| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takeru Ueno, Manabu Yamanaka, Wataru Taniguchi, Naoko Nishio, Yuki Matsuyama, Ryo Miyake, Yuta Kaimochi, Terumasa Nakatsuka, Hiroshi Yamad. Methylglyoxal activates Transient receptor potential A1/V1 via reactive oxygen species in the spinal dorsal horn. Molecular pain. 2024-02-07. PMID:38323375. |
these results suggest that mgo increases spontaneous glutamate release from the presynaptic terminal to spinal dorsal horn neurons through trpa1, trpv1, and ros and could enhance excitatory synaptic transmission. |
2024-02-07 |
2024-02-09 |
rat |
| Bruno Pradier, Daniel Segelcke, Sylvia Reichl, P K Zahn, E M Pogatzki-Zah. Spinal GABA transporter 1 contributes to evoked-pain related behavior but not resting pain after incision injury. Frontiers in molecular neuroscience. vol 16. 2023-12-22. PMID:38130683. |
further, we determined the expression profile of spinal dorsal horn gat-1 and glutamate decarboxylase 65/67 (gad65/67) by protein expression analyses at four time points post-incision. |
2023-12-22 |
2023-12-24 |
rat |
| b' Yuying Huang \\xe9\\xbb\\x84\\xe7\\x8e\\x89\\xe8\\x8e\\xb9, Hong Chen \\xe9\\x99\\x88\\xe7\\xba\\xa2, Daozhong Jin \\xe9\\x87\\x91\\xe9\\x81\\x93\\xe5\\xbf\\xa0, Shao-Rui Chen \\xe9\\x99\\x88\\xe5\\xb0\\x91\\xe7\\x91\\x9e, Hui-Lin Pan \\xe6\\xbd\\x98\\xe6\\x83\\xa0\\xe9\\xba\\x9. NMDA receptors at primary afferent-excitatory neuron synapses differentially drive chemotherapy- and nerve trauma-induced pain hypersensitivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-05-15. PMID:37185237.' |
the spinal dorsal horn contains vesicular glutamate transporter-2 (vglut2)-expressing excitatory neurons and vesicular gaba transporter (vgat)-expressing inhibitory neurons, which normally have different roles in nociceptive transmission. |
2023-05-15 |
2023-08-14 |
mouse |
| Suting Liu, Hao Cheng, Liying Cui, Li Jin, Yunzi Li, Chao Zhu, Qing Ji, Jun Tan. Astrocytic purinergic signaling contributes to the development and maintenance of neuropathic pain via modulation of glutamate release. Journal of neurochemistry. 2023-03-04. PMID:36869630. |
importantly, the decreases in the levels of astrocytic glutamate transporter-1 (glt-1) in the spinal dorsal horn result in enhanced excitatory transmission and cause persistent pain. |
2023-03-04 |
2023-08-14 |
rat |
| Suting Liu, Hao Cheng, Liying Cui, Li Jin, Yunzi Li, Chao Zhu, Qing Ji, Jun Tan. Astrocytic purinergic signaling contributes to the development and maintenance of neuropathic pain via modulation of glutamate release. Journal of neurochemistry. 2023-03-04. PMID:36869630. |
conversely, in naïve rats, p2y1r overexpression induced a canonical np-like phenotype and spontaneous hypernociceptive responses, as well as increased the concentration of glutamate in the spinal dorsal horn. |
2023-03-04 |
2023-08-14 |
rat |
| Fen Li, Dongsheng Li, Jianguang Liu, Shifan Tang, Jie Yan, Hongwei Li, Zhengyun Wan, Lian Wang, Xisheng Ya. Activation of protease-activated receptor-1 causes chronic pain in lupus-prone mice via suppressing spinal glial glutamate transporter function and enhancing glutamatergic synaptic activity. The journal of pain. 2023-01-14. PMID:36641029. |
furthermore, we also identified that the enhanced glutamatergic synaptic activity and suppressed activity of glial glutamate transporters in the spinal dorsal horn of mrl/lpr mice are caused by activation of the par1 and suppression of ampk signaling pathways. |
2023-01-14 |
2023-08-14 |
mouse |
| b' Shao-Rui Chen \\xe9\\x99\\x88\\xe5\\xb0\\x91\\xe7\\x91\\x9e, Hong Chen \\xe9\\x99\\x88\\xe7\\xba\\xa2, Daozhong Jin \\xe9\\x87\\x91\\xe9\\x81\\x93\\xe5\\xbf\\xa0, Hui-Lin Pan \\xe6\\xbd\\x98\\xe6\\x83\\xa0\\xe9\\xba\\x9. Brief opioid exposure paradoxically augments primary afferent input to spinal excitatory neurons via \\xce\\xb12\\xce\\xb4-1-dependent presynaptic NMDA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-11-15. PMID:36379705.' |
