| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aineng Peng, Jianbo Chai, Haiyuan Wu, Bing Bai, Huihui Yang, Weizhi He, Yonghou Zha. New Therapeutic Targets and Drugs for Schizophrenia Beyond Dopamine D2 Receptor Antagonists. Neuropsychiatric disease and treatment. vol 20. 2024-03-25. PMID:38525480. |
according to recent research, several receptors, including 5-hydroxytryptamine, glutamate, γ-aminobutyric acid, acetylcholine receptors and norepinephrine, play a role in the development of schizophrenia. |
2024-03-25 |
2024-03-27 |
Not clear |
| Shiv Verma, Vaibhav Singh, VijayKrishna Nagampalli, Lee E Ponsky, Chiang-Shan R Li, Herta Chao, Sanjay Gupt. Ligand-gated ion channels as potential biomarkers for ADT-mediated cognitive decline in prostate cancer patients. Molecular carcinogenesis. 2024-03-14. PMID:38482990. |
gene-disease association assigned forgetfulness, intellectual disability, visuospatial deficit, bipolar disorder, and other neurocognitive impairment with upregulation of type-1 angiotensin ii receptor, brain-derived neurotrophic factor, gaba type b receptor subunit 2 (gabbr2), gabra3, gabra5, gabrb1, glycine receptor beta, glutamate ionotropic receptor n-methyl-d-aspartate receptor (nmda) type subunit 1, glutamate ionotropic receptor nmda type subunit 2d, 5-hydroxytryptamine receptor 1d, interferon beta 1, and nuclear receptor subfamily 3 group c member 1 as top differentially expressed genes. |
2024-03-14 |
2024-03-16 |
human |
| L Sophie Gullino, Cara Fuller, Poppy Dunn, Helen M Collins, Salah El Mestikawy, Trevor Shar. Evidence for a Role of 5-HT-glutamate Co-releasing Neurons in Acute Stress Mechanisms. ACS chemical neuroscience. 2024-02-20. PMID:38377469. |
a major subpopulation of midbrain 5-hydroxytryptamine (5-ht) neurons expresses the vesicular glutamate transporter 3 (vglut3) and co-releases 5-ht and glutamate, but the function of this co-release is unclear. |
2024-02-20 |
2024-02-23 |
mouse |
| Linhong Jiang, Zhenyang Yu, Yanbin Zhao, Daqiang Yi. Obesogenic potentials of environmental artificial sweeteners with disturbances on both lipid metabolism and neural responses. The Science of the total environment. 2024-02-10. PMID:38340820. |
moreover, they also interfered neurotransmitters including serotonin (5-ht), dopamine (da) and acetylcholine (ach), with influences in gsα (e.g., via expressions of gsα-1, ser-7), glutamate (e.g., mgl-1), and cgmp-dependent signaling pathways (e.g., egl-4). |
2024-02-10 |
2024-02-14 |
caenorhabditis_elegans |
| Kamini R Shirsath, Vaishnavi K Patil, Sanjay N Awathale, Sameer N Goyal, Kartik T Nakhat. Pathophysiological and Therapeutic Implications of Neuropeptide S System in Neurological Disorders. Peptides. 2024-02-07. PMID:38325715. |
nps interacts with several neurotransmitters including glutamate, noradrenaline, serotonin, corticotropin-releasing factor, and gamma-aminobutyric acid. |
2024-02-07 |
2024-02-10 |
Not clear |
| Kelly E Dunham, B Jill Vento. Electrochemical and biosensor techniques to monitor neurotransmitter changes with depression. Analytical and bioanalytical chemistry. 2024-01-30. PMID:38289354. |
three neurotransmitters: serotonin, histamine, and glutamate, have been proposed to be key mediators of depression. |
2024-01-30 |
2024-02-01 |
Not clear |
| Maria Bove, Maria Grazia Morgese, Stefania Dimonte, Vladyslav Sikora, Lisa Pia Agosti, Maria Adelaide Palmieri, Paolo Tucci, Stefania Schiavone, Luigia Trabac. Increased stress vulnerability in the offspring of socially isolated rats: Behavioural, neurochemical and redox dysfunctions. Progress in neuro-psychopharmacology & biological psychiatry. 2024-01-19. PMID:38242425. |
levels of noradrenaline (na), serotonin (5-ht), 5-hydroxyindoleacetic acid (5-hiaa), glutamate (glu) and gaba were assessed in the prefrontal cortex (pfc). |
2024-01-19 |
2024-01-22 |
rat |
| Saché M Coury, Vanessa López, Zia Bajwa, Jordan M Garcia, Giana I Teresi, Kate R Kuhlman, Yan Li, Steve Cole, David J Miklowitz, Ioannis Pappas, Tiffany C H. Protocol for teen inflammation glutamate emotion research (TIGER): Toward predictors of treatment response and clinical course in depressed adolescents. Brain, behavior, & immunity - health. vol 35. 2024-01-18. PMID:38235411. |
