| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Xu, Xuxia Wei, Feng Gao, Xiongxiong Zhong, Ruixian Guo, Yun Ji, Xin Zhou, Jialiang Chen, Peiwen Yao, Xianguo Liu, Xuhong We. Nicotinamide adenine dinucleotide phosphate oxidase 2-derived reactive oxygen species contribute to long-term potentiation of C-fiber-evoked field potentials in spinal dorsal horn and persistent mirror-image pain following high-frequency stimulus of the sciatic nerve. Pain. vol 161. issue 4. 2021-04-21. PMID:32195784. |
this study provided electrophysiological and behavioral evidence that nox2-derived ros in the spinal cord contributed to persistent mirror-image pain by enhancing the synaptic transmission, which was mediated by increasing presynaptic glutamate release and activation of nmda receptor and nf-κb in the spinal dorsal horn. |
2021-04-21 |
2023-08-13 |
rat |
| Ayaka Haruta-Tsukamoto, Yu Miyahara, Hideki Funahashi, Toshikazu Nishimori, Yasushi Ishid. Perampanel attenuates scratching behavior induced by acute or chronic pruritus in mice. Biochemical and biophysical research communications. vol 533. issue 4. 2021-03-26. PMID:33028486. |
glutamate is a major excitatory neurotransmitter in the mammalian central nervous system and has a crucial role in pruriceptive processing in the spinal dorsal horn. |
2021-03-26 |
2023-08-13 |
mouse |
| Wei-Ting Liu, Meng-Hong Jiang, Zhi-Fu Wang, Mei-Feng Zheng, Xiao-Mei Chen, Liang-Ping Zhang, Sheng-Xiang Liang, Xiang-Mei Y. [Effect of wrist-ankle acupuncture on the expression of glutamate and NMDA receptor of the spinal dorsal horn in rats with neuropathic pain]. Zhen ci yan jiu = Acupuncture research. vol 45. issue 8. 2020-10-09. PMID:32869571. |
[effect of wrist-ankle acupuncture on the expression of glutamate and nmda receptor of the spinal dorsal horn in rats with neuropathic pain]. |
2020-10-09 |
2023-08-13 |
rat |
| Aifen Liu, Xiaopeng Wang, Hui Wang, Guoyi Lv, Yize Li, Hongmei L. Δ-opioid receptor inhibition prevents remifentanil-induced post-operative hyperalgesia via regulating GluR1 trafficking and AMPA receptor function. Experimental and therapeutic medicine. vol 15. issue 2. 2020-10-01. PMID:29434817. |
a previous study by our group suggested that the trafficking and function of glutamate receptor 1 (glur1) subunits contributes to remifentanil-induced hyperalgesia by regulating the phosphorylation of glur1 in dorsal horn neurons. |
2020-10-01 |
2023-08-13 |
rat |
| Allison J Bigbee, Mahnaz Akhavan, Leif A Havto. Plasticity of Select Primary Afferent Projections to the Dorsal Horn after a Lumbosacral Ventral Root Avulsion Injury and Root Replantation in Rats. Frontiers in neurology. vol 8. 2020-09-30. PMID:28824522. |
at 8 weeks after a unilateral l6 + s1 vra injury, quantitative morphological studies of the adjacent l5 dorsal horn showed reduced immunoreactivity (ir) for the vesicular glutamate transporter, vglut1 and isolectin b4 (ib4) binding, whereas ir for calcitonin gene-related peptide (cgrp) was unchanged. |
2020-09-30 |
2023-08-13 |
rat |
| Jinshan Shi, Ke Jiang, Zhaoduan L. Involvement of spinal glutamate transporter-1 in the development of mechanical allodynia and hyperalgesia associated with type 2 diabetes. Journal of pain research. vol 9. 2020-09-29. PMID:27932896. |
it was found that zdf rats developed mechanical hyperalgesia and allodynia, which were associated with increased basal extracellular levels of glutamate and attenuated levels of glt-1 expression in the spinal cord, particularly in the dorsal horn. |
2020-09-29 |
2023-08-13 |
rat |
| Karin N Westlund, Ying Lu, Liping Zhang, Todd C Pappas, Wen-Ru Zhang, Giulio Taglialatela, Sabrina L McIlwrath, Terry A McNearne. Tyrosine Kinase Inhibitors Reduce NMDA NR1 Subunit Expression, Nuclear Translocation, and Behavioral Pain Measures in Experimental Arthritis. Frontiers in physiology. vol 11. 2020-09-28. PMID:32536874. |
