| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Suting Liu, Hao Cheng, Liying Cui, Li Jin, Yunzi Li, Chao Zhu, Qing Ji, Jun Tan. Astrocytic purinergic signaling contributes to the development and maintenance of neuropathic pain via modulation of glutamate release. Journal of neurochemistry vol issue 2023 36869630 |
importantly, the decreases in the levels of astrocytic glutamate transporter-1 (glt-1) in the spinal dorsal horn result in enhanced excitatory transmission and cause persistent pain. |
2023-03-04 |
2023-03-06 |
rat |
| Suting Liu, Hao Cheng, Liying Cui, Li Jin, Yunzi Li, Chao Zhu, Qing Ji, Jun Tan. Astrocytic purinergic signaling contributes to the development and maintenance of neuropathic pain via modulation of glutamate release. Journal of neurochemistry vol issue 2023 36869630 |
conversely, in na\xc3\xafve rats, p2y1r overexpression induced a canonical np-like phenotype and spontaneous hypernociceptive responses, as well as increased the concentration of glutamate in the spinal dorsal horn. |
2023-03-04 |
2023-03-06 |
rat |
| Fen Li, Dongsheng Li, Jianguang Liu, Shifan Tang, Jie Yan, Hongwei Li, Zhengyun Wan, Lian Wang, Xisheng Ya. Activation of protease-activated receptor-1 causes chronic pain in lupus-prone mice via suppressing spinal glial glutamate transporter function and enhancing glutamatergic synaptic activity. The journal of pain vol issue 2023 36641029 |
furthermore, we also identified that the enhanced glutamatergic synaptic activity and suppressed activity of glial glutamate transporters in the spinal dorsal horn of mrl/lpr mice are caused by activation of the par1 and suppression of ampk signaling pathways. |
2023-01-14 |
2023-01-30 |
mouse |
| Shao-Rui Chen \\xe9\\x99\\x88\\xe5\\xb0\\x91\\xe7\\x91\\x9e, Hong Chen \\xe9\\x99\\x88\\xe7\\xba\\xa2, Daozhong Jin \\xe9\\x87\\x91\\xe9\\x81\\x93\\xe5\\xbf\\xa0, Hui-Lin Pan \\xe6\\xbd\\x98\\xe6\\x83\\xa0\\xe9\\xba\\x9. Brief opioid exposure paradoxically augments primary afferent input to spinal excitatory neurons via \\xce\\xb12\\xce\\xb4-1-dependent presynaptic NMDA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience vol issue 2022 36379705 |
here, we determined whether opioid-elicited ltp involves vesicular glutamate transporter-2 (vglut2) or vesicular gaba transporter (vgat) neurons in the spinal dorsal horn of male and female mice and identified underlying signaling mechanisms. |
2022-11-15 |
2023-01-30 |
mouse |
| Ming-Ming Zhang, Ming-Zhe Zhang, Yawen Wei, Ya-Cheng Lu, Jian Wang, Shan-Ming Yang, Ziying Zhu, Qian Chen, Mingwei Zhao, Jiaxue Dong, Xingwu Yang, Kun Yan. Postsynaptic glutamate response downregulates within presynaptic exaggerated glutamate release by activating TRPV1 in the spinal dorsal horn. Biochemical and biophysical research communications vol 625 issue 2022 35952610 |
postsynaptic glutamate response downregulates within presynaptic exaggerated glutamate release by activating trpv1 in the spinal dorsal horn. |
2022-08-11 |
2023-01-30 |
Not clear |
| Rita Bardon. Experimental Protocols and Analytical Procedures for Studying Synaptic Transmission in Rodent Spinal Cord Dorsal Horn. Current protocols vol 2 issue 4 2022 35435326 |
basic protocol 1: spinal cord dissection and acute slice preparation basic protocol 2: stimulation of the dorsal root and extracellular recording (compound action potentials and field potentials) basic protocol 3: patch-clamp recording from dorsal horn neurons: action potential firing patterns and evoked synaptic inputs basic protocol 4: analysis of parameters responsible for changes in synaptic efficacy basic protocol 5: recording and analysis of currents mediated by astrocytic glutamate. |
2022-04-18 |
2023-01-27 |
Not clear |
