Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
T Nishizaki, T Nomura, T Matuoka, T Kondoh, G Enikolopov, G Enikolopo, K Sumikawa, S Watabe, T Shiotani, M Yoshi. The anti-dementia drug nefiracetam facilitates hippocampal synaptic transmission by functionally targeting presynaptic nicotinic ACh receptors. Brain research. Molecular brain research. vol 80. issue 1. 2001-03-01. PMID:11039729. |
in addition, the drug caused a marked increase in the glutamate release from electrically stimulated guinea pig hippocampal slices, and the effect was abolished by the nicotinic ach receptor antagonists, alpha-bungarotoxin and mecamylamine. |
2001-03-01 |
2023-08-12 |
rat |
T Nishizaki, T Nomura, T Matuoka, T Kondoh, G Enikolopov, G Enikolopo, K Sumikawa, S Watabe, T Shiotani, M Yoshi. The anti-dementia drug nefiracetam facilitates hippocampal synaptic transmission by functionally targeting presynaptic nicotinic ACh receptors. Brain research. Molecular brain research. vol 80. issue 1. 2001-03-01. PMID:11039729. |
the results of the present study, thus, suggest that nefiracetam enhances activity of nicotinic ach receptors by interacting with a pkc pathway, thereby increasing glutamate release from presynaptic terminals, and then leading to a sustained facilitation of hippocampal neurotransmission. |
2001-03-01 |
2023-08-12 |
rat |
F Peña, R Tapi. Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels. Neuroscience. vol 101. issue 3. 2001-03-01. PMID:11113304. |
infusion of the k(+) channel blocker 4-aminopyridine in the hippocampus induces the release of glutamate, as well as seizures and neurodegeneration. |
2001-03-01 |
2023-08-12 |
rat |
F Peña, R Tapi. Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels. Neuroscience. vol 101. issue 3. 2001-03-01. PMID:11113304. |
tetrodotoxin largely prevented the increase of extracellular glutamate, the electroencephalographic epileptic discharges and the neuronal death in the ca1 and ca3 hippocampal regions. |
2001-03-01 |
2023-08-12 |
rat |
C G Hatalski, K L Brunson, B Tantayanubutr, Y Chen, T Z Bara. Neuronal activity and stress differentially regulate hippocampal and hypothalamic corticotropin-releasing hormone expression in the immature rat. Neuroscience. vol 101. issue 3. 2001-03-01. PMID:11113306. |
corticotropin-releasing hormone, a major neuromodulator of the neuroendocrine stress response, is expressed in the immature hippocampus, where it enhances glutamate receptor-mediated excitation of principal cells. |
2001-03-01 |
2023-08-12 |
rat |
V L Rao, A Dogan, K K Bowen, K G Todd, R J Dempse. Antisense knockdown of the glial glutamate transporter GLT-1 exacerbates hippocampal neuronal damage following traumatic injury to rat brain. The European journal of neuroscience. vol 13. issue 1. 2001-03-01. PMID:11135010. |
antisense knockdown of the glial glutamate transporter glt-1 exacerbates hippocampal neuronal damage following traumatic injury to rat brain. |
2001-03-01 |
2023-08-12 |
rat |
M Kubota, Y Iida, Y Magata, Y Kitamura, H Kawashima, H Saj. Mechanisms of [2,3-butanedione bis(N4-dimethylthiosemicarbazone)]zinc (Zn-ATSM2)-induced protection of cultured hippocampal neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity. Japanese journal of pharmacology. vol 84. issue 3. 2001-03-01. PMID:11138735. |
mechanisms of [2,3-butanedione bis(n4-dimethylthiosemicarbazone)]zinc (zn-atsm2)-induced protection of cultured hippocampal neurons against n-methyl-d-aspartate receptor-mediated glutamate cytotoxicity. |
2001-03-01 |
2023-08-12 |
rat |
G Sierra-Paredes, A Senra-Vidal, G Sierra-Marcuñ. Effect of extracellular long-time microperfusion of high concentrations of glutamate and glycine on picrotoxin seizure thresholds in the hippocampus of freely moving rats. Brain research. vol 888. issue 1. 2001-03-01. PMID:11146048. |
effect of extracellular long-time microperfusion of high concentrations of glutamate and glycine on picrotoxin seizure thresholds in the hippocampus of freely moving rats. |
2001-03-01 |
2023-08-12 |
rat |
G Sierra-Paredes, A Senra-Vidal, G Sierra-Marcuñ. Effect of extracellular long-time microperfusion of high concentrations of glutamate and glycine on picrotoxin seizure thresholds in the hippocampus of freely moving rats. Brain research. vol 888. issue 1. 2001-03-01. PMID:11146048. |
the effect of high concentrations of glutamate and glycine on picrotoxin seizure thresholds was investigated by perfusion through microdialysis probes in the hippocampus of freely moving rats. |
2001-03-01 |
2023-08-12 |
rat |