in the lumbar spinal cord dorsal horn, release of afferent nerve glutamate activates the neurons that relay information about injury pain. |
2020-09-28 |
2023-08-13 |
Not clear |
| Stephen G Woodhams, Robert Markus, Peter R W Gowler, Timothy J Self, Victoria Chapma. Cell type-specific super-resolution imaging reveals an increase in calcium-permeable AMPA receptors at spinal peptidergic terminals as an anatomical correlate of inflammatory pain. Pain. vol 160. issue 11. 2020-09-10. PMID:31425488. |
here, we apply combined confocal/direct stochastic optical reconstruction microscopy (dstorm) to reveal changes in calcium-permeable subunits of ampa-type glutamate receptors (glua1) at identified spinal cord dorsal horn (scdh) peptidergic axon terminals in a model of inflammatory pain. |
2020-09-10 |
2023-08-13 |
mouse |
| Takeshi Onishi, Tatsunori Watanabe, Mika Sasaki, Yoshinori Kamiya, Masao Horie, Hiroaki Tsukano, Ryuichi Hishida, Tatsuro Kohno, Hirohide Takebayashi, Hiroshi Baba, Katsuei Shibuk. Acute spatial spread of NO-mediated potentiation during hindpaw ischaemia in mice. The Journal of physiology. vol 597. issue 13. 2020-07-27. PMID:31087329. |
we also found that no production induced by ischaemia is not observed in the presence of an antagonist for group ii metabotropic glutamate receptors (mglurs) and that neuronal no synthase-positive dorsal horn neurons express group ii mglurs. |
2020-07-27 |
2023-08-13 |
mouse |
| Wan-You He, Bin Zhang, Wei-Cheng Zhao, Jian He, Lei Zhang, Qing-Ming Xiong, Jing Wang, Han-Bing Wan. Contributions of mTOR Activation-Mediated Upregulation of Synapsin II and Neurite Outgrowth to Hyperalgesia in STZ-Induced Diabetic Rats. ACS chemical neuroscience. vol 10. issue 5. 2020-05-29. PMID:30785256. |
synapsin ii is primarily expressed in the spinal dorsal horn, and its upregulation mediates a superfluous release of glutamate and a deficiency of gabaergic interneuron synaptic transmission, which is directly implicated in the facilitation of pain signals in the hyperalgesic nociceptive response. |
2020-05-29 |
2023-08-13 |
rat |
| Yong-Tao He, Xing-Lian Duan, Zhen Guo, Hu-Ling Li, Zhan-Wei Suo, Xian Yang, Meng-Yuan Zhang, Xiao-Dong H. A synthetic peptide disturbing GluN2A/SHP1 interaction in dorsal root ganglion attenuated pathological pain. European journal of pharmacology. vol 854. 2019-12-16. PMID:30951721. |
src homology 2 domain-containing protein tyrosine phosphatase 1 (shp1) interacts specifically with glun2a subunit of n-methyl-d-aspartate (nmda) subtype of glutamate receptors in spinal cord dorsal horn. |
2019-12-16 |
2023-08-13 |
Not clear |
| Rasmus Kordt Christensen, Rodolfo Delgado-Lezama, Raúl E Russo, Barbara Lykke Lind, Emanuel Loeza Alcocer, Martin Fredensborg Rath, Gabriela Fabbiani, Nicole Schmitt, Martin Lauritzen, Anders Victor Petersen, Eva Meier Carlsen, Jean-François Perrie. Spinal dorsal horn astrocytes release GABA in response to synaptic activation. The Journal of physiology. vol 596. issue 20. 2019-11-04. PMID:30079574. |
here we show that in the dorsal horn of the spinal cord, astrocytes respond to glutamate by releasing gaba. |
2019-11-04 |
2023-08-13 |
Not clear |
| Alexandra Pallottie, Ayomi Ratnayake, Li Ni, Cigdem Acioglu, Lun Li, Ersilia Mirabelli, Robert F Heary, Stella Elkabe. A toll-like receptor 9 antagonist restores below-level glial glutamate transporter expression in the dorsal horn following spinal cord injury. Scientific reports. vol 8. issue 1. 2019-10-09. PMID:29880832. |
a toll-like receptor 9 antagonist restores below-level glial glutamate transporter expression in the dorsal horn following spinal cord injury. |
