| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ebru Alp, Sibel Doguizi, Fadime Mutlu Icduygu, Egemen Akgun, Mehmet Ali Sekeroglu, Murat Atabey Oze. An analysis of the relationship between ABCC8 and KCNJ11 gene polymorphisms and diabetic retinopathy in Turkish population. Ophthalmic genetics. 2024-02-27. PMID:38411150. |
katp and related genes (kcnj11 and abcc8) play an important role in insulin secretion by glucose-stimulated pancreatic beta cells and the regulation of insulin secretion. |
2024-02-27 |
2024-03-02 |
Not clear |
| Valentina Mancioppi, Erica Pozzi, Sara Zanetta, Anna Missineo, Silvia Savastio, Fabrizio Barbetti, Simona Mellone, Mara Giordano, Ivana Rabbon. Case report: Better late than never, but sooner is better: switch from CSII to sulfonylureas in two patients with neonatal diabetes due to KCNJ11 variants. Frontiers in endocrinology. vol 14. 2023-05-30. PMID:37251668. |
after the acute phase, patients with abcc8 or kcnj11 mutations treated with insulin therapy can switch to hypoglycemic sulfonylureas (su). |
2023-05-30 |
2023-08-14 |
Not clear |
| Chenxi Qin, Lina-Marcela Diaz-Gallo, Bowen Tang, Yunzhang Wang, Thuy-Dung Nguyen, Arvid Harder, Yi Lu, Leonid Padyukov, Johan Askling, Sara Häg. Repurposing antidiabetic drugs for rheumatoid arthritis: results from a two-sample Mendelian randomization study. European journal of epidemiology. 2023-04-13. PMID:37052755. |
corresponding ors (95%cis) were 0.83 (0.44-1.55) for genetic variation in the targets of insulin and its analogues (gene: insr), and 1.12 (0.83, 1.49) 1.25 (0.78-2.00) for genetic variation in the sulfonylurea targets (gene: abcc8 and kcnj11). |
2023-04-13 |
2023-08-14 |
Not clear |
| Tohru Yorifuji, Yoh Watanabe, Kana Kitayama, Yuki Yamada, Shinji Higuchi, Jun Mori, Masaru Kato, Toru Takahashi, Tokuko Okuda, Takane Aoyam. Targeted gene panel analysis of Japanese patients with maturity-onset diabetes of the young-like diabetes mellitus: Roles of inactivating variants in the ABCC8 and insulin resistance genes. Journal of diabetes investigation. 2022-12-12. PMID:36504295. |
targeted gene panel analysis of japanese patients with maturity-onset diabetes of the young-like diabetes mellitus: roles of inactivating variants in the abcc8 and insulin resistance genes. |
2022-12-12 |
2023-08-14 |
Not clear |
| Parth Sha. Genomic Editing and Diabetes. Advances in experimental medicine and biology. vol 1396. 2022-12-01. PMID:36454469. |
there are several established genes such as abcc8, tcf7l2, slc2a2, and capn10 which are known to influence blood insulin and glucose levels. |
2022-12-01 |
2023-08-14 |
Not clear |
| Jacqueline V Reyes Diaz, Yulin Jin, Kathryn Garber, Kristina M Cossen, Yujing Li, Peng Jin, Hong Li, Jee-Young Nina Ha. A homozygous exonic variant leading to exon skipping in ABCC8 as the cause of severe congenital hyperinsulinism. American journal of medical genetics. Part A. 2022-05-27. PMID:35621279. |
the abcc8 gene encodes the sulfonylurea receptor 1 (sur1), a key player in insulin secretion, and pathogenic variants in abcc8 are the most common cause of chi. |
2022-05-27 |
2023-08-13 |
Not clear |
| Vishal Musale, R Charlotte Moffett, Bosede Owolabi, J Michael Conlon, Peter R Flatt, Yasser H A Abdel-Waha. Mechanisms of action of the antidiabetic peptide [S4K]CPF-AM1 in db/db mice. Journal of molecular endocrinology. vol 66. issue 2. 2021-06-16. PMID:33252358. |
genes associated with insulin secretion (abcc8, kcnj11, slc2a2, cacn1c, glp1r, gipr) were significantly upregulated by treatment with [s4k]cpf-am1. |
2021-06-16 |
2023-08-13 |
mouse |
