| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li-Han Sun, Lung Yu, Ya-Hsuan Chan, Min-Han Chin, Chi-Pin Lee, Yi-Han Lia. Combining brief recall and ketamine treatment prevents stress-primed methamphetamine memory reinstatement via heightening mPFC GABA activity. European journal of pharmacology. 2024-04-08. PMID:38588768. |
such combination also produced glutamate metabotropic receptor 5 (mglur5) upregulation in animals' medial prefrontal cortex (mpfc) γ-amino-butyric acid (gaba) neuron. |
2024-04-08 |
2024-04-11 |
mouse |
| Shelby Travaglianti, Ahmed Alotaibi, Woonyen Wong, Magid Abou-Gharbia, Wayne Childers, Youssef Sar. Effects of novel GLT-1 modulator, MC-100093, on neuroinflammatory and neurotrophic biomarkers in mesocorticolimbic brain regions of male alcohol preferring rats exposed chronically to ethanol. Brain research bulletin. 2024-04-03. PMID:38570076. |
chronic ethanol consumption can lead to increased extracellular glutamate concentrations in key reward brain regions, such as medial prefrontal cortex (mpfc) and nucleus accumbens (nac), and consequently leading to oxidative stress and neuroinflammation. |
2024-04-03 |
2024-04-06 |
rat |
| Kazuro Shibata, Kosuke Enomoto, Takahiro Tsutsumi, Hiroyuki Muraoka, Tatsu Fuwa, Masahiko Kawano, Jun Ishigooka, Ken Inada, Katsuji Nishimura, Hidehiro Oshibuch. Effect of intermittent subchronic MK-801 administration on dopamine synthesis capacity and responsiveness in the prefrontal cortex. Neuropsychopharmacology reports. 2024-02-20. PMID:38376999. |
the therapeutic potential of n-methyl-d-aspartate glutamate receptor (nmdar) antagonists, particularly ketamine, in mood disorders, is linked to their modulation of dopamine dynamics in the medial prefrontal cortex (mpfc). |
2024-02-20 |
2024-02-23 |
Not clear |
| Nicholas Pintori, Alessandro Piva, Francesca Mottarlini, Fernando Castillo Díaz, Coralie Maggi, Lucia Caffino, Fabio Fumagalli, Cristiano Chiamuler. Brief exposure to enriched environment rapidly shapes the glutamate synapses in the rat brain: A metaplastic fingerprint. The European journal of neuroscience. 2024-02-20. PMID:38378276. |
adult male sprague-dawley rats were exposed to ee for 22 h and the expression of critical elements of the glutamate synapse was measured 2 h after the end of ee in the medial prefrontal cortex (mpfc), nucleus accumbens (nac) and hippocampus (hipp) brain areas, which are critical for reward and memory. |
2024-02-20 |
2024-02-23 |
rat |
| Chao Zhang, Kaihua Zhang, Xin Hu, Xianyun Cai, Yufan Chen, Fei Gao, Guangbin Wan. Regional GABA levels modulate abnormal resting-state network functional connectivity and cognitive impairment in multiple sclerosis. Cerebral cortex (New York, N.Y. : 1991). 2024-01-25. PMID:38271282. |
for this purpose, we used a combination of magnetic resonance spectroscopy and resting-state functional magnetic resonance imaging to study gamma-aminobutyric acid and glutamate concentrations in the posterior cingulate cortex, medial prefrontal cortex and left hippocampus, and inter-network functional connectivity in 29 relapsing-remitting multiple sclerosis patients and 34 matched healthy controls. |
2024-01-25 |
2024-01-28 |
Not clear |
| Kim H Tran, Jessica Luki, Sarah Hanstock, Christopher C Hanstock, Peter Seres, Katherine Aitchison, Tami Shandro, Jean-Michel Le Melled. The impact of matching for reproductive status on the comparison of magnetic spectroscopic measurements of glutamate and gamma-aminobutyric acid + in the medial prefrontal cortex of women with major depression. Journal of affective disorders. 2024-01-20. PMID:38244791. |
the impact of matching for reproductive status on the comparison of magnetic spectroscopic measurements of glutamate and gamma-aminobutyric acid + in the medial prefrontal cortex of women with major depression. |
2024-01-20 |
2024-01-23 |
