All Relations between glutamate and dorsal raphe

Publication Sentence Publish Date Extraction Date Species
Hui-Quan Li, Wuji Jiang, Li Ling, Marta Pratelli, Cong Chen, Vaidehi Gupta, Swetha K Godavarthi, Nicholas C Spitze. Generalized fear after acute stress is caused by change in neuronal cotransmitter identity. Science (New York, N.Y.). vol 383. issue 6688. 2024-03-14. PMID:38484078. in this study, we show that generalized fear in mice results from a transmitter switch from glutamate to γ-aminobutyric acid (gaba) in serotonergic neurons of the lateral wings of the dorsal raphe. 2024-03-14 2024-03-17 mouse
b' Giovanni Hernandez, Willemieke M Kouwenhoven, Emmanuelle Poirier, Karim Lebied, Daniel L\\xc3\\xa9vesque, Pierre-Paul Rompr\\xc3\\xa. Dorsal raphe stimulation relays a reward signal to the ventral tegmental area via GluN2C NMDA receptors. PloS one. vol 18. issue 11. 2023-11-06. PMID:37930965.' glutamate relays a reward signal from the dorsal raphe (dr) to the ventral tegmental area (vta). 2023-11-06 2023-11-08 Not clear
Xin-Yue Wang, Wen-Bin Jia, Xiang Xu, Rui Chen, Liang-Biao Wang, Xiao-Jing Su, Peng-Fei Xu, Xiao-Qing Liu, Jie Wen, Xiao-Yuan Song, Yuan-Yuan Liu, Zhi Zhang, Xin-Feng Liu, Yan Zhan. A glutamatergic DRN-VTA pathway modulates neuropathic pain and comorbid anhedonia-like behavior in mice. Nature communications. vol 14. issue 1. 2023-08-23. PMID:37612268. here using a mouse model, we report a pathway from vesicular glutamate transporter 3 neurons in the dorsal raphe nucleus to dopamine neurons in the ventral tegmental area (vglut3 2023-08-23 2023-09-07 mouse
Saida Oubraim, Roh-Yu Shen, Samir Haj-Dahman. Oxytocin excites dorsal raphe serotonin neurons and bidirectionally gates their glutamate synapses. iScience. vol 26. issue 5. 2023-05-30. PMID:37250336. oxytocin excites dorsal raphe serotonin neurons and bidirectionally gates their glutamate synapses. 2023-05-30 2023-08-14 Not clear
Hui-Quan Li, Wuji Jiang, Lily Ling, Vaidehi Gupta, Cong Chen, Marta Pratelli, Swetha K Godavarthi, Nicholas C Spitze. Generalized fear following acute stress is caused by change in co-transmitter identity of serotonergic neurons. bioRxiv : the preprint server for biology. 2023-05-23. PMID:37214936. here we show that generalized fear in mice in response to footshock results from a transmitter switch from glutamate to gaba in serotonergic neurons of the lateral wings of the dorsal raphe. 2023-05-23 2023-08-14 mouse
Daniil Grinchii, Lubica Lacinova, Eliyahu Dremenco. Effects of the acute administration of delta-opioid receptor ligands on the excitability of rat hippocampal glutamate and brainstem monoamine neurons in vivo. General physiology and biophysics. vol 42. issue 3. 2023-04-26. PMID:37098742. the present study aimed to investigate the acute effects of these ligands on the firing activity of hippocampal cornu ammonis 1/3 (ca1/3) glutamate, dorsal raphe nucleus (drn) serotonin (5-ht), locus coeruleus (lc) noradrenaline, and ventral tegmental area (vta) dopamine neurons in in vivo conditions. 2023-04-26 2023-08-14 rat
Carla V Argañaraz, Tamara S Adjimann, Paula P Perissinotti, Mariano Soiza-Reill. Selective refinement of glutamate and GABA synapses on dorsal raphe 5-HT neurons during postnatal life. Development (Cambridge, England). 2022-12-02. PMID:36458556. selective refinement of glutamate and gaba synapses on dorsal raphe 5-ht neurons during postnatal life. 2022-12-02 2023-08-14 mouse
