-related kinase b (trkb) signaling. |
2022-03-23 |
2023-08-13 |
rat |
| Jie-Dan Mu, Liang-Xiao Ma, Zhou Zhang, Wen-Yan Yu, Tian-Yi Sun, Xu Qian, Yuan Tian, Jun-Xiang Wan. Acupuncture alleviates spinal hyperreflexia and motor dysfunction in post-ischemic stroke rats with spastic hypertonia via KCC2-mediated spinal GABA Experimental neurology. 2022-03-04. PMID:35245503. |
evidence suggests that some deficits in the kcc2 expression in the spinal cord along with maladaptive endogenous plasticity via gaba |
2022-03-04 |
2023-08-13 |
rat |
| Wayne Barnaby, Hanna E Dorman Barclay, Akanksha Nagarkar, Matthew Perkins, Gregory Teicher, Josef G Trapani, Gerald B Downe. GABAA α Subunit Control of Hyperactive Behavior in Developing Zebrafish. Genetics. 2022-02-02. PMID:35106556. |
gabaa receptors mediate rapid responses to the neurotransmitter gaba and are robust regulators of the brain and spinal cord neural networks that control locomotor behaviors, such as walking and swimming. |
2022-02-02 |
2023-08-13 |
zebrafish |
| Liting Sun, Changgeng Peng, Elbert Joosten, Chi Wai Cheung, Fei Tan, Wencheng Jiang, Xiafeng She. Spinal Cord Stimulation and Treatment of Peripheral or Central Neuropathic Pain: Mechanisms and Clinical Application. Neural plasticity. vol 2021. 2021-11-24. PMID:34721569. |
evidence from recent research publications indicates that nociceptive processing at peripheral and central sensory systems is thought to be modulated by scs through (i) inhibition of the ascending nociceptive transmission by the release of analgesic neurotransmitters such as gaba and endocannabinoids at the spinal dorsal horn; (ii) facilitation of the descending inhibition by release of noradrenalin, dopamine, and serotonin acting on their receptors in the spinal cord; and (iii) activation of a variety of supraspinal brain areas related to pain perception and emotion. |
2021-11-24 |
2023-08-13 |
Not clear |
| Andrew R Brown, Marina Martine. Chronic inactivation of the contralesional hindlimb motor cortex after thoracic spinal cord hemisection impedes locomotor recovery in the rat. Experimental neurology. vol 343. 2021-11-09. PMID:34081986. |
in adult rats, left hindlimb paralysis was induced by sectioning half of the spinal cord at the thoracic level (hemisection) and we used a continuous infusion of muscimol (gaba |
2021-11-09 |
2023-08-13 |
rat |
| ChenZi Gong, Xiaolong Zheng, FangLiang Guo, YaNan Wang, Song Zhang, Jing Chen, XueJiao Sun, Sayed Zulfiqar Ali Shah, YiFeng Zheng, Xiao Li, Yatao Yin, Qian Li, XiaoLin Huang, Tiecheng Guo, Xiaohua Han, Su-Chun Zhang, Wei Wang, Hong Che. Human spinal GABA neurons alleviate spasticity and improve locomotion in rats with spinal cord injury. Cell reports. vol 34. issue 12. 2021-10-01. PMID:33761348. |
human spinal gaba neurons alleviate spasticity and improve locomotion in rats with spinal cord injury. |
2021-10-01 |
2023-08-13 |
human |
| ChenZi Gong, Xiaolong Zheng, FangLiang Guo, YaNan Wang, Song Zhang, Jing Chen, XueJiao Sun, Sayed Zulfiqar Ali Shah, YiFeng Zheng, Xiao Li, Yatao Yin, Qian Li, XiaoLin Huang, Tiecheng Guo, Xiaohua Han, Su-Chun Zhang, Wei Wang, Hong Che. Human spinal GABA neurons alleviate spasticity and improve locomotion in rats with spinal cord injury. Cell reports. vol 34. issue 12. 2021-10-01. PMID:33761348. |
after transplantation into the injured rat spinal cord, the dreadd (designer receptors exclusively activated by designer drug)-expressing spinal progenitors differentiate into gaba neurons, mitigating spasticity-like response of the rat hindlimbs and locomotion deficits in 3 months. |
2021-10-01 |
2023-08-13 |
human |
| Weipang Chang, Andrea Pedroni, Maria Bertuzzi, Caghan Kizil, András Simon, Konstantinos Ampatzi. Locomotion dependent neuron-glia interactions control neurogenesis and regeneration in the adult zebrafish spinal cord. Nature communications. vol 12. issue 1. 2021-08-23. PMID:34381039. |
we also show that gaba acts in a non-synaptic fashion to maintain neural stem/progenitor cell quiescence in the spinal cord and that training-induced activation of neurogenesis requires a reduction of gaba |
2021-08-23 |
2023-08-13 |
zebrafish |
| Beatriz Shantal Jiménez-Zárate, Celia Piña-Leyva, Marina Rodríguez-Sánchez, Benjamín Florán-Garduño, Luis Antonio Jiménez-Zamudio, Ismael Jiménez-Estrad. Day-Night Variations in the Concentration of Neurotransmitters in the Rat Lumbar Spinal Cord. Journal of circadian rhythms. vol 19. 2021-07-31. PMID:34326881. |
the gamma-aminobutyric acid (gaba), glutamate (glu), dopamine, serotonin, epinephrine (e), and norepinephrine (ne) levels in each extracted spinal cord were measured with high-pressure liquid chromatography (hplc)-eq and hplc-fluorescence systems. |
2021-07-31 |
2023-08-13 |
rat |
| Yaqing Li, Krishnapriya Hari, Ana M Lucas-Osma, Keith K Fenrich, David J Bennett, Ingela Hammar, Elzbieta Jankowsk. Branching points of primary afferent fibers are vital for the modulation of fiber excitability by epidural DC polarization and by GABA in the rat spinal cord. Journal of neurophysiology. vol 124. issue 1. 2021-07-19. PMID:32459560. |
branching points of primary afferent fibers are vital for the modulation of fiber excitability by epidural dc polarization and by gaba in the rat spinal cord. |
2021-07-19 |
2023-08-13 |
rat |
| Eva Koetsier, Glenn Franken, Jacques Debets, Lonne Heijmans, Sander M J van Kuijk, Bengt Linderoth, Elbert A Joosten, Paolo Main. Mechanism of dorsal root ganglion stimulation for pain relief in painful diabetic polyneuropathy is not dependent on GABA release in the dorsal horn of the spinal cord. CNS neuroscience & therapeutics. vol 26. issue 1. 2021-06-25. PMID:31334605. |
mechanism of dorsal root ganglion stimulation for pain relief in painful diabetic polyneuropathy is not dependent on gaba release in the dorsal horn of the spinal cord. |
2021-06-25 |
2023-08-13 |
Not clear |
| Eva Koetsier, Glenn Franken, Jacques Debets, Lonne Heijmans, Sander M J van Kuijk, Bengt Linderoth, Elbert A Joosten, Paolo Main. Mechanism of dorsal root ganglion stimulation for pain relief in painful diabetic polyneuropathy is not dependent on GABA release in the dorsal horn of the spinal cord. CNS neuroscience & therapeutics. vol 26. issue 1. 2021-06-25. PMID:31334605. |
it is hypothesized that dorsal root ganglion stimulation (drgs), sharing some of the mechanisms of traditional spinal cord stimulation (scs) of the dorsal columns, induces γ-aminobutyric acid (gaba) release from interneurons in the spinal dorsal horn. |
2021-06-25 |
2023-08-13 |
Not clear |