| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel Castellano-Castillo, Bruno Ramos-Molina, María Dolores Frutos, Isabel Arranz-Salas, Armando Reyes-Engel, María Isabel Queipo-Ortuño, Fernando Cardon. RNA expression changes driven by altered epigenetics status related to NASH etiology. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 174. 2024-04-05. PMID:38579398. |
nash subjects showed transcriptional downregulation for lipid and glucose metabolic pathways (e.g., abc transporters, ampk, foxo or insulin pathways). |
2024-04-05 |
2024-04-10 |
human |
| Khang Nguyen, Jialing Tang, Sungji Cho, Fan Ying, Hye Kyoung Sung, Kostas Pantopoulos, Gary Sweene. Salubrinal promotes phospho-eIF2α-dependent activation of UPR leading to autophagy-mediated attenuation of iron-induced insulin resistance. Molecular metabolism. 2024-03-25. PMID:38527647. |
insulin sensitivity was assessed using cells engineered to express an akt biosensor, based on nuclear foxo localization, as well as western blotting for insulin signaling proteins. |
2024-03-25 |
2024-03-28 |
mouse |
| Amene Saghazade. Exploring the pharmacological versatility of ficus carica: Modulating classical immunometabolism and beyond. Pharmacological research. vol 198. 2023-11-26. PMID:37995897. |
it reveals a variety of cellular and molecular targets for fcdp: cytokines (tnf-α, il-1β, il-6, il-10, il-12, il-18, ifn-γ), chemokines (ccl2), other inflammatory mediators (crp, pge2), immune receptors (tlr-2, tlr-4, fcεri), oxidative stress-related markers (sod, gsh, mda, gpx, catalase, ros, no, protein carbonyls), kinases (mapks, hexokinase, g6pase, fbpase, pepck, akt, ampk, gsk3, cdks), other enzymes (cox-2, inos, mmps, caspases), growth factors/receptors (vegf, egfr), hormones (dheas, prolactin, gnrh, fsh, lh, estradiol, dht, insulin), cell death-related markers (bcl-2, bax, bak, fasl, gasdermins, cytochrome c), glucose transporter protein (glut4), and transcription factors (nf-κb, hnf-4α, foxo, pgc-1α, ppar-γ, c/ebp-α, creb, nfatc1, stat3). |
2023-11-26 |
2023-11-28 |
Not clear |
| Jun-Jie Chen, Xiao-Xiao Liu, Peng-Hui Guo, Nicholas M Teets, Jin-Cheng Zhou, Wan-Bin Chen, Qiao-Zhi Luo, Nipapan Kanjana, Yu-Yan Li, Li-Sheng Zhan. Regulation of forkhead box O transcription factor by insulin signaling pathway controls the reproductive diapause of the lady beetle, Coccinella septempunctata. International journal of biological macromolecules. 2023-11-17. PMID:37977460. |
in some insects, insulin signaling, in conjunction with the downstream transcription factor forkhead box o (foxo), are master regulators of multiple physiological processes involved in diapause, but it is unclear whether insulin signaling and foxo affect the diapause of c. septempunctata. |
2023-11-17 |
2023-11-20 |
Not clear |
| Jun-Jie Chen, Xiao-Xiao Liu, Peng-Hui Guo, Nicholas M Teets, Jin-Cheng Zhou, Wan-Bin Chen, Qiao-Zhi Luo, Nipapan Kanjana, Yu-Yan Li, Li-Sheng Zhan. Regulation of forkhead box O transcription factor by insulin signaling pathway controls the reproductive diapause of the lady beetle, Coccinella septempunctata. International journal of biological macromolecules. 2023-11-17. PMID:37977460. |
in this study, we use a combination of approaches to demonstrate that insulin signaling and foxo mediate the diapause response in c. septempunctata. |
2023-11-17 |
2023-11-20 |
Not clear |
| Jun-Jie Chen, Xiao-Xiao Liu, Peng-Hui Guo, Nicholas M Teets, Jin-Cheng Zhou, Wan-Bin Chen, Qiao-Zhi Luo, Nipapan Kanjana, Yu-Yan Li, Li-Sheng Zhan. Regulation of forkhead box O transcription factor by insulin signaling pathway controls the reproductive diapause of the lady beetle, Coccinella septempunctata. International journal of biological macromolecules. 2023-11-17. PMID:37977460. |
taken together, these results suggest that a shutdown of insulin signaling prompts the activation of the downstream foxo gene, leading to the diapause phenotype. |
2023-11-17 |
2023-11-20 |
Not clear |
