All Relations between glutamate and hippocampus

Publication Sentence Publish Date Extraction Date Species
Sohrab Anvari, Mohammad Javan, Javad Mirnajafi-Zadeh, Yaghoub Fathollah. Repeated Morphine Exposure Alters Temporoamonic-CA1 Synaptic Plasticity in Male Rat Hippocampus. Neuroscience. 2024-03-21. PMID:38513764. in this study, the electrophysiological and biochemical consequences of repeated exposure to morphine in male rats on glutamatergic synaptic transmission, synaptic plasticity, the expression of gaba receptors and glutamate receptors at the temporoammonic-ca1 synapse along the longitudinal axis of the hippocampus (dorsal, intermediate, ventral, dh, ih, vh, respectively) were investigated. 2024-03-21 2024-03-24 rat
Yanlan Long, Zhen Zhao, Wanting Xie, Jinhui Shi, Fengyu Yang, Dan Zhu, Ping Jiang, Qilong Tang, Zhou Ti, Bin Jiang, Xia Yang, Guoquan Gao, Weiwei Q. Kallistatin leads to cognition impairment via downregulating glutamine synthetase. Pharmacological research. 2024-03-16. PMID:38492829. baseline glutamate levels were elevated and miniature excitatory postsynaptic current (mepsc) frequency was increased in the hippocampus, suggesting the impairment of glutamate homeostasis in kal-tg mice. 2024-03-16 2024-03-19 mouse
Peng Ren, Jing-Ya Wang, Hong-Lei Chen, Yue Wang, Lin-Yu Cui, Jing-Yao Duan, Wen-Zhi Guo, Yong-Qi Zhao, Yun-Feng L. Activation of σ-1 receptor mitigates estrogen withdrawal-induced anxiety/depressive-like behavior in mice via restoration of GABA/glutamate signaling and neuroplasticity in the hippocampus. Journal of pharmacological sciences. vol 154. issue 4. 2024-03-14. PMID:38485341. in the present study, excitatory/inhibitory signaling in the hippocampus was reflected by gaba and glutamate and their associated excitatory-inhibitory receptor proteins, the hpa axis hormones in the hippocampus were assessed by elisa. 2024-03-14 2024-03-17 mouse
Alena O Burnyasheva, Natalia A Stefanova, Nataliya G Kolosova, Darya V Telegin. Changes in the Glutamate/GABA System in the Hippocampus of Rats with Age and during Alzheimer's Disease Signs Development. Biochemistry. Biokhimiia. vol 88. issue 12. 2024-03-10. PMID:38462444. here we analyzed the age-related alterations of the levels of glutamate, gaba, as well as enzymes that synthesize them (glutaminase, glutamine synthetase, gaba-t, and gad67), transporters (glast, glt-1, and gat1), and relevant receptors (glua1, nmdar1, nmda2b, and gabaar1) in the whole hippocampus of the wistar rats and of the senescence-accelerated oxys rats, a model of the most common (> 95%) sporadic ad. 2024-03-10 2024-03-14 rat
Alena O Burnyasheva, Natalia A Stefanova, Nataliya G Kolosova, Darya V Telegin. Changes in the Glutamate/GABA System in the Hippocampus of Rats with Age and during Alzheimer's Disease Signs Development. Biochemistry. Biokhimiia. vol 88. issue 12. 2024-03-10. PMID:38462444. our results suggest that there is a decline in glutamate and gaba signaling with age in hippocampus of the both rat strains. 2024-03-10 2024-03-14 rat
Kohei Takahashi, Kazuhiro Kurokawa, Kazuya Miyagawa, Atsumi Mochida-Saito, Hiroshi Takeda, Minoru Tsuj. Repeated antibiotic drug treatment negatively affects memory function and glutamatergic nervous system of the hippocampus in mice. Neuroscience letters. 2024-03-03. PMID:38432356. in our study, a mouse dysbiosis model showed impaired memory-related behavior in the passive avoidance test; decreased expression levels of glutaminase, excitatory amino acid transporter (eaat)1, eaat2, vesicular glutamate transporter 2, synaptophysin, brain-derived neurotrophic factor, doublecortin, neuronal nuclear protein, glial fibrillary acidic protein, and s100β; and decreased phosphorylation of n-methyl-d-aspartate receptor subunit 1, calmodulin-dependent protein kinase ii, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit 1, and camp response element-binding protein in the hippocampus. 2024-03-03 2024-03-06 mouse