here, we describe the scientific rationale and protocol for the teen inflammation glutamate emotion research (tiger) study, a prospective 18-month investigation of 160 depressed adolescents who will be assessed before and after treatment with selective serotonin reuptake inhibitors. |
2024-01-18 |
2024-01-20 |
Not clear |
| Đorđe Đorović, Vesna Lazarevic, Jovana Aranđelović, Vladimir Stevanović, Wojciech Paslawski, Xiaoqun Zhang, Milica Velimirović, Nataša Petronijević, Laslo Puškaš, Miroslav M Savić, Per Svenningsso. Maternal deprivation causes CaMKII downregulation and modulates glutamate, norepinephrine and serotonin in limbic brain areas in a rat model of single prolonged stress. Journal of affective disorders. 2024-01-10. PMID:38199412. |
maternal deprivation causes camkii downregulation and modulates glutamate, norepinephrine and serotonin in limbic brain areas in a rat model of single prolonged stress. |
2024-01-10 |
2024-01-13 |
rat |
| Đorđe Đorović, Vesna Lazarevic, Jovana Aranđelović, Vladimir Stevanović, Wojciech Paslawski, Xiaoqun Zhang, Milica Velimirović, Nataša Petronijević, Laslo Puškaš, Miroslav M Savić, Per Svenningsso. Maternal deprivation causes CaMKII downregulation and modulates glutamate, norepinephrine and serotonin in limbic brain areas in a rat model of single prolonged stress. Journal of affective disorders. 2024-01-10. PMID:38199412. |
an intricate relationship exists between various neurotransmitters (such as glutamate, norepinephrine or serotonin), calcium/calmodulin-dependent protein kinase ii (camkii), as an important regulator of glutamatergic synaptic function, and ptsd. |
2024-01-10 |
2024-01-13 |
rat |
| Kyle A Brown, Todd D Goul. Targeting metaplasticity mechanisms to promote sustained antidepressant actions. Molecular psychiatry. 2024-01-04. PMID:38177353. |
specifically, while the initiating mechanisms of these therapies may differ (e.g., cell type-specificity, n-methyl-d-aspartate receptor (nmdar) subtype-selective inhibition vs activation, metabotropic glutamate receptor 2/3 antagonism, ampa receptor potentiation, 5-ht receptor-activating psychedelics, etc. |
2024-01-04 |
2024-01-07 |
Not clear |
| Uriel Heresco-Levy, Bernard Lere. Synergistic psychedelic - NMDAR modulator treatment for neuropsychiatric disorders. Molecular psychiatry. 2023-11-09. PMID:37945694. |
serotonergic psychedelics enhance neuroplasticity via serotonin 2 a receptors (5ht2ar) activation and complex serotonergic-glutamatergic interactions involving the ionotropic glutamate receptors, tropomyosin receptor kinase b (trkb) and the mammalian target of rapamycin (mtor). |
2023-11-09 |
2023-11-20 |
Not clear |
| Georgia E Hodes, Debra Bangasser, Ioannis Sotiropoulos, Nikolaos Kokras, Christina Dall. Sex Differences in Stress Response: Classical Mechanisms and Beyond. Current neuropharmacology. 2023-10-19. PMID:37855285. |
then, we present sex differences in neurotransmitter levels, such as serotonin, dopamine, glutamate and gaba, as well as indices of neurodegeneration, such as amyloid β and tau. |
2023-10-19 |
2023-11-08 |
Not clear |
| Mohammad Asif, Mazen M Almehmadi, Ahad Amer Alsaiar. Diverse pharmacological potential of pyridazine analogs against various diseases. Medicinal chemistry (Shariqah (United Arab Emirates)). 2023-09-15. PMID:37711126. |
they also possess cyclooxygenase (cox) inhibitors, dipeptidyl peptidase inhibitors, phosphodiesterase inhibitors, glutamate transporter activators, adenosine receptor antagonists, serotonin receptors antagonists, lipooxygenase, cholinesterase, vasodilator, and anesthetics. |
2023-09-15 |
2023-10-07 |
Not clear |
| Na Su, Pingping Cai, Zhiqiang Dou, Xiaoxue Yin, Hongmin Xu, Jing He, Zhaofeng Li, Changzhong L. Brain nuclei and neural circuits in neuropathic pain and brain modulation mechanisms of acupuncture: a review on animal-based experimental research. Frontiers in neuroscience. vol 17. 2023-09-15. PMID:37712096. |
moreover, acupuncture and injurious information can affect different brain regions and influence brain functions via multiple aspects to play an analgesic role and improve synaptic plasticity by regulating the morphology and structure of brain synapses and the expression of synapse-related proteins; maintain the balance of excitatory and inhibitory neurons by regulating the secretion of glutamate, γ-aminobutyric acid, 5-hydroxytryptamine, and other neurotransmitters and receptors in the brain tissues; inhibit the overactivation of glial cells and reduce the release of pro-inflammatory mediators such as interleukins to reduce neuroinflammation in brain regions; maintain homeostasis of glucose metabolism and regulate the metabolic connections in the brain; and play a role in analgesia through the mediation of signaling pathways and signal transduction molecules. |