| María Concepción Izquierdo, Michael Harris, Niroshan Shanmugarajah, Kendra Zhong, Lale Ozcan, Gabrielle Fredman, Rebecca A Haeusle. Insulin sensitization by hepatic FoxO deletion is insufficient to lower atherosclerosis in mice. bioRxiv : the preprint server for biology. 2023-10-31. PMID:37905094. |
insulin sensitization by hepatic foxo deletion is insufficient to lower atherosclerosis in mice. |
2023-10-31 |
2023-11-08 |
mouse |
| Yinglin Lu, Jing Zhou, Fan Li, Heng Cao, Xingyu Zhang, Debing Yu, Zongliang He, Hongjie Ji, Kunpeng Lv, Guansuo Wu, Minli Y. The Integration of Genome-Wide DNA Methylation and Transcriptomics Identifies the Potential Genes That Regulate the Development of Skeletal Muscles in Ducks. International journal of molecular sciences. vol 24. issue 20. 2023-10-30. PMID:37895154. |
the kyoto encyclopedia of genes and genomes (keggs) analysis showed significant enrichment in mapk signaling, wnt signaling, apelin signaling, insulin signaling, and foxo signaling. |
2023-10-30 |
2023-11-08 |
Not clear |
| Rong Zhou, Yue Yu, Huan Miao, Na Zhao, Yuanqing Bu, Houhu Zhan. Contribution of differential alteration in oxidative stress and anti-oxidation related molecular signals to toxicity difference between atrazine and its main metabolites in nematodes. Ecotoxicology and environmental safety. vol 263. 2023-08-18. PMID:37595346. |
moreover, atrazine and its two main metabolites differentially activated the daf-16 encoding foxo transcriptional factor in insulin signaling pathway during the control of downstream target of sod-3. |
2023-08-18 |
2023-10-07 |
human |
| Xiaoming Ni, Hao Zhou, Yang Liu, Jingjing Zhan, Qian Meng, Hongyu Song, Xianliang Y. Toxic effects of tire wear particles and the leachate on the Chinese mitten crab (Eriocheir sinensis). Environmental pollution (Barking, Essex : 1987). 2023-08-11. PMID:37567401. |
however, twps could affect the expression of genes enriched in immune-related pathways, while the leachate regulated the enrichment of some other signaling pathways including foxo signaling pathway, insulin signaling pathway, rig-i-like receptor signaling pathway, nod-like receptor signaling pathway, ppar signaling pathway and neuroactive ligand-receptor interaction. |
2023-08-11 |
2023-08-16 |
Not clear |
| Jie Zhang, Siyu Wu, Yingjie Wen, Duo Lai, Shizi Kuang, Ruonan Zhang, Xiaoxia Xu, Fengliang Jin, Hanhong Xu, Xiao-Qiang Yu, Xuehua Sha. Eurycomanone (EN) Activates Transcription Factor FoxO by Inhibiting the Insulin Signaling Pathway to Suppress the Development of Journal of agricultural and food chemistry. 2023-06-29. PMID:37384556. |
eurycomanone (en) activates transcription factor foxo by inhibiting the insulin signaling pathway to suppress the development of the insulin-like signaling (iis) pathway is essential for insect growth and development. |
2023-06-29 |
2023-08-14 |
Not clear |
| Ying Deng, Shuai Jiang, Xueguang Lin, Bo Wang, Bo Chen, Jindong Tong, Weijun Shi, Bo Yu, Jingdong Tan. Differential expression profile of miRNAs between stable and vulnerable plaques of carotid artery stenosis patients. Genes & genetic systems. 2023-04-30. PMID:37121730. |
this indicated that the target genes of the identified demirnas were mainly enriched in protein phosphorylation, transcription, nitrogen compound metabolism, endocytosis and autophagy, and related to signaling pathways of hippo, mapk, insulin, tgf-β, foxo, ampk and p53. |
2023-04-30 |
2023-08-14 |
Not clear |
| Xi Sun, Yumeng Wang, Chaohui Wang, Yibin Wang, Zhouzheng Ren, Xin Yang, Xiaojun Yang, Yanli Li. Genome analysis reveals hepatic transcriptional reprogramming changes mediated by enhancers during chick embryonic development. Poultry science. vol 102. issue 4. 2023-02-10. PMID:36764138. |
further, some kegg pathways enriched from target genes of typical enhancer were overlapped with those from degs in transcriptome analysis such as insulin, foxo, mapk signaling pathways which were related to lipid metabolism. |