| Rui Lu, Shan-Shan Cui, Xiao-Xia Wang, Lei Chen, Fei Liu, Jing Gao, Wei Wan. Astrocytic c-Jun N-terminal kinase-histone deacetylase-2 cascade contributes to glutamate transporter-1 decrease and mechanical allodynia following peripheral nerve injury in rats. Brain research bulletin vol 175 issue 2021 34333051 |
decrease of glutamate transporter-1 (glt-1) in the spinal dorsal horn after nerve injury induces enhanced excitatory transmission and causes persistent pain. |
2021-12-10 |
2023-01-26 |
rat |
| Julia C Quindlen-Hotek, Sonia Kartha, Beth A Winkelstei. Immediate inhibition of spinal secretory phospholipase A2 prevents the pain and elevated spinal neuronal hyperexcitability and neuroimmune regulatory genes that develop with nerve root compression. Neuroreport vol 31 issue 15 2021 32881777 |
this study investigated whether inhibiting spinal spla2 at the time of nerve root compression (nrc) modulates the pain, dorsal horn hyperexcitability, and spinal genes involved in glutamate signaling, nociception, and inflammation that are seen early after injury. |
2021-10-22 |
2023-01-26 |
rat |
| Cong Wang, Qi Wu, Ze Wang, Liang Hu, Charles Marshall, Ming Xia. Aquaporin 4 knockout increases complete freund's adjuvant-induced spinal central sensitization. Brain research bulletin vol 156 issue 2021 31927062 |
cfa caused activation of astrocytes with upregulated expression levels of aqp4 and glutamate transporter 1 (glt1) in the dorsal horn of the spinal cord. |
2021-08-20 |
2023-01-26 |
mouse |
| Xiao-Min Wang, Pan Gu, Leorey Saligan, Michael Iadarola, Stanley Sau Ching Wong, Lian Kah Ti, Chi Wai Cheun. Dysregulation of EAAT2 and VGLUT2 Spinal Glutamate Transports via Histone Deacetylase 2 (HDAC2) Contributes to Paclitaxel-induced Painful Neuropathy. Molecular cancer therapeutics vol 19 issue 10 2021 32847971 |
paclitaxel (2 mg/kg, i.p., cumulative dose 8 mg/kg) induced long-lasting mechanical allodynia (>28 days) with increased glutamate concentration and decreased eaat2 expression with no changes in gaba/glycine or vgat (vesicular gaba transporter) in rat spinal dorsal horn. |
2021-08-06 |
2023-01-26 |
rat |
| Sui-Bin Ma, Hang Xian, Wen-Bin Wu, Shuo-Yao Ma, Yu-Ke Liu, Yu-Tong Liang, Huan Guo, Jun-Jun Kang, Ying-Ying Liu, Hui Zhang, Sheng-Xi Wu, Ceng Luo, Rou-Gang Xi. CCL2 facilitates spinal synaptic transmission and pain via interaction with presynaptic CCR2 in spinal nociceptor terminals. Molecular brain vol 13 issue 1 2021 33228784 |
in conclusion, we suggest that ccl2 can directly act on the ccr2 on presynaptic terminals of sensory neurons in the spinal dorsal horn, leading to an increase in the release of presynaptic glutamate and participate in the formation of central sensitization. |
2021-08-05 |
2023-01-26 |
Not clear |
| Santa Temi, Christopher Rudyk, Jennifer Armstrong, Jeffrey A Landrigan, Chris Dedek, Natalina Salmaso, Michael E Hildebran. Differential expression of GluN2 NMDA receptor subunits in the dorsal horn of male and female rats. Channels (Austin, Tex.) vol 15 issue 1 2021 33509021 |
n-methyl-d-aspartate receptors (nmdars) are excitatory ionotropic glutamate receptors expressed throughout the cns, including in the spinal dorsal horn. |
2021-07-29 |
2023-01-26 |
rat |
| Jingsheng Xia, Yannong Dou, Yixiao Mei, Frances M Munoz, Ruby Gao, Xinghua Gao, Daling Li, Patrick Osei-Owusu, James Schiffenhaus, Alex Bekker, Yuan-Xiang Tao, Huijuan H. Orai1 is a crucial downstream partner of group I metabotropic glutamate receptor signaling in dorsal horn neurons. Pain vol issue 2021 34252911 |
orai1 is a crucial downstream partner of group i metabotropic glutamate receptor signaling in dorsal horn neurons. |
2021-07-17 |
2023-01-26 |
mouse |