Dingding Lv, Bin Xiao, Huaying Liu, Linping Wang, Yingshun Li, Yin Hua Zhang, Qinghua Ji. Enhanced NMDA receptor pathway and glutamate transmission in the hippocampal dentate gyrus mediate the spatial learning and memory impairment of obese rats. Pflugers Archiv : European journal of physiology. 2024-02-28. PMID:38416255. enhanced nmda receptor pathway and glutamate transmission in the hippocampal dentate gyrus mediate the spatial learning and memory impairment of obese rats. 2024-02-28 2024-03-01 rat
Dingding Lv, Bin Xiao, Huaying Liu, Linping Wang, Yingshun Li, Yin Hua Zhang, Qinghua Ji. Enhanced NMDA receptor pathway and glutamate transmission in the hippocampal dentate gyrus mediate the spatial learning and memory impairment of obese rats. Pflugers Archiv : European journal of physiology. 2024-02-28. PMID:38416255. since glutamatergic transmission and nmda receptor neural pathways in hippocampal dentate gyrus (dg) are essential in the learning and memory, we aimed to investigate glutamate (glu) and nmda receptor signaling of dg in spatial learning and memory in diet-induced obesity (dio) rats. 2024-02-28 2024-03-01 rat
Shao-Hua Yang, Yuanhong Sun, Raymond Berry, Gourav Roy Choudhury, Ali Winters, Kiran Chaudhari, Ran Li. Glutamate Provides Cytoprotective Effect for Astrocytes Against Ischemic Insult and Promotes Astrogliosis. Aging and disease. 2024-02-20. PMID:38377020. the cytoprotective effect of glutamate appears to be astrocyte-specific, as glutamate dose-dependently induces cytotoxic action in murine hippocampal ht-22 cell line. 2024-02-20 2024-02-23 Not clear
Nicholas Pintori, Alessandro Piva, Francesca Mottarlini, Fernando Castillo Díaz, Coralie Maggi, Lucia Caffino, Fabio Fumagalli, Cristiano Chiamuler. Brief exposure to enriched environment rapidly shapes the glutamate synapses in the rat brain: A metaplastic fingerprint. The European journal of neuroscience. 2024-02-20. PMID:38378276. adult male sprague-dawley rats were exposed to ee for 22 h and the expression of critical elements of the glutamate synapse was measured 2 h after the end of ee in the medial prefrontal cortex (mpfc), nucleus accumbens (nac) and hippocampus (hipp) brain areas, which are critical for reward and memory. 2024-02-20 2024-02-23 rat
Niklas Reich, Christian Hölsche. Cholecystokinin (CCK): a neuromodulator with therapeutic potential in Alzheimer's and Parkinson's disease. Frontiers in neuroendocrinology. 2024-02-12. PMID:38346453. the neuropeptide facilitates hippocampal glutamate release and gates gabaergic basket cell activity, which improves declarative memory acquisition, but inhibits consolidation. 2024-02-12 2024-02-15 Not clear
Christopher J E Denning, Lauren E Madory, Jessica N Herbert, Ryan A Cabrera, Karen K Szumlinsk. Neuropharmacological Evidence Implicating Drug-Induced Glutamate Receptor Dysfunction in Affective and Cognitive Sequelae of Subchronic Methamphetamine Self-Administration in Mice. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339206. relative to naïve controls, ma-experienced mice exhibited several changes in the expression of certain glutamate receptor-related proteins and their downstream effectors within the ventral and dorsal areas of the prefrontal cortex, the hippocampus, and the amygdala, many of which were sex-selective. 2024-02-10 2024-02-12 mouse
