| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shelby Travaglianti, Ahmed Alotaibi, Woonyen Wong, Magid Abou-Gharbia, Wayne Childers, Youssef Sar. Effects of novel GLT-1 modulator, MC-100093, on neuroinflammatory and neurotrophic biomarkers in mesocorticolimbic brain regions of male alcohol preferring rats exposed chronically to ethanol. Brain research bulletin. 2024-04-03. PMID:38570076. |
chronic ethanol consumption can lead to increased extracellular glutamate concentrations in key reward brain regions, such as medial prefrontal cortex (mpfc) and nucleus accumbens (nac), and consequently leading to oxidative stress and neuroinflammation. |
2024-04-03 |
2024-04-06 |
rat |
| Nicholas Pintori, Alessandro Piva, Francesca Mottarlini, Fernando Castillo Díaz, Coralie Maggi, Lucia Caffino, Fabio Fumagalli, Cristiano Chiamuler. Brief exposure to enriched environment rapidly shapes the glutamate synapses in the rat brain: A metaplastic fingerprint. The European journal of neuroscience. 2024-02-20. PMID:38378276. |
adult male sprague-dawley rats were exposed to ee for 22 h and the expression of critical elements of the glutamate synapse was measured 2 h after the end of ee in the medial prefrontal cortex (mpfc), nucleus accumbens (nac) and hippocampus (hipp) brain areas, which are critical for reward and memory. |
2024-02-20 |
2024-02-23 |
rat |
| Luis Gerardo Balcazar-Ochoa, Rosa Ventura-Martínez, Guadalupe Esther Ángeles-López, Claudia Gómez-Acevedo, Omar Francisco Carrasco, Raúl Sampieri-Cabrera, Anahí Chavarría, Abimael González-Hernánde. Clavulanic Acid and its Potential Therapeutic Effects on the Central Nervous System. Archives of medical research. vol 55. issue 1. 2023-12-01. PMID:38039802. |
studies have revealed that clav can increase glt-1 expression in the nucleus accumbens (nacc), medial prefrontal cortex (pfc), and spinal cord of rodents, to affect glutamate and dopaminergic neurotransmission, and exert an anti-inflammatory effect by modulating the levels of the cytokines tnf-α and interleukin 10 (il-10). |
2023-12-01 |
2023-12-10 |
Not clear |
| Mauricio Quezada, Carolina Ponce, Pablo Berríos-Cárcamo, Daniela Santapau, Javiera Gallardo, Cristian De Gregorio, María Elena Quintanilla, Paola Morales, Marcelo Ezquer, Mario Herrera-Marschitz, Yedy Israel, Paula Andrés-Herrera, Lucia Hipólito, Fernando Ezque. Amelioration of morphine withdrawal syndrome by systemic and intranasal administration of mesenchymal stem cell-derived secretome in preclinical models of morphine dependence. CNS neuroscience & therapeutics. 2023-11-06. PMID:37927136. |
the morphine-induced increases in neuroinflammation, brain oxidative stress, and alteration of glutamate levels in the hippocampus and nucleus accumbens have been associated with morphine dependence and a higher severity of withdrawal symptoms. |
2023-11-06 |
2023-11-08 |
human |
| Elaine Zhu, Dave Mathew, Hyun Jung Jee, Mengqi Sun, Weizhuo Liu, Qiaosheng Zhang, Jing Wan. AMPAkines have site-specific analgesic effects in the cortex. Molecular pain. 2023-11-03. PMID:37921508. |
prior research has shown that ampakines, a class of drugs that increase glutamate signaling, can enhance descending inhibition from the prefrontal cortex (pfc) and nucleus accumbens. |
2023-11-03 |
2023-11-08 |
rat |
| Tracy L Fetterly, Amanda M Catalfio, Carrie R Ferrari. Effects of junk-food on food-motivated behavior and nucleus accumbens glutamate plasticity; insights into the mechanism of calcium-permeable AMPA receptor recruitment. Neuropharmacology. vol 242. 2023-11-03. PMID:37898332. |
