| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guo-Liang Wang, Hong-Jie Yuan, Qiao-Qiao Kong, Jie Zhang, Xiao Han, Shuai Gong, Ming-Tao Xu, Nan He, Ming-Jiu Luo, Jing-He Ta. High glucose exposure of preimplantation embryos causes glucose intolerance and insulin resistance in F1 and F2 male offspring. Biochimica et biophysica acta. Molecular basis of disease. 2023-10-25. PMID:37879502. |
high glucose exposure of preimplantation embryos causes glucose intolerance and insulin resistance in f1 and f2 male offspring. |
2023-10-25 |
2023-11-08 |
Not clear |
| Shengqiang Han, Long You, Yeye Hu, Shuai Wei, Tingwu Liu, Jae Youl Cho, Weicheng H. Ginsenoside F2 enhances glucose metabolism by modulating insulin signal transduction in human hepatocarcinoma cells. Journal of ginseng research. vol 47. issue 3. 2023-05-30. PMID:37252284. |
ginsenoside f2 enhances glucose metabolism by modulating insulin signal transduction in human hepatocarcinoma cells. |
2023-05-30 |
2023-08-14 |
human |
| Leonardo Toshio Oshio, Ana Eliza Andreazzi, Jéssica Ferraz Lopes, Jackson Pereira de Sá, Mariana Bolotari, Vinícius Moreira Gonçalves Costa, Martha de Oliveira Guerra, Vera Maria Peter. A paternal hypercaloric diet affects the metabolism and fertility of F1 and F2 Wistar rat generations. Journal of developmental origins of health and disease. vol 11. issue 6. 2021-09-13. PMID:31937389. |
body weight, adiposity, f1 and f2 prepubertal age evaluations, oral glucose tolerance test, insulin tolerance test, organ weights, sperm count and morphology assessments, and histometric testicular analyses were performed. |
2021-09-13 |
2023-08-13 |
rat |
| Maribel Huerta-Cervantes, Donovan J Peña-Montes, Miguel Ángel López-Vázquez, Rocío Montoya-Pérez, Christian Cortés-Rojo, María Esther Olvera-Cortés, Alfredo Saavedra-Molin. Effects of Gestational Diabetes in Cognitive Behavior, Oxidative Stress and Metabolism on the Second-Generation Off-Spring of Rats. Nutrients. vol 13. issue 5. 2021-07-20. PMID:34066827. |
we also observed metabolic disturbances, particularly in the lipid and insulin levels of male and female f2 gd offspring. |
2021-07-20 |
2023-08-13 |
rat |
| M P R Machado, L A Gama, A P S Beckmann, A T Hauschildt, D J R Dall'Agnol, J R A Miranda, L A Corá, M F Améric. Paternal obesity and its transgenerational effects on gastrointestinal function in male rat offspring. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 54. issue 9. 2021-06-03. PMID:34076145. |
insulin levels decreased in f1, f2, and f3 generations. |
2021-06-03 |
2023-08-13 |
rat |
| Maria A Abrantes, Arwin M Valencia, Fayez Bany-Mohammed, Jacob V Aranda, Kay D Beharr. Intergenerational Influence of Antenatal Betamethasone on Growth, Growth Factors, and Neurological Outcomes in Rats. Reproductive sciences (Thousand Oaks, Calif.). vol 27. issue 1. 2020-12-07. PMID:32046399. |
by p70, growth was comparable, but glucose was higher, insulin was lower, and memory was retarded in the b group, and transmitted to the unexposed f2 offspring of b-exposed rats. |
2020-12-07 |
2023-08-13 |
rat |
| Wanyi Zhang, Rina Su, Hui Feng, Li Lin, Chen Wang, Huixia Yan. Transgenerational Obesity and Alteration of ARHGEF11 in the Rat Liver Induced by Intrauterine Hyperglycemia. Journal of diabetes research. vol 2019. 2020-04-13. PMID:31612150. |
the results showed severe growth restriction in f1 offspring and obesity, fatty liver, and insulin resistance in female f2 offspring, especially the offspring of female intrauterine hyperglycemia-exposed parents (f2g♀c♂) and both (f2g♀g♂). |