Asiye Nurten, M Zafer Gören, Nurdan Tekin, Mert Kaşkal, Nurhan Engina. Assessing effects of tamoxifen on tolerance, dependence, and glutamate and glutamine levels in frontal cortex and hippocampus in chronic morphine treatment. Behavioural brain research. 2024-02-08. PMID:38331101. assessing effects of tamoxifen on tolerance, dependence, and glutamate and glutamine levels in frontal cortex and hippocampus in chronic morphine treatment. 2024-02-08 2024-02-11 mouse
Asiye Nurten, M Zafer Gören, Nurdan Tekin, Mert Kaşkal, Nurhan Engina. Assessing effects of tamoxifen on tolerance, dependence, and glutamate and glutamine levels in frontal cortex and hippocampus in chronic morphine treatment. Behavioural brain research. 2024-02-08. PMID:38331101. in contrast to previous reports, glutamate and glutamine levels in the hippocampus and frontal cortex did not change in the morphine-vehicle group. 2024-02-08 2024-02-11 mouse
Asiye Nurten, M Zafer Gören, Nurdan Tekin, Mert Kaşkal, Nurhan Engina. Assessing effects of tamoxifen on tolerance, dependence, and glutamate and glutamine levels in frontal cortex and hippocampus in chronic morphine treatment. Behavioural brain research. 2024-02-08. PMID:38331101. confirming previous findings, tamoxifen (2mg/kg) decreased glutamate and glutamine concentrations in the hippocampus in animals with placebo pellets. 2024-02-08 2024-02-11 mouse
Ekaterina P Aleksandrova, Andrey P Ivlev, Alexey A Kulikov, Alexandra A Naumova, Margarita V Glazova, Elena V Chernigovskay. Audiogenic kindling activates glutamatergic system in the hippocampus of rats with genetic predisposition to audiogenic seizures. Brain research. 2024-02-07. PMID:38325559. thus, after 14 ags, simultaneous increase in metabotropic glutamate receptor mglur1 and decrease in ionotropic n-methyl-d-aspartate (nmda) receptors could reflect compensatory anti-epileptic mechanism, while further kindling progression induced upregulation of ionotropic receptors, probably, contributing to the hippocampal epileptization. 2024-02-07 2024-02-10 rat
Ekaterina P Aleksandrova, Andrey P Ivlev, Alexey A Kulikov, Alexandra A Naumova, Margarita V Glazova, Elena V Chernigovskay. Audiogenic kindling activates glutamatergic system in the hippocampus of rats with genetic predisposition to audiogenic seizures. Brain research. 2024-02-07. PMID:38325559. altogether, obtained results suggested that overactivation of glutamate production in the hippocampus strongly contributed to tle development in km rats. 2024-02-07 2024-02-10 rat
Bin Mei, Xiaoxia Xu, Juntao Weng, Yueyue Yang, Peng Wang, Gaolin Qiu, Chi Zhang, Qunlin Zhang, Yao Lu, Xuesheng Li. Activating astrocytic α2A adrenoceptors in hippocampus reduces glutamate toxicity to attenuate sepsis-associated encephalopathy in mice. Brain, behavior, and immunity. 2024-02-06. PMID:38320682. activating astrocytic α2a adrenoceptors in hippocampus reduces glutamate toxicity to attenuate sepsis-associated encephalopathy in mice. 2024-02-06 2024-02-09 mouse
Bin Mei, Xiaoxia Xu, Juntao Weng, Yueyue Yang, Peng Wang, Gaolin Qiu, Chi Zhang, Qunlin Zhang, Yao Lu, Xuesheng Li. Activating astrocytic α2A adrenoceptors in hippocampus reduces glutamate toxicity to attenuate sepsis-associated encephalopathy in mice. Brain, behavior, and immunity. 2024-02-06. PMID:38320682. this study was performed to determine whether hippocampal astrocytic α2a-ar activation confers neuroprotection against sae and whether this protective effect is astrocyte specific and achieved by the modulation of glutamate metabolism. 2024-02-06 2024-02-09 mouse
Liam T Ralph, John Georgiou, Graham L Collingridge, Patrick Tidbal. Sex-dependence of synaptic depression induced by activation of metabotropic glutamate receptors in rat hippocampus. Brain and neuroscience advances. vol 8. 2024-02-01. PMID:38298523. sex-dependence of synaptic depression induced by activation of metabotropic glutamate receptors in rat hippocampus. 2024-02-01 2024-02-03 rat