2019-10-09 |
2023-08-13 |
mouse |
| Kunyuan Han, Anqi Zhang, Yunchang Mo, Tingting Mao, Binbin Ji, Dan Li, Xiuxiu Zhuang, Meizi Qian, Shuangdong Chen, Zhen Wang, Junlu Wan. Islet-cell autoantigen 69 mediates the antihyperalgesic effects of electroacupuncture on inflammatory pain by regulating spinal glutamate receptor subunit 2 phosphorylation through protein interacting with C-kinase 1 in mice. Pain. vol 160. issue 3. 2019-06-26. PMID:30699097. |
ica69 knockout led to reduced protein interacting with c-kinase 1 (pick1) expression and increased glutamate receptor subunit 2 (glur2) phosphorylation at ser880 in spinal dorsal horn. |
2019-06-26 |
2023-08-13 |
mouse |
| Xisheng Yan, Fen Li, Dylan W Maixner, Ruchi Yadav, Mei Gao, Mourad Wagdy Ali, Shelley B Hooks, Han-Rong Wen. Interleukin-1beta released by microglia initiates the enhanced glutamatergic activity in the spinal dorsal horn during paclitaxel-associated acute pain syndrome. Glia. vol 67. issue 3. 2019-06-13. PMID:30578561. |
il-1β also acted on neurons to increase presynaptic glutamate release and postsynaptic ampa receptor activity in the spinal dorsal horn. |
2019-06-13 |
2023-08-13 |
mouse |
| Meichun Deng, Shao-Rui Chen, Hui-Lin Pa. Presynaptic NMDA receptors control nociceptive transmission at the spinal cord level in neuropathic pain. Cellular and molecular life sciences : CMLS. vol 76. issue 10. 2019-05-28. PMID:30788514. |
increased presynaptic nmdar activity can potentiate glutamate release from primary afferent terminals to spinal dorsal horn neurons, which is crucial for the synaptic plasticity associated with neuropathic pain caused by traumatic nerve injury and chemotherapy-induced peripheral neuropathy. |
2019-05-28 |
2023-08-13 |
Not clear |
| P J Kristensen, G Gegelashvili, G Munro, A M Heegaard, O J Bjerru. The β-lactam clavulanic acid mediates glutamate transport-sensitive pain relief in a rat model of neuropathic pain. European journal of pain (London, England). vol 22. issue 2. 2018-12-11. PMID:28984398. |
following nerve injury, down-regulation of astroglial glutamate transporters (gluts) with subsequent extracellular glutamate accumulation is a key factor contributing to hyperexcitability within the spinal dorsal horn. |
2018-12-11 |
2023-08-13 |
rat |
| Georgi Gegelashvili, Ole Jannik Bjerru. Glutamate Transport System as a Novel Therapeutic Target in Chronic Pain: Molecular Mechanisms and Pharmacology. Advances in neurobiology. vol 16. 2018-09-25. PMID:28828613. |
the vast majority of peripheral neurons sensing noxious stimuli and conducting pain signals to the dorsal horn of the spinal cord utilize glutamate as a chemical transmitter of excitation. |
2018-09-25 |
2023-08-13 |
Not clear |
| Houda Radwani, Olivier Roca-Lapirot, Franck Aby, Maria José Lopez-Gonzalez, Rabia Benazzouz, Mohammed Errami, Alexandre Favereaux, Marc Landry, Pascal Fossa. Group I metabotropic glutamate receptor plasticity after peripheral inflammation alters nociceptive transmission in the dorsal of the spinal cord in adult rats. Molecular pain. vol 13. 2018-09-04. PMID:29020860. |
dorsal horn neurons of the spinal cord express group i metabotropic glutamate receptors (group i mglurs) that exert a complex role in nociceptive transmission. |
2018-09-04 |
2023-08-13 |
rat |
| Wei Liu, Yanling Lv, Facheng Re. PI3K/Akt Pathway is Required for Spinal Central Sensitization in Neuropathic Pain. Cellular and molecular neurobiology. vol 38. issue 3. 2018-08-29. PMID:28849293. |
cci also facilitated miniature excitatory postsynaptic potential of dorsal horn substantia gelatinosa neurons, increased phosphorylation of glutamate receptor subunit glua1 and synapsin at the synapse, and induced mechanic allodynia. |
2018-08-29 |
2023-08-13 |
rat |