effects of junk-food on food-motivated behavior and nucleus accumbens glutamate plasticity; insights into the mechanism of calcium-permeable ampa receptor recruitment. |
2023-11-03 |
2023-11-08 |
rat |
| Alaa AlHarthi, Fawaz Alasmari, Shakir D AlSharari, Nouf M Alrasheed, Musaad A Alshammari, Tahani K Alshammar. Investigating Behavioral and Neuronal Changes in Adolescent Mice Following Prenatal Exposure to Electronic Cigarette (E-Cigarette) Vapor Containing Nicotine. Brain sciences. vol 13. issue 10. 2023-10-30. PMID:37891786. |
at a molecular level, the mrnas of metabotropic glutamate receptors and transporters in the nucleus accumbens were not altered. |
2023-10-30 |
2023-11-08 |
mouse |
| Etna J E Engeli, Andrea G Russo, Sara Ponticorvo, Niklaus Zoelch, Andreas Hock, Lea M Hulka, Matthias Kirschner, Katrin H Preller, Erich Seifritz, Boris B Quednow, Fabrizio Esposito, Marcus Herdene. Accumbal-thalamic connectivity and associated glutamate alterations in human cocaine craving: A state-dependent rs-fMRI and NeuroImage. Clinical. vol 39. 2023-08-28. PMID:37639901. |
in animal models, impaired prefrontal-striatal signalling leading to altered glutamate release in the nucleus accumbens appear to be the prerequisite for cocaine-seeking. |
2023-08-28 |
2023-09-07 |
human |
| Melissa C Knouse, Andre U Deutschmann, Miroslav N Nenov, Mathieu E Wimmer, Lisa A Brian. Sex differences in pre- and post-synaptic glutamate signaling in the nucleus accumbens core. Biology of sex differences. vol 14. issue 1. 2023-08-21. PMID:37596655. |
glutamate signaling within the nucleus accumbens underlies motivated behavior and is involved in psychiatric disease. |
2023-08-21 |
2023-09-07 |
Not clear |
| Lauren Faget, Lucie Oriol, Wen-Chun Lee, Cody Sargent, Dhakshin Ramanathan, Thomas S Hnask. Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types. bioRxiv : the preprint server for biology. 2023-07-28. PMID:37502884. |
however, vp glut neurons evoked da in reward-associated ventromedial nucleus accumbens (nac), but reduced da in aversion-associated dorsomedial nac. |
2023-07-28 |
2023-08-14 |
human |
| Dillon J McGovern, Abigail M Polter, Emily D Prévost, Annie Ly, Connor J McNulty, Bodhi Rubinstein, David H Roo. Ventral tegmental area glutamate neurons establish a mu-opioid receptor gated circuit to mesolimbic dopamine neurons and regulate opioid-seeking behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-07-05. PMID:37407648. |
this vta glutamate to vta dopamine pathway regulated dopamine release to the nucleus accumbens through mu-opioid receptor activity in vivo. |
2023-07-05 |
2023-08-14 |
mouse |
| Danielle M Giangrasso, Kaliana M Veros, Maureen M Timm, Peter J West, Karen S Wilcox, Kristen A Keef. Glutamate dynamics in the dorsolateral striatum of rats with goal-directed and habitual cocaine-seeking behavior. Frontiers in molecular neuroscience. vol 16. 2023-05-30. PMID:37251646. |
evidence from the nucleus accumbens of cocaine-experienced rats suggests that decreased transporter-mediated glutamate clearance and enhanced synaptic glutamate release contribute to the potentiated glutamate signaling that underlies the enduring vulnerability to relapse. |
2023-05-30 |
2023-08-14 |
rat |
| Lorraine Madur, Christian Ineichen, Giorgio Bergamini, Alexandra Greter, Giulia Poggi, Nagiua Cuomo-Haymour, Hannes Sigrist, Yaroslav Sych, Jean-Charles Paterna, Klaus D Bornemann, Coralie Viollet, Francesc Fernandez-Albert, Gregorio Alanis-Lobato, Bastian Hengerer, Christopher R Pryc. Stress deficits in reward behaviour are associated with and replicated by dysregulated amygdala-nucleus accumbens pathway function in mice. Communications biology. vol 6. issue 1. 2023-04-15. PMID:37061616. |
