| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marjan Hosseini, Zohreh Karami, Mahmood Yousefifard, Atousa Janzadeh, Elham Zamani, Farinaz Nasirinezha. Simultaneous intrathecal injection of muscimol and endomorphin-1 alleviates neuropathic pain in rat model of spinal cord injury. Brain and behavior. vol 10. issue 5. 2021-06-24. PMID:32189472. |
the purpose of this study is to investigate the analgesic effect of simultaneous administration of gaba agonist and endomorphin-1 on neuropathic pain in rat model of spinal cord injury (sci). |
2021-06-24 |
2023-08-13 |
rat |
| Maycon I O Milanez, Erika E Nishi, Antônio A Rocha, Cássia T Bergamaschi, Ruy R Campo. Interaction between angiotensin II and GABA in the spinal cord regulates sympathetic vasomotor activity in Goldblatt hypertension. Neuroscience letters. vol 728. 2021-05-17. PMID:32304717. |
interaction between angiotensin ii and gaba in the spinal cord regulates sympathetic vasomotor activity in goldblatt hypertension. |
2021-05-17 |
2023-08-13 |
rat |
| Sang Wan Ryu, Yeo Ok Kim, Han-Byul Kim, Seog Bae Oh, Jeong Il Choi, Myung Ha Yoo. Antinociceptive effect of intrathecal P7C3 via GABA in a rat model of inflammatory pain. European journal of pharmacology. vol 899. 2021-05-17. PMID:33727053. |
the expression of gad and the concentration of gaba in the spinal cord were evaluated. |
2021-05-17 |
2023-08-13 |
rat |
| Sang Wan Ryu, Yeo Ok Kim, Han-Byul Kim, Seog Bae Oh, Jeong Il Choi, Myung Ha Yoo. Antinociceptive effect of intrathecal P7C3 via GABA in a rat model of inflammatory pain. European journal of pharmacology. vol 899. 2021-05-17. PMID:33727053. |
these results suggest that p7c3 increases gad activity and then increases the gaba concentration in the spinal cord, which in turn may act on gaba receptors causing the antinociceptive effect against pain evoked by formalin injection. |
2021-05-17 |
2023-08-13 |
rat |
| Yuya Ogawa, Masahiro Irifune, Akari Mukai, Yoshitaka Shimizu, Mitsuru Doi, Kana Oue, Mitsuhiro Yoshida, Takashi Kanematsu, Norimitsu Morioka, Yoshihiro Nakata, Norio Saka. The indirect γ-aminobutyric acid (GABA) receptor agonist gabaculine-induced loss of the righting reflex may inhibit the descending analgesic pathway. Pharmacology, biochemistry, and behavior. vol 198. 2021-04-13. PMID:32910929. |
in the spinal cord, γ-aminobutyric acid (gaba) interneurons play an essential role in antinociception. |
2021-04-13 |
2023-08-13 |
Not clear |
| Takamasa Mizoguchi, Michi Fukada, Miku Iihama, Xuehui Song, Shun Fukagawa, Shuhei Kuwabara, Shuhei Omaru, Shin-Ichi Higashijima, Motoyuki Ito. Transient activation of the Notch-her15.1 axis plays an important role in the maturation of V2b interneurons. Development (Cambridge, England). vol 147. issue 16. 2021-03-23. PMID:32855202. |
later, v2b cells extend axons along the ipsilateral side of the spinal cord and express the inhibitory transmitter gaba. |
2021-03-23 |
2023-08-13 |
zebrafish |
| Willias Masocha, Subramanian S Parvath. Preventative and therapeutic effects of a GABA transporter 1 inhibitor administered systemically in a mouse model of paclitaxel-induced neuropathic pain. PeerJ. vol 4. 2020-10-01. PMID:27994987. |
gamma-aminobutyric acid transporter-1 (gat-1) whose expression is increased in the brain and spinal cord during paclitaxel-induced neuropathic pain (pinp) might be a potential therapeutic target for managing pinp. |
2020-10-01 |
2023-08-13 |
mouse |