Not clear |
| Kim H Tran, Jessica Luki, Sarah Hanstock, Christopher C Hanstock, Peter Seres, Katherine Aitchison, Tami Shandro, Jean-Michel Le Melled. The impact of matching for reproductive status on the comparison of magnetic spectroscopic measurements of glutamate and gamma-aminobutyric acid + in the medial prefrontal cortex of women with major depression. Journal of affective disorders. 2024-01-20. PMID:38244791. |
the role played by medial prefrontal cortex (mpfc) glutamate (glu) and gamma-aminobutyric acid (gaba) in the pathophysiology and the treatment of major depression (md) is increasingly recognized. |
2024-01-20 |
2024-01-23 |
Not clear |
| Nicholas Spitzer, Marta Pratelli, Anna Hakimi, Arth Thaker, Hui-Quan Li, Swetha Godavarth. Drug-induced change in transmitter identity is a shared mechanism generating cognitive deficits. Research square. 2024-01-03. PMID:38168375. |
we find that both phencyclidine and methamphetamine, despite differing in their targets in the brain, cause the same glutamatergic neurons in the medial prefrontal cortex to gain a gabaergic phenotype and decrease their expression of the vesicular glutamate transporter. |
2024-01-03 |
2024-01-06 |
Not clear |
| Luis Gerardo Balcazar-Ochoa, Rosa Ventura-Martínez, Guadalupe Esther Ángeles-López, Claudia Gómez-Acevedo, Omar Francisco Carrasco, Raúl Sampieri-Cabrera, Anahí Chavarría, Abimael González-Hernánde. Clavulanic Acid and its Potential Therapeutic Effects on the Central Nervous System. Archives of medical research. vol 55. issue 1. 2023-12-01. PMID:38039802. |
studies have revealed that clav can increase glt-1 expression in the nucleus accumbens (nacc), medial prefrontal cortex (pfc), and spinal cord of rodents, to affect glutamate and dopaminergic neurotransmission, and exert an anti-inflammatory effect by modulating the levels of the cytokines tnf-α and interleukin 10 (il-10). |
2023-12-01 |
2023-12-10 |
Not clear |
| Mélodie Derome, Petya Kozuharova, Andrea Diaconescu, Sophie Denève, Renaud Jardri, Paul Alle. Functional connectivity and glutamate levels of the medial prefrontal cortex in schizotypy are related to sensory amplification in a probabilistic reasoning task. NeuroImage. 2023-07-17. PMID:37460012. |
functional connectivity and glutamate levels of the medial prefrontal cortex in schizotypy are related to sensory amplification in a probabilistic reasoning task. |
2023-07-17 |
2023-08-14 |
human |
| Mélodie Derome, Petya Kozuharova, Andrea Diaconescu, Sophie Denève, Renaud Jardri, Paul Alle. Functional connectivity and glutamate levels of the medial prefrontal cortex in schizotypy are related to sensory amplification in a probabilistic reasoning task. NeuroImage. 2023-07-17. PMID:37460012. |
participants also underwent a 1h-magnetic resonance spectroscopy (mrs) scan to measure medial prefrontal cortex (mpfc) glutamate metabolite levels, and a functional magnetic resonance imaging (fmri) scan to measure rsfc of the medial prefrontal cortex (mpfc). |
2023-07-17 |
2023-08-14 |
human |
| Kfir Asraf, Hiba Zaidan, Baylasan Natoor, Inna Gaisler-Salomo. Synergistic, long-term effects of glutamate dehydrogenase 1 deficiency and mild stress on cognitive function and mPFC gene and miRNA expression. Translational psychiatry. vol 13. issue 1. 2023-07-07. PMID:37419882. |
glutamate abnormalities in the medial prefrontal cortex (mpfc) are associated with cognitive deficits. |
2023-07-07 |
2023-08-14 |
mouse |
| Saida Oubraim, Roh-Yu Shen, Samir Haj-Dahman. Oxytocin excites dorsal raphe serotonin neurons and bidirectionally gates their glutamate synapses. iScience. vol 26. issue 5. 2023-05-30. PMID:37250336. |
neuronal mapping demonstrates that oxt preferentially potentiates glutamate synapses of 5-ht neurons projecting to medial prefrontal cortex (mpfc) and depresses glutamatergic inputs to 5-ht neurons projecting to lateral habenula (lhb) and central amygdala (cea). |