here, we determined whether opioid-elicited ltp involves vesicular glutamate transporter-2 (vglut2) or vesicular gaba transporter (vgat) neurons in the spinal dorsal horn of male and female mice and identified underlying signaling mechanisms. |
2022-11-15 |
2023-08-14 |
mouse |
| Ming-Ming Zhang, Ming-Zhe Zhang, Yawen Wei, Ya-Cheng Lu, Jian Wang, Shan-Ming Yang, Ziying Zhu, Qian Chen, Mingwei Zhao, Jiaxue Dong, Xingwu Yang, Kun Yan. Postsynaptic glutamate response downregulates within presynaptic exaggerated glutamate release by activating TRPV1 in the spinal dorsal horn. Biochemical and biophysical research communications. vol 625. 2022-08-11. PMID:35952610. |
postsynaptic glutamate response downregulates within presynaptic exaggerated glutamate release by activating trpv1 in the spinal dorsal horn. |
2022-08-11 |
2023-08-14 |
Not clear |
| Rita Bardon. Experimental Protocols and Analytical Procedures for Studying Synaptic Transmission in Rodent Spinal Cord Dorsal Horn. Current protocols. vol 2. issue 4. 2022-04-18. PMID:35435326. |
basic protocol 1: spinal cord dissection and acute slice preparation basic protocol 2: stimulation of the dorsal root and extracellular recording (compound action potentials and field potentials) basic protocol 3: patch-clamp recording from dorsal horn neurons: action potential firing patterns and evoked synaptic inputs basic protocol 4: analysis of parameters responsible for changes in synaptic efficacy basic protocol 5: recording and analysis of currents mediated by astrocytic glutamate. |
2022-04-18 |
2023-08-13 |
Not clear |
| Rui Lu, Shan-Shan Cui, Xiao-Xia Wang, Lei Chen, Fei Liu, Jing Gao, Wei Wan. Astrocytic c-Jun N-terminal kinase-histone deacetylase-2 cascade contributes to glutamate transporter-1 decrease and mechanical allodynia following peripheral nerve injury in rats. Brain research bulletin. vol 175. 2021-12-10. PMID:34333051. |
decrease of glutamate transporter-1 (glt-1) in the spinal dorsal horn after nerve injury induces enhanced excitatory transmission and causes persistent pain. |
2021-12-10 |
2023-08-13 |
rat |
| Dakai Yang, Xingwu J Yang, Caifeng Shao, Kun Yan. Isoflurane decreases substantia gelatinosa neuron excitability and synaptic transmission from periphery in the rat spinal dorsal horn. Neuroreport. vol 32. issue 2. 2021-11-29. PMID:33323835. |
by using acute spinal cord slices from adult rats and the whole-cell recording technique, we found that aqueous isoflurane at the minimum alveolar concentration decreased postsynaptic neural excitability and enhanced membrane conductance, while suppressing glutamate release from presynaptic afferent onto substantia gelatinosa (lamina ii) neurons in the dorsal horn. |
2021-11-29 |
2023-08-13 |
rat |
| Julia C Quindlen-Hotek, Sonia Kartha, Beth A Winkelstei. Immediate inhibition of spinal secretory phospholipase A2 prevents the pain and elevated spinal neuronal hyperexcitability and neuroimmune regulatory genes that develop with nerve root compression. Neuroreport. vol 31. issue 15. 2021-10-22. PMID:32881777. |
this study investigated whether inhibiting spinal spla2 at the time of nerve root compression (nrc) modulates the pain, dorsal horn hyperexcitability, and spinal genes involved in glutamate signaling, nociception, and inflammation that are seen early after injury. |
2021-10-22 |
2023-08-13 |
rat |
| Cong Wang, Qi Wu, Ze Wang, Liang Hu, Charles Marshall, Ming Xia. Aquaporin 4 knockout increases complete freund's adjuvant-induced spinal central sensitization. Brain research bulletin. vol 156. 2021-08-20. PMID:31927062. |
cfa caused activation of astrocytes with upregulated expression levels of aqp4 and glutamate transporter 1 (glt1) in the dorsal horn of the spinal cord. |
2021-08-20 |
2023-08-13 |
mouse |
