All Relations between glutamate and spinal cord posterior horn

Publication Sentence Publish Date Extraction Date Species
Ming-Chun Hsieh, Yu-Cheng Ho, Cheng-Yuan Lai, Dylan Chou, Hsueh-Hsiao Wang, Gin-Den Chen, Tzer-Bin Lin, Hsien-Yu Pen. Melatonin impedes Tet1-dependent mGluR5 promoter demethylation to relieve pain. Journal of pineal research. vol 63. issue 4. 2018-06-11. PMID:28718992. in addition, enhanced tet1 expression, tet1-metabotropic glutamate receptor subtype 5 (mglur5) promoter coupling, demethylation at the mglur5 promoter, and mglur5 expression in dorsal horn neurons were observed. 2018-06-11 2023-08-13 rat
Yuangui Lin, Lian Liu, Haixia Jiang, Jieshu Zhou, Yuying Tan. Inhibition of interleukin-6 function attenuates the central sensitization and pain behavior induced by osteoarthritis. European journal of pharmacology. vol 811. 2018-05-30. PMID:28663035. blockade of il-6 function by tocilizumab markedly suppressed the activation of astrocytes and microglia in the ipsilateral dorsal horn, reduced c-fos immunoreactivity in dorsal horn neurons, and attenuated the upregulation of glutamate receptor subunits glur1 and nr2b in dorsal horn in the rats with mia-induced oa. 2018-05-30 2023-08-13 rat
Bin Hong, LingLing Yao, Linhui Ni, Li Wang, XingYue H. Antinociceptive effect of botulinum toxin A involves alterations in AMPA receptor expression and glutamate release in spinal dorsal horn neurons. Neuroscience. vol 357. 2018-05-22. PMID:28606856. antinociceptive effect of botulinum toxin a involves alterations in ampa receptor expression and glutamate release in spinal dorsal horn neurons. 2018-05-22 2023-08-13 Not clear
Bin Hong, LingLing Yao, Linhui Ni, Li Wang, XingYue H. Antinociceptive effect of botulinum toxin A involves alterations in AMPA receptor expression and glutamate release in spinal dorsal horn neurons. Neuroscience. vol 357. 2018-05-22. PMID:28606856. our results show that (1) btx-a can undergo retrograde axonal transport to the dorsal horn after peripheral application; (2) peripheral pretreatment with btx-a decreases the expression and function of ampa receptors in the spinal cord dorsal horn neurons; (3) peripheral pretreatment with btx-a does not change basal glutamate release, but decreases the effect of formalin-evoked release of glutamate in spinal cord dorsal horn neurons. 2018-05-22 2023-08-13 Not clear
Bin Hong, LingLing Yao, Linhui Ni, Li Wang, XingYue H. Antinociceptive effect of botulinum toxin A involves alterations in AMPA receptor expression and glutamate release in spinal dorsal horn neurons. Neuroscience. vol 357. 2018-05-22. PMID:28606856. these results suggest that peripheral application of btx-a can change ampa receptor expression in, and glutamate release from, spinal dorsal horn neurons, which may have significance in its central antinociceptive effects. 2018-05-22 2023-08-13 Not clear
Shafaq Sikandar, Ynette Gustavsson, Marc J Marino, Anthony H Dickenson, Tony L Yaksh, Linda S Sorkin, Roshni Ramachandra. Effects of intraplantar botulinum toxin-B on carrageenan-induced changes in nociception and spinal phosphorylation of GluA1 and Akt. The European journal of neuroscience. vol 44. issue 1. 2017-12-22. PMID:27108664. intraplantar carrageenan resulted in edema and mechanical allodynia in the injected paw and increased phosphorylation of a glutamate subunit (pglua1ser845) and a serine/threonine-specific protein kinase (paktser473) in spinal dorsal horn along with an increased incidence of spinal c-fos positive cells. 2017-12-22 2023-08-13 mouse
Kathleen Vincent, Shu Fan Wang, André Laferrière, Naresh Kumar, Terence J Coderr. Spinal intracellular metabotropic glutamate receptor 5 (mGluR5) contributes to pain and c-fos expression in a rat model of inflammatory pain. Pain. vol 158. issue 4. 2017-11-07. PMID:28030475. metabotropic glutamate receptor 5 (mglur5) is an excitatory g-protein-coupled receptor (gpcr) present in the spinal cord dorsal horn (scdh) where it has a well-established role in pain. 2017-11-07 2023-08-13 rat