| Vishal Musale, R Charlotte Moffett, J Michael Conlon, Peter R Flatt, Yasser H Abdel-Waha. Beneficial actions of the [A14K] analog of the frog skin peptide PGLa-AM1 in mice with obesity and degenerative diabetes: A mechanistic study. Peptides. vol 136. 2021-06-10. PMID:33338546. |
peptide administration resulted in a significant (p < 0.01) increase in islet expression of the gene encoding pdx-1, a major transcription factor in islet cells determining β-cell survival and function, resulting in increased expression of genes involved with insulin secretion (abcc8, kcnj11, slc2a2, cacn1c) together with the genes encoding the incretin receptors glp1r and gipr. |
2021-06-10 |
2023-08-13 |
mouse |
| Monta Ustinova, Ivars Silamikelis, Ineta Kalnina, Laura Ansone, Vita Rovite, Ilze Elbere, Ilze Radovica-Spalvina, Davids Fridmanis, Jekaterina Aladyeva, Ilze Konrade, Valdis Pirags, Janis Klovin. Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals. PloS one. vol 14. issue 11. 2020-03-24. PMID:31703101. |
in addition to universal effects, 4 clusters of functionally related genes with a subject-specific differential expression were distinguished, including genes relevant to insulin production (hnf1b, hnf1a, hnf4a, gck, ins, neurod1, pax4, pdx1, abcc8, kcnj11) and cholesterol homeostasis (apob, ldlr, pcsk9). |
2020-03-24 |
2023-08-13 |
Not clear |
| T Koblas, I Leontovyc, S Loukotová, F Saude. Reprogramming of Human Pancreatic Organoid Cells into Insulin-Producing β-Like Cells by Small Molecules and in Vitro Transcribed Modified mRNA Encoding Neurogenin 3 Transcription Factor. Folia biologica. vol 65. issue 3. 2020-03-09. PMID:31638558. |
upon the reprogramming, ipcs formed 4.6 ± 1.2 % of the total cells and expressed typical markers (insulin, glucokinase, abcc8, kcnj11, slc2a2, slc30a8) and transcription factors (pdx1, neurod1, mafa, nkx2.2, nkx6.1, pax4, pax6) needed for the proper function of pancreatic β-cells. |
2020-03-09 |
2023-08-13 |
human |
| Lisa R Letourneau, Siri Atma W Greele. Congenital forms of diabetes: the beta-cell and beyond. Current opinion in genetics & development. vol 50. 2019-03-08. PMID:29454299. |
ongoing follow-up of patients with kcnj11 and abcc8 mutations has supported the safety and efficacy of sulfonylureas, as well as the use of insulin pumps and continuous glucose monitors in infants with insulin-requiring forms of monogenic diabetes. |
2019-03-08 |
2023-08-13 |
Not clear |
| Peter A Kropp, Jennifer C Dunn, Bethany A Carboneau, Doris A Stoffers, Maureen Ganno. Cooperative function of Pdx1 and Oc1 in multipotent pancreatic progenitors impacts postnatal islet maturation and adaptability. American journal of physiology. Endocrinology and metabolism. vol 314. issue 4. 2019-02-18. PMID:29351489. |
gene expression analysis at this age revealed significantly decreased expression of many genes important for glucose-stimulated insulin secretion (e.g., glut2, pcsk1/2, abcc8) exclusively in double heterozygotes. |
2019-02-18 |
2023-08-13 |
mouse |
| Sonya Galcheva, Sara Al-Khawaga, Khalid Hussai. Diagnosis and management of hyperinsulinaemic hypoglycaemia. Best practice & research. Clinical endocrinology & metabolism. vol 32. issue 4. 2018-12-11. PMID:30086874. |
recent advances in genetics have linked congenital hh to mutations in 14 different genes that play a key role in regulating insulin secretion (abcc8, kcnj11, glud1, gck, hadh, slc16a1, ucp2, hnf4a, hnf1a, hk1, pgm1, ppm2, cacna1d, foxa2). |
2018-12-11 |
2023-08-13 |
Not clear |
| Hüseyin Demirbilek, Khalid Hussai. Congenital Hyperinsulinism: Diagnosis and Treatment Update. Journal of clinical research in pediatric endocrinology. vol 9. issue Suppl 2. 2018-08-06. PMID:29280746. |