2023-09-15 |
2023-10-07 |
Not clear |
| Licia Vellucci, Mariateresa Ciccarelli, Elisabetta Filomena Buonaguro, Michele Fornaro, Giordano D'Urso, Giuseppe De Simone, Felice Iasevoli, Annarita Barone, Andrea de Bartolomei. The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in Psychosis, Translational Issues for Treatment-Resistant Schizophrenia. Biomolecules. vol 13. issue 8. 2023-08-26. PMID:37627285. |
an integrative view exploring this topic should take into account the following aspects: (i) the implication for glutamate, dopamine, and serotonin neurotransmission as demonstrated by genetic findings; (ii) the growing neuroimaging evidence of the common brain regions and dysfunctional circuits involved in both diseases; (iii) the pharmacological modulation of dopaminergic, serotoninergic, and glutamatergic systems as current therapeutic strategies in schizophrenia ocs; (iv) the recent discovery of midbrain dopamine neurons and dopamine d1- and d2-like receptors as orchestrating hubs in repetitive and psychotic behaviors; (v) the contribution of n-methyl-d-aspartate receptor subunits to both psychosis and ocd neurobiology. |
2023-08-26 |
2023-09-07 |
Not clear |
| Yunjiang Yu, Shihui Tan, Dongli Xie, Hongyan Li, Haibo Chen, Yao Dang, Mingdeng Xian. Photoaged microplastics induce neurotoxicity associated with damage to serotonergic, glutamatergic, dopaminergic, and GABAergic neuronal systems in Caenorhabditis elegans. The Science of the total environment. 2023-07-30. PMID:37517734. |
based on pearson's correlation, locomotion behaviors were negatively correlated with the neurotransmission of serotonin, glutamate, dopamine, and gaba. |
2023-07-30 |
2023-08-14 |
caenorhabditis_elegans |
| Dora Steel, Kimberley M Reid, Antonio Pisani, Ellen J Hess, Susan Fox, Manju A Kuria. Advances in targeting neurotransmitter systems in dystonia. International review of neurobiology. vol 169. 2023-07-23. PMID:37482394. |
in this chapter we discuss the physiology of key neurotransmitters, including dopamine, noradrenaline, serotonin (5-hydroxytryptamine), acetylcholine, gaba, glutamate, adenosine and cannabinoids, and their role in dystonia. |
2023-07-23 |
2023-08-14 |
Not clear |
| Jayakrishna S Madabushi, Priyal Khurana, Nihit Gupta, Mayank Gupt. Gut Biome and Mental Health: Do Probiotics Work? Cureus. vol 15. issue 6. 2023-07-14. PMID:37448433. |
several neurotransmitters, such as gaba (gamma-aminobutyric acid), serotonin, and glutamate, are produced in the gut, which are associated with anxiety and depressive symptoms. mental health and the gut have been linked closely, and many mental illnesses have been associated with gut dysbiosis. probiotics are marketed to improve gut health, act as mood enhancers, and be effective in reducing stress as unregulated over-the-counter supplements. given healthcare disparities and patient-doctor gaps across the globe, this review aims to appraise the literature on probiotics for the prevention and treatment of mental disorders. pubmed and google scholar databases were searched till march 2023 using the mesh words "prebiotics," "probiotics," "synbiotics," and "psychobiotics." |
2023-07-14 |
2023-08-14 |
Not clear |
| Carla Fonseca, Miren Ettcheto, Joana Bicker, Maria José Fernandes, Amílcar Falcão, Antoni Camins, Ana Fortun. Under the umbrella of depression and Alzheimer's disease physiopathology: can cannabinoids be a dual-pleiotropic therapy? Ageing research reviews. 2023-07-06. PMID:37414155. |
besides the well-known imbalance of neurotransmitter levels, including serotonin, noradrenaline, dopamine and glutamate, recent scientific evidence highlights aberrant spine density, neuroinflammation, dysregulation of neurotrophic factor levels and formation of amyloid beta (aβ) peptides, as the main physiopathological mechanisms compromised in depression and ad. |
2023-07-06 |
2023-08-14 |
Not clear |