2020-04-13 |
2023-08-13 |
rat |
| Chiung-Huei Peng, Hsing-Chun Lin, Chih-Li Lin, Chau-Jong Wang, Chien-Ning Huan. Abelmoschus esculentus subfractions improved nephropathy with regulating dipeptidyl peptidase-4 and type 1 glucagon-like peptide receptor in type 2 diabetic rats. Journal of food and drug analysis. vol 27. issue 1. 2020-03-23. PMID:30648566. |
f1, f2 and fraction residues (fr) showed advantage on different aspects, which attenuates insulin resistance and metabolic disorder in vivo, and prevents renal-tubular change in vitro. |
2020-03-23 |
2023-08-13 |
rat |
| Cagri Camsari, Joseph K Folger, Sandeep K Rajput, Devin McGee, Keith E Latham, George W Smit. Transgenerational Effects of Periconception Heavy Metal Administration on Adipose Weight and Glucose Homeostasis in Mice at Maturity. Toxicological sciences : an official journal of the Society of Toxicology. vol 168. issue 2. 2020-03-12. PMID:30629257. |
indices of impaired glucose homeostasis were observed in matrilineally descended f2 male offspring, including reduced glucose tolerance, along with increased basal phosphorylation of insulin receptor substrate 1 (irs1) at serine 307 suggesting altered insulin signaling. |
2020-03-12 |
2023-08-13 |
mouse |
| Chien-Ning Huang, Chau-Jong Wang, Chih-Li Lin, An-Ting Yen, Hsin-Hua Li, Chiung-Huei Pen. Abelmoschus esculentus subfractions attenuate beta amyloid-induced neuron apoptosis by regulating DPP-4 with improving insulin resistance signals. PloS one. vol 14. issue 6. 2020-02-24. PMID:31237881. |
previously we reported dipeptidyl peptidase-4 (dpp-4) mediate insulin resistance signals, and abelmoschus esculentus (ae) subfractions f1 (rich in quercetin glucosides and triterpene ester) and f2 (containing large amount of polysaccharides) attenuate dpp-4-mediated apoptosis. |
2020-02-24 |
2023-08-13 |
Not clear |
| Chien-Ning Huang, Chau-Jong Wang, Chih-Li Lin, An-Ting Yen, Hsin-Hua Li, Chiung-Huei Pen. Abelmoschus esculentus subfractions attenuate beta amyloid-induced neuron apoptosis by regulating DPP-4 with improving insulin resistance signals. PloS one. vol 14. issue 6. 2020-02-24. PMID:31237881. |
in the present study, we aim to investigate if aβ induce neuron death by regulating dpp-4 and insulin resistance signals, and the putative effect of f1 and f2. |
2020-02-24 |
2023-08-13 |
Not clear |
| Amita Bansal, Cetewayo Rashid, Frances Xin, Changhong Li, Erzsebet Polyak, Anna Duemler, Tom van der Meer, Martha Stefaniak, Sana Wajid, Nicolai Doliba, Marisa S Bartolomei, Rebecca A Simmon. Sex- and Dose-Specific Effects of Maternal Bisphenol A Exposure on Pancreatic Islets of First- and Second-Generation Adult Mice Offspring. Environmental health perspectives. vol 125. issue 9. 2018-07-30. PMID:29161229. |
we recently demonstrated that perinatal bpa exposure is associated with higher body fat, impaired glucose tolerance, and reduced insulin secretion in first- (f1) and second-generation (f2) c57bl/6j male mice offspring. |
2018-07-30 |
2023-08-13 |
mouse |
| N Wang, C E Ren, Y Y Lou, F Le, L Y Wang, X Z Liu, Q T Zhan, L N Mao, H Y Lou, F Ji. Inter-generational effects of the in vitro maturation technique on pregnancy outcomes, early development, and cognition of offspring in mouse model. Clinica chimica acta; international journal of clinical chemistry. vol 473. 2018-05-07. PMID:27871845. |
increased body weights in the f1 generation and mouse number per litter in the f2 generation were observed in both the ivm and vvm groups; however, no insulin resistance was detected. |