mutations in 12 different key genes (abcc8, kcnj11, glud1, gck, hadh, slc16a1, ucp2, hnf4a, hnf1a, hk1, pgm1 and pmm2) that are involved in the regulation of insulin secretion from pancreatic β-cells have been described to be responsible for the underlying molecular mechanisms leading to congenital hh. |
2018-08-06 |
2023-08-13 |
Not clear |
| Oliver Clifford-Mobley, Gill Rumsby, Swati Kanodia, Mohammed Didi, Richard Holt, Senthil Senniappa. Glycolate oxidase deficiency in a patient with congenital hyperinsulinism and unexplained hyperoxaluria. Pediatric nephrology (Berlin, Germany). vol 32. issue 11. 2018-06-12. PMID:28752386. |
from day 1 of life she had severe hypoglycaemia with an inappropriately elevated insulin concentration consistent with congenital hyperinsulinism (chi), confirmed by the finding of a homozygous mutation in abcc8 (encoding the sulfonylurea receptor 1). |
2018-06-12 |
2023-08-13 |
Not clear |
| Dragan Katanic, Ivana Vorgučin, Andrew Hattersley, Sian Ellard, Jayne A L Houghton, Dragana Obreht, Marija Knežević Pogančev, Jovan Vlaški, Danijela Pavko. A successful transition to sulfonylurea treatment in male infant with neonatal diabetes caused by the novel abcc8 gene mutation and three years follow-up. Diabetes research and clinical practice. vol 129. 2017-12-14. PMID:28511139. |
a case of two months aged male infant with life threatening diabetic ketoacidosis is presented with novel abcc8 gene mutation (p.f577l), successful transition from insulin to sulfonylurea and follow-up of three years. |
2017-12-14 |
2023-08-13 |
Not clear |
| Yanyan Zhao, Kun Shi, Xiaomei Su, Liqiang Xie, Yunjun Ya. Microcystin-LR induces dysfunction of insulin secretion in rat insulinoma (INS-1) cells: Implications for diabetes mellitus. Journal of hazardous materials. vol 314. 2017-10-16. PMID:27107231. |
a transcriptomic analysis revealed several key genes (e.g., pdx-1, neurod1, and abcc8) involved in insulin secretion are significantly differentially expressed in ins-1 cells in response to mc-lr exposure. |
2017-10-16 |
2023-08-13 |
human |
| Opeolu O Ojo, Dinesh K Srinivasan, Bosede O Owolabi, Mary K McGahon, R Charlotte Moffett, Tim M Curtis, J Michael Conlon, Peter R Flatt, Yasser H A Abdel-Waha. Molecular mechanisms mediating the beneficial metabolic effects of [Arg4]tigerinin-1R in mice with diet-induced obesity and insulin resistance. Biological chemistry. vol 397. issue 8. 2017-06-15. PMID:26966929. |
peptide administration resulted in up-regulation of key functional genes in islets involved insulin secretion (abcc8, kcnj11, cacna1c and slc2a2) and in skeletal muscle involved with insulin action (insr, irs1, pdk1, pik3ca, and slc2a4). |
2017-06-15 |
2023-08-13 |
mouse |
| Elif Ozsu, Dinesh Giri, Gulcan Seymen Karabulut, Senthil Senniappa. Successful transition to sulfonylurea therapy in two Iraqi siblings with neonatal diabetes mellitus and iDEND syndrome due to ABCC8 mutation. Journal of pediatric endocrinology & metabolism : JPEM. vol 29. issue 12. 2017-04-20. PMID:27849623. |
we report the successful transition from insulin to su in two iraqi siblings with pndm due to abcc8 mutation, one with idend. |
2017-04-20 |
2023-08-13 |
Not clear |
| Valerio Costa, Antonio Federico, Carla Pollastro, Carmela Ziviello, Simona Cataldi, Pietro Formisano, Alfredo Ciccodicol. Computational Analysis of Single Nucleotide Polymorphisms Associated with Altered Drug Responsiveness in Type 2 Diabetes. International journal of molecular sciences. vol 17. issue 7. 2017-03-15. PMID:27347941. |
inter-individual variability is principally due to single nucleotide polymorphisms, and differential drug responsiveness has been correlated to alteration in genes involved in drug metabolism (cyp2c9) or insulin signaling (irs1, abcc8, kcnj11 and pparg). |
2017-03-15 |
2023-08-13 |
Not clear |