glutamate neurons in basal amygdala (ba) project to various regions including nucleus accumbens (nac). |
2023-04-15 |
2023-08-14 |
mouse |
| Laura C Ornelas, Giorgia Boero, Kalynn Van Voorhies, Todd K O'Buckley, Joyce Besheer, A Leslie Morro. Pharmacological administration of 3α,5α-THP into nucleus accumbens core increases 3α,5α-THP expression and reduces alcohol self-administration. Alcoholism, clinical and experimental research. 2023-01-01. PMID:36587947. |
alcohol affects multiple circuits in the brain, mainly disrupting the delicate balance between inhibitory γ-aminobutyric acid (gaba) transmission and excitatory glutamate signaling in brain areas involved in reward circuits, such as amygdala, nucleus accumbens (acb) and ventral tegmental area (vta), causing loss of control in circuits that regulate behavioral control of craving, alcohol-seeking and intake. |
2023-01-01 |
2023-08-14 |
human |
| Alaa M Hammad, Asma'a Naser, Haneen Amawi, F Scott Hall, Amit K Tiwari, Bahaa Al-Tra. Effect of Amoxicillin/Clavulanic acid in attenuating Pregabalin-induced Condition Place Preference. Behavioural brain research. 2022-12-05. PMID:36470419. |
moreover, like other drugs of abuse, pregabalin also produced alterations in glutamate homeostasis, reducing the mrna expression of slc1a2 and slc7a11 in the nucleus accumbens (nac) and medial prefrontal cortex (mpfc). |
2022-12-05 |
2023-08-14 |
Not clear |
| Lan-Yuan Zhang, Andrew Y Kim, Joseph F Chee. Regulation of glutamate homeostasis in the nucleus accumbens by astrocytic CB1 receptors and its role in cocaine-motivated behaviors. Addiction neuroscience. vol 3. 2022-11-24. PMID:36419922. |
regulation of glutamate homeostasis in the nucleus accumbens by astrocytic cb1 receptors and its role in cocaine-motivated behaviors. |
2022-11-24 |
2023-08-14 |
Not clear |
| Lan-Yuan Zhang, Andrew Y Kim, Joseph F Chee. Regulation of glutamate homeostasis in the nucleus accumbens by astrocytic CB1 receptors and its role in cocaine-motivated behaviors. Addiction neuroscience. vol 3. 2022-11-24. PMID:36419922. |
here, we review key facets of cb1r-mediated astroglia regulation of synaptic glutamate transmission in the nucleus accumbens with a specific emphasis on cocaine-directed behaviors. |
2022-11-24 |
2023-08-14 |
Not clear |
| Peter J Vollbrecht, Kathryn M Nesbitt, Victoria M Addis, Keenan M Boulnemour, Daniel A Micheli, Kendall B Smith, Darleen A Sandoval, Robert T Kennedy, Carrie R Ferrari. Differential Regulation of Nucleus Accumbens Glutamate and GABA in Obesity-Prone and Obesity-Resistant Rats. Journal of neurochemistry. 2022-11-06. PMID:36336816. |
differential regulation of nucleus accumbens glutamate and gaba in obesity-prone and obesity-resistant rats. |
2022-11-06 |
2023-08-14 |
rat |
| Daozhong Jin, Hong Chen, Shao-Rui Chen, Hui-Lin Pa. α2δ-1 Protein drives opioid-induced conditioned reward and synaptic NMDA receptor hyperactivity in the nucleus accumbens. Journal of neurochemistry. 2022-10-12. PMID:36222452. |
glutamate nmda receptors (nmdars) in the nucleus accumbens (nac) are critically involved in drug dependence and reward. |
2022-10-12 |
2023-08-14 |
mouse |
| Shuo Li, Xiao-Qin Zhang, Chuan-Chuan Liu, Zhi-Yuan Wang, Guan-Yi Lu, Hao-Wei Shen, Ning Wu, Jin Li, Fei L. IRAS/Nischarin modulates morphine reward by glutamate receptor activation in the nucleus accumbens of mouse brain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-09-09. PMID:36076473. |
iras/nischarin modulates morphine reward by glutamate receptor activation in the nucleus accumbens of mouse brain. |
2022-09-09 |
2023-08-14 |
mouse |