Carla V Argañaraz, Tamara S Adjimann, Paula P Perissinotti, Mariano Soiza-Reill. Selective refinement of glutamate and GABA synapses on dorsal raphe 5-HT neurons during postnatal life. Development (Cambridge, England). 2022-12-02. PMID:36458556. we investigated in mice the postnatal trajectory of glutamate and gaba synaptic inputs to dorsal raphe nucleus (drn) 5-ht neurons, the main source of forebrain 5-ht. 2022-12-02 2023-08-14 mouse
Marc Schneeberger, Nicola L Brice, Kyle Pellegrino, Luca Parolari, Jordan T Shaked, Keith J Page, François Marchildon, Douglas W Barrows, Thomas S Carroll, Thomas Tolpiko, Victoria M Mulligan, Robert Newman, Kevin Doyle, Roland Bürli, Daniel F Barker, Angela Glen, María José Ortuño, Alexander R Nectow, Nicolas Renier, Paul Cohen, Mark Carlton, Nathaniel Heintz, Jeffrey M Friedma. Pharmacological targeting of glutamatergic neurons within the brainstem for weight reduction. Nature metabolism. 2022-11-21. PMID:36411386. food intake and body weight are tightly regulated by neurons within specific brain regions, including the brainstem, where acute activation of dorsal raphe nucleus (drn) glutamatergic neurons expressing the glutamate transporter vglut3 (drn 2022-11-21 2023-08-14 Not clear
Emilio Garro-Martínez, Maria Neus Fullana, Eva Florensa-Zanuy, Julia Senserrich, Verónica Paz, Esther Ruiz-Bronchal, Albert Adell, Elena Castro, Álvaro Díaz, Ángel Pazos, Analía Bortolozzi, Fuencisla Pilar-Cuélla. mTOR Knockdown in the Infralimbic Cortex Evokes A Depressive-like State in Mouse. International journal of molecular sciences. vol 22. issue 16. 2021-09-15. PMID:34445375. in parallel, decreased brain-derived neurotrophic factor (bdnf) expression was found bilaterally in both il and prl cortices along with a dysregulation of serotonin (5-ht) and glutamate (glu) release in the dorsal raphe nucleus (drn). 2021-09-15 2023-08-13 mouse
Stephanie C Gantz, Khaled Moussawi, Holly S Hak. Delta glutamate receptor conductance drives excitation of mouse dorsal raphe neurons. eLife. vol 9. 2021-04-07. PMID:32234214. delta glutamate receptor conductance drives excitation of mouse dorsal raphe neurons. 2021-04-07 2023-08-13 mouse
Daniel F Cardozo Pinto, Hongbin Yang, Iskra Pollak Dorocic, Johannes W de Jong, Vivian J Han, James R Peck, Yichen Zhu, Christine Liu, Kevin T Beier, Marten P Smidt, Stephan Lamme. Characterization of transgenic mouse models targeting neuromodulatory systems reveals organizational principles of the dorsal raphe. Nature communications. vol 10. issue 1. 2020-02-04. PMID:31604921. the dorsal raphe (dr) is a heterogeneous nucleus containing dopamine (da), serotonin (5ht), γ-aminobutyric acid (gaba) and glutamate neurons. 2020-02-04 2023-08-13 mouse
Roberta Monteiro Incrocci, Franciely Paliarin, Manoel Jorge Nobr. Prelimbic NMDA receptors stimulation mimics the attenuating effects of clozapine on the auditory electrophysiological rebound induced by ketamine withdrawal. Neurotoxicology. vol 69. 2019-03-15. PMID:30170016. these data suggest that the long-term ket treatment disrupts the collicular auditory field potentials, possibly through influencing prl glutamate activity on intrinsic 5-ht mechanisms in the dorsal raphe and cic. 2019-03-15 2023-08-13 rat
Samir Haj-Dahmane, Jean Claude Béïque, Roh-Yu She. GluA2-Lacking AMPA Receptors and Nitric Oxide Signaling Gate Spike-Timing-Dependent Potentiation of Glutamate Synapses in the Dorsal Raphe Nucleus. eNeuro. vol 4. issue 3. 2018-03-28. PMID:28580416. glua2-lacking ampa receptors and nitric oxide signaling gate spike-timing-dependent potentiation of glutamate synapses in the dorsal raphe nucleus. 2018-03-28 2023-08-13 rat