| Wuping Sun, Qian Zhou, Xiyuan Ba, Xiaojin Feng, Xuexue Hu, Xiaoe Cheng, Tao Liu, Jing Guo, Lizu Xiao, Jin Jiang, Donglin Xiong, Yue Hao, Zixian Chen, Changyu Jian. Oxytocin Relieves Neuropathic Pain Through GABA Release and Presynaptic TRPV1 Inhibition in Spinal Cord. Frontiers in molecular neuroscience. vol 11. 2020-10-01. PMID:30065629. |
oxytocin relieves neuropathic pain through gaba release and presynaptic trpv1 inhibition in spinal cord. |
2020-10-01 |
2023-08-13 |
Not clear |
| Michelino Puopol. The hypothalamic-spinal dopaminergic system: a target for pain modulation. Neural regeneration research. vol 14. issue 6. 2020-10-01. PMID:30761995. |
descending modulatory pathways to the spinal cord comprise, among others, noradrenergic, serotonergic, γ-aminobutyric acid (gaba)ergic, and dopaminergic fibers. |
2020-10-01 |
2023-08-13 |
human |
| Karin R Aubrey, Stéphane Supplisso. Heterogeneous Signaling at GABA and Glycine Co-releasing Terminals. Frontiers in synaptic neuroscience. vol 10. 2020-09-30. PMID:30524262. |
in the brainstem and spinal cord, gaba and glycine cotransmission is facilitated by a shared vesicular transporter viaat (also named vgat), and occurs at many immature inhibitory synapses. |
2020-09-30 |
2023-08-13 |
mouse |
| Daniel Romaus-Sanjurjo, María Celina Rodicio, Antón Barreiro-Iglesia. Gamma-aminobutyric acid (GABA) promotes recovery from spinal cord injury in lampreys: role of GABA receptors and perspective on the translation to mammals. Neural regeneration research. vol 14. issue 10. 2020-09-30. PMID:31169176. |
gamma-aminobutyric acid (gaba) promotes recovery from spinal cord injury in lampreys: role of gaba receptors and perspective on the translation to mammals. |
2020-09-30 |
2023-08-13 |
Not clear |
| Istvan Mod. The GAD-given Right of Dentate Gyrus Granule Cells to Become GABAergic. Epilepsy currents. vol 2. issue 5. 2020-09-29. PMID:15309121. |
other examples of two fast neurotransmitters released from the same neuron include gaba and glycine in interneurons of the spinal cord (5) and glutamate and dopamine in ventral midbrain dopamine neurons (6). |
2020-09-29 |
2023-08-12 |
Not clear |
| Kyujin Hwang, Kwangsoo Jung, Il-Sun Kim, Miri Kim, Jungho Han, Joohee Lim, Jeong Eun Shin, Jae-Hyung Jang, Kook In Par. Glial Cell Line-derived Neurotrophic Factor-overexpressing Human Neural Stem/Progenitor Cells Enhance Therapeutic Efficiency in Rat with Traumatic Spinal Cord Injury. Experimental neurobiology. vol 28. issue 6. 2020-09-28. PMID:31902156. |
finally grafted gdnf-hnspcs substantially reversed the increased expression of voltage-gated sodium channels and neuropeptide y, and elevated expression of gaba in the injured spinal cord, which are involved in the attenuation of neuropathic pain after sci. |
2020-09-28 |
2023-08-13 |
human |
| Daniel Sobrido-Cameán, Diego Robledo, Daniel Romaus-Sanjurjo, Vanessa Pérez-Cedrón, Laura Sánchez, María Celina Rodicio, Antón Barreiro-Iglesia. Inhibition of Gamma-Secretase Promotes Axon Regeneration After a Complete Spinal Cord Injury. Frontiers in cell and developmental biology. vol 8. 2020-09-28. PMID:32266257. |
in a recent study, we showed that gaba and baclofen (a gabab receptor agonist) inhibit caspase activation and promote axon regeneration in descending neurons of the sea lamprey brainstem after a complete spinal cord injury (romaus-sanjurjo et al., 2018a). |
2020-09-28 |
2023-08-13 |
Not clear |