| Xiao-Min Wang, Pan Gu, Leorey Saligan, Michael Iadarola, Stanley Sau Ching Wong, Lian Kah Ti, Chi Wai Cheun. Dysregulation of EAAT2 and VGLUT2 Spinal Glutamate Transports via Histone Deacetylase 2 (HDAC2) Contributes to Paclitaxel-induced Painful Neuropathy. Molecular cancer therapeutics. vol 19. issue 10. 2021-08-06. PMID:32847971. |
paclitaxel (2 mg/kg, i.p., cumulative dose 8 mg/kg) induced long-lasting mechanical allodynia (>28 days) with increased glutamate concentration and decreased eaat2 expression with no changes in gaba/glycine or vgat (vesicular gaba transporter) in rat spinal dorsal horn. |
2021-08-06 |
2023-08-13 |
rat |
| Xiao-Min Wang, Pan Gu, Leorey Saligan, Michael Iadarola, Stanley Sau Ching Wong, Lian Kah Ti, Chi Wai Cheun. Dysregulation of EAAT2 and VGLUT2 Spinal Glutamate Transports via Histone Deacetylase 2 (HDAC2) Contributes to Paclitaxel-induced Painful Neuropathy. Molecular cancer therapeutics. vol 19. issue 10. 2021-08-06. PMID:32847971. |
these findings indicate that loss of the balance between glutamate release and reuptake due to dysregulation eaat2/vglut2/synaptophysin cascade in the spinal dorsal horn plays an important role in the development of paclitaxel-induced neuropathic pain. |
2021-08-06 |
2023-08-13 |
rat |
| Sui-Bin Ma, Hang Xian, Wen-Bin Wu, Shuo-Yao Ma, Yu-Ke Liu, Yu-Tong Liang, Huan Guo, Jun-Jun Kang, Ying-Ying Liu, Hui Zhang, Sheng-Xi Wu, Ceng Luo, Rou-Gang Xi. CCL2 facilitates spinal synaptic transmission and pain via interaction with presynaptic CCR2 in spinal nociceptor terminals. Molecular brain. vol 13. issue 1. 2021-08-05. PMID:33228784. |
in conclusion, we suggest that ccl2 can directly act on the ccr2 on presynaptic terminals of sensory neurons in the spinal dorsal horn, leading to an increase in the release of presynaptic glutamate and participate in the formation of central sensitization. |
2021-08-05 |
2023-08-13 |
Not clear |
| Santa Temi, Christopher Rudyk, Jennifer Armstrong, Jeffrey A Landrigan, Chris Dedek, Natalina Salmaso, Michael E Hildebran. Differential expression of GluN2 NMDA receptor subunits in the dorsal horn of male and female rats. Channels (Austin, Tex.). vol 15. issue 1. 2021-07-29. PMID:33509021. |
n-methyl-d-aspartate receptors (nmdars) are excitatory ionotropic glutamate receptors expressed throughout the cns, including in the spinal dorsal horn. |
2021-07-29 |
2023-08-13 |
rat |
| Jingsheng Xia, Yannong Dou, Yixiao Mei, Frances M Munoz, Ruby Gao, Xinghua Gao, Daling Li, Patrick Osei-Owusu, James Schiffenhaus, Alex Bekker, Yuan-Xiang Tao, Huijuan H. Orai1 is a crucial downstream partner of group I metabotropic glutamate receptor signaling in dorsal horn neurons. Pain. 2021-07-17. PMID:34252911. |
orai1 is a crucial downstream partner of group i metabotropic glutamate receptor signaling in dorsal horn neurons. |
2021-07-17 |
2023-08-13 |
mouse |
| Tzer-Bin Lin, Cheng-Yuan Lai, Ming-Chun Hsieh, Yu-Cheng Ho, Hsueh-Hsiao Wang, Po-Sheng Yang, Jen-Kun Cheng, Gin-Den Chen, Soo-Cheen Ng, Hsien-Yu Pen. Inhibiting MLL1-WDR5 interaction ameliorates neuropathic allodynia by attenuating histone H3 lysine 4 trimethylation-dependent spinal mGluR5 transcription. Pain. vol 161. issue 9. 2021-05-14. PMID:32345914. |
here, we show that mll1, which is induced in dorsal horn neuron after spinal nerve ligation (snl), is responsible for mechanical allodynia and increased h3k4me3 at metabotropic glutamate receptor subtype 5 (mglur5) promoter. |
2021-05-14 |
2023-08-13 |
Not clear |
| Hao Cheng, Lidong Zhang, Fei Xia, Li Jin, Suting Liu, Hongwei Ren, Chao Zhu, Qing Ji, Jun Tan. Astrocytic NDRG2 is critical in the maintenance of neuropathic pain. Brain, behavior, and immunity. vol 89. 2021-04-27. PMID:32688030. |
suppression of ndrg2 by intrathecal injection of an ndrg2-rnai-adenovirus significantly alleviated snl-induced mechanical and thermal hypersensitivity, as well as elevated astrocytic glutamate transporter 1 (glt-1) expression and downregulated pro-inflammatory cytokine levels, in the spinal dorsal horn of rats on day 10 after snl. |
2021-04-27 |
2023-08-13 |
rat |