| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Vrettou, Liying Yan, Kent W Nilsson, Åsa Wallén-Mackenzie, Ingrid Nylander, Erika Comasc. DNA methylation of Vesicular Glutamate Transporters in the mesocorticolimbic brain following early-life stress and adult ethanol exposure-an explorative study. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:34321562. |
the present study aimed to investigate whether dna methylation of the vesicular glutamate transporters (vglut)1-3 is related to previously observed vglut1-3 transcriptional differences in the ventral tegmental area (vta), nucleus accumbens (acb), dorsal striatum (dstr) and medial prefrontal cortex (mpfc) of adult rats exposed to els, modelled by maternal separation, and voluntary ethanol consumption. |
2021-11-08 |
2023-08-13 |
rat |
| Alessandro Piva, Lucia Caffino, Francesca Mottarlini, Nicholas Pintori, Fernando Castillo Díaz, Fabio Fumagalli, Cristiano Chiamuler. Metaplastic Effects of Ketamine and MK-801 on Glutamate Receptors Expression in Rat Medial Prefrontal Cortex and Hippocampus. Molecular neurobiology. vol 58. issue 7. 2021-11-03. PMID:33723767. |
metaplastic effects of ketamine and mk-801 on glutamate receptors expression in rat medial prefrontal cortex and hippocampus. |
2021-11-03 |
2023-08-13 |
rat |
| Jason Smucny, Cameron S Carter, Richard J Maddoc. Medial Prefrontal Cortex Glutamate Is Reduced in Schizophrenia and Moderated by Measurement Quality: A Meta-analysis of Proton Magnetic Resonance Spectroscopy Studies. Biological psychiatry. vol 90. issue 9. 2021-11-01. PMID:34344534. |
medial prefrontal cortex glutamate is reduced in schizophrenia and moderated by measurement quality: a meta-analysis of proton magnetic resonance spectroscopy studies. |
2021-11-01 |
2023-08-13 |
Not clear |
| Jason J Paris, Xi Chen, Joseph Anderson, Alaa N Qrareya, Fakhri Mahdi, Fei Du, Jay P McLaughlin, Marc J Kaufma. In vivo proton magnetic resonance spectroscopy detection of metabolite abnormalities in aged Tat-transgenic mouse brain. GeroScience. vol 43. issue 4. 2021-10-28. PMID:33818687. |
aged tat-tg mice demonstrated measurable tat mrna brain expression and had lower medial prefrontal cortex (mpfc) gaba, glutamate, and taurine levels and lower striatal gaba and taurine levels. |
2021-10-28 |
2023-08-13 |
mouse |
| Luana Freese, Marilise Fraga de Souza, Maurício Schüler Nin, Greice Calleti, Valéria Flores Peres, Rosane Gomez, Helena Maria Tannhauser Barro. Elevated GABA levels in the medial prefrontal cortex and lower estrogen levels abolish cocaine sensitization behavior in ovariectomized female rats. Brain research. vol 1749. 2021-10-27. PMID:33038296. |
here we investigated the in vivo changes on gaba, glutamate, and taurine levels in the medial prefrontal cortex (mpfc) of gonadal intact or ovariectomized female rats after a cocaine challenge administration. |
2021-10-27 |
2023-08-13 |
rat |
| Tianyun Zhao, Yanxin Chen, Zhixiang Sun, Ziwen Shi, Jingwen Qin, Junming Lu, Chuanxiang Li, Daqing Ma, Libing Zhou, Xingrong Son. Prenatal sevoflurane exposure causes neuronal excitatory/inhibitory imbalance in the prefrontal cortex and neurofunctional abnormality in rats. Neurobiology of disease. vol 146. 2021-10-25. PMID:33007389. |
we found a significant increase of parvalbumin-positive neurons, vesicular gaba transporter (vgat) and gad67 expression, and gaba neurotransmitter, and a significant decrease of vesicular glutamate transporter 1 (vglut1) expression and glutamate in the medial prefrontal cortex (mpfc) of offspring. |
2021-10-25 |
2023-08-13 |
rat |
| Zixiu Xiang, Xiaohui Lv, Xin Lin, Daniel E O'Brien, Molly K Altman, Craig W Lindsley, Jonathan A Javitch, Colleen M Niswender, P Jeffrey Con. Input-specific regulation of glutamatergic synaptic transmission in the medial prefrontal cortex by mGlu Science signaling. vol 14. issue 677. 2021-10-08. PMID:33824180. |