b' J Gasull-Cam\\xc3\\xb3s, M Tarr\\xc3\\xa9s-Gatius, F Artigas, A Casta\\xc3\\xb1\\xc3\\xa. Glial GLT-1 blockade in infralimbic cortex as a new strategy to evoke rapid antidepressant-like effects in rats. Translational psychiatry. vol 7. issue 2. 2017-11-16. PMID:28221365.' the dhk-evoked antidepressant-like responses appear to be mediated by an ampa-r-driven enhancement of serotonergic activity, as (i) they were prevented by nbqx 2,3-dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt) and mimicked by s-ampa; (ii) dhk and s-ampa elevated similarly extracellular glutamate in il and prl, although extracellular 5-ht and c-fos expression in the midbrain dorsal raphe increased only when these agents were applied in il; and (iii) dhk antidepressant-like responses were prevented by 5-ht synthesis inhibition and mimicked by citalopram microinfusion in il. 2017-11-16 2023-08-13 rat
Alexander R Nectow, Marc Schneeberger, Hongxing Zhang, Bianca C Field, Nicolas Renier, Estefania Azevedo, Bindiben Patel, Yupu Liang, Siddhartha Mitra, Marc Tessier-Lavigne, Ming-Hu Han, Jeffrey M Friedma. Identification of a Brainstem Circuit Controlling Feeding. Cell. vol 170. issue 3. 2017-08-08. PMID:28753423. here, we show that neurons in the dorsal raphe nucleus, expressing vesicular transporters for gaba or glutamate (hereafter, drn 2017-08-08 2023-08-13 Not clear
Sean D Geddes, Saleha Assadzada, Alexandra Sokolovski, Richard Bergeron, Samir Haj-Dahmane, Jean-Claude Béïqu. Time-dependent modulation of glutamate synapses onto 5-HT neurons by antidepressant treatment. Neuropharmacology. vol 95. 2016-03-08. PMID:25747603. here, we show that sustained administration of the ssri citalopram leads to a homeostatic-like increase in the strength of excitatory glutamate synapses onto 5-ht neurons of the dorsal raphe nucleus that was apparent following one week of treatment. 2016-03-08 2023-08-13 Not clear
Enza Palazzo, Rosaria Romano, Livio Luongo, Serena Boccella, Danilo De Gregorio, Maria Elvira Giordano, Francesca Rossi, Ida Marabese, Maria Antonietta Scafuro, Vito de Novellis, Sabatino Maion. MMPIP, an mGluR7-selective negative allosteric modulator, alleviates pain and normalizes affective and cognitive behavior in neuropathic mice. Pain. vol 156. issue 6. 2016-02-04. PMID:25760470. mglur7 expression, mainly associated with vesicular glutamate transporter, increased in the hippocampus and decreased in the bla, plc, and dorsal raphe in sni mice. 2016-02-04 2023-08-13 mouse
b' Giovanni Hernandez, Ali Khodami-Pour, Daniel L\\xc3\\xa9vesque, Pierre-Paul Rompr\\xc3\\xa. Reduction in Ventral Midbrain NMDA Receptors Reveals Two Opposite Modulatory Roles for Glutamate on Reward. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 7. 2016-01-25. PMID:25578795.' we conclude that vm glutamate relays the reward signal initiated by dorsal raphe electrical stimulation by acting on nmdars devoid of glun2a/2d subunits and exerts an inhibition on this reward signal by acting on glun2a-containing nmdars most likely located on afferent terminals. 2016-01-25 2023-08-13 Not clear
Klaus A Miczek, Joseph F DeBold, Lara S Hwa, Emily L Newman, Rosa M M de Almeid. Alcohol and violence: neuropeptidergic modulation of monoamine systems. Annals of the New York Academy of Sciences. vol 1349. 2015-12-07. PMID:26285061. the modulation of 5-hydroxytryptamine impulse flow by gamma-aminobutyric acid (gaba) and glutamate, acting via distinct ionotropic and metabotropic receptor subtypes in the dorsal raphe nucleus during alcohol consumption, is of critical significance in the suppression and escalation of aggressive behavior. 2015-12-07 2023-08-13 Not clear