| Tzer-Bin Lin, Cheng-Yuan Lai, Ming-Chun Hsieh, Yu-Cheng Ho, Hsueh-Hsiao Wang, Po-Sheng Yang, Jen-Kun Cheng, Gin-Den Chen, Soo-Cheen Ng, Hsien-Yu Pen. Inhibiting MLL1-WDR5 interaction ameliorates neuropathic allodynia by attenuating histone H3 lysine 4 trimethylation-dependent spinal mGluR5 transcription. Pain vol 161 issue 9 2021 32345914 |
here, we show that mll1, which is induced in dorsal horn neuron after spinal nerve ligation (snl), is responsible for mechanical allodynia and increased h3k4me3 at metabotropic glutamate receptor subtype 5 (mglur5) promoter. |
2021-05-14 |
2023-01-26 |
Not clear |
| Hao Cheng, Lidong Zhang, Fei Xia, Li Jin, Suting Liu, Hongwei Ren, Chao Zhu, Qing Ji, Jun Tan. Astrocytic NDRG2 is critical in the maintenance of neuropathic pain. Brain, behavior, and immunity vol 89 issue 2021 32688030 |
suppression of ndrg2 by intrathecal injection of an ndrg2-rnai-adenovirus significantly alleviated snl-induced mechanical and thermal hypersensitivity, as well as elevated astrocytic glutamate transporter 1 (glt-1) expression and downregulated pro-inflammatory cytokine levels, in the spinal dorsal horn of rats on day 10 after snl. |
2021-04-27 |
2023-01-26 |
rat |
| Ayaka Haruta-Tsukamoto, Yu Miyahara, Hideki Funahashi, Toshikazu Nishimori, Yasushi Ishid. Perampanel attenuates scratching behavior induced by acute or chronic pruritus in mice. Biochemical and biophysical research communications vol 533 issue 4 2021 33028486 |
glutamate is a major excitatory neurotransmitter in the mammalian central nervous system and has a crucial role in pruriceptive processing in the spinal dorsal horn. |
2021-03-26 |
2023-01-26 |
mouse |
| Wei-Ting Liu, Meng-Hong Jiang, Zhi-Fu Wang, Mei-Feng Zheng, Xiao-Mei Chen, Liang-Ping Zhang, Sheng-Xiang Liang, Xiang-Mei Y. [Effect of wrist-ankle acupuncture on the expression of glutamate and NMDA receptor of the spinal dorsal horn in rats with neuropathic pain]. Zhen ci yan jiu = Acupuncture research vol 45 issue 8 2020 32869571 |
[effect of wrist-ankle acupuncture on the expression of glutamate and nmda receptor of the spinal dorsal horn in rats with neuropathic pain]. |
2020-10-09 |
2023-01-26 |
rat |
| Aifen Liu, Xiaopeng Wang, Hui Wang, Guoyi Lv, Yize Li, Hongmei L. \\xce\\x94-opioid receptor inhibition prevents remifentanil-induced post-operative hyperalgesia via regulating GluR1 trafficking and AMPA receptor function. Experimental and therapeutic medicine vol 15 issue 2 2020 29434817 |
a previous study by our group suggested that the trafficking and function of glutamate receptor 1 (glur1) subunits contributes to remifentanil-induced hyperalgesia by regulating the phosphorylation of glur1 in dorsal horn neurons. |
2020-10-01 |
2023-01-26 |
rat |
| Allison J Bigbee, Mahnaz Akhavan, Leif A Havto. Plasticity of Select Primary Afferent Projections to the Dorsal Horn after a Lumbosacral Ventral Root Avulsion Injury and Root Replantation in Rats. Frontiers in neurology vol 8 issue 2020 28824522 |
at 8\xe2\x80\x89weeks after a unilateral l6\xe2\x80\x89+\xe2\x80\x89s1 vra injury, quantitative morphological studies of the adjacent l5 dorsal horn showed reduced immunoreactivity (ir) for the vesicular glutamate transporter, vglut1 and isolectin b4 (ib4) binding, whereas ir for calcitonin gene-related peptide (cgrp) was unchanged. |
2020-09-30 |
2023-01-26 |
rat |
| Jinshan Shi, Ke Jiang, Zhaoduan L. Involvement of spinal glutamate transporter-1 in the development of mechanical allodynia and hyperalgesia associated with type 2 diabetes. Journal of pain research vol 9 issue 2020 27932896 |
it was found that zdf rats developed mechanical hyperalgesia and allodynia, which were associated with increased basal extracellular levels of glutamate and attenuated levels of glt-1 expression in the spinal cord, particularly in the dorsal horn. |
2020-09-29 |
2023-01-26 |
rat |