2023-05-30 |
2023-08-14 |
Not clear |
| Jae Soon Kang, Ji Hyeong Baek, Mi Yeong Song, Naveed Ur Rehman, Hye Jin Chung, Dong Kun Lee, Dae Young Yoo, Hyun Joon Ki. Long-term exposure changes the environmentally relevant bis(2-ethylhexyl) phthalate to be a neuro-hazardous substance disrupting neural homeostasis in emotional and cognitive functions. Environmental pollution (Barking, Essex : 1987). 2023-03-04. PMID:36870594. |
long-term dehp ingestion induced collapse of glutamate (glu) and glutamine (gln) homeostasis as a result of disruption of the glu-gln cycle in the medial prefrontal cortex and hippocampus. |
2023-03-04 |
2023-08-14 |
mouse |
| Xi Chen, Xiaopeng Song, Dost Öngür, Fei D. Association of default-mode network neurotransmitters and inter-network functional connectivity in first episode psychosis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-02-14. PMID:36788375. |
we detected higher glutamate (glu) levels in the medial prefrontal cortex (mpfc) in fep compared to healthy controls without a significant difference in gaba. |
2023-02-14 |
2023-08-14 |
Not clear |
| Samuel C Woodburn, Helina S Asrat, James K Flurer, Hana C Schwierling, Justin L Bollinger, Lauren L Vollmer, Eric S Wohle. Depletion of microglial BDNF increases susceptibility to the behavioral and synaptic effects of chronic unpredictable stress. Brain, behavior, and immunity. 2023-01-21. PMID:36681359. |
in the medial prefrontal cortex (pfc), chronic stress reduces synaptic expression of glutamate receptors, leading to decreased excitatory signaling from layer v pyramidal neurons and working memory deficits. |
2023-01-21 |
2023-08-14 |
mouse |
| Alaa M Hammad, Asma'a Naser, Haneen Amawi, F Scott Hall, Amit K Tiwari, Bahaa Al-Tra. Effect of Amoxicillin/Clavulanic acid in attenuating Pregabalin-induced Condition Place Preference. Behavioural brain research. 2022-12-05. PMID:36470419. |
moreover, like other drugs of abuse, pregabalin also produced alterations in glutamate homeostasis, reducing the mrna expression of slc1a2 and slc7a11 in the nucleus accumbens (nac) and medial prefrontal cortex (mpfc). |
2022-12-05 |
2023-08-14 |
Not clear |
| Nguyen Thi Mai Loan, Céline Defaix, Indira Mendez-David, Laurent Tritschler, Isabelle Etting, Jean-Claude Alvarez, Walid Choucha, Romain Colle, Emmanuelle Corruble, Denis J David, Alain M Gardie. Intranasal (R, S)-ketamine delivery induces sustained antidepressant effects associated with changes in cortical balance of excitatory/inhibitory synaptic activity. Neuropharmacology. 2022-12-03. PMID:36462636. |
at sub-anesthetic doses, (±)-ketamine, a non-competitive glutamate n-methyl-d-aspartate (nmda) receptor antagonist, increases the overall excitability of the medial prefrontal cortex (mpfc), an effect being essential for its rapid antidepressant activity. |
2022-12-03 |
2023-08-14 |
mouse |
| Megan L Bertholomey, Vidhya Nagarajan, Dana M Smith, Mary M Torregross. Sex- and age-dependent effects of chronic corticosterone exposure on depressive-like, anxiety-like, and fear-related behavior: Role of amygdala glutamate receptors in the rat. Frontiers in behavioral neuroscience. vol 16. 2022-10-10. PMID:36212195. |
basolateral amygdala (bla) and medial prefrontal cortex (mpfc) glutamate receptor subunit levels were then measured. |
2022-10-10 |
2023-08-14 |
rat |
| Alexander Papadogiannis, Eugene Dimitro. A possible mechanism for development of working memory impairment in male mice subjected to inflammatory pain. Neuroscience. 2022-09-13. PMID:36100034. |
we studied the effects of inflammatory pain on working memory and correlated the pain effects with changes in dendritic spine density and glutamate signaling in the medial prefrontal cortex (mpfc) of male and female mice. |
2022-09-13 |
2023-08-14 |
mouse |