Yahyah Aman, Thomas Pitcher, Raffaele Simeoli, Clive Ballard, Marzia Malcangi. Reduced thermal sensitivity and increased opioidergic tone in the TASTPM mouse model of Alzheimer's disease. Pain. vol 157. issue 10. 2017-11-06. PMID:27306045. in the spinal cord, β-amyloid (app/aβ) immunoreactivity was observed in dorsal and ventral horn neurons, and the expression of vesicular glutamate transporter 2 (vglut2) was significantly reduced, while the expression of the inhibitory peptides enkephalins was increased in tastpm dorsal horn, consistent with an increased inhibitory tone. 2017-11-06 2023-08-13 mouse
Andreas J Forstner, Julian Hecker, Andrea Hofmann, Anna Maaser, Céline S Reinbold, Thomas W Mühleisen, Markus Leber, Jana Strohmaier, Franziska Degenhardt, Jens Treutlein, Manuel Mattheisen, Johannes Schumacher, Fabian Streit, Sandra Meier, Stefan Herms, Per Hoffmann, André Lacour, Stephanie H Witt, Andreas Reif, Bertram Müller-Myhsok, Susanne Lucae, Wolfgang Maier, Markus Schwarz, Helmut Vedder, Jutta Kammerer-Ciernioch, Andrea Pfennig, Michael Bauer, Martin Hautzinger, Susanne Moebus, Lorena M Schenk, Sascha B Fischer, Sugirthan Sivalingam, Piotr M Czerski, Joanna Hauser, Jolanta Lissowska, Neonila Szeszenia-Dabrowska, Paul Brennan, James D McKay, Adam Wright, Philip B Mitchell, Janice M Fullerton, Peter R Schofield, Grant W Montgomery, Sarah E Medland, Scott D Gordon, Nicholas G Martin, Valery Krasnov, Alexander Chuchalin, Gulja Babadjanova, Galina Pantelejeva, Lilia I Abramova, Alexander S Tiganov, Alexey Polonikov, Elza Khusnutdinova, Martin Alda, Cristiana Cruceanu, Guy A Rouleau, Gustavo Turecki, Catherine Laprise, Fabio Rivas, Fermin Mayoral, Manolis Kogevinas, Maria Grigoroiu-Serbanescu, Tim Becker, Thomas G Schulze, Marcella Rietschel, Sven Cichon, Heide Fier, Markus M Nöthe. Identification of shared risk loci and pathways for bipolar disorder and schizophrenia. PloS one. vol 12. issue 2. 2017-08-25. PMID:28166306. the enriched gene-sets included calcium- and glutamate signaling, neuropathic pain signaling in dorsal horn neurons, and calmodulin binding. 2017-08-25 2023-08-13 Not clear
Itsaso Buesa, Zigor Aira, Jon Jatsu Azku. Regulation of Nociceptive Plasticity Threshold and DARPP-32 Phosphorylation in Spinal Dorsal Horn Neurons by Convergent Dopamine and Glutamate Inputs. PloS one. vol 11. issue 9. 2017-08-08. PMID:27610622. regulation of nociceptive plasticity threshold and darpp-32 phosphorylation in spinal dorsal horn neurons by convergent dopamine and glutamate inputs. 2017-08-08 2023-08-13 Not clear
Xisheng Yan, Dylan W Maixner, Fen Li, Han-Rong Wen. Chronic pain and impaired glial glutamate transporter function in lupus-prone mice are ameliorated by blocking macrophage colony-stimulating factor-1 receptors. Journal of neurochemistry. vol 140. issue 6. 2017-07-13. PMID:28072466. we provide evidence that the suppressed activity of glial glutamate transporters in the spinal dorsal horn in mrl/lpr mice is caused by activation of the csf-1 and il-1β signaling pathways. 2017-07-13 2023-08-13 mouse
Zigor Aira, Teresa Barrenetxea, Itsaso Buesa, Gontzal García Del Caño, Jon Jatsu Azku. Dopamine D1-like Receptors Regulate Constitutive, μ-Opioid Receptor-Mediated Repression of Use-Dependent Synaptic Plasticity in Dorsal Horn Neurons: More Harm than Good? The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 20. 2017-06-26. PMID:27194343. neurons expressing the d1 subtype were immunopositive for met-enkephalin and vesicular glutamate transporter vglut2, but not for gabaergic marker vgat.nerve ligation was followed by increased immunoreactivity for d1 in synaptic compartment (p3) in dorsal horn homogenates and presynaptic met-enkephalin-containing boutons. 2017-06-26 2023-08-13 rat