2023-02-10 |
2023-08-14 |
chicken |
| Yongting Zhao, Ruxin Wang, Qi Qin, Jiaojiao Yu, Hui Che, Lihong Wan. Differentially expressed tRNA-derived fragments and their roles in primary cardiomyocytes stimulated by high glucose. Frontiers in endocrinology. vol 13. 2023-01-30. PMID:36714586. |
the differential expression of 4 upregulated trfs was primarily involved in cardiac dysfunction-related processes, such as autophagy, age-rage signaling pathway in diabetic complications, mapk signaling pathway, insulin signaling pathway, foxo signaling pathway, insulin resistance and peroxisome pathways based on kyoto encyclopedia of genes and genomes (kegg) pathway enrichment analysis. |
2023-01-30 |
2023-08-14 |
Not clear |
| Saif Rehman, Hanane Hadj-Moussa, Liam Hawkins, Kenneth Store. Role of FOXO transcription factors in the tolerance of whole-body freezing in the wood frog, Rana sylvatica. Cryobiology. 2022-12-20. PMID:36539050. |
in this study, the role of forkhead box 'other' (foxo) transcription factors in freeze tolerance, and related changes to the insulin pathway, are investigated. |
2022-12-20 |
2023-08-14 |
Not clear |
| Christie M Penniman, Gourav Bhardwaj, Colette J Nowers, Chandler U Brown, Taylor L Junck, Cierra K Boyer, Jayashree Jena, Jordan D Fuqua, Vitor A Lira, Brian T O'Neil. Loss of FoxOs in muscle increases strength and mitochondrial function during aging. Journal of cachexia, sarcopenia and muscle. 2022-11-28. PMID:36442857. |
foxo transcription factors are targets of insulin action and deletion of foxos improves mitochondrial function in diabetes. |
2022-11-28 |
2023-08-14 |
Not clear |
| Atharva Shinde, Gargi Deore, Kedar P Navsariwala, Heena Tabassum, Minal Wan. We are all aging, and here's why. Aging medicine (Milton (N.S.W)). vol 5. issue 3. 2022-10-17. PMID:36247337. |
a few of the molecular pathways which are crucial in modulating the process of aging, such as the nutrient-sensing mtor pathway, insulin signaling, nrf2, foxo, pi3-akt, sirtuins, and ampk, and their effects are also covered in paramount detail. |
2022-10-17 |
2023-08-14 |
Not clear |
| Hui Xue, Xingxing Huang, Guofeng Chang, Weihua Ma, J Joe Hull, Lizhen Che. Reproductive capacity in Adelphocoris suturalis (Hemiptera: Miridae) is regulated by the insulin signaling pathway. Pesticide biochemistry and physiology. vol 187. 2022-09-20. PMID:36127067. |
here, we used rna interference (rnai)-mediated knockdown to examine the role of three critical insulin signaling pathway components (insulin receptor, inr; insulin receptor substrate 1, irs1; and forkhead box o, foxo) on reproductive capacity in the mirid adelphocoris suturalis. |
2022-09-20 |
2023-08-14 |
Not clear |
| Peng Ren, Jingbo Liu, Donghao Zhang, Chaowu Yang, Chunlin Yu, Meiying Chen, Zhongzhen Lin, Yiping Li. Transcriptome analysis of breast muscle and liver in full-sibling hybrid broilers at different ages. Gene. 2022-08-12. PMID:35961440. |
kegg annotation presented that total 5 pathways related to growth and development were determined in breast muscle, including cell cycle, insulin signaling pathway, foxo signaling pathway, focal adhesion and adrenergic signaling in cardiomyocytes. |
2022-08-12 |
2023-08-14 |
chicken |
| Andrés López-Cortés, Lavanya Prathap, Esteban Ortiz-Prado, Nikolaos C Kyriakidis, Ángela León Cáceres, Isaac Armendáriz-Castillo, Antonella Vera-Guapi, Verónica Yumiceba, Katherine Simbaña-Rivera, Gabriela Echeverría-Garcés, Jennyfer M García-Cárdenas, Andy Pérez-Villa, Patricia Guevara-Ramírez, Andrea Abad-Sojos, Jhommara Bautista, Lourdes Puig San Andrés, Nelson Varela, Santiago Guerrer. The close interaction between hypoxia-related proteins and metastasis in pancarcinomas. Scientific reports. vol 12. issue 1. 2022-06-30. PMID:35773405. |
the most significantly associated signaling pathways were hif-1, pi3k-akt, thyroid hormone, erbb, foxo, mtor, insulin, mapk, ras, ampk, and vegf. |
2022-06-30 |
2023-08-14 |
Not clear |