2018-05-07 |
2023-08-13 |
mouse |
| Chien-Ning Huang, Chau-Jong Wang, Chih-Li Lin, Hui-Ting Lin, Chiung-Huei Pen. The nutraceutical benefits of subfractions of Abelmoschus esculentus in treating type 2 diabetes mellitus. PloS one. vol 12. issue 12. 2017-12-26. PMID:29216237. |
f2, rich in polysaccharides and carbohydrates, was most effective in attenuating hyperglycemia and insulin resistance (glucose: 200 mg/dl; homa-ir: 5.3) and especially hba1c (from 8.0% to 6.5%). |
2017-12-26 |
2023-08-13 |
rat |
| Philip M Coan, Oliver Hummel, Ana Garcia Diaz, Marjorie Barrier, Neza Alfazema, Penny J Norsworthy, Michal Pravenec, Enrico Petretto, Norbert Hübner, Timothy J Aitma. Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat. Disease models & mechanisms. vol 10. issue 3. 2017-12-05. PMID:28130354. |
we previously mapped hypertension-related insulin resistance quantitative trait loci (qtls) to rat chromosomes 4, 12 and 16 using adipocytes from f2 crosses between spontaneously hypertensive (shr) and wistar kyoto (wky) rats, and subsequently identified |
2017-12-05 |
2023-08-13 |
rat |
| Mervat Y Hanafi, Taha M Abdelkhalek, Mohamed I Saad, Moustafa M Saleh, Maha M Haiba, Maher A Kame. Diabetes-induced perturbations are subject to intergenerational transmission through maternal line. Journal of physiology and biochemistry. vol 72. issue 2. 2017-03-06. PMID:27038466. |
these groups were mated with normal healthy rats to assess the effect of grand-maternal diabetes on pregnancy outcome in f2 rats, as well as glucose-sensing parameters, insulin resistance, and glucose tolerance prenatally and postnatally. |
2017-03-06 |
2023-08-13 |
human |
| Mervat Y Hanafi, Taha M Abdelkhalek, Mohamed I Saad, Moustafa M Saleh, Maha M Haiba, Maher A Kame. Diabetes-induced perturbations are subject to intergenerational transmission through maternal line. Journal of physiology and biochemistry. vol 72. issue 2. 2017-03-06. PMID:27038466. |
we found that f2 offspring of diabetic mothers had impaired glucose sensing, increased oxidative stress, insulin resistance, and impaired glucose tolerance, and these effects were more prominent in the f2 offspring of f1 female rats (f2-df1f). |
2017-03-06 |
2023-08-13 |
human |
| Rina Su, Jie Yan, Huixia Yan. Transgenerational Glucose Intolerance of Tumor Necrosis Factor with Epigenetic Alteration in Rat Perirenal Adipose Tissue Induced by Intrauterine Hyperglycemia. Journal of diabetes research. vol 2016. 2016-12-20. PMID:26881249. |
additionally, f1 and f2 offspring that were exposed to intrauterine hyperglycemia had impaired insulin secretion from the islets. |
2016-12-20 |
2023-08-13 |
rat |
| Chun Xiao, Qingping Wu, Yizhen Xie, Jumei Zhang, Jianbin Ta. Hypoglycemic effects of Grifola frondosa (Maitake) polysaccharides F2 and F3 through improvement of insulin resistance in diabetic rats. Food & function. vol 6. issue 11. 2016-08-22. PMID:26311233. |
hypoglycemic effects of grifola frondosa (maitake) polysaccharides f2 and f3 through improvement of insulin resistance in diabetic rats. |
2016-08-22 |
2023-08-13 |
rat |
| Chun Xiao, Qingping Wu, Yizhen Xie, Jumei Zhang, Jianbin Ta. Hypoglycemic effects of Grifola frondosa (Maitake) polysaccharides F2 and F3 through improvement of insulin resistance in diabetic rats. Food & function. vol 6. issue 11. 2016-08-22. PMID:26311233. |
f2 and f3 are presumed to cause an improvement in insulin resistance, triggered by the reactivation of ir and irs-1. |
2016-08-22 |
2023-08-13 |
rat |