Dylan W Maixner, Xisheng Yan, Shelley B Hooks, Han-Rong Wen. AMPKα1 knockout enhances nociceptive behaviors and spinal glutamatergic synaptic activities via production of reactive oxygen species in the spinal dorsal horn. Neuroscience. vol 326. 2017-06-22. PMID:27058143. this is concomitantly associated with increased glutamatergic synaptic activities in neurons located in the superficial spinal dorsal horn, which results from the increased glutamate release from presynaptic terminals and function of ligand-gated glutamate receptors at the postsynaptic neurons. 2017-06-22 2023-08-13 mouse
Yongming Xu, Guangxia Cheng, Yanrong Zhu, Xin Zhang, Shaofeng Pu, Junzhen Wu, Yingying Lv, Dongping D. Anti-nociceptive roles of the glia-specific metabolic inhibitor fluorocitrate in paclitaxel-evoked neuropathic pain. Acta biochimica et biophysica Sinica. vol 48. issue 10. 2017-02-27. PMID:27563006. to explore the mechanisms involved, the expression of glial glutamate transporter 1 (glt-1) and the activation of mitogen-activated protein kinases in the spinal dorsal horn were analyzed. 2017-02-27 2023-08-13 Not clear
Aditi Falnikar, Tamara J Hala, David J Poulsen, Angelo C Lepor. GLT1 overexpression reverses established neuropathic pain-related behavior and attenuates chronic dorsal horn neuron activation following cervical spinal cord injury. Glia. vol 64. issue 3. 2016-10-06. PMID:26496514. following sci, chronic dysregulation of extracellular glutamate homeostasis has been shown to play a key role in persistent central hyperexcitability of superficial dorsal horn neurons that mediate pain neurotransmission, leading to various forms of neuropathic pain. 2016-10-06 2023-08-13 mouse
Aditi Falnikar, Tamara J Hala, David J Poulsen, Angelo C Lepor. GLT1 overexpression reverses established neuropathic pain-related behavior and attenuates chronic dorsal horn neuron activation following cervical spinal cord injury. Glia. vol 64. issue 3. 2016-10-06. PMID:26496514. in our unilateral cervical contusion model of mouse sci that is associated with ipsilateral forepaw heat hypersensitivity (a form of chronic at-level neuropathic pain-related behavior), we previously reported significant and long-lasting reductions in glt1 expression and functional glt1-mediated glutamate uptake in cervical spinal cord dorsal horn. 2016-10-06 2023-08-13 mouse
Xisheng Yan, Enshe Jiang, Han-Rong Wen. Activation of toll like receptor 4 attenuates GABA synthesis and postsynaptic GABA receptor activities in the spinal dorsal horn via releasing interleukin-1 beta. Journal of neuroinflammation. vol 12. 2016-08-08. PMID:25571780. through recording gabaergic currents in neurons and glial glutamate transporter currents in astrocytes in rodent spinal slices, we determined whether and how tlr4 modulates gabaergic synaptic activities in the superficial spinal dorsal horn. 2016-08-08 2023-08-13 Not clear
Fei Meng, Hong-You Ge, Yong-Hui Wang, Shou-Wei Yu. A afferent fibers are involved in the pathology of central changes in the spinal dorsal horn associated with myofascial trigger spots in rats. Experimental brain research. vol 233. issue 11. 2016-08-04. PMID:26210690. the results showed that in the spinal dorsal horn associated with mtrs, the expression of glutamate receptor (mglur1α/mglur5/nmdar1) increased, while the mean size of mtrs-related neurons was smaller than normal. 2016-08-04 2023-08-13 rat
Ying Wang, Zhi-Ping Lin, Hui-Zhe Zheng, Shuang Zhang, Zong-Luan Zhang, Yan Chen, Yi-Sheng You, Ming-Hua Yan. Abnormal DNA methylation in the lumbar spinal cord following chronic constriction injury in rats. Neuroscience letters. vol 610. 2016-05-09. PMID:26515497. glutamate decarboxylase 67 (gad 67) is a key synthetic enzyme for the main inhibitory transmitter gamma-aminobutyric acid (gaba), and diminishes in the spinal dorsal horn in rats following chronic constriction injury (cci). 2016-05-09 2023-08-13 rat
Xisheng Yan, Dylan W Maixner, Ruchi Yadav, Mei Gao, Pei Li, Michael G Bartlett, Han-Rong Wen. Paclitaxel induces acute pain via directly activating toll like receptor 4. Molecular pain. vol 11. 2016-02-22. PMID:25868824. through activating tlr4, paclitaxel increases glutamatergic synaptic activities and reduces glial glutamate transporter activities in the dorsal horn. 2016-02-22 2023-08-13 Not clear