input-specific regulation of glutamatergic synaptic transmission in the medial prefrontal cortex by mglu metabotropic glutamate receptors (mglurs) are g protein-coupled receptors that regulate various aspects of central nervous system processing in normal physiology and in disease. |
2021-10-08 |
2023-08-13 |
Not clear |
| Jae Soon Kang, Ji Hyeong Baek, Soonwoong Jung, Hye Jin Chung, Dong Kun Lee, Hyun Joon Ki. Ingestion of Bis(2-ethylhexyl) phthalate (DEHP) during adolescence causes depressive-like behaviors through hypoactive glutamatergic signaling in the medial prefrontal cortex. Environmental pollution (Barking, Essex : 1987). vol 289. 2021-09-29. PMID:34426190. |
in the medial prefrontal cortex (mpfc), glutamate and glutamine were decreased, and glutamine synthetase showed lower activity compared to the control group, suggesting imbalanced glutamatergic signaling. |
2021-09-29 |
2023-08-13 |
mouse |
| Claudia Rangel-Barajas, Israel Coronel, Yanping Zhang, Maribel Hernández, Stephen L Boehm I. Low-level developmental lead exposure does not predispose to adult alcohol self-administration, but does increase the risk of relapsing to alcohol seeking in mice: Contrasting role of GLT1 and xCT brain expression. Neuropharmacology. vol 181. 2021-09-23. PMID:33010299. |
because pb exposure is associated with increased glutamatergic tone, we also studied the effects on the expression of synaptic and non-synaptic glutamate transporters in brain regions associated with drug addiction such as the nucleus accumbens (nac), dorsomedial striatum (dms), dorsolateral striatum (dls), and medial prefrontal cortex (mpfc). |
2021-09-23 |
2023-08-13 |
mouse |
| Li Yang, Ming Chen, Qianqian Ma, Huan Sheng, Dongyang Cui, Da Shao, Bin Lai, Ping Zhen. Morphine selectively disinhibits glutamatergic input from mPFC onto dopamine neurons of VTA, inducing reward. Neuropharmacology. vol 176. 2021-08-13. PMID:32679049. |
using optogenetic strategy combined with whole-cell patch-clamp, qrt-pcr, immunofluorescence and chemical genetic approach combined with behavioral methods, our results show that: 1) morphine promotes glutamate release from glutamatergic terminals of medial prefrontal cortex (mpfc) neurons projecting to vta-da neurons but does not on those from glutamatergic terminals of the lateral hypothalamus (lh) neurons projecting to vta-da neurons; 2) different response of glutamatergic neurons projecting to vta-da neurons from the mpfc or the lh to morphine is related to the expression of gaba |
2021-08-13 |
2023-08-13 |
Not clear |
| Sharon Sima Lander, Sergiy Chornyy, Hazem Safory, Amit Gross, Herman Wolosker, Inna Gaisler-Salomo. Glutamate dehydrogenase deficiency disrupts glutamate homeostasis in hippocampus and prefrontal cortex and impairs recognition memory. Genes, brain, and behavior. vol 19. issue 6. 2021-07-16. PMID:31898404. |
here, we first asked whether mice with a homozygous deletion of glud1 in cns (cns-glud1 -/- mice) express different levels of glutamate in hippocampus, and found elevated glutamate as well as glutamine in dorsal and ventral hippocampus, and increased glutamine in medial prefrontal cortex (mpfc). |
2021-07-16 |
2023-08-13 |
mouse |
| Xiao-Yuan Jing, Yan Wang, Hua-Wei Zou, Zi-Lin Li, Ying-Juan Liu, Lai-Fu L. mGlu2/3 receptor in the prelimbic cortex is implicated in stress resilience and vulnerability in mice. European journal of pharmacology. vol 906. 2021-07-16. PMID:34090896. |
metabotropic glutamate receptors (mglu2/3 and mglu5) within the medial prefrontal cortex (mpfc) have been recently recognized as promising therapeutic targets for rapid-acting antidepressant treatment. |
2021-07-16 |
2023-08-13 |
mouse |
| Meriem Haddar, Kyosuke Uno, Katsunori Azuma, Shin-Ichi Muramatsu, Atsumi Nitt. Inhibitory effects of Shati/Nat8l overexpression in the medial prefrontal cortex on methamphetamine-induced conditioned place preference in mice. Addiction biology. vol 25. issue 3. 2021-06-24. PMID:30950164. |