F Mauler, T Fahrig, E Horváth, R Jor. Inhibition of evoked glutamate release by the neuroprotective 5-HT(1A) receptor agonist BAY x 3702 in vitro and in vivo. Brain research. vol 888. issue 1. 2001-03-01. PMID:11146061. |
in rat hippocampal slices bay x 3702 inhibited evoked glutamate release in a dose-dependent manner (ic(50)=1 microm). |
2001-03-01 |
2023-08-12 |
rat |
F Ventriglia, V Di Mai. A Brownian model of glutamate diffusion in excitatory synapses of hippocampus. Bio Systems. vol 58. issue 1-3. 2001-03-01. PMID:11164632. |
a brownian model of glutamate diffusion in excitatory synapses of hippocampus. |
2001-03-01 |
2023-08-12 |
Not clear |
M Marti, G Bregola, A Binaschi, A Gemignani, M Simonat. Kindled seizure-evoked somatostatin release in the hippocampus: inhibition by MK-801. Neuroreport. vol 11. issue 14. 2001-02-22. PMID:11043550. |
the aim of this study was to evaluate the contribution of ionotropic glutamate receptors to kindled seizure-evoked somatostatin release in the hippocampus, using a microdialysis approach. |
2001-02-22 |
2023-08-12 |
rat |
A Rao, E M Cha, A M Crai. Mismatched appositions of presynaptic and postsynaptic components in isolated hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 22. 2001-02-22. PMID:11069941. |
to determine whether presynaptic input is necessary for postsynaptic differentiation, we isolated hippocampal neurons in microisland culture and thus deprived pyramidal cells of gaba input and gabaergic neurons of glutamate input. |
2001-02-22 |
2023-08-12 |
Not clear |
C Frank, S Sagratell. Neuroprotective effects of allopregnenolone on hippocampal irreversible neurotoxicity in vitro. Progress in neuro-psychopharmacology & biological psychiatry. vol 24. issue 7. 2001-02-22. PMID:11131176. |
the exposition of the primary hippocampal cultured cells to glutamate 0.5 mm for 10 min was followed by a sustained elevation of [ca2+]i, that persisted at 70-80% of maximal increase for the rest of the experiment (60 min). |
2001-02-22 |
2023-08-12 |
rat |
E Gursoy, A Cardounel, M Kalim. The environmental estrogenic compound bisphenol A exerts estrogenic effects on mouse hippocampal (HT-22) cells: neuroprotection against glutamate and amyloid beta protein toxicity. Neurochemistry international. vol 38. issue 2. 2001-02-22. PMID:11137887. |
the environmental estrogenic compound bisphenol a exerts estrogenic effects on mouse hippocampal (ht-22) cells: neuroprotection against glutamate and amyloid beta protein toxicity. |
2001-02-22 |
2023-08-12 |
mouse |
E Gursoy, A Cardounel, M Kalim. The environmental estrogenic compound bisphenol A exerts estrogenic effects on mouse hippocampal (HT-22) cells: neuroprotection against glutamate and amyloid beta protein toxicity. Neurochemistry international. vol 38. issue 2. 2001-02-22. PMID:11137887. |
we have examined using immortalized clonal mouse hippocampal cell line (ht-22) whether the environmental estrogenic compound bisphenol a (bpa), like estrogen, has any neuroprotective effect against glutamate and amyloid beta protein-induced neurotoxicity. |
2001-02-22 |
2023-08-12 |
mouse |
F M Ross, J Cassidy, M Wilson, S N Davie. Developmental regulation of hippocampal excitatory synaptic transmission by metabotropic glutamate receptors. British journal of pharmacology. vol 131. issue 3. 2001-02-15. PMID:11015295. |
developmental regulation of hippocampal excitatory synaptic transmission by metabotropic glutamate receptors. |
2001-02-15 |
2023-08-12 |
rat |
P Saransaari, S S Oj. Involvement of metabotropic glutamate receptors in ischemia-induced taurine release in the developing and adult hippocampus. Neurochemical research. vol 25. issue 8. 2001-02-15. PMID:11055743. |
involvement of metabotropic glutamate receptors in ischemia-induced taurine release in the developing and adult hippocampus. |
2001-02-15 |
2023-08-12 |
mouse |
L Medina-Ceja, A Morales-Villagrán, R Tapi. Action of 4-aminopyridine on extracellular amino acids in hippocampus and entorhinal cortex: a dual microdialysis and electroencehalographic study in awake rats. Brain research bulletin. vol 53. issue 3. 2001-02-15. PMID:11113578. |
likewise, infusion of 4-ap into the hippocampus resulted in a major increase in glutamate, as well as slight increases in taurine and glycine. |
2001-02-15 |
2023-08-12 |
rat |
C L Won, Y S O. cAMP-induced stellation in primary astrocyte cultures with regional heterogeneity. Brain research. vol 887. issue 2. 2001-02-15. PMID:11134613. |
interestingly, glutamate blockage on camp-induced astrocyte stellation was brain region-specific in that cerebral and hippocampal astrocytes were effectively blocked by glutamate when compared to other regional astrocytes. |
2001-02-15 |
2023-08-12 |
rat |