| Daniel Sobrido-Cameán, Diego Robledo, Daniel Romaus-Sanjurjo, Vanessa Pérez-Cedrón, Laura Sánchez, María Celina Rodicio, Antón Barreiro-Iglesia. Inhibition of Gamma-Secretase Promotes Axon Regeneration After a Complete Spinal Cord Injury. Frontiers in cell and developmental biology. vol 8. 2020-09-28. PMID:32266257. |
gaba treated larval sea lampreys with their controls were analyzed 29 days after a complete spinal cord injury and baclofen treated larvae with their controls 9 days after the injury. |
2020-09-28 |
2023-08-13 |
Not clear |
| Daisuke Uta, Tsuyoshi Hattori, Megumu Yoshimur. Differential Effects of Alpha 1-Adrenoceptor Antagonists on the Postsynaptic Sensitivity: Using Slice Patch-Clamp Technique for Inhibitory Postsynaptic Current in Substantia Gelatinosa Neurons From Lumbosacral Spinal Cord in Rats. International neurourology journal. vol 24. issue 2. 2020-09-28. PMID:32615674. |
the goal of the present study was to clarify the effect of α1- adrenoceptor antagonists on γ-aminobutyric acid (gaba)/glycine-mediated outward currents of the inhibitory postsynaptic current (ipsc) in substantia gelatinosa (sg) neurons from the lumbosacral spinal cord in rats. |
2020-09-28 |
2023-08-13 |
rat |
| Wanalee Klomjai, Nicolas Roche, Jean-Charles Lamy, Peter Bede, Alain Giron, Bernard Bussel, Djamel Bensmail, Rose Katz, Alexandra Lackmy-Vallé. Furosemide Unmasks Inhibitory Dysfunction after Spinal Cord Injury in Humans: Implications for Spasticity. Journal of neurotrauma. vol 36. issue 9. 2020-09-04. PMID:30417726. |
animal studies consistently have demonstrated a downregulation of kcc2 activity after spinal cord transection, causing a shift from the inhibitory action of gamma-aminobutyric acid and glycine to an excitatory effect. |
2020-09-04 |
2023-08-13 |
human |
| Koen P V Meuwissen, Luuk E de Vries, Jianwen Wendy Gu, Tianhe C Zhang, Elbert A J Jooste. Burst and Tonic Spinal Cord Stimulation Both Activate Spinal GABAergic Mechanisms to Attenuate Pain in a Rat Model of Chronic Neuropathic Pain. Pain practice : the official journal of World Institute of Pain. vol 20. issue 1. 2020-08-17. PMID:31424152. |
experimental and clinical studies have shown that tonic spinal cord stimulation (scs) releases gamma-aminobutyric acid (gaba) in the spinal dorsal horn. |
2020-08-17 |
2023-08-13 |
rat |
| Hao Wu, Yulin Huang, Xinyu Tian, Zuoxia Zhang, Ying Zhang, Yanting Mao, Chenchen Wang, Shuai Yang, Yue Liu, Wei Zhang, Zhengliang M. Preoperative anxiety-induced glucocorticoid signaling reduces GABAergic markers in spinal cord and promotes postoperative hyperalgesia by affecting neuronal PAS domain protein 4. Molecular pain. vol 15. 2020-05-26. PMID:31041873. |
here, single prolonged stress rats' lumbar spinal cord showed reduced glutamic acid decarboxylase-65, glutamic acid decarboxylase-67, gaba type a receptor alpha 1 subunit, and gaba type a receptor gamma 2 subunit, indicating an impairment of gabaergic system. |
2020-05-26 |
2023-08-13 |
rat |
| Laurence Meyer, Omar Taleb, Christine Patte-Mensah, Ayikoe-Guy Mensah-Nyaga. Neurosteroids and neuropathic pain management: Basic evidence and therapeutic perspectives. Frontiers in neuroendocrinology. vol 55. 2020-04-10. PMID:31562849. |
neurosteroids promote peripheral analgesia mediated by t-type calcium and gamma-aminobutyric acid type a channels, counteract chemotherapy-induced neuropathic pain and ameliorate neuropathic symptoms of injured spinal cord animals by stimulating anti-inflammatory, remyelinating and neuroprotective processes. |
2020-04-10 |
2023-08-13 |
Not clear |