meanwhile, dopamine (da) and glutamate dysregulations have been reported in the medial prefrontal cortex (mpfc) and nac after meth self-administration and during reinstatement. |
2021-06-24 |
2023-08-13 |
mouse |
| Badari Birur, Nina Vanessa Kraguljac, Lawrence VerHoef, Charity J Morgan, Ripu Daman Jindal, Meredith Amanda Reid, Austin Luker, Adrienne Carol Laht. Neurometabolic correlates of 6 and 16 weeks of treatment with risperidone in medication-naive first-episode psychosis patients. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32066680. |
we enrolled 29 medication-naive first-episode patients (fep) and 22 matched healthy controls (hc) in this magnetic resonance spectroscopy (mrs) study, examining the levels of combined glutamate and glutamine (commonly referred to as glx) in the bilateral medial prefrontal cortex (mpfc) with a press sequence (tr/te = 2000/80 ms) before initiation of antipsychotic treatment, after 6 and 16 weeks of treatment with risperidone. |
2021-06-18 |
2023-08-13 |
Not clear |
| Gang Lei, Fei Liu, Peng Liu, Tong Jiao, Liu Yang, Zheng Chu, Li-Sha Deng, Yan Li, Yong-Hui Dan. Does genetic mouse model of constitutive Hint1 deficiency exhibit schizophrenia-like behaviors? Schizophrenia research. vol 222. 2021-06-17. PMID:32439293. |
total glutamate was decreased in the medial prefrontal cortex, nucleus accumbens (nac), and hip of ko mice. |
2021-06-17 |
2023-08-13 |
mouse |
| Lailun Nahar, Caleb A Grant, Cameron Hewett, Diego Cortes, Ashlie N Reker, Seungwoo Kang, Doo-Sup Choi, Hyung W Na. Regulation of Pv-specific interneurons in the medial prefrontal cortex and reward-seeking behaviors. Journal of neurochemistry. vol 156. issue 2. 2021-04-08. PMID:32594517. |
interestingly, our microdialysis results demonstrate that alcohol exposure inhibits pv-fsi functioning in the medial prefrontal cortex (mpfc) and this consequently can regulate glutamate levels downstream in the nucleus accumbens. |
2021-04-08 |
2023-08-13 |
mouse |
| Brendan D Hare, Santosh Pothula, Ralph J DiLeone, Ronald S Duma. Ketamine increases vmPFC activity: Effects of (R)- and (S)-stereoisomers and (2R,6R)-hydroxynorketamine metabolite. Neuropharmacology. vol 166. 2021-04-02. PMID:31926944. |
ketamine, an nmda receptor antagonist and fast acting antidepressant, produces a rapid burst of glutamate in the ventral medial prefrontal cortex (mpfc). |
2021-04-02 |
2023-08-13 |
mouse |
| Lucas Aschidamini Marcondes, Eduarda Godfried Nachtigall, André Zanluchi, Jociane de Carvalho Myskiw, Ivan Izquierdo, Cristiane Regina Guerino Furin. Involvement of medial prefrontal cortex NMDA and AMPA/kainate glutamate receptors in social recognition memory consolidation. Neurobiology of learning and memory. vol 168. 2021-01-13. PMID:31881354. |
involvement of medial prefrontal cortex nmda and ampa/kainate glutamate receptors in social recognition memory consolidation. |
2021-01-13 |
2023-08-13 |
rat |
| Danielle M Gerhard, Santosh Pothula, Rong-Jian Liu, Min Wu, Xiao-Yuan Li, Matthew J Girgenti, Seth R Taylor, Catharine H Duman, Eric Delpire, Marina Picciotto, Eric S Wohleb, Ronald S Duma. GABA interneurons are the cellular trigger for ketamine's rapid antidepressant actions. The Journal of clinical investigation. vol 130. issue 3. 2020-11-03. PMID:31743111. |
the results demonstrated that the antidepressant actions of ketamine were blocked by glun2b-nmdar knockdown on gaba (gad1) interneurons, as well as subtypes expressing somatostatin (sst) or parvalbumin (pvalb), but not glutamate principle neurons in the medial prefrontal cortex (mpfc). |
2020-11-03 |
2023-08-13 |
Not clear |
| Kelsey M Moore, Wyatt L Oelberg, M Rose Glass, Matthew D Johnson, Laura E Been, Robert L Meise. Glutamate Afferents From the Medial Prefrontal Cortex Mediate Nucleus Accumbens Activation by Female Sexual Behavior. Frontiers in behavioral neuroscience. vol 13. 2020-10-01. PMID:31636548. |
glutamate afferents from the medial prefrontal cortex mediate nucleus accumbens activation by female sexual behavior. |
2020-10-01 |
2